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The map label for this gene is tcp [H]

Identifier: 73539053

GI number: 73539053

Start: 1976638

End: 1978194

Strand: Direct

Name: tcp [H]

Synonym: Reut_B5230

Alternate gene names: 73539053

Gene position: 1976638-1978194 (Clockwise)

Preceding gene: 73539051

Following gene: 73539054

Centisome position: 72.51

GC content: 66.99

Gene sequence:

>1557_bases
ATGCTGCAAAACCTGAGTCTGAGGAAAAAGCTCTTGCTGCCACTGGTGCTGAGCTGGGTATGCCTGCTTGGCATCACGCT
GTGGAATGCATGGCAGATGCGCGCGCTGCGCATGGAGGAGCGCCGGCTTGACCTGGCACACGTCACGGATACCGCGGTGT
CAGTGGTGGCCGGGTATGAGGCGCTGGCCAAGGCGGGCAAGATGCCGCCGGAAGAAGCCAAAGAGCAGGCGCTGGAGCGC
GTGCGCGCGATGCGCTTTGGCGACGACGGCTACTTCACGCTGATGCGCTCCGACACCGAAGTGCTCATGCATCCGTTCAA
GACCGACATGATCGGCAAGAAGATGGAGGACATGAAGGATCCCAACGGCACGTACCTGTTCCGCGATATCGCCGCCATCG
GCAAGGGCGCCGGCAAGGGCTTCGTCAACTACCTGTGGCCCAGGCCAGGCGCCGAGGCGCCGCAGCCCAAGCTCAGCTAT
GTCGCCAACTTCCGCCCCTGGGACTGGAACTTTATCGCCGGCCTGTACCTGGACGACATCGAGGCCGCGTTCCGCACGTC
GCTGCTCAACGCGCTCGGGCTGCTGCTCGGCGTGGGCGCGCTGATGACGGTGGTCATGCTGCGCGTGGCCGGCAGCCTGC
AGAAGCAGCTCGGCGGCGAGCCTGCGCTCACGTCGCAGATCGCCACGCGCATCGCCGAAGGCAACCTGAGCACCATGGTC
GAGGTGCAGCCCGGCGACGAGCACAGCGTGCTTTACGCCATGCAGCAGATGCAGTCGCGCCTGACCGGCGCAATAGGCAG
CATCCGGGGTTCGGCCGATTCAATCGCGGGCGCGGCCAAGCAGATTTCCGCCGGCAACTCCGACCTGTCGCGCCGCAGCG
AAGAGCAGGCGGCCTCGCTGGAGCAAACCGCAGCCAGCATGGAGCAGCTCACCAGCACGGTGCGCCAGAGCGCCGACAAT
GCGCGCCAGGCCAGCCGCCTGGCCGAGGGCGCATCCGAGATCGCGGTGCGCGGCGGCAGCATCGTGAGCCAGGTGGTCAC
GACCATGGGCGACATCAAGGAAGCGTCGGGCAAGGTGGTCGACATCATCGCCGTGATCGAAGGCATTGCGTTCCAGACCA
ATATCCTGGCGCTGAACGCCGCGGTGGAAGCCGCGCGCGCCGGCGAGCAGGGCCGCGGCTTTGCCGTGGTAGCCGGCGAG
GTGCGCACGCTGGCCCAGCGCAGCGCCACTGCTGCCAAGGAGATCAAGGCATTGATCGGCAATTCGGCGCAGCGCGTGGA
AGACGGCGCGGTGCTGGTCGAAGGTGCGGGCAAGGCCATGGACGAGATCGTCGAGGCGGTCAAGCGCGTCACGGACCTGA
TGGGCGAGATGCGGGCAGCCACCGAAGAGCAGACCGGCGGCATCGAGCAGGTCAACCAGGCGGTGTCGCAGATGGACCAG
ATGGCGCAGCAGAACGCGGCGCTGGTGGAAGAAGCTGCCGCCGCTGCCGCGTCGCTGGAAGACCAGGCAGCCGCACTGCA
CCACGCGGTCGGCCAGTTCCGGCTCGCCGGCGGCTGA

Upstream 100 bases:

>100_bases
AGGTATTACCCCAATCAAGTTAGTCAAAGCGGTCGCCGTTATGGCGGGGACGGACGCCAAAAGTCCGATTACACCGAGCA
TATGGGGAGAAACAGAGGCA

Downstream 100 bases:

>100_bases
TCGGCTAAGCGGCTAAGCGGCTAAGCGGCTGGGCGGCTGGGCGGCTGGGCATGGCGAGCCATGCCACCTGCCGTGGCCGC
GTATATTATGGATCGCAGCG

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: Citrate chemoreceptor protein [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MLQNLSLRKKLLLPLVLSWVCLLGITLWNAWQMRALRMEERRLDLAHVTDTAVSVVAGYEALAKAGKMPPEEAKEQALER
VRAMRFGDDGYFTLMRSDTEVLMHPFKTDMIGKKMEDMKDPNGTYLFRDIAAIGKGAGKGFVNYLWPRPGAEAPQPKLSY
VANFRPWDWNFIAGLYLDDIEAAFRTSLLNALGLLLGVGALMTVVMLRVAGSLQKQLGGEPALTSQIATRIAEGNLSTMV
EVQPGDEHSVLYAMQQMQSRLTGAIGSIRGSADSIAGAAKQISAGNSDLSRRSEEQAASLEQTAASMEQLTSTVRQSADN
ARQASRLAEGASEIAVRGGSIVSQVVTTMGDIKEASGKVVDIIAVIEGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE
VRTLAQRSATAAKEIKALIGNSAQRVEDGAVLVEGAGKAMDEIVEAVKRVTDLMGEMRAATEEQTGGIEQVNQAVSQMDQ
MAQQNAALVEEAAAAAASLEDQAAALHHAVGQFRLAGG

Sequences:

>Translated_518_residues
MLQNLSLRKKLLLPLVLSWVCLLGITLWNAWQMRALRMEERRLDLAHVTDTAVSVVAGYEALAKAGKMPPEEAKEQALER
VRAMRFGDDGYFTLMRSDTEVLMHPFKTDMIGKKMEDMKDPNGTYLFRDIAAIGKGAGKGFVNYLWPRPGAEAPQPKLSY
VANFRPWDWNFIAGLYLDDIEAAFRTSLLNALGLLLGVGALMTVVMLRVAGSLQKQLGGEPALTSQIATRIAEGNLSTMV
EVQPGDEHSVLYAMQQMQSRLTGAIGSIRGSADSIAGAAKQISAGNSDLSRRSEEQAASLEQTAASMEQLTSTVRQSADN
ARQASRLAEGASEIAVRGGSIVSQVVTTMGDIKEASGKVVDIIAVIEGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE
VRTLAQRSATAAKEIKALIGNSAQRVEDGAVLVEGAGKAMDEIVEAVKRVTDLMGEMRAATEEQTGGIEQVNQAVSQMDQ
MAQQNAALVEEAAAAAASLEDQAAALHHAVGQFRLAGG
>Mature_518_residues
MLQNLSLRKKLLLPLVLSWVCLLGITLWNAWQMRALRMEERRLDLAHVTDTAVSVVAGYEALAKAGKMPPEEAKEQALER
VRAMRFGDDGYFTLMRSDTEVLMHPFKTDMIGKKMEDMKDPNGTYLFRDIAAIGKGAGKGFVNYLWPRPGAEAPQPKLSY
VANFRPWDWNFIAGLYLDDIEAAFRTSLLNALGLLLGVGALMTVVMLRVAGSLQKQLGGEPALTSQIATRIAEGNLSTMV
EVQPGDEHSVLYAMQQMQSRLTGAIGSIRGSADSIAGAAKQISAGNSDLSRRSEEQAASLEQTAASMEQLTSTVRQSADN
ARQASRLAEGASEIAVRGGSIVSQVVTTMGDIKEASGKVVDIIAVIEGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE
VRTLAQRSATAAKEIKALIGNSAQRVEDGAVLVEGAGKAMDEIVEAVKRVTDLMGEMRAATEEQTGGIEQVNQAVSQMDQ
MAQQNAALVEEAAAAAASLEDQAAALHHAVGQFRLAGG

Specific function: Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=289, Percent_Identity=59.8615916955017, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI2367378, Length=383, Percent_Identity=51.4360313315927, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1787690, Length=389, Percent_Identity=48.8431876606684, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1788194, Length=286, Percent_Identity=58.041958041958, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1789453, Length=311, Percent_Identity=37.2990353697749, Blast_Score=195, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR003122
- InterPro:   IPR004091
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 55241; Mature: 55241

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8419927; 11677609 [H]