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The map label for this gene is caiD [C]

Identifier: 73539068

GI number: 73539068

Start: 1995751

End: 1996527

Strand: Direct

Name: caiD [C]

Synonym: Reut_B5245

Alternate gene names: 73539068

Gene position: 1995751-1996527 (Clockwise)

Preceding gene: 73539067

Following gene: 73539070

Centisome position: 73.21

GC content: 65.77

Gene sequence:

>777_bases
ATGAGCGAACACGCCTCCAACACGCACGCCGGCGTCGAGATCGACGAGCGCGGCGTTGCCACGCTGACCATCCGTGAAGC
GGGATCGCTGAACATCCTGGGCACGTCGGTGATTGCGGACCTCACGCGCGTGGTCAACGCACTGGCCGCCAATGACGCCG
TGCGGGTGCTGGTGGTACGCGGTGCTGGCGAGAAGGGATTCATCGGCGGCGCCGATATCAAGGAGATGGCCGCGCTCACA
CGCGAATCCGCCGAAGTCTTCATCAGCGGCCTGCGCGGCCTTTGTGATGCGCTGCGGCACTTTCCGGTACCCGTGATTGC
ACGCATGCCGGGCTGGTGCCTCGGTGGCGGACTGGAACTGGCACTCGCCTGCGATATCCGCATTGCCGCGGACAACGCGC
AGCTCGGCATGCCCGAGGTCAAGGTCGGCATCCCGTCCGTGATTCATGCCGCGCTGATGCCGCGGCTGATCGGCAACGCT
CGCGCTGCCTGGATGCTGCTGACGGGAGAACTGTGCGGCGCGGAAGAAGCGCTGTCGTGGGGGATGGTGAACCGCGTAGT
GCCGCTCGCGGAACTGGACGCGGAAGTCGAGCGCATTGCCGCGCTGTTCGCAGGCTTCGGCCCGCAGGTCGTGCGCCAGC
AGAAGCGCCTGCTGCGAGAGTGGGAAGAAGCGCCGCTCGATGTATCGATCAACAACAGCGTGGCCGAGTTCGGCCGCGCG
TTCGATACGGGTGAGCCGCAGCATCACATGGCGACGTTCCTGAATCGCAAGCGGTAA

Upstream 100 bases:

>100_bases
TTCGGCGACCTGATCCGCACGCAGAACGCGCATTGGAAGAAGGTGGTCGAGGATATCCACTTCACGAAGCTGCAATAAGC
CACACATCGAGGAATACATC

Downstream 100 bases:

>100_bases
ATCAACGCAGTCATCACGGTGCGGTCGACGCGACCGTACCGCCCTCGCGCGTGGCCGCCACGCGCGGGTCATTGAGCAGG
AACTGCACGAACGCAGCCGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSEHASNTHAGVEIDERGVATLTIREAGSLNILGTSVIADLTRVVNALAANDAVRVLVVRGAGEKGFIGGADIKEMAALT
RESAEVFISGLRGLCDALRHFPVPVIARMPGWCLGGGLELALACDIRIAADNAQLGMPEVKVGIPSVIHAALMPRLIGNA
RAAWMLLTGELCGAEEALSWGMVNRVVPLAELDAEVERIAALFAGFGPQVVRQQKRLLREWEEAPLDVSINNSVAEFGRA
FDTGEPQHHMATFLNRKR

Sequences:

>Translated_258_residues
MSEHASNTHAGVEIDERGVATLTIREAGSLNILGTSVIADLTRVVNALAANDAVRVLVVRGAGEKGFIGGADIKEMAALT
RESAEVFISGLRGLCDALRHFPVPVIARMPGWCLGGGLELALACDIRIAADNAQLGMPEVKVGIPSVIHAALMPRLIGNA
RAAWMLLTGELCGAEEALSWGMVNRVVPLAELDAEVERIAALFAGFGPQVVRQQKRLLREWEEAPLDVSINNSVAEFGRA
FDTGEPQHHMATFLNRKR
>Mature_257_residues
SEHASNTHAGVEIDERGVATLTIREAGSLNILGTSVIADLTRVVNALAANDAVRVLVVRGAGEKGFIGGADIKEMAALTR
ESAEVFISGLRGLCDALRHFPVPVIARMPGWCLGGGLELALACDIRIAADNAQLGMPEVKVGIPSVIHAALMPRLIGNAR
AAWMLLTGELCGAEEALSWGMVNRVVPLAELDAEVERIAALFAGFGPQVVRQQKRLLREWEEAPLDVSINNSVAEFGRAF
DTGEPQHHMATFLNRKR

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=241, Percent_Identity=29.8755186721992, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502327, Length=200, Percent_Identity=35, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI31542718, Length=219, Percent_Identity=30.5936073059361, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI68989263, Length=159, Percent_Identity=33.9622641509434, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI20127408, Length=190, Percent_Identity=32.1052631578947, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI70995211, Length=166, Percent_Identity=31.9277108433735, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI221142681, Length=175, Percent_Identity=38.2857142857143, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788682, Length=175, Percent_Identity=37.1428571428571, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790281, Length=181, Percent_Identity=34.2541436464088, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787659, Length=244, Percent_Identity=29.0983606557377, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788597, Length=190, Percent_Identity=30.5263157894737, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI87082183, Length=252, Percent_Identity=25.3968253968254, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787660, Length=209, Percent_Identity=33.9712918660287, Blast_Score=71, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=240, Percent_Identity=34.1666666666667, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17540714, Length=201, Percent_Identity=32.8358208955224, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=245, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560910, Length=188, Percent_Identity=29.7872340425532, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=199, Percent_Identity=29.6482412060301, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=218, Percent_Identity=26.1467889908257, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=233, Percent_Identity=27.0386266094421, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=174, Percent_Identity=31.0344827586207, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=174, Percent_Identity=31.0344827586207, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=228, Percent_Identity=27.6315789473684, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=174, Percent_Identity=31.0344827586207, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540306, Length=187, Percent_Identity=28.3422459893048, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=201, Percent_Identity=24.8756218905473, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24653139, Length=249, Percent_Identity=29.718875502008, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI20129971, Length=244, Percent_Identity=29.5081967213115, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653477, Length=244, Percent_Identity=29.5081967213115, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922422, Length=243, Percent_Identity=23.8683127572016, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357171, Length=197, Percent_Identity=28.9340101522843, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583077, Length=163, Percent_Identity=35.5828220858896, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583079, Length=163, Percent_Identity=35.5828220858896, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921000, Length=162, Percent_Identity=35.8024691358025, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650670, Length=159, Percent_Identity=31.4465408805031, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920382, Length=210, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27588; Mature: 27457

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHASNTHAGVEIDERGVATLTIREAGSLNILGTSVIADLTRVVNALAANDAVRVLVVR
CCCCCCCCCCCCEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEEE
GAGEKGFIGGADIKEMAALTRESAEVFISGLRGLCDALRHFPVPVIARMPGWCLGGGLEL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEECCCCEE
ALACDIRIAADNAQLGMPEVKVGIPSVIHAALMPRLIGNARAAWMLLTGELCGAEEALSW
EEEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHEEEEEECCCCCHHHHHHH
GMVNRVVPLAELDAEVERIAALFAGFGPQVVRQQKRLLREWEEAPLDVSINNSVAEFGRA
HHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHH
FDTGEPQHHMATFLNRKR
CCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SEHASNTHAGVEIDERGVATLTIREAGSLNILGTSVIADLTRVVNALAANDAVRVLVVR
CCCCCCCCCCCEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEEE
GAGEKGFIGGADIKEMAALTRESAEVFISGLRGLCDALRHFPVPVIARMPGWCLGGGLEL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEECCCCEE
ALACDIRIAADNAQLGMPEVKVGIPSVIHAALMPRLIGNARAAWMLLTGELCGAEEALSW
EEEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHEEEEEECCCCCHHHHHHH
GMVNRVVPLAELDAEVERIAALFAGFGPQVVRQQKRLLREWEEAPLDVSINNSVAEFGRA
HHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHH
FDTGEPQHHMATFLNRKR
CCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA