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The map label for this gene is echA12 [H]

Identifier: 73539816

GI number: 73539816

Start: 136956

End: 137789

Strand: Reverse

Name: echA12 [H]

Synonym: Reut_A0110

Alternate gene names: 73539816

Gene position: 137789-136956 (Counterclockwise)

Preceding gene: 73539817

Following gene: 73539815

Centisome position: 3.62

GC content: 67.15

Gene sequence:

>834_bases
ATGACCACACCGACTCCTGCGCCTACACCGCTGTCTTCCCGCTACGAACGCTATCGCGCACTCACGCTGCGCCAGCATGG
CCCGATCCTGGAAATCGTCATGGGCGCGGCGCAGTCCGCCAACCAGAAGCTGGCCACCGCGGATGCCAATATGCACCGCG
AGCTCGCCGAAATCTGGCGCGATGTATCGGCCGACCCCGACGTGCGCGTGGCGCTGATCCGCGGCGAGGGCAAGGGCTTT
TCCGCCGGTGGCGACCTGTCGCTCGTCGAAGACATGGCCAATGATTTCGAGACGCGCACGCGCGTGTGGCACGAGGCGCG
CGACCTCGTCTACAACGTCATCAACTGCGACAAGCCGGTGGTCTCGGCCATGCACGGGCCGGCCGTCGGCGCAGGCCTCG
TGGCCGGGCTGCTTGCCGATATCTCGATCGCGGCGAAGACCGCGCGCATCGTCGACGGGCACACGCGCCTGGGCGTGGCC
GCGGGCGACCATGCGGCGATCGTGTGGCCCCTGCTGTGCGGAATGGCCAAGGCCAAGTACTATCTGATGCTGTGCGAGTC
GGTCAGCGGCGAGGAAGCCGAGCGGATCGGCCTGGTCTCGCTGGCGGTGGAAGAGGAAGAACTGGTCGGGCGCGCGTTCG
AGGTGGCCAACCGGCTGGCGGCTGGTTCGCAGACGGCGATCCGCTGGACCAAGTACGCTCTCAACAACTGGCTGCGCATG
GCCGGTCCCGCTTTCGATTCCTCGCTGGCGCTCGAATTCATGGGCTTTGCCGGCCCCGACGTGCACGAAGGCATGGCGAG
CCTGCGCCAGAAGCGGCCGCCTCAGTTCAAGTAG

Upstream 100 bases:

>100_bases
GACAGGGCCGTGCCGGATGTGCATATAATTTACCGACCGGCCGGTTGGTGAATTGTTCCATGCACCCGGCACGGCCCTTT
TTCCATTCCACAGGCCTGCC

Downstream 100 bases:

>100_bases
TCCAACCAGATCGGATGGAGACAGACCGCGGCGCCCCTTGCCTGCCCGGCTGCCTCTACCACGGAGCGCGCGACATGTTC
GGACAGATTCCCGATTTCAC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MTTPTPAPTPLSSRYERYRALTLRQHGPILEIVMGAAQSANQKLATADANMHRELAEIWRDVSADPDVRVALIRGEGKGF
SAGGDLSLVEDMANDFETRTRVWHEARDLVYNVINCDKPVVSAMHGPAVGAGLVAGLLADISIAAKTARIVDGHTRLGVA
AGDHAAIVWPLLCGMAKAKYYLMLCESVSGEEAERIGLVSLAVEEEELVGRAFEVANRLAAGSQTAIRWTKYALNNWLRM
AGPAFDSSLALEFMGFAGPDVHEGMASLRQKRPPQFK

Sequences:

>Translated_277_residues
MTTPTPAPTPLSSRYERYRALTLRQHGPILEIVMGAAQSANQKLATADANMHRELAEIWRDVSADPDVRVALIRGEGKGF
SAGGDLSLVEDMANDFETRTRVWHEARDLVYNVINCDKPVVSAMHGPAVGAGLVAGLLADISIAAKTARIVDGHTRLGVA
AGDHAAIVWPLLCGMAKAKYYLMLCESVSGEEAERIGLVSLAVEEEELVGRAFEVANRLAAGSQTAIRWTKYALNNWLRM
AGPAFDSSLALEFMGFAGPDVHEGMASLRQKRPPQFK
>Mature_276_residues
TTPTPAPTPLSSRYERYRALTLRQHGPILEIVMGAAQSANQKLATADANMHRELAEIWRDVSADPDVRVALIRGEGKGFS
AGGDLSLVEDMANDFETRTRVWHEARDLVYNVINCDKPVVSAMHGPAVGAGLVAGLLADISIAAKTARIVDGHTRLGVAA
GDHAAIVWPLLCGMAKAKYYLMLCESVSGEEAERIGLVSLAVEEEELVGRAFEVANRLAAGSQTAIRWTKYALNNWLRMA
GPAFDSSLALEFMGFAGPDVHEGMASLRQKRPPQFK

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=228, Percent_Identity=25, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4502327, Length=241, Percent_Identity=26.9709543568465, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=222, Percent_Identity=30.1801801801802, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787660, Length=250, Percent_Identity=30.4, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI221142681, Length=210, Percent_Identity=30.952380952381, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788597, Length=228, Percent_Identity=26.7543859649123, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=236, Percent_Identity=26.6949152542373, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=237, Percent_Identity=27.4261603375527, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=235, Percent_Identity=26.8085106382979, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=183, Percent_Identity=26.2295081967213, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=25.1231527093596, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17535521, Length=219, Percent_Identity=23.7442922374429, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24654903, Length=197, Percent_Identity=25.8883248730964, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922422, Length=256, Percent_Identity=25.78125, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20129971, Length=234, Percent_Identity=24.3589743589744, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24653477, Length=234, Percent_Identity=24.3589743589744, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24653139, Length=236, Percent_Identity=26.6949152542373, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29954; Mature: 29822

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTPAPTPLSSRYERYRALTLRQHGPILEIVMGAAQSANQKLATADANMHRELAEIWR
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DVSADPDVRVALIRGEGKGFSAGGDLSLVEDMANDFETRTRVWHEARDLVYNVINCDKPV
HCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VSAMHGPAVGAGLVAGLLADISIAAKTARIVDGHTRLGVAAGDHAAIVWPLLCGMAKAKY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
YLMLCESVSGEEAERIGLVSLAVEEEELVGRAFEVANRLAAGSQTAIRWTKYALNNWLRM
HHHHHCCCCCCHHHHHHHHHEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AGPAFDSSLALEFMGFAGPDVHEGMASLRQKRPPQFK
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTPTPAPTPLSSRYERYRALTLRQHGPILEIVMGAAQSANQKLATADANMHRELAEIWR
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DVSADPDVRVALIRGEGKGFSAGGDLSLVEDMANDFETRTRVWHEARDLVYNVINCDKPV
HCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VSAMHGPAVGAGLVAGLLADISIAAKTARIVDGHTRLGVAAGDHAAIVWPLLCGMAKAKY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
YLMLCESVSGEEAERIGLVSLAVEEEELVGRAFEVANRLAAGSQTAIRWTKYALNNWLRM
HHHHHCCCCCCHHHHHHHHHEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AGPAFDSSLALEFMGFAGPDVHEGMASLRQKRPPQFK
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]