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The map label for this gene is uvrY [H]

Identifier: 73539827

GI number: 73539827

Start: 148924

End: 149556

Strand: Direct

Name: uvrY [H]

Synonym: Reut_A0121

Alternate gene names: 73539827

Gene position: 148924-149556 (Clockwise)

Preceding gene: 73539826

Following gene: 73539828

Centisome position: 3.91

GC content: 60.66

Gene sequence:

>633_bases
ATGATCCGCGTCCTGATCGCCGATGATCACGAGATTGTTCGCGCAGGGCTGCGCCAGTTTCTTGCTGACGAACCCGATAT
CCAGGTCACCGGCGAGGCCGGCAGCGGCGACGAAGTCATGGCGCAATTGCGCGACGGCGAATTCGACGTGCTGGTGCTCG
ACATCTCGATGCCCGAGCGCAACGGCATCGATGTGCTCAAACTGATCCGACAGCGCAAGCCTGACCTGCCTGTGCTGATT
CTTTCGACTTATCCGGAAGACCAGTACGCGATCAACCTGATCCGCGCGGGCGCTTCGGGTTATCTCACCAAGGAAAGCGC
GCCGGATGACTTGGTCAAGGCCATTCGCACCGTGGCCCAGGGCCGCCGCTATGTCAGCGCGGCTGTGGCGGACCTGCTGA
TCGGCGGGCTCGACAAGCCAACCGAACAGCCGGTGCACCAGATGCTGTCCGAGCGCGAGTTCCAGATCTTCTGCAAGCTG
TCACGCGGCCAGTCGGTATCGGTGATCGCGGACGAACTCTTCCTGAGCGTGAAGACCGTCAGCACTTACCGTTCGCGCAT
CCTGGAGAAAATGGGCATGAAAACCAACGCGGACCTGACCTACTACGCCATCAAGAACGGCCTGGTCGAATGA

Upstream 100 bases:

>100_bases
GACAGTCCGCGGCGCCTTGCGGCACTACAATGCTTACACGGCAAGCGGTTCCGCCTGCACCCGAATCTATTAGGCGAAAG
CCCCACCAGTGGAGCCCATG

Downstream 100 bases:

>100_bases
CGGCCAGGAGATCCCGACGCGAACGCTGCATCACGCGCCGGGTGAACCGTCCCACTGAACGTTTTTGAAGAATGTCGGAG
CAGGCTTCGAACTCCCCATA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIRVLIADDHEIVRAGLRQFLADEPDIQVTGEAGSGDEVMAQLRDGEFDVLVLDISMPERNGIDVLKLIRQRKPDLPVLI
LSTYPEDQYAINLIRAGASGYLTKESAPDDLVKAIRTVAQGRRYVSAAVADLLIGGLDKPTEQPVHQMLSEREFQIFCKL
SRGQSVSVIADELFLSVKTVSTYRSRILEKMGMKTNADLTYYAIKNGLVE

Sequences:

>Translated_210_residues
MIRVLIADDHEIVRAGLRQFLADEPDIQVTGEAGSGDEVMAQLRDGEFDVLVLDISMPERNGIDVLKLIRQRKPDLPVLI
LSTYPEDQYAINLIRAGASGYLTKESAPDDLVKAIRTVAQGRRYVSAAVADLLIGGLDKPTEQPVHQMLSEREFQIFCKL
SRGQSVSVIADELFLSVKTVSTYRSRILEKMGMKTNADLTYYAIKNGLVE
>Mature_210_residues
MIRVLIADDHEIVRAGLRQFLADEPDIQVTGEAGSGDEVMAQLRDGEFDVLVLDISMPERNGIDVLKLIRQRKPDLPVLI
LSTYPEDQYAINLIRAGASGYLTKESAPDDLVKAIRTVAQGRRYVSAAVADLLIGGLDKPTEQPVHQMLSEREFQIFCKL
SRGQSVSVIADELFLSVKTVSTYRSRILEKMGMKTNADLTYYAIKNGLVE

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=38.8625592417062, Blast_Score=161, Evalue=2e-41,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=38.5, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788712, Length=205, Percent_Identity=28.780487804878, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=32.4742268041237, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1786747, Length=200, Percent_Identity=31, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=30.6010928961749, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788546, Length=208, Percent_Identity=27.8846153846154, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082052, Length=134, Percent_Identity=32.8358208955224, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23324; Mature: 23324

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVLIADDHEIVRAGLRQFLADEPDIQVTGEAGSGDEVMAQLRDGEFDVLVLDISMPER
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCEEEEEEEECCCCC
NGIDVLKLIRQRKPDLPVLILSTYPEDQYAINLIRAGASGYLTKESAPDDLVKAIRTVAQ
CCHHHHHHHHHCCCCCCEEEEECCCCCHHEEEEEECCCCCCEECCCCCHHHHHHHHHHHH
GRRYVSAAVADLLIGGLDKPTEQPVHQMLSEREFQIFCKLSRGQSVSVIADELFLSVKTV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
STYRSRILEKMGMKTNADLTYYAIKNGLVE
HHHHHHHHHHHCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MIRVLIADDHEIVRAGLRQFLADEPDIQVTGEAGSGDEVMAQLRDGEFDVLVLDISMPER
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCEEEEEEEECCCCC
NGIDVLKLIRQRKPDLPVLILSTYPEDQYAINLIRAGASGYLTKESAPDDLVKAIRTVAQ
CCHHHHHHHHHCCCCCCEEEEECCCCCHHEEEEEECCCCCCEECCCCCHHHHHHHHHHHH
GRRYVSAAVADLLIGGLDKPTEQPVHQMLSEREFQIFCKLSRGQSVSVIADELFLSVKTV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
STYRSRILEKMGMKTNADLTYYAIKNGLVE
HHHHHHHHHHHCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]