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The map label for this gene is pcp

Identifier: 73539798

GI number: 73539798

Start: 110606

End: 111256

Strand: Direct

Name: pcp

Synonym: Reut_A0092

Alternate gene names: 73539798

Gene position: 110606-111256 (Clockwise)

Preceding gene: 73539797

Following gene: 73539799

Centisome position: 2.91

GC content: 66.67

Gene sequence:

>651_bases
ATGCGCACCGTTTTGCTGACCGGTTTCGAACCGTTCGAGAACGAGCCGATCAATCCGTCGTGGGAGGCGGTACGCGCGCT
CGACGGCGAACGCATCGGCGATGCCGTCGTCGTCGCGCGCCAGTTGCCATGTGTGTTCGGTGCGGCGATCGATGGCATGG
CCGCGCTGCTGCGCGAGTTGAAGCCCGCCATCGCCATAGCGGTCGGGCAGGCGGGCGGCCGCACCGAGATGTCGGTCGAG
CGCGTCGCGATCAATGTCGACGATGCGCGCATTGCCGACAATGCGGGCGCGCAGCCCATCGATACCGTGATCGCCGCGAA
AGGCCCGGCCGCATACTTCTCCACGCTGCCGATCAAGGCAATCGTGCGCGATATGCGTGCAGCGGGTGTCCCCGCCGCCG
TGTCGCAGACGGCGGGGACGTTCGTCTGCAATCATGTGTTCTACGGGCTGATGCACGCACTGGCCACGCCGGCAGGCGAG
GGCGTGCGTGGCGGCTTCATCCACATTCCCTATCTGCCGGAGCAGGCCGCGCGCCATCCAGGAGAGGCCAGCATGTCGCT
GGAGTCGATGGTTCGCGGCATTCGGCAGGCTATCGCGACTACGCTGGCGACGGAGGTAGACGTGCGCGAGCAGGGCGGTC
AGTTGCACTGA

Upstream 100 bases:

>100_bases
CAAGAACGCCGTGATTCGCGCGCAGGTGCCGACCGCACTGGCGATCCTCGTCGCGAATATCGCGCTGCTGTATTTCCTGA
TGTAAGCGAGGAGAGTTGCC

Downstream 100 bases:

>100_bases
GTCCAGGTATCAAGACGCCCGGTGGTTCCTCCCCTCTCCCGCTAGCGGGAGAGGGGCTGGGTGAGGGCCGGTGCCTCCGC
GAAGTCCCCCGCAGGCGGTC

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRTVLLTGFEPFENEPINPSWEAVRALDGERIGDAVVVARQLPCVFGAAIDGMAALLRELKPAIAIAVGQAGGRTEMSVE
RVAINVDDARIADNAGAQPIDTVIAAKGPAAYFSTLPIKAIVRDMRAAGVPAAVSQTAGTFVCNHVFYGLMHALATPAGE
GVRGGFIHIPYLPEQAARHPGEASMSLESMVRGIRQAIATTLATEVDVREQGGQLH

Sequences:

>Translated_216_residues
MRTVLLTGFEPFENEPINPSWEAVRALDGERIGDAVVVARQLPCVFGAAIDGMAALLRELKPAIAIAVGQAGGRTEMSVE
RVAINVDDARIADNAGAQPIDTVIAAKGPAAYFSTLPIKAIVRDMRAAGVPAAVSQTAGTFVCNHVFYGLMHALATPAGE
GVRGGFIHIPYLPEQAARHPGEASMSLESMVRGIRQAIATTLATEVDVREQGGQLH
>Mature_216_residues
MRTVLLTGFEPFENEPINPSWEAVRALDGERIGDAVVVARQLPCVFGAAIDGMAALLRELKPAIAIAVGQAGGRTEMSVE
RVAINVDDARIADNAGAQPIDTVIAAKGPAAYFSTLPIKAIVRDMRAAGVPAAVSQTAGTFVCNHVFYGLMHALATPAGE
GVRGGFIHIPYLPEQAARHPGEASMSLESMVRGIRQAIATTLATEVDVREQGGQLH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_CUPPJ (Q477F9)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_294318.1
- ProteinModelPortal:   Q477F9
- SMR:   Q477F9
- MEROPS:   C15.001
- GeneID:   3611158
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A0092
- NMPDR:   fig|264198.3.peg.604
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   REUT264198:REUT_A0092-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22706; Mature: 22706

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 143-143 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVLLTGFEPFENEPINPSWEAVRALDGERIGDAVVVARQLPCVFGAAIDGMAALLREL
CCEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KPAIAIAVGQAGGRTEMSVERVAINVDDARIADNAGAQPIDTVIAAKGPAAYFSTLPIKA
CHHHEEEECCCCCCCCCEEEEEEEECCCHHHCCCCCCCHHHHHHHCCCCHHHHHHCCHHH
IVRDMRAAGVPAAVSQTAGTFVCNHVFYGLMHALATPAGEGVRGGFIHIPYLPEQAARHP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHCCC
GEASMSLESMVRGIRQAIATTLATEVDVREQGGQLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRTVLLTGFEPFENEPINPSWEAVRALDGERIGDAVVVARQLPCVFGAAIDGMAALLREL
CCEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KPAIAIAVGQAGGRTEMSVERVAINVDDARIADNAGAQPIDTVIAAKGPAAYFSTLPIKA
CHHHEEEECCCCCCCCCEEEEEEEECCCHHHCCCCCCCHHHHHHHCCCCHHHHHHCCHHH
IVRDMRAAGVPAAVSQTAGTFVCNHVFYGLMHALATPAGEGVRGGFIHIPYLPEQAARHP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHCCC
GEASMSLESMVRGIRQAIATTLATEVDVREQGGQLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA