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The map label for this gene is pamO [H]

Identifier: 73539283

GI number: 73539283

Start: 2251663

End: 2253255

Strand: Direct

Name: pamO [H]

Synonym: Reut_B5461

Alternate gene names: 73539283

Gene position: 2251663-2253255 (Clockwise)

Preceding gene: 73539280

Following gene: 73539284

Centisome position: 82.59

GC content: 63.78

Gene sequence:

>1593_bases
ATGGACAACTACGACGCCATTGTGGTGGGAGCCGGATTCTCCGGCCTGTATATGCTGCATCGCCTGCGTGAAGCGGGCCT
GTCGGCACGGGTCTACGAGGCCGGCGACAACGTCGGCGGCGTCTGGTACTGGAACCGCTATCCGGGCGCCAGGTGCGATG
TCGAGAGCATCTACTACAACTTTACGTTCTCGAAGGAGTTACTCGCCGAGTGGACCTGGACGAGCCGGTATGCCGAACAG
CCCGAGATCCTTGCCTACCTGAACCACGTGGCGGACCGTTTCGATCTGCGCCGCGACATCGAGTTCAGCACGCGCGTCGT
CTCGGCACACTTCGACGCCAGCGCCGGCAAGTGGCGGGTGCAGACTGACGATGGCCGCGTGGCCACGGCCAAGTATTTCA
TCTCGGGCGTGGGTTGCCTGTCCACATCGAGCACACCGCGCTTCAAGGGCCTGGACAGCTTCCGAGGCGAGCAGTACCAC
ACGGGAACGTGGCCGCATGAGCCGGTCAGCTTCGCCGGCAAGCGGGTCGGCGTGATCGGCACCGGTTCGAGCGGCATTCA
GGCCATCCCGCAGATCGCCGCGCAGGCCACGCAACTGTTCGTGTTTCAGCGTACCGCGCAATACAGCACGCCAGCGGCCA
ACCGGCCCTATGACAGCGAATACGTGGCGCAGGTCAAAGCGAACTATCCCGCGCTCAGGCAGCAGGTCCTGAAGTCCTGG
GGCGGCACGACGACGCGGCCGCGCCCGGATCGATCGACGTTCGAGGATACCGAAGCCCAGCGCCAGCAGCGCTATGAGGC
GGCCTGGACCGAAGGCGGCTGGATGCATGGCCTGTACAAGGATCTCGTCACCGACGCGAGCGCCAACGAGACCGTGTGCG
AATTCATCCGCGACAAGATCCGCACGGTCGTGAAGGATCCGGAAATCGCCGCAAAGCTCACGCCGACCTATCTGTACGGC
GTGAAGCGCCCGGTCATGGATACCGGCTACTTCGAAACCTACAACCGCGACAACGTGACGCTGGTCGACGTGAAGGCCGC
GCCCATCGTCGAATTCACGCCGACGGGCCTGCGTACCGCCGACGCCGAGTATCCGCTCGACGTCATCGTCTTCGCCACCG
GCTACGACGCCATGACGGGCGCACTGTTCCGGATCGACATCCGCGGCAAGGACGGCATGACGCTGCGCGAGAAGTGGGCG
GAAGGCGAGCGCATCCAGACCTATCTGGGCCTGGCGACCGCCGGCTTCCCGAACATGTTCATGATCACCGGCCCGGAAAG
CCCGTCGGTGCTGTCCAACATGGTGTGGTCAATCGAACAGCACGTCGAGTGGATCGATGCGTGCATTCGCCAGATGGAGC
AGAACGGTACCGCTGTCATCGAAGCGAAGCCGCAGGCCGAAGCGGCATGGAGCCGGCACTGCCATGAAGTCGCCGATGCC
ACACTCTTCCCAAAGGGCGAATCCTGGTACAACGGCTCGAACGTCGAAGGCAAGAAGATGAGCTTCCCGATCTACCTGGC
GGGCATCAGCGTCTATCGCGAGCTGTGCGCTCGCGTGGCGGCGAACGGGTACGACGGCTTCCTGCAGGCGTAA

Upstream 100 bases:

>100_bases
AATTGGACAGTGCCGACGCGCGGGTGCGAGCATAAAAAGCCAAACGACACGCATGGTCCCCGCACGGGGGCCAGTCGCGC
AGAAAGAAGGAGACAACAAG

Downstream 100 bases:

>100_bases
GCCGGGCCACAACAACTACGACGGAGACAAGAGACCATGGCGCTCGACGAGCAGGCCCGCTACATCCTTGACATGATTGC
GTCGGCAGGACGGCCGCCAT

Product: flavin-containing monooxygenase FMO

Products: NA

Alternate protein names: PAMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MDNYDAIVVGAGFSGLYMLHRLREAGLSARVYEAGDNVGGVWYWNRYPGARCDVESIYYNFTFSKELLAEWTWTSRYAEQ
PEILAYLNHVADRFDLRRDIEFSTRVVSAHFDASAGKWRVQTDDGRVATAKYFISGVGCLSTSSTPRFKGLDSFRGEQYH
TGTWPHEPVSFAGKRVGVIGTGSSGIQAIPQIAAQATQLFVFQRTAQYSTPAANRPYDSEYVAQVKANYPALRQQVLKSW
GGTTTRPRPDRSTFEDTEAQRQQRYEAAWTEGGWMHGLYKDLVTDASANETVCEFIRDKIRTVVKDPEIAAKLTPTYLYG
VKRPVMDTGYFETYNRDNVTLVDVKAAPIVEFTPTGLRTADAEYPLDVIVFATGYDAMTGALFRIDIRGKDGMTLREKWA
EGERIQTYLGLATAGFPNMFMITGPESPSVLSNMVWSIEQHVEWIDACIRQMEQNGTAVIEAKPQAEAAWSRHCHEVADA
TLFPKGESWYNGSNVEGKKMSFPIYLAGISVYRELCARVAANGYDGFLQA

Sequences:

>Translated_530_residues
MDNYDAIVVGAGFSGLYMLHRLREAGLSARVYEAGDNVGGVWYWNRYPGARCDVESIYYNFTFSKELLAEWTWTSRYAEQ
PEILAYLNHVADRFDLRRDIEFSTRVVSAHFDASAGKWRVQTDDGRVATAKYFISGVGCLSTSSTPRFKGLDSFRGEQYH
TGTWPHEPVSFAGKRVGVIGTGSSGIQAIPQIAAQATQLFVFQRTAQYSTPAANRPYDSEYVAQVKANYPALRQQVLKSW
GGTTTRPRPDRSTFEDTEAQRQQRYEAAWTEGGWMHGLYKDLVTDASANETVCEFIRDKIRTVVKDPEIAAKLTPTYLYG
VKRPVMDTGYFETYNRDNVTLVDVKAAPIVEFTPTGLRTADAEYPLDVIVFATGYDAMTGALFRIDIRGKDGMTLREKWA
EGERIQTYLGLATAGFPNMFMITGPESPSVLSNMVWSIEQHVEWIDACIRQMEQNGTAVIEAKPQAEAAWSRHCHEVADA
TLFPKGESWYNGSNVEGKKMSFPIYLAGISVYRELCARVAANGYDGFLQA
>Mature_530_residues
MDNYDAIVVGAGFSGLYMLHRLREAGLSARVYEAGDNVGGVWYWNRYPGARCDVESIYYNFTFSKELLAEWTWTSRYAEQ
PEILAYLNHVADRFDLRRDIEFSTRVVSAHFDASAGKWRVQTDDGRVATAKYFISGVGCLSTSSTPRFKGLDSFRGEQYH
TGTWPHEPVSFAGKRVGVIGTGSSGIQAIPQIAAQATQLFVFQRTAQYSTPAANRPYDSEYVAQVKANYPALRQQVLKSW
GGTTTRPRPDRSTFEDTEAQRQQRYEAAWTEGGWMHGLYKDLVTDASANETVCEFIRDKIRTVVKDPEIAAKLTPTYLYG
VKRPVMDTGYFETYNRDNVTLVDVKAAPIVEFTPTGLRTADAEYPLDVIVFATGYDAMTGALFRIDIRGKDGMTLREKWA
EGERIQTYLGLATAGFPNMFMITGPESPSVLSNMVWSIEQHVEWIDACIRQMEQNGTAVIEAKPQAEAAWSRHCHEVADA
TLFPKGESWYNGSNVEGKKMSFPIYLAGISVYRELCARVAANGYDGFLQA

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=210, Percent_Identity=29.0476190476191, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4503755, Length=212, Percent_Identity=29.2452830188679, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI50541965, Length=229, Percent_Identity=27.9475982532751, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI50541961, Length=229, Percent_Identity=27.9475982532751, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI221316674, Length=226, Percent_Identity=26.9911504424779, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI221316672, Length=226, Percent_Identity=26.9911504424779, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI221316678, Length=226, Percent_Identity=26.9911504424779, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI4503759, Length=221, Percent_Identity=25.3393665158371, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25150462, Length=252, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25145785, Length=233, Percent_Identity=26.6094420600858, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.92 [H]

Molecular weight: Translated: 59377; Mature: 59377

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNYDAIVVGAGFSGLYMLHRLREAGLSARVYEAGDNVGGVWYWNRYPGARCDVESIYYN
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCCCHHHEEEE
FTFSKELLAEWTWTSRYAEQPEILAYLNHVADRFDLRRDIEFSTRVVSAHFDASAGKWRV
EEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCEEEE
QTDDGRVATAKYFISGVGCLSTSSTPRFKGLDSFRGEQYHTGTWPHEPVSFAGKRVGVIG
ECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHCCCCEECCCCCCCCHHHCCCEEEEEE
TGSSGIQAIPQIAAQATQLFVFQRTAQYSTPAANRPYDSEYVAQVKANYPALRQQVLKSW
CCCHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHC
GGTTTRPRPDRSTFEDTEAQRQQRYEAAWTEGGWMHGLYKDLVTDASANETVCEFIRDKI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
RTVVKDPEIAAKLTPTYLYGVKRPVMDTGYFETYNRDNVTLVDVKAAPIVEFTPTGLRTA
HHHHCCCCHHEECCHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCCEEEECCCCCEEC
DAEYPLDVIVFATGYDAMTGALFRIDIRGKDGMTLREKWAEGERIQTYLGLATAGFPNMF
CCCCCEEEEEEEECCHHHCCEEEEEEECCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCEE
MITGPESPSVLSNMVWSIEQHVEWIDACIRQMEQNGTAVIEAKPQAEAAWSRHCHEVADA
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCC
TLFPKGESWYNGSNVEGKKMSFPIYLAGISVYRELCARVAANGYDGFLQA
EECCCCCCCCCCCCCCCCEEECCEEEHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDNYDAIVVGAGFSGLYMLHRLREAGLSARVYEAGDNVGGVWYWNRYPGARCDVESIYYN
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCCCHHHEEEE
FTFSKELLAEWTWTSRYAEQPEILAYLNHVADRFDLRRDIEFSTRVVSAHFDASAGKWRV
EEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCEEEE
QTDDGRVATAKYFISGVGCLSTSSTPRFKGLDSFRGEQYHTGTWPHEPVSFAGKRVGVIG
ECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHCCCCEECCCCCCCCHHHCCCEEEEEE
TGSSGIQAIPQIAAQATQLFVFQRTAQYSTPAANRPYDSEYVAQVKANYPALRQQVLKSW
CCCHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHC
GGTTTRPRPDRSTFEDTEAQRQQRYEAAWTEGGWMHGLYKDLVTDASANETVCEFIRDKI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
RTVVKDPEIAAKLTPTYLYGVKRPVMDTGYFETYNRDNVTLVDVKAAPIVEFTPTGLRTA
HHHHCCCCHHEECCHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCCEEEECCCCCEEC
DAEYPLDVIVFATGYDAMTGALFRIDIRGKDGMTLREKWAEGERIQTYLGLATAGFPNMF
CCCCCEEEEEEEECCHHHCCEEEEEEECCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCEE
MITGPESPSVLSNMVWSIEQHVEWIDACIRQMEQNGTAVIEAKPQAEAAWSRHCHEVADA
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCC
TLFPKGESWYNGSNVEGKKMSFPIYLAGISVYRELCARVAANGYDGFLQA
EECCCCCCCCCCCCCCCCEEECCEEEHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA