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The map label for this gene is coaX

Identifier: 73539809

GI number: 73539809

Start: 129843

End: 130670

Strand: Direct

Name: coaX

Synonym: Reut_A0103

Alternate gene names: 73539809

Gene position: 129843-130670 (Clockwise)

Preceding gene: 73539808

Following gene: 73539810

Centisome position: 3.41

GC content: 70.41

Gene sequence:

>828_bases
ATGAGCGCACCCGTGCTGCTGATCGATATCGGCAATACGCGCCTCAAATGGGCCTGGTGCAATGCCGGCGAGGTCGCCGT
GCAGGAACCGGGCCGGCTGCCGACGCCATGGCAGCACAGCGGCGCGGTCACGCATACCGACGACAGCGCCATGAACACGC
TGGCTGCCGTATTGCGCAACCTGCGCGGCGAGGGTCCGGTTCCGTCGGTATGGATTACCAATGTGGCCGGGCCGGTGATT
GCCGGCCAGGTCGATGCCGCGCTCAACGCAGCATTTGGCGATGGCGCATCGGTGCAATGGGTGCGCAGCGCCGCCGCCCA
TGGGAGTCTCGTCAGCGGCTACCGCGAGCCCACGCAACTGGGCGTGGACCGTTGGGTCGGCAGCATCGGCGCGCACCGCT
GGCTCCCCGGCGAGACGCTGCTGATCGTCACGGCGGGCACGGCGACGACGCTCGATATCGTCACGGCGCAGCCTGGCGGG
CAGGGCCGCTTCGAAGGCGGGCTGATCCTGCCGGGCCTGGCGCTGATGCTGGCCGCGCTTGCGCGCAATACCGCGCAACT
GCCGGCGCTGGATGTCGAGGACACCGGCACCGCGGCGGCCTCGCGCCTGCCGTGGGCCGACAACACGCACGATGCCATTG
CCGCTGGCTGCCTGGCCGCGCAGGCCGGCGCCATCGAGCGGACGTGGCGCACGCTGAGCGAACGCGGGCCGACGCGCTGC
CTGCTGTCGGGCGGCGCGCGGCACGCATTGGCCGGGGCGCTCGCTGTGCCATTCGAGATGCACGATAATCTCGTGCTGCT
CGGCCTGCATGCAATGGCAACGGCCTGA

Upstream 100 bases:

>100_bases
GGGGCGTCGACGGCGAGGGCCATCTGCTGCTGGAAACGCCTGCCGGTCTCGAACGCATTACCAGTGGCGAGCTGTCGTTG
CGGCCGGCCGGAGGCGCGGC

Downstream 100 bases:

>100_bases
GCGCAGCTCTGCCGCCGCATCTCGGTGATTCCGCCATCGTCAATGCGCCGACCCTTTCCCAACGCGCCGCCCCCATGTTC
CGCCTAGATCCGCCCGACCA

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSAPVLLIDIGNTRLKWAWCNAGEVAVQEPGRLPTPWQHSGAVTHTDDSAMNTLAAVLRNLRGEGPVPSVWITNVAGPVI
AGQVDAALNAAFGDGASVQWVRSAAAHGSLVSGYREPTQLGVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTAQPGG
QGRFEGGLILPGLALMLAALARNTAQLPALDVEDTGTAAASRLPWADNTHDAIAAGCLAAQAGAIERTWRTLSERGPTRC
LLSGGARHALAGALAVPFEMHDNLVLLGLHAMATA

Sequences:

>Translated_275_residues
MSAPVLLIDIGNTRLKWAWCNAGEVAVQEPGRLPTPWQHSGAVTHTDDSAMNTLAAVLRNLRGEGPVPSVWITNVAGPVI
AGQVDAALNAAFGDGASVQWVRSAAAHGSLVSGYREPTQLGVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTAQPGG
QGRFEGGLILPGLALMLAALARNTAQLPALDVEDTGTAAASRLPWADNTHDAIAAGCLAAQAGAIERTWRTLSERGPTRC
LLSGGARHALAGALAVPFEMHDNLVLLGLHAMATA
>Mature_274_residues
SAPVLLIDIGNTRLKWAWCNAGEVAVQEPGRLPTPWQHSGAVTHTDDSAMNTLAAVLRNLRGEGPVPSVWITNVAGPVIA
GQVDAALNAAFGDGASVQWVRSAAAHGSLVSGYREPTQLGVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTAQPGGQ
GRFEGGLILPGLALMLAALARNTAQLPALDVEDTGTAAASRLPWADNTHDAIAAGCLAAQAGAIERTWRTLSERGPTRCL
LSGGARHALAGALAVPFEMHDNLVLLGLHAMATA

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_CUPPJ (Q477E8)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_294329.1
- ProteinModelPortal:   Q477E8
- SMR:   Q477E8
- GeneID:   3611263
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A0103
- NMPDR:   fig|264198.3.peg.615
- HOGENOM:   HBG634537
- OMA:   RTTIRSR
- ProtClustDB:   PRK13328
- BioCyc:   REUT264198:REUT_A0103-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 28424; Mature: 28292

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: ACT_SITE 123-123 BINDING 114-114 BINDING 147-147 BINDING 209-209

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPVLLIDIGNTRLKWAWCNAGEVAVQEPGRLPTPWQHSGAVTHTDDSAMNTLAAVLRN
CCCCEEEEECCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHH
LRGEGPVPSVWITNVAGPVIAGQVDAALNAAFGDGASVQWVRSAAAHGSLVSGYREPTQL
HCCCCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCCCCHHHH
GVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTAQPGGQGRFEGGLILPGLALMLAAL
HHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHH
ARNTAQLPALDVEDTGTAAASRLPWADNTHDAIAAGCLAAQAGAIERTWRTLSERGPTRC
HCCCCCCCEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
LLSGGARHALAGALAVPFEMHDNLVLLGLHAMATA
EECCCCHHHHHHHHCCCEECCCCEEEEEEHHHHCC
>Mature Secondary Structure 
SAPVLLIDIGNTRLKWAWCNAGEVAVQEPGRLPTPWQHSGAVTHTDDSAMNTLAAVLRN
CCCEEEEECCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHH
LRGEGPVPSVWITNVAGPVIAGQVDAALNAAFGDGASVQWVRSAAAHGSLVSGYREPTQL
HCCCCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCCCCHHHH
GVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTAQPGGQGRFEGGLILPGLALMLAAL
HHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHH
ARNTAQLPALDVEDTGTAAASRLPWADNTHDAIAAGCLAAQAGAIERTWRTLSERGPTRC
HCCCCCCCEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
LLSGGARHALAGALAVPFEMHDNLVLLGLHAMATA
EECCCCHHHHHHHHCCCEECCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA