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The map label for this gene is fsr [H]

Identifier: 73539759

GI number: 73539759

Start: 68010

End: 69269

Strand: Direct

Name: fsr [H]

Synonym: Reut_A0053

Alternate gene names: 73539759

Gene position: 68010-69269 (Clockwise)

Preceding gene: 73539757

Following gene: 73539760

Centisome position: 1.79

GC content: 66.43

Gene sequence:

>1260_bases
ATGAGCACTACCATCGACTCCGGTTCCGCCGCTTCCGGCGTTTCCGGCATTTCCGGCACTCCCGCCGCCAAGACCGAACA
CGCCGCCGAGCGTACGGGCTACCGCGTGCTGTACGCGATCAGCTTCGCGCACTTTCTCAACGACATGATCCAGTCGTTGA
TCCTGGCTATCTACCCGATGCTGAAGGGCGGCTTCAACTTGAGCTTCGTGCAGATCGGCTTTCTGACCATGACTTACCAG
GTCACGGCATCGCTGCTGCAGCCGGTGGTGGGCCTGTACACCGACAAGCATCCGAAGCCGCGCTCGCTCGCGATCGGCAT
GGGCTTCACGCTTGGCGGGCTGCTGCTGCTGTCCGTGGCGCCGACTTATGGCGTGCTGCTGGTCGCGGCCGCGCTGGTCG
GCACCGGGTCGTCGATCTTCCATCCGGAATCGTCGCGCGTGGCGCGCATGGCCTCGGGCGGGCGGCACGGGCTGGCGCAG
TCGATCTTCCAGGTCGGCGGCAACGGCGGCAGCGCCATGGGGCCGCTGCTGGCCGCCGGCATCGTGCACAAGCAGGCGAG
CCTGGCGTGGTTCTCGCTGGCAGCGCTGTTGGCCATTGCGGTGCTGTGGAAGATCGGCGGCTGGTACGCGGAGCAGATCG
CGCACCGCGCACGCAAGGGCAAGGCGGGCGGCGCCGTGGCCAGTCCGGTGCCGACGCGCGTGGTGGTGCGGGCCATGCTG
GTGCTGATGGTGCTGGTGTTCTCCAAGTACTTCTACATGGCGAGCCTGACCACCTATTACACCTTCTACCTGATGGAGAA
GTTCGGCCTGGCACGCCAGTCCGCGCAAATCTATCTGTTCGTATTCTTGTTCGCGGTGGCGGCCGGCACGATCCTGGGCG
GCCCGATCGGCGACCGCATCGGCCGCAAGCGTGTGATCTGGGCGTCGATCCTCGGCGTCGCGCCGTTCACGCTGGTGCTG
CCGCACGTGGGCCTGTTCTGGACCGGCGTGCTGACCTTCATCATCGGCTTCATCCTGGCCTCGGCGTTTTCGGCGATTCT
GGTGTTCGCGCAGGAGCTGATTCCCGGCAAAGTCGGCATGGTGTCGGGCATGTTCTTCGGCTTCGCGTTCGGCATGGGCG
GCATCGGCGCCGCGGTGCTGGGCGGGCTGGCCGATACGCATGGCATCGAAGCGGTGTACCAGCTGTGCGCGTTCCTGCCG
CTGCTGGGCCTGCTCGCGGTGTTCCTGCCAGACCTCGGCGGCAAGCGCAAGCCAGCCTGA

Upstream 100 bases:

>100_bases
TTCTCGCAGGACAGGCGCGCTTCAGCCAGTTAGCATCGCCTCTCACACCGTCCCGGCGAGCGCCCCCCTGGTTCGTCGTT
TTGTCCTGTCGAGACCGCCA

Downstream 100 bases:

>100_bases
CGGCGCTAACGCGCGCCCGCGCACAGAGCGCCCTGACGCCCCGCCTTGGCGGGGCGTTTTCACTGGCGCCGGCGTCTCCT
ACACTGGGATGACTATGCCT

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSTTIDSGSAASGVSGISGTPAAKTEHAAERTGYRVLYAISFAHFLNDMIQSLILAIYPMLKGGFNLSFVQIGFLTMTYQ
VTASLLQPVVGLYTDKHPKPRSLAIGMGFTLGGLLLLSVAPTYGVLLVAAALVGTGSSIFHPESSRVARMASGGRHGLAQ
SIFQVGGNGGSAMGPLLAAGIVHKQASLAWFSLAALLAIAVLWKIGGWYAEQIAHRARKGKAGGAVASPVPTRVVVRAML
VLMVLVFSKYFYMASLTTYYTFYLMEKFGLARQSAQIYLFVFLFAVAAGTILGGPIGDRIGRKRVIWASILGVAPFTLVL
PHVGLFWTGVLTFIIGFILASAFSAILVFAQELIPGKVGMVSGMFFGFAFGMGGIGAAVLGGLADTHGIEAVYQLCAFLP
LLGLLAVFLPDLGGKRKPA

Sequences:

>Translated_419_residues
MSTTIDSGSAASGVSGISGTPAAKTEHAAERTGYRVLYAISFAHFLNDMIQSLILAIYPMLKGGFNLSFVQIGFLTMTYQ
VTASLLQPVVGLYTDKHPKPRSLAIGMGFTLGGLLLLSVAPTYGVLLVAAALVGTGSSIFHPESSRVARMASGGRHGLAQ
SIFQVGGNGGSAMGPLLAAGIVHKQASLAWFSLAALLAIAVLWKIGGWYAEQIAHRARKGKAGGAVASPVPTRVVVRAML
VLMVLVFSKYFYMASLTTYYTFYLMEKFGLARQSAQIYLFVFLFAVAAGTILGGPIGDRIGRKRVIWASILGVAPFTLVL
PHVGLFWTGVLTFIIGFILASAFSAILVFAQELIPGKVGMVSGMFFGFAFGMGGIGAAVLGGLADTHGIEAVYQLCAFLP
LLGLLAVFLPDLGGKRKPA
>Mature_418_residues
STTIDSGSAASGVSGISGTPAAKTEHAAERTGYRVLYAISFAHFLNDMIQSLILAIYPMLKGGFNLSFVQIGFLTMTYQV
TASLLQPVVGLYTDKHPKPRSLAIGMGFTLGGLLLLSVAPTYGVLLVAAALVGTGSSIFHPESSRVARMASGGRHGLAQS
IFQVGGNGGSAMGPLLAAGIVHKQASLAWFSLAALLAIAVLWKIGGWYAEQIAHRARKGKAGGAVASPVPTRVVVRAMLV
LMVLVFSKYFYMASLTTYYTFYLMEKFGLARQSAQIYLFVFLFAVAAGTILGGPIGDRIGRKRVIWASILGVAPFTLVLP
HVGLFWTGVLTFIIGFILASAFSAILVFAQELIPGKVGMVSGMFFGFAFGMGGIGAAVLGGLADTHGIEAVYQLCAFLPL
LGLLAVFLPDLGGKRKPA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=397, Percent_Identity=66.4987405541562, Blast_Score=494, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43995; Mature: 43864

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
STTIDSGSAASGVSGISGTPAAKTEHAAERTGYRVLYAISFAHFLNDMIQSLILAIYPM
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGGFNLSFVQIGFLTMTYQVTASLLQPVVGLYTDKHPKPRSLAIGMGFTLGGLLLLSVA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHH
PTYGVLLVAAALVGTGSSIFHPESSRVARMASGGRHGLAQSIFQVGGNGGSAMGPLLAAG
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
IVHKQASLAWFSLAALLAIAVLWKIGGWYAEQIAHRARKGKAGGAVASPVPTRVVVRAML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
VLMVLVFSKYFYMASLTTYYTFYLMEKFGLARQSAQIYLFVFLFAVAAGTILGGPIGDRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GRKRVIWASILGVAPFTLVLPHVGLFWTGVLTFIIGFILASAFSAILVFAQELIPGKVGM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VSGMFFGFAFGMGGIGAAVLGGLADTHGIEAVYQLCAFLPLLGLLAVFLPDLGGKRKPA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]