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The map label for this gene is qor [C]

Identifier: 73539525

GI number: 73539525

Start: 2530279

End: 2530803

Strand: Direct

Name: qor [C]

Synonym: Reut_B5703

Alternate gene names: 73539525

Gene position: 2530279-2530803 (Clockwise)

Preceding gene: 73539524

Following gene: 73539528

Centisome position: 92.82

GC content: 57.71

Gene sequence:

>525_bases
ATGTTCGTCGGTAATCCGCCAGGCGGTTCTGCAACCGAGACAGCTCGTCAGATGAGAAACACGCGAATCATCGTCACGCA
TTACGGCGGTCCGGATTCGCTTCAGGTAATAGATGAAGAGTGTCCCGGGCCAAAGAACGGAGAGGTGCGGGTAAGGGTGC
TGGCAGCCGGTGTGCGCCAGACCGACCTGATGATGCGCGAAGGCTTTCATCCTGAAACGCCTCGTTTGCCTTTCACACCG
GGGTGGGACCTGATTGGACTGGTGGATCGAGTTGGTGCCGGAGTTGCCGAAGTGGATTCAGGCCAGTGGGTCGCCGCACT
ATCCATCACCGGTGCGTATTCCGAGTTCGTCTGTCTGCCGCAGTGTGAGCTTGTTCCCGTGCCTTTCGGATTGGACGCTG
CCGAGGCTCCAGTGGCTCAAGCGGATGCGGCCAGCATTGTTTCGCCACGACCTGATCGCCTTGTTCGATTTGCTTCAACA
GAAGAAAATCGAGACGCTGATCGCCGCAAGGTTTTCACTGGCTGA

Upstream 100 bases:

>100_bases
TACCCGGAACGACGTGAGGATATTTCGCGTGACGCCCACGGTCATTTCCGTCCTCGACTACTCGAAAGGTTTCGGACACA
CGGACCTGGTCGTGTGCTAA

Downstream 100 bases:

>100_bases
GGCAAGACAGGCGCATGAATTGCTTGGAGAGCCGAGTGTTACAGGCAAAATCGTGTTGGTACCCAAAGGCGTTGAGCGAT
TGCGAACTTCAATGATGGCC

Product: putative NADPH:quinone reductase and related Zn-dependent oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: Quinone Oxidoreductase; NADPHQuinone Reductase; NAD(P)H Quinone Oxidoreductase PIG3 Family; Oxidoreductase; Alcohol Dehydrogenase GroES Domain-Containing Protein; PIG3 Family NAD(P)H Quinone Oxidoreductase; Dehydrogenase; Alcohol Dehydrogenase Zinc-Containing; Zinc-Containing Alcohol Dehydrogenase Superfamily Protein; NADPH Quinone Oxidoreductase; NAD(P)H Quinone Oxidoreductase PIG3 Family Protein; Alcohol Dehydrogenase GroES Domain Protein; Oxydoreductase Protein Zinc-Containing; NADPHQuinone Reductase-Like Zn-Dependent Oxidoreductase; NAD(P)H Quinone Oxidoreductase Pig3 Family; Zn-Dependent Oxidoreductase NADphQuinone Reductase

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MFVGNPPGGSATETARQMRNTRIIVTHYGGPDSLQVIDEECPGPKNGEVRVRVLAAGVRQTDLMMREGFHPETPRLPFTP
GWDLIGLVDRVGAGVAEVDSGQWVAALSITGAYSEFVCLPQCELVPVPFGLDAAEAPVAQADAASIVSPRPDRLVRFAST
EENRDADRRKVFTG

Sequences:

>Translated_174_residues
MFVGNPPGGSATETARQMRNTRIIVTHYGGPDSLQVIDEECPGPKNGEVRVRVLAAGVRQTDLMMREGFHPETPRLPFTP
GWDLIGLVDRVGAGVAEVDSGQWVAALSITGAYSEFVCLPQCELVPVPFGLDAAEAPVAQADAASIVSPRPDRLVRFAST
EENRDADRRKVFTG
>Mature_174_residues
MFVGNPPGGSATETARQMRNTRIIVTHYGGPDSLQVIDEECPGPKNGEVRVRVLAAGVRQTDLMMREGFHPETPRLPFTP
GWDLIGLVDRVGAGVAEVDSGQWVAALSITGAYSEFVCLPQCELVPVPFGLDAAEAPVAQADAASIVSPRPDRLVRFAST
EENRDADRRKVFTG

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24308257, Length=122, Percent_Identity=31.1475409836066, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 18716; Mature: 18716

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVGNPPGGSATETARQMRNTRIIVTHYGGPDSLQVIDEECPGPKNGEVRVRVLAAGVRQ
CCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCCCCEEEEEEECCCCH
TDLMMREGFHPETPRLPFTPGWDLIGLVDRVGAGVAEVDSGQWVAALSITGAYSEFVCLP
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHEEECC
QCELVPVPFGLDAAEAPVAQADAASIVSPRPDRLVRFASTEENRDADRRKVFTG
CCCEEECCCCCCCCCCCCCCCCCHHHCCCCHHHEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFVGNPPGGSATETARQMRNTRIIVTHYGGPDSLQVIDEECPGPKNGEVRVRVLAAGVRQ
CCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCCCCEEEEEEECCCCH
TDLMMREGFHPETPRLPFTPGWDLIGLVDRVGAGVAEVDSGQWVAALSITGAYSEFVCLP
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHEEECC
QCELVPVPFGLDAAEAPVAQADAASIVSPRPDRLVRFASTEENRDADRRKVFTG
CCCEEECCCCCCCCCCCCCCCCCHHHCCCCHHHEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA