Definition | Ralstonia eutropha JMP134 chromosome 1, complete sequence. |
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Accession | NC_007347 |
Length | 3,806,533 |
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The map label for this gene is metH [H]
Identifier: 73539825
GI number: 73539825
Start: 145216
End: 147963
Strand: Direct
Name: metH [H]
Synonym: Reut_A0119
Alternate gene names: 73539825
Gene position: 145216-147963 (Clockwise)
Preceding gene: 73539824
Following gene: 73539826
Centisome position: 3.81
GC content: 64.88
Gene sequence:
>2748_bases ATGAGCACGAACCAACTGCCCCCGCGCCCGATGCGCCTGTCCGGCCTGGAGCCGTTCACGATCGACGACGACACGCTGTT CGTCAACGTCGGCGAACGCACCAACGTCACAGGCTCGAAGGCCTTCGCCCGCATGATCCTGAACGGCCAGTTCGACGAGG CGCTGGCGGTCGCACGCCAGCAGGTCGAGAACGGCGCGCAGATCATCGACATCAACATGGACGAGGCGATGCTCGATTCG AAAGCGGCGATGGTCCGCTTCCTGAATCTGATCGCCTCCGAGCCGGACATCGCGCGCGTGCCGATCATGATCGATTCTTC CAAGTGGGAAGTGATCGAGGCCGGCCTGCAGTGCGTGCAGGGCAAGCCCGTGGTGAACTCGATCTCGCTCAAGGAAGGCG AGGAACAGTTCCGCCACCATGCCGAGCTGATCCGCCGCTATGGCGCGGCCACCGTCGTGATGGCCTTCGACGAGAAAGGC CAGGCCGACACCTTCGAGCGCAAGACCGCGATCTGCAAGCGCAGCTATGACTTCCTCGTGAACGAAGTCGGCTTCCCGCC CGAGGACATCATCTTCGACCCGAACATCTTCGCGGTGGCGACGGGTATCGAGGAACACAACAACTACGCGGTCGACTTCA TCGAAGCGACGCGCTGGATCAAGCAGAACCTGCCGTATGCGAAGGTGAGCGGCGGCGTGTCGAACGTGTCGTTCTCGTTC CGCGGCAATGACCTGGTGCGCGAGGCGATCCACACCGTGTTCCTGTTCCACGCCATCGAGGCGGGCATGGACATGGGCAT CGTCAATGCGGGCCAGCTCGGCGTGTACGACCAGCTTGATCCCGAACTGCGCGAGCGCGTGGAAGACGTGGTGCTGAACC GCCGCGACGACGCCACCGATCGCCTGCTGGAGATCGCCGACAAGTTCAAGGGCGGCGGCGCCAAGAAGGAAGAGAACCTG GCCTGGCGCGGCACGCCCGAGCAGCCGGTGCCGGTGGCAAAGCGCCTCGCGCACGCGCTGGTGCACGGCATCACCAATTT CATCGTCGACGATACCGAGGAGGCGCGCCAGGAAATCGCCGCGCGCGGCGGCCGTCCGATCGAGGTGATCGAAGGCCCGC TGATGGATGGCATGAACGTTGTCGGCGACCTGTTCGGCGCCGGCAAGATGTTCCTGCCGCAGGTGGTCAAGAGCGCGCGC GTGATGAAGCAGGCGGTGGCACACTTGCTGCCGTTCATCGAGGAAGAGAAGCGCCTGCTGGCCCAGGCCGGCGGCGACGT GCGCTCGCGTGGCAAGATCGTGATCGCCACCGTGAAGGGCGACGTGCACGACATCGGCAAGAACATCGTGTCGGTGGTGC TCCAGTGCAACAACTTCGAAGTGGTCAACATGGGCGTGATGGTCCCGTGCAACGAGATCCTGGCCAAGGCCAAGGTCGAG GGCGCGGACATCGTCGGCCTGTCGGGCCTGATCACGCCGTCGCTCGAGGAAATGGCCTACGTGGCCTCCGAGATGCAGCG TGACGACTACTTCCGCGTGAAGAAGATTCCGCTGCTGATCGGCGGCGCGACCACGTCGCGCGTGCATACGGCGGTGAAGA TCGCGCCGAACTACGAAGGCCCGGTGGTGTACGTGCCGGACGCTTCGCGTTCGGTCAGTGTGGCGTCGAGCCTGTTGTCG GACGAAGGCGCCGCGAAGTACCTGGACGACCTGAAGACCGACTACGAACGCATCCGCGTCCAGCACGCGGGCAAGAAGGC CACGCCGATGGTGACGCTGGCCCAGGCGCGCGCGAACAAGACGCCGATCGACTGGAGCGGTTACGTGCCGCCGAAGCCGA AGTTCATCGGCCGGCGCGTGTTCCGCAACTACGATCTCGCGGAACTGGCCAACTTCATCGACTGGGGCCCGTTCTTTCAG ACATGGGACCTGGCAGGCAAATTCCCGGACATCCTCAACGACGAGATCGTCGGCGAGTCCGCGCGCCGCGTGTTCTCGGA CGGCAAGGCCATGCTGTCGCGCCTGATCCAGGGCCGCTGGCTGACCGCCAACGGCGTGATGGCACTGCTGCCGGCCAATA CGGTGAACGATGATGACATCGAGATCTATACCGACGAGACGCGCAGCAAGGTCGCGCTGACGTGGCACAACGTGCGCCAG CAGAGCGAGCGCCCGGTGGTCGACGGCGTGCGTCGCCCGAACCGCTGCCTGTCCGATTTCATCGCGCCGAAATCGTCGGG CGTTGCCGACTACATCGGCCTGTTCGCGGTCACGGCCGGCATCGGCGTGGACAAGAAGGAAGCGCAGTTCGAGGCCGATC ACGACGACTACAGCGCGATCATGCTCAAGGCGCTGGCGGACCGCTTCGCCGAGGCCTTCGCCGAATGCCTGCATCAGCGC GTGCGGACCGACCTTTGGGGCTATGACGCGGCCGAGCACCTGAGCAACGACGAACTGATCGCCGAAAAGTACCGCGGCAT CCGCCCGGCTCCGGGCTATCCGGCGTGCCCCGAGCACACCGTCAAGGGTCCGATGTTCGAGTACCTCGATTGCGCCGAGA TCGGCATGGGCATCACCGAAGCCCTCGCCATGACGCCGGCCGCATCGGTCAGCGGCTTCTACCTTTCGCATCCGGACTCG ACCTACTTCACGATCGGCAAGATCGGCCAGGACCAGGTCGACGACATGGCGGCCCGCCGCCATGAAGACCGCAACGCCGT GGCGCGGGCGCTGGCCCCCAACCTGTAA
Upstream 100 bases:
>100_bases GAACACATTGCCGCCATCGCCGAGCGCATGGCGAAGCGGAACCCGCGCACGTGGCCGGGCCAGTACAGCGAAGCCGCCTG AGCCAGCGAGACAACAAGAC
Downstream 100 bases:
>100_bases CCGCATGCGTCGCCGGGGCGCCGCTATCGCGCGGCGCCTGCTCTGGCGCAGGTCCTTGATGCGGCAGGGAAATTCGCCTT GCATCGCAGCATCGCCATAC
Product: methionine synthase (B12-dependent)
Products: NA
Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]
Number of amino acids: Translated: 915; Mature: 914
Protein sequence:
>915_residues MSTNQLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQIIDINMDEAMLDS KAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLQCVQGKPVVNSISLKEGEEQFRHHAELIRRYGAATVVMAFDEKG QADTFERKTAICKRSYDFLVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF RGNDLVREAIHTVFLFHAIEAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATDRLLEIADKFKGGGAKKEENL AWRGTPEQPVPVAKRLAHALVHGITNFIVDDTEEARQEIAARGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSAR VMKQAVAHLLPFIEEEKRLLAQAGGDVRSRGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILAKAKVE GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSVSVASSLLS DEGAAKYLDDLKTDYERIRVQHAGKKATPMVTLAQARANKTPIDWSGYVPPKPKFIGRRVFRNYDLAELANFIDWGPFFQ TWDLAGKFPDILNDEIVGESARRVFSDGKAMLSRLIQGRWLTANGVMALLPANTVNDDDIEIYTDETRSKVALTWHNVRQ QSERPVVDGVRRPNRCLSDFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAIMLKALADRFAEAFAECLHQR VRTDLWGYDAAEHLSNDELIAEKYRGIRPAPGYPACPEHTVKGPMFEYLDCAEIGMGITEALAMTPAASVSGFYLSHPDS TYFTIGKIGQDQVDDMAARRHEDRNAVARALAPNL
Sequences:
>Translated_915_residues MSTNQLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQIIDINMDEAMLDS KAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLQCVQGKPVVNSISLKEGEEQFRHHAELIRRYGAATVVMAFDEKG QADTFERKTAICKRSYDFLVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF RGNDLVREAIHTVFLFHAIEAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATDRLLEIADKFKGGGAKKEENL AWRGTPEQPVPVAKRLAHALVHGITNFIVDDTEEARQEIAARGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSAR VMKQAVAHLLPFIEEEKRLLAQAGGDVRSRGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILAKAKVE GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSVSVASSLLS DEGAAKYLDDLKTDYERIRVQHAGKKATPMVTLAQARANKTPIDWSGYVPPKPKFIGRRVFRNYDLAELANFIDWGPFFQ TWDLAGKFPDILNDEIVGESARRVFSDGKAMLSRLIQGRWLTANGVMALLPANTVNDDDIEIYTDETRSKVALTWHNVRQ QSERPVVDGVRRPNRCLSDFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAIMLKALADRFAEAFAECLHQR VRTDLWGYDAAEHLSNDELIAEKYRGIRPAPGYPACPEHTVKGPMFEYLDCAEIGMGITEALAMTPAASVSGFYLSHPDS TYFTIGKIGQDQVDDMAARRHEDRNAVARALAPNL >Mature_914_residues STNQLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQIIDINMDEAMLDSK AAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLQCVQGKPVVNSISLKEGEEQFRHHAELIRRYGAATVVMAFDEKGQ ADTFERKTAICKRSYDFLVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSFR GNDLVREAIHTVFLFHAIEAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATDRLLEIADKFKGGGAKKEENLA WRGTPEQPVPVAKRLAHALVHGITNFIVDDTEEARQEIAARGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARV MKQAVAHLLPFIEEEKRLLAQAGGDVRSRGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILAKAKVEG ADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSVSVASSLLSD EGAAKYLDDLKTDYERIRVQHAGKKATPMVTLAQARANKTPIDWSGYVPPKPKFIGRRVFRNYDLAELANFIDWGPFFQT WDLAGKFPDILNDEIVGESARRVFSDGKAMLSRLIQGRWLTANGVMALLPANTVNDDDIEIYTDETRSKVALTWHNVRQQ SERPVVDGVRRPNRCLSDFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAIMLKALADRFAEAFAECLHQRV RTDLWGYDAAEHLSNDELIAEKYRGIRPAPGYPACPEHTVKGPMFEYLDCAEIGMGITEALAMTPAASVSGFYLSHPDST YFTIGKIGQDQVDDMAARRHEDRNAVARALAPNL
Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]
COG id: COG1410
COG function: function code E; Methionine synthase I, cobalamin-binding domain
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 pterin-binding domain [H]
Homologues:
Organism=Homo sapiens, GI169790923, Length=920, Percent_Identity=53.2608695652174, Blast_Score=940, Evalue=0.0, Organism=Escherichia coli, GI1790450, Length=922, Percent_Identity=61.7136659436009, Blast_Score=1098, Evalue=0.0, Organism=Caenorhabditis elegans, GI17535405, Length=930, Percent_Identity=53.8709677419355, Blast_Score=941, Evalue=0.0,
Paralogues:
None
Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006158 - InterPro: IPR011005 - InterPro: IPR003759 - InterPro: IPR011822 - InterPro: IPR000489 - InterPro: IPR003726 - InterPro: IPR004223 [H]
Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]
EC number: =2.1.1.13 [H]
Molecular weight: Translated: 100959; Mature: 100828
Theoretical pI: Translated: 5.06; Mature: 5.06
Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50972 PTERIN_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTNQLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQ CCCCCCCCCCCEECCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH QVENGAQIIDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLQCVQ HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHC GKPVVNSISLKEGEEQFRHHAELIRRYGAATVVMAFDEKGQADTFERKTAICKRSYDFLV CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH NEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF HHCCCCCHHEEECCCCEEEEECCHHCCCEEEHHHHHHHHHHHCCCCEEECCCCCEEEEEE RGNDLVREAIHTVFLFHAIEAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATD CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHH RLLEIADKFKGGGAKKEENLAWRGTPEQPVPVAKRLAHALVHGITNFIVDDTEEARQEIA HHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH ARGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLLPFIEEEKRLL HCCCCEEHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH AQAGGDVRSRGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILAKAKVE HHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHCC GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEG CCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECEEEEECCCHHHEEEEEEECCCCCC PVVYVPDASRSVSVASSLLSDEGAAKYLDDLKTDYERIRVQHAGKKATPMVTLAQARANK CEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHCCC TPIDWSGYVPPKPKFIGRRVFRNYDLAELANFIDWGPFFQTWDLAGKFPDILNDEIVGES CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCCCHHHCHHHHCHH ARRVFSDGKAMLSRLIQGRWLTANGVMALLPANTVNDDDIEIYTDETRSKVALTWHNVRQ HHHHHHCHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEHHHHH QSERPVVDGVRRPNRCLSDFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAI CCCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHH MLKALADRFAEAFAECLHQRVRTDLWGYDAAEHLSNDELIAEKYRGIRPAPGYPACPEHT HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCC VKGPMFEYLDCAEIGMGITEALAMTPAASVSGFYLSHPDSTYFTIGKIGQDQVDDMAARR CCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHH HEDRNAVARALAPNL HHHHHHHHHHHCCCC >Mature Secondary Structure STNQLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQ CCCCCCCCCCEECCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH QVENGAQIIDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLQCVQ HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHC GKPVVNSISLKEGEEQFRHHAELIRRYGAATVVMAFDEKGQADTFERKTAICKRSYDFLV CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH NEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF HHCCCCCHHEEECCCCEEEEECCHHCCCEEEHHHHHHHHHHHCCCCEEECCCCCEEEEEE RGNDLVREAIHTVFLFHAIEAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATD CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHH RLLEIADKFKGGGAKKEENLAWRGTPEQPVPVAKRLAHALVHGITNFIVDDTEEARQEIA HHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH ARGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLLPFIEEEKRLL HCCCCEEHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH AQAGGDVRSRGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILAKAKVE HHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHCC GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEG CCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECEEEEECCCHHHEEEEEEECCCCCC PVVYVPDASRSVSVASSLLSDEGAAKYLDDLKTDYERIRVQHAGKKATPMVTLAQARANK CEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHCCC TPIDWSGYVPPKPKFIGRRVFRNYDLAELANFIDWGPFFQTWDLAGKFPDILNDEIVGES CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCCCHHHCHHHHCHH ARRVFSDGKAMLSRLIQGRWLTANGVMALLPANTVNDDDIEIYTDETRSKVALTWHNVRQ HHHHHHCHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEHHHHH QSERPVVDGVRRPNRCLSDFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAI CCCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHH MLKALADRFAEAFAECLHQRVRTDLWGYDAAEHLSNDELIAEKYRGIRPAPGYPACPEHT HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCC VKGPMFEYLDCAEIGMGITEALAMTPAASVSGFYLSHPDSTYFTIGKIGQDQVDDMAARR CCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHH HEDRNAVARALAPNL HHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12620739 [H]