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The map label for this gene is degS [H]

Identifier: 73539829

GI number: 73539829

Start: 150088

End: 151488

Strand: Reverse

Name: degS [H]

Synonym: Reut_A0123

Alternate gene names: 73539829

Gene position: 151488-150088 (Counterclockwise)

Preceding gene: 73539832

Following gene: 73539823

Centisome position: 3.98

GC content: 66.31

Gene sequence:

>1401_bases
ATGTTCAAGCAGTCTTTCCTTCCACATACCCTGCTGCTCGCTGGCGGCATCCTGCTGACCCTGGCCGTGCTGGTCGCGTC
AGAGACCGGCAACGTACGCCTGCGCGAAAGCTACAACGAGGTCATCCGCTCGCAGCGCGTGCAGACGCAACTGGCCGCGC
TCAATGGCGAACTGGTCAATGCCGAGGCGGGCCAGCGCGGCTTCCTGCTCACCGGCAAGGACAGCTACCTGGATCCCTAT
TACCAGGCCCTGCCGCGCATCAACGAGCTGATGGCGCACATCCGCGCCGACTACGCGGCCGATCCCGAAGCGCTGCAGAT
GTTTGGCGAGACCTCCAAGCAGATCAGCAGCAAGCTCAATGAGATGGCGCTCACGCTGCTGTACGGCAAGCGCGACCTGG
CGGTGGCGCTGGACCTGGTGCGCACCGACTACGGCAAGCAGACCATGGACAACGCGCGCCGCGGCCTGGACCGGCTGCAG
GCGCGCGAAGCCGATACCGTCGCGCACCGGCTGGAGGGCGCCGAGCGCGACGTGCAGCTTTCGCGCTATGGCATCGCCTT
GCTGACCGCCATCAATATCGTGCTGCTGATCGCCGTGGGACTCGGCCATGCCAAGCGCCTGACCATGTCGGAATCAGCGC
GCGCGCAGGCCGAGGAGGAAGGCCTGCGGCTCGATCGCAAGGTGCGCGCGCGCACACGCCAGCTATCGGCGCTCGCAGGC
CACCTGCAGCGCGTGACCGAGGACGAGAAGACCAGGCTTGCGCGGGAGCTGCACGACGAACTCGGCGCGATCCTGACTGC
CATCAAGCTGGACTTGCACTGGGTGCGCCGGCGCGTACAGGAAAGCCAGCCGGAAGCCGCCGAAAAGCTGTCGCGCGTGA
TGCTTCACGTGGACCAGGGCATCCAGATCAAGCGCCGCCTGATCGAAGACCTGCGGCCGACCGTGCTGCTCAACCTCGGC
CTGCGTGCCGCGCTGCTCCAGCTGGTCGAGGACGTTGCCGGGCGTAACCACTGGGAATCCGAAGTCAGCGTGCCGGAAGA
ACTGCCACGCCTGCGCGACGACGCCGCGATCGCGCTCTACCGCATCGCCCAGGAGTCACTCACCAACGCCAGCAAGTATT
CGCAGGCCACGCATATCCGGCTGTCGGTCGGTTGCACCGACGAACAGCTGACGCTGACCGTTCACGACGATGGCAAGGGC
CTGCCGCCCGATTTCGATGCCGGCAGCACCGCAGGACACCATGGCCTGCTAGGCATGGAGCAGCGCGTGACAGCGCTGGG
CGGCAGCATGGAGATCGTGTCGTCGCCCAATACCGGGGTGAGCATCCGCGTCGAAGTCCCGCTCACCGCATCGGTCCTGG
CACCGGCGGAAGAACCCATCGGCGAGACGCAGCCGGAATAG

Upstream 100 bases:

>100_bases
CCGAAAGTGGCCGCAACCACTTTCAAAGGTTGACCTCGCCGTGAGGATGTGATCCCATGGCCGCACCCCGGCGGCAAGCG
CCCCACCGAGGAATTGCCTC

Downstream 100 bases:

>100_bases
ACTGAAATACGGTAATTCGGGACATACGAGGAGTGTGGAGAAGCGCGCGTCAGGCACCTGCGGCCGCCCGCTCCTCGATC
ACGCGGAACACCTGCTCCAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MFKQSFLPHTLLLAGGILLTLAVLVASETGNVRLRESYNEVIRSQRVQTQLAALNGELVNAEAGQRGFLLTGKDSYLDPY
YQALPRINELMAHIRADYAADPEALQMFGETSKQISSKLNEMALTLLYGKRDLAVALDLVRTDYGKQTMDNARRGLDRLQ
AREADTVAHRLEGAERDVQLSRYGIALLTAINIVLLIAVGLGHAKRLTMSESARAQAEEEGLRLDRKVRARTRQLSALAG
HLQRVTEDEKTRLARELHDELGAILTAIKLDLHWVRRRVQESQPEAAEKLSRVMLHVDQGIQIKRRLIEDLRPTVLLNLG
LRAALLQLVEDVAGRNHWESEVSVPEELPRLRDDAAIALYRIAQESLTNASKYSQATHIRLSVGCTDEQLTLTVHDDGKG
LPPDFDAGSTAGHHGLLGMEQRVTALGGSMEIVSSPNTGVSIRVEVPLTASVLAPAEEPIGETQPE

Sequences:

>Translated_466_residues
MFKQSFLPHTLLLAGGILLTLAVLVASETGNVRLRESYNEVIRSQRVQTQLAALNGELVNAEAGQRGFLLTGKDSYLDPY
YQALPRINELMAHIRADYAADPEALQMFGETSKQISSKLNEMALTLLYGKRDLAVALDLVRTDYGKQTMDNARRGLDRLQ
AREADTVAHRLEGAERDVQLSRYGIALLTAINIVLLIAVGLGHAKRLTMSESARAQAEEEGLRLDRKVRARTRQLSALAG
HLQRVTEDEKTRLARELHDELGAILTAIKLDLHWVRRRVQESQPEAAEKLSRVMLHVDQGIQIKRRLIEDLRPTVLLNLG
LRAALLQLVEDVAGRNHWESEVSVPEELPRLRDDAAIALYRIAQESLTNASKYSQATHIRLSVGCTDEQLTLTVHDDGKG
LPPDFDAGSTAGHHGLLGMEQRVTALGGSMEIVSSPNTGVSIRVEVPLTASVLAPAEEPIGETQPE
>Mature_466_residues
MFKQSFLPHTLLLAGGILLTLAVLVASETGNVRLRESYNEVIRSQRVQTQLAALNGELVNAEAGQRGFLLTGKDSYLDPY
YQALPRINELMAHIRADYAADPEALQMFGETSKQISSKLNEMALTLLYGKRDLAVALDLVRTDYGKQTMDNARRGLDRLQ
AREADTVAHRLEGAERDVQLSRYGIALLTAINIVLLIAVGLGHAKRLTMSESARAQAEEEGLRLDRKVRARTRQLSALAG
HLQRVTEDEKTRLARELHDELGAILTAIKLDLHWVRRRVQESQPEAAEKLSRVMLHVDQGIQIKRRLIEDLRPTVLLNLG
LRAALLQLVEDVAGRNHWESEVSVPEELPRLRDDAAIALYRIAQESLTNASKYSQATHIRLSVGCTDEQLTLTVHDDGKG
LPPDFDAGSTAGHHGLLGMEQRVTALGGSMEIVSSPNTGVSIRVEVPLTASVLAPAEEPIGETQPE

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=205, Percent_Identity=28.780487804878, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082311, Length=212, Percent_Identity=30.6603773584906, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788812, Length=206, Percent_Identity=28.1553398058252, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51410; Mature: 51410

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKQSFLPHTLLLAGGILLTLAVLVASETGNVRLRESYNEVIRSQRVQTQLAALNGELVN
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
AEAGQRGFLLTGKDSYLDPYYQALPRINELMAHIRADYAADPEALQMFGETSKQISSKLN
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EMALTLLYGKRDLAVALDLVRTDYGKQTMDNARRGLDRLQAREADTVAHRLEGAERDVQL
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
SRYGIALLTAINIVLLIAVGLGHAKRLTMSESARAQAEEEGLRLDRKVRARTRQLSALAG
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLQRVTEDEKTRLARELHDELGAILTAIKLDLHWVRRRVQESQPEAAEKLSRVMLHVDQG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
IQIKRRLIEDLRPTVLLNLGLRAALLQLVEDVAGRNHWESEVSVPEELPRLRDDAAIALY
HHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHH
RIAQESLTNASKYSQATHIRLSVGCTDEQLTLTVHDDGKGLPPDFDAGSTAGHHGLLGME
HHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHH
QRVTALGGSMEIVSSPNTGVSIRVEVPLTASVLAPAEEPIGETQPE
HHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MFKQSFLPHTLLLAGGILLTLAVLVASETGNVRLRESYNEVIRSQRVQTQLAALNGELVN
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
AEAGQRGFLLTGKDSYLDPYYQALPRINELMAHIRADYAADPEALQMFGETSKQISSKLN
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EMALTLLYGKRDLAVALDLVRTDYGKQTMDNARRGLDRLQAREADTVAHRLEGAERDVQL
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
SRYGIALLTAINIVLLIAVGLGHAKRLTMSESARAQAEEEGLRLDRKVRARTRQLSALAG
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLQRVTEDEKTRLARELHDELGAILTAIKLDLHWVRRRVQESQPEAAEKLSRVMLHVDQG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
IQIKRRLIEDLRPTVLLNLGLRAALLQLVEDVAGRNHWESEVSVPEELPRLRDDAAIALY
HHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHH
RIAQESLTNASKYSQATHIRLSVGCTDEQLTLTVHDDGKGLPPDFDAGSTAGHHGLLGME
HHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHH
QRVTALGGSMEIVSSPNTGVSIRVEVPLTASVLAPAEEPIGETQPE
HHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]