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The map label for this gene is yngJ [H]

Identifier: 73539131

GI number: 73539131

Start: 2071177

End: 2072352

Strand: Reverse

Name: yngJ [H]

Synonym: Reut_B5308

Alternate gene names: 73539131

Gene position: 2072352-2071177 (Counterclockwise)

Preceding gene: 73539132

Following gene: 73539130

Centisome position: 76.02

GC content: 67.18

Gene sequence:

>1176_bases
ATGTTCGAATACCTGACCAATCCGCTGTTGACCGAGACGCGTGCCGCCGTCCGGCGCTTTATCGACGAAGAACTGCGGCC
GCTCGAACGCGAACTGGGCCTGGGCTCGGAAGACCCGTGGCCGGTCGAAACGCTGCGCAACGTGTGGCGCCGCTCCAGCG
AGCTTGGCCTCTACGCCGCCTGCTTGCCGGTGGCGCTCGGCGGCAAGGGCCTGAATATTGCCGAGCAATGCGCGCTCAAG
GCGGACCTTGCGGCGAGCGGCTGCGTGCTGGCGCCGCACGTGCTCGGCGACCTGGGGGGGCCGCCGCGCGTGGGCAATAT
GCTCAAGTACGCGACCCCGGAGCAGCTCGACCGCTACTTCCTGCCGGTGATCCGCGGCGAGAAGTCGACCTGCTTCGCGC
TCACCGAGACGCATTCGGGCTCCGACGCCCAGAGCATTGCCACGACCGCAGTGGCCGATGGCGACACGCTCGTCGTCAAC
GGCAGCAAGCACTACATCAGCGGCGCGCCGTTCGCGAGCTTCGCCATCGTCATGTGCGTCACCGATGCGACCGTATCGCC
GCCCGCGATCAGCGCCGTGCTGGTGGACCTGGACCTGCCGGGCGTGACCGTCACGCAGGCCTACGTGCCGATGTCGGGCC
AGCATATCGATGCCGATATCGCTTTCGACAACGTGCGCGTGCCCCGCGCCAACATCCTCGGCGGCGAGGGCAATGGCTTC
AAGCTGGGCATGTCGCGCATCAACGTCAACCGGCTGCTGCATTGCCCGTCCATGCTCGGACTTGCAACCAGCGCTTACCG
GTCGTCGCTGGAATACGCGGGCAAGCGGCGCCAGTTCGGTGGCCCGATCGCGCGCTTCCAGGCCATCCAGCACATGCTGG
CCGACATGGCAGCGGCGCTGTGGGCGTGCGAGAGCATGATCGCGCAGACGGCCGCGCTGGCCGATGCCGGCGCGGACCTG
CGCATGAAGGCGGCGGCGTGCAAGCTGTTCGTTTCGGAGCGCTGCTTCGAGGTCGCGGACAAGGCCGTGCAGATCCACGG
CAACGTGGGCGTCACGCGCGGCCATCCGGTGGAGCAGGCCTTCCGCAAACTGCGCATGTTCCGCGTGTTCACGGGCACCA
GCGAGATCCAGCGCAATACCATCGCCAAGGCGATTCTCGAACCTGCGACGAAATAG

Upstream 100 bases:

>100_bases
GCCAGCGGCAAGCTGGCCCGCAAGCTGGTGCGCGAGCCGTACTGGCAGGGCGCATCGCGCCGCGTGAATTGATAAAGCCG
AGAAAGCCGAGGAAGCCACC

Downstream 100 bases:

>100_bases
CCGCCCGCCCACGGCACGGCAACGACATACCCAGACAATAGGCGGTGCAGGACACTGCCCGCCAGCCACGGAGACAACCA
TGAACCGCCGACAATGGCTT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MFEYLTNPLLTETRAAVRRFIDEELRPLERELGLGSEDPWPVETLRNVWRRSSELGLYAACLPVALGGKGLNIAEQCALK
ADLAASGCVLAPHVLGDLGGPPRVGNMLKYATPEQLDRYFLPVIRGEKSTCFALTETHSGSDAQSIATTAVADGDTLVVN
GSKHYISGAPFASFAIVMCVTDATVSPPAISAVLVDLDLPGVTVTQAYVPMSGQHIDADIAFDNVRVPRANILGGEGNGF
KLGMSRINVNRLLHCPSMLGLATSAYRSSLEYAGKRRQFGGPIARFQAIQHMLADMAAALWACESMIAQTAALADAGADL
RMKAAACKLFVSERCFEVADKAVQIHGNVGVTRGHPVEQAFRKLRMFRVFTGTSEIQRNTIAKAILEPATK

Sequences:

>Translated_391_residues
MFEYLTNPLLTETRAAVRRFIDEELRPLERELGLGSEDPWPVETLRNVWRRSSELGLYAACLPVALGGKGLNIAEQCALK
ADLAASGCVLAPHVLGDLGGPPRVGNMLKYATPEQLDRYFLPVIRGEKSTCFALTETHSGSDAQSIATTAVADGDTLVVN
GSKHYISGAPFASFAIVMCVTDATVSPPAISAVLVDLDLPGVTVTQAYVPMSGQHIDADIAFDNVRVPRANILGGEGNGF
KLGMSRINVNRLLHCPSMLGLATSAYRSSLEYAGKRRQFGGPIARFQAIQHMLADMAAALWACESMIAQTAALADAGADL
RMKAAACKLFVSERCFEVADKAVQIHGNVGVTRGHPVEQAFRKLRMFRVFTGTSEIQRNTIAKAILEPATK
>Mature_391_residues
MFEYLTNPLLTETRAAVRRFIDEELRPLERELGLGSEDPWPVETLRNVWRRSSELGLYAACLPVALGGKGLNIAEQCALK
ADLAASGCVLAPHVLGDLGGPPRVGNMLKYATPEQLDRYFLPVIRGEKSTCFALTETHSGSDAQSIATTAVADGDTLVVN
GSKHYISGAPFASFAIVMCVTDATVSPPAISAVLVDLDLPGVTVTQAYVPMSGQHIDADIAFDNVRVPRANILGGEGNGF
KLGMSRINVNRLLHCPSMLGLATSAYRSSLEYAGKRRQFGGPIARFQAIQHMLADMAAALWACESMIAQTAALADAGADL
RMKAAACKLFVSERCFEVADKAVQIHGNVGVTRGHPVEQAFRKLRMFRVFTGTSEIQRNTIAKAILEPATK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=33.6814621409922, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4501859, Length=376, Percent_Identity=31.3829787234043, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI187960098, Length=388, Percent_Identity=29.3814432989691, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI4557231, Length=388, Percent_Identity=29.3814432989691, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=33.0729166666667, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4557235, Length=384, Percent_Identity=33.0729166666667, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI7656849, Length=349, Percent_Identity=30.6590257879656, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=27.8947368421053, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI21361497, Length=386, Percent_Identity=31.6062176165803, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=27.9373368146214, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI226958414, Length=349, Percent_Identity=28.080229226361, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI38505218, Length=423, Percent_Identity=27.1867612293144, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI48976061, Length=410, Percent_Identity=26.8292682926829, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI211971008, Length=410, Percent_Identity=26.8292682926829, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4503943, Length=280, Percent_Identity=26.7857142857143, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI7669494, Length=191, Percent_Identity=31.413612565445, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786223, Length=338, Percent_Identity=31.6568047337278, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI87081958, Length=288, Percent_Identity=30.5555555555556, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87081702, Length=336, Percent_Identity=25.5952380952381, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=29.5212765957447, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=30.9895833333333, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=32.1621621621622, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=30.5699481865285, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=30.3430079155673, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=31.728045325779, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17506239, Length=382, Percent_Identity=29.5811518324607, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17533517, Length=384, Percent_Identity=29.6875, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17551932, Length=341, Percent_Identity=29.6187683284457, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17505929, Length=342, Percent_Identity=28.9473684210526, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71990804, Length=290, Percent_Identity=29.3103448275862, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71985192, Length=300, Percent_Identity=30.3333333333333, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17562446, Length=361, Percent_Identity=26.3157894736842, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=27.3722627737226, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI32563615, Length=187, Percent_Identity=29.9465240641711, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=26.8595041322314, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=285, Percent_Identity=25.6140350877193, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646207, Length=387, Percent_Identity=32.0413436692506, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=31.4814814814815, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=31.5649867374005, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21356377, Length=340, Percent_Identity=32.6470588235294, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=34.593023255814, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21355753, Length=386, Percent_Identity=29.2746113989637, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19920834, Length=293, Percent_Identity=26.2798634812287, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42018; Mature: 42018

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEYLTNPLLTETRAAVRRFIDEELRPLERELGLGSEDPWPVETLRNVWRRSSELGLYAA
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHH
CLPVALGGKGLNIAEQCALKADLAASGCVLAPHVLGDLGGPPRVGNMLKYATPEQLDRYF
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHCCCCCCCCCCHHCCCCHHHHHHHH
LPVIRGEKSTCFALTETHSGSDAQSIATTAVADGDTLVVNGSKHYISGAPFASFAIVMCV
HHHEECCCCEEEEEEECCCCCCHHHHHHHEECCCCEEEEECCCCEECCCCHHHHEEEEEE
TDATVSPPAISAVLVDLDLPGVTVTQAYVPMSGQHIDADIAFDNVRVPRANILGGEGNGF
ECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEECEEEECCEECCCCCEECCCCCCE
KLGMSRINVNRLLHCPSMLGLATSAYRSSLEYAGKRRQFGGPIARFQAIQHMLADMAAAL
EEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
WACESMIAQTAALADAGADLRMKAAACKLFVSERCFEVADKAVQIHGNVGVTRGHPVEQA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHH
FRKLRMFRVFTGTSEIQRNTIAKAILEPATK
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFEYLTNPLLTETRAAVRRFIDEELRPLERELGLGSEDPWPVETLRNVWRRSSELGLYAA
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHH
CLPVALGGKGLNIAEQCALKADLAASGCVLAPHVLGDLGGPPRVGNMLKYATPEQLDRYF
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHCCCCCCCCCCHHCCCCHHHHHHHH
LPVIRGEKSTCFALTETHSGSDAQSIATTAVADGDTLVVNGSKHYISGAPFASFAIVMCV
HHHEECCCCEEEEEEECCCCCCHHHHHHHEECCCCEEEEECCCCEECCCCHHHHEEEEEE
TDATVSPPAISAVLVDLDLPGVTVTQAYVPMSGQHIDADIAFDNVRVPRANILGGEGNGF
ECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEECEEEECCEECCCCCEECCCCCCE
KLGMSRINVNRLLHCPSMLGLATSAYRSSLEYAGKRRQFGGPIARFQAIQHMLADMAAAL
EEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
WACESMIAQTAALADAGADLRMKAAACKLFVSERCFEVADKAVQIHGNVGVTRGHPVEQA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHH
FRKLRMFRVFTGTSEIQRNTIAKAILEPATK
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]