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The map label for this gene is fumC [H]

Identifier: 73539339

GI number: 73539339

Start: 2313701

End: 2315107

Strand: Reverse

Name: fumC [H]

Synonym: Reut_B5517

Alternate gene names: 73539339

Gene position: 2315107-2313701 (Counterclockwise)

Preceding gene: 73539341

Following gene: 73539338

Centisome position: 84.92

GC content: 65.1

Gene sequence:

>1407_bases
ATGTCCGCACCGTCTTCCTCCGCCACCCGCATCGAAAAAGACAGTCTCGGCGATGTGCCAGTCCCCGCCGACCACTTGTG
GGGGGCGCAGACCGAACGCTCGCGCCAGAATTTCCGCATCGGCAATGAAAAGATGCCGCCGGCGCTGATTGAAGCGTTTG
CCATCCTCAAGCTGTGTGCCGCGCGCGCCAACCGCGAGCTTGACGTGCTGCCACAGGAATTGGCAGGCGCCATCGAGCAA
GCAGCAAGCGAAGTGATCGAAGGCCGCTGGCCCGATGAATTCCCGCTTTCGGTGTGGCAGACCGGCTCTGGCACGCAGAC
CAACATGAACCTCAACGAGGTCATCGCCAACCGCGCCATCCAGCTGCTTGGCGGCCAGGTCGGCAGCAAGAAGCCCGTGC
ACCCGAACGACCACGTCAACGCGAGCCAGTCGTCCAACGACAGCTTCCCGACGGCCATGCACATCGCCGCCACGCGCGCG
ATCCAGCAGAAGCTGCTGCCCGCGCTCGAGACGCTGCAGCAGACGTTCGCGCGCAAGGTCGATGCGTTCGCCGACATCGT
CAAGGTCGGGCGCACGCACCTGCAGGATGCCGTGCCGCTGACGCTCGGCCAGGAGTTCTCTGGCTATATGACGCAGGTCG
CCGATGCCCAATCGCGGTTGCAGCAGGCCATGCTTCGCGCGATGCCTGTCGCGCAGGGCGGCACGGCGGTGGGCACCGGC
CTGAACGCGCCGCCGGGATTCGCCGCCGCATTCGCGCGCGCGCTGGCCGACTACACCGGCCTGCCATTCGAGCCCGCACC
GAACCGCTATGCGCTGCAGGCCGCCCACGATGCGCTGGCCGACCTGTCCGGCGCCCTCAATACGACGGCCTCATCGTTCC
TGAAGATCGCGCGCGATTTCATGCTGCTGGGCTCGGGCCCGCGCGCCGGCTTTGCCGAACTGCAGCTTCCGGCCAACGAA
CCGGGTTCGTCGATCATGCCGGGCAAGGTCAATCCGACGCAGGCGGAAGCGCTCGCCATGGTCTGCTGCCGCGTGATCGG
AAACCACACCACGGTCACGCTGGCGAATGCGCTCGGCACGCTCGAACTCAATGCGTACAAGCCGGTGATCGTCTACAGCC
TGCTGCAGTCGGTGACACTGCTTGCGGATGCCGCATCGAGCTTCGCCGAACACATGGTCGAAGGCGTGGAAGCCGACCGC
GAGCGCATTGCCGAACTGCTCGAACGCTCGCTGATGCCGGTAACCGCGCTCAATCCGCATATCGGCTACGACAAGGCTGC
GGAAATCGCCAAGCTGGCCGTCAAGCGCAACCTGTCGCTGCGCGAGGCGGCGATTGCTTCGGGTCATGTAACCGAGGAGC
AGTTTGCGCAGTGGATCGATCTGAAGGGGATGACCAAAGAGGTGTAA

Upstream 100 bases:

>100_bases
TCACAATGAAGCACTATTCTAGAGGACGGCCACGTGACGGGCCGCCAGATGGCCATGCACCGCGTCCCTCTCTCTCTCCC
TCGTAGCCAGGAGCTTGTCA

Downstream 100 bases:

>100_bases
GGCCTGAGAACGCCGGGGCGCAACTGTCGCTCCGGCAATACCTAACGATCTTGCCTACCGGGAACATCGAATTGTCTACC
GACCTCGCCCAATCCTGGCT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSAPSSSATRIEKDSLGDVPVPADHLWGAQTERSRQNFRIGNEKMPPALIEAFAILKLCAARANRELDVLPQELAGAIEQ
AASEVIEGRWPDEFPLSVWQTGSGTQTNMNLNEVIANRAIQLLGGQVGSKKPVHPNDHVNASQSSNDSFPTAMHIAATRA
IQQKLLPALETLQQTFARKVDAFADIVKVGRTHLQDAVPLTLGQEFSGYMTQVADAQSRLQQAMLRAMPVAQGGTAVGTG
LNAPPGFAAAFARALADYTGLPFEPAPNRYALQAAHDALADLSGALNTTASSFLKIARDFMLLGSGPRAGFAELQLPANE
PGSSIMPGKVNPTQAEALAMVCCRVIGNHTTVTLANALGTLELNAYKPVIVYSLLQSVTLLADAASSFAEHMVEGVEADR
ERIAELLERSLMPVTALNPHIGYDKAAEIAKLAVKRNLSLREAAIASGHVTEEQFAQWIDLKGMTKEV

Sequences:

>Translated_468_residues
MSAPSSSATRIEKDSLGDVPVPADHLWGAQTERSRQNFRIGNEKMPPALIEAFAILKLCAARANRELDVLPQELAGAIEQ
AASEVIEGRWPDEFPLSVWQTGSGTQTNMNLNEVIANRAIQLLGGQVGSKKPVHPNDHVNASQSSNDSFPTAMHIAATRA
IQQKLLPALETLQQTFARKVDAFADIVKVGRTHLQDAVPLTLGQEFSGYMTQVADAQSRLQQAMLRAMPVAQGGTAVGTG
LNAPPGFAAAFARALADYTGLPFEPAPNRYALQAAHDALADLSGALNTTASSFLKIARDFMLLGSGPRAGFAELQLPANE
PGSSIMPGKVNPTQAEALAMVCCRVIGNHTTVTLANALGTLELNAYKPVIVYSLLQSVTLLADAASSFAEHMVEGVEADR
ERIAELLERSLMPVTALNPHIGYDKAAEIAKLAVKRNLSLREAAIASGHVTEEQFAQWIDLKGMTKEV
>Mature_467_residues
SAPSSSATRIEKDSLGDVPVPADHLWGAQTERSRQNFRIGNEKMPPALIEAFAILKLCAARANRELDVLPQELAGAIEQA
ASEVIEGRWPDEFPLSVWQTGSGTQTNMNLNEVIANRAIQLLGGQVGSKKPVHPNDHVNASQSSNDSFPTAMHIAATRAI
QQKLLPALETLQQTFARKVDAFADIVKVGRTHLQDAVPLTLGQEFSGYMTQVADAQSRLQQAMLRAMPVAQGGTAVGTGL
NAPPGFAAAFARALADYTGLPFEPAPNRYALQAAHDALADLSGALNTTASSFLKIARDFMLLGSGPRAGFAELQLPANEP
GSSIMPGKVNPTQAEALAMVCCRVIGNHTTVTLANALGTLELNAYKPVIVYSLLQSVTLLADAASSFAEHMVEGVEADRE
RIAELLERSLMPVTALNPHIGYDKAAEIAKLAVKRNLSLREAAIASGHVTEEQFAQWIDLKGMTKEV

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=58.008658008658, Blast_Score=532, Evalue=1e-151,
Organism=Escherichia coli, GI1787896, Length=453, Percent_Identity=55.4083885209713, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=39.8268398268398, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1790398, Length=342, Percent_Identity=27.1929824561404, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17553882, Length=457, Percent_Identity=56.8927789934354, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI32565146, Length=323, Percent_Identity=55.7275541795666, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324993, Length=456, Percent_Identity=55.4824561403509, Blast_Score=518, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24640179, Length=458, Percent_Identity=54.1484716157205, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24640177, Length=458, Percent_Identity=54.1484716157205, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI78710009, Length=459, Percent_Identity=53.1590413943355, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=51.8358531317495, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24583245, Length=455, Percent_Identity=48.3516483516484, Blast_Score=452, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49982; Mature: 49851

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPSSSATRIEKDSLGDVPVPADHLWGAQTERSRQNFRIGNEKMPPALIEAFAILKLCA
CCCCCCCHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
ARANRELDVLPQELAGAIEQAASEVIEGRWPDEFPLSVWQTGSGTQTNMNLNEVIANRAI
HHCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCCCCCCCCCHHHHHHHHHH
QLLGGQVGSKKPVHPNDHVNASQSSNDSFPTAMHIAATRAIQQKLLPALETLQQTFARKV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAFADIVKVGRTHLQDAVPLTLGQEFSGYMTQVADAQSRLQQAMLRAMPVAQGGTAVGTG
HHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
LNAPPGFAAAFARALADYTGLPFEPAPNRYALQAAHDALADLSGALNTTASSFLKIARDF
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLGSGPRAGFAELQLPANEPGSSIMPGKVNPTQAEALAMVCCRVIGNHTTVTLANALGT
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHCE
LELNAYKPVIVYSLLQSVTLLADAASSFAEHMVEGVEADRERIAELLERSLMPVTALNPH
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IGYDKAAEIAKLAVKRNLSLREAAIASGHVTEEQFAQWIDLKGMTKEV
CCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SAPSSSATRIEKDSLGDVPVPADHLWGAQTERSRQNFRIGNEKMPPALIEAFAILKLCA
CCCCCCHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
ARANRELDVLPQELAGAIEQAASEVIEGRWPDEFPLSVWQTGSGTQTNMNLNEVIANRAI
HHCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCCCCCCCCCHHHHHHHHHH
QLLGGQVGSKKPVHPNDHVNASQSSNDSFPTAMHIAATRAIQQKLLPALETLQQTFARKV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAFADIVKVGRTHLQDAVPLTLGQEFSGYMTQVADAQSRLQQAMLRAMPVAQGGTAVGTG
HHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
LNAPPGFAAAFARALADYTGLPFEPAPNRYALQAAHDALADLSGALNTTASSFLKIARDF
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLGSGPRAGFAELQLPANEPGSSIMPGKVNPTQAEALAMVCCRVIGNHTTVTLANALGT
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHCE
LELNAYKPVIVYSLLQSVTLLADAASSFAEHMVEGVEADRERIAELLERSLMPVTALNPH
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IGYDKAAEIAKLAVKRNLSLREAAIASGHVTEEQFAQWIDLKGMTKEV
CCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856685; 12597275 [H]