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The map label for this gene is groL [H]

Identifier: 73539017

GI number: 73539017

Start: 1937765

End: 1939399

Strand: Direct

Name: groL [H]

Synonym: Reut_B5194

Alternate gene names: 73539017

Gene position: 1937765-1939399 (Clockwise)

Preceding gene: 73539014

Following gene: 73539018

Centisome position: 71.08

GC content: 65.32

Gene sequence:

>1635_bases
ATGCCCGAAAAAACTCTTATCTTCCACCAGAGCGCGCGACGCGAGATGCTTCATGGTGTGGAATTGCTCGCGCGGGCCGT
CAAGGTCACGCTGGGACCGGGCGGGCGCAATGTCATCGTAGAACGCCGCGACATGGTGCCCCTGGTCGCCAACTCCGGGG
TGGTGGTAGCCAAGTCCGTCTCGCTGCCCGACCCGTTCGCCGATATGGGCGCCCGCCTGCTCTGCGAAGCAGCGGTCCGA
ACCAGCGAGATCGCCGGCGACGGCACCACGACTGCGACGACCCTTGCCCACGCCATCGTGGCGGAAGGGGTGAAGTACGT
CGAGGCCGGACACGACCCGATGCAACTCAAACGAGGCATCGAAGCGGCCGGAAAACTAGTCTCGGAGCATTTGCTGGCAA
GTGCGAAGCCGTGCGGCGGTACTGACGAAATGAGGCAGATTGCGACCATCTCGGCCAGCGGCGACCACACTGTCGGAACG
CTGGTCGCCCAGGCCGTGGAACACGTGGGCAAGGACGGCGCCATCAGCGTCGAAGACGGTTCCAAACTTGACGACGAGCT
GGATATTGCCGAAGGCGCACTGATCGACCGCGGCTACCTGTCTCCGCTGTTCGCGACCACGGAGAGCCGCGCTGTCGTGC
TCGAATCTCCGCTGGTACTGCTTTGTGACGCAAGTATCTCGTCGATAGCACAGTTGCTGCCGATCCTGGAAGCTGTGACG
CGGGCAGGCCGGTCGTTGCTGGTCATTGCCAACGATGTGGAAGGCGAAGCGCTGGCGACGCTGGTCGTCAACAACCTGCG
CGGCGCACTGAAGAGCTGCGCGGTAAAGTCCCCTGGCTTTGGCGACTCTCGCACCGAGCAACTTGGGGATCTCGCTGCGC
TGACCGGCGCGACGGTGGTGTCGCCGCAAACGGGCACATCCCTTGAGCATGTCGGACTGGAACAACTGGGCGAGGCACGG
CGCGTGGAAATCAACAAGGACGCGACGACGCTGGTGGGCTCCGGCGCCGATGCATCCCGCGTAGCCGCGCGCATCGCCGT
ACTGCGCAGCCGGGTGCCCGACGCACGCTCGGACTACGACCGCGAAGGATTGCAGCGTCGCATCGCCCGGCTGACGGGCG
GCGTCGCCGTCATCAAGGTCGGCGCGGCTACCGAGAGCGCATTGCATGAACGCAAGAACCGGTTCCAGGACGCATTGCAT
GCTACGCGCGCCGCAGTGGACGAGGGCATCGTCGCAGGTGGAGGCGTGGCGCTGCTGCGTGCCCGTACCGTGCTGCAGGA
CTGGCAAGCGCCAAATGCGGAACAGGCTGCCGGTGCACGCATCGTCCACGCAGCGCTGGCGGCGCCAATGCGGCAGATCG
TCGCGAATGCCGGCGCCGACGCCGATGCGGTCGTTCACCGGGTATGCGAGGCGTCGGGAACCATCGGCTACGATGCCGGG
GGCGAGCGCTTTGGCGACATGCTCGAACTCGGCGTGATCGACCCGGTCAAGGTCGTACGCACCGCGCTGCAGAATGCCGT
CTCCATCGCTTCATTGCTGCTCACGACCGACTGCATGATTGCGATCGAGCGCATCCCCCACGGCTCCGCGGAGAACGCTG
CCGCGGGAGCCCGCATGTTCGGCGAAGAATTCTGA

Upstream 100 bases:

>100_bases
GCCATCGCGCATCGTCGCCCTTGCGTTACATCAACGCGCGCGTCGCCACGGCACCTACGGTAGAGCCGTTGCCAACCTGG
ATCACGATGCGGAATTCGCC

Downstream 100 bases:

>100_bases
CCAGCTTGCCCCGGATGCAGCAGGTAAGCGCGCTCTCGCATGCCCACCAGGCCAAAGGACCCCGGCTTGCGCGGACTCGC
GGGGTCGAAACCTGCCGGTC

Product: chaperonin Cpn60/TCP-1

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MPEKTLIFHQSARREMLHGVELLARAVKVTLGPGGRNVIVERRDMVPLVANSGVVVAKSVSLPDPFADMGARLLCEAAVR
TSEIAGDGTTTATTLAHAIVAEGVKYVEAGHDPMQLKRGIEAAGKLVSEHLLASAKPCGGTDEMRQIATISASGDHTVGT
LVAQAVEHVGKDGAISVEDGSKLDDELDIAEGALIDRGYLSPLFATTESRAVVLESPLVLLCDASISSIAQLLPILEAVT
RAGRSLLVIANDVEGEALATLVVNNLRGALKSCAVKSPGFGDSRTEQLGDLAALTGATVVSPQTGTSLEHVGLEQLGEAR
RVEINKDATTLVGSGADASRVAARIAVLRSRVPDARSDYDREGLQRRIARLTGGVAVIKVGAATESALHERKNRFQDALH
ATRAAVDEGIVAGGGVALLRARTVLQDWQAPNAEQAAGARIVHAALAAPMRQIVANAGADADAVVHRVCEASGTIGYDAG
GERFGDMLELGVIDPVKVVRTALQNAVSIASLLLTTDCMIAIERIPHGSAENAAAGARMFGEEF

Sequences:

>Translated_544_residues
MPEKTLIFHQSARREMLHGVELLARAVKVTLGPGGRNVIVERRDMVPLVANSGVVVAKSVSLPDPFADMGARLLCEAAVR
TSEIAGDGTTTATTLAHAIVAEGVKYVEAGHDPMQLKRGIEAAGKLVSEHLLASAKPCGGTDEMRQIATISASGDHTVGT
LVAQAVEHVGKDGAISVEDGSKLDDELDIAEGALIDRGYLSPLFATTESRAVVLESPLVLLCDASISSIAQLLPILEAVT
RAGRSLLVIANDVEGEALATLVVNNLRGALKSCAVKSPGFGDSRTEQLGDLAALTGATVVSPQTGTSLEHVGLEQLGEAR
RVEINKDATTLVGSGADASRVAARIAVLRSRVPDARSDYDREGLQRRIARLTGGVAVIKVGAATESALHERKNRFQDALH
ATRAAVDEGIVAGGGVALLRARTVLQDWQAPNAEQAAGARIVHAALAAPMRQIVANAGADADAVVHRVCEASGTIGYDAG
GERFGDMLELGVIDPVKVVRTALQNAVSIASLLLTTDCMIAIERIPHGSAENAAAGARMFGEEF
>Mature_543_residues
PEKTLIFHQSARREMLHGVELLARAVKVTLGPGGRNVIVERRDMVPLVANSGVVVAKSVSLPDPFADMGARLLCEAAVRT
SEIAGDGTTTATTLAHAIVAEGVKYVEAGHDPMQLKRGIEAAGKLVSEHLLASAKPCGGTDEMRQIATISASGDHTVGTL
VAQAVEHVGKDGAISVEDGSKLDDELDIAEGALIDRGYLSPLFATTESRAVVLESPLVLLCDASISSIAQLLPILEAVTR
AGRSLLVIANDVEGEALATLVVNNLRGALKSCAVKSPGFGDSRTEQLGDLAALTGATVVSPQTGTSLEHVGLEQLGEARR
VEINKDATTLVGSGADASRVAARIAVLRSRVPDARSDYDREGLQRRIARLTGGVAVIKVGAATESALHERKNRFQDALHA
TRAAVDEGIVAGGGVALLRARTVLQDWQAPNAEQAAGARIVHAALAAPMRQIVANAGADADAVVHRVCEASGTIGYDAGG
ERFGDMLELGVIDPVKVVRTALQNAVSIASLLLTTDCMIAIERIPHGSAENAAAGARMFGEEF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=42.5855513307985, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=42.5855513307985, Blast_Score=404, Evalue=1e-112,
Organism=Escherichia coli, GI1790586, Length=521, Percent_Identity=52.0153550863724, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=44.3396226415094, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI193210679, Length=213, Percent_Identity=46.0093896713615, Blast_Score=183, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323288, Length=522, Percent_Identity=45.2107279693487, Blast_Score=438, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45550936, Length=519, Percent_Identity=43.5452793834297, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45550132, Length=519, Percent_Identity=43.5452793834297, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45550935, Length=519, Percent_Identity=43.5452793834297, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=43.1558935361217, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=43.1558935361217, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI17864606, Length=527, Percent_Identity=40.607210626186, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24584129, Length=516, Percent_Identity=37.2093023255814, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI19921262, Length=516, Percent_Identity=37.2093023255814, Blast_Score=298, Evalue=5e-81,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56596; Mature: 56465

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKTLIFHQSARREMLHGVELLARAVKVTLGPGGRNVIVERRDMVPLVANSGVVVAKSV
CCCCEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCEEEECCCEEEEECC
SLPDPFADMGARLLCEAAVRTSEIAGDGTTTATTLAHAIVAEGVKYVEAGHDPMQLKRGI
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHH
EAAGKLVSEHLLASAKPCGGTDEMRQIATISASGDHTVGTLVAQAVEHVGKDGAISVEDG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEECCC
SKLDDELDIAEGALIDRGYLSPLFATTESRAVVLESPLVLLCDASISSIAQLLPILEAVT
CCCCCHHHHHCCCEECCCCCCHHHHCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHH
RAGRSLLVIANDVEGEALATLVVNNLRGALKSCAVKSPGFGDSRTEQLGDLAALTGATVV
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEE
SPQTGTSLEHVGLEQLGEARRVEINKDATTLVGSGADASRVAARIAVLRSRVPDARSDYD
CCCCCCCHHHCCHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
REGLQRRIARLTGGVAVIKVGAATESALHERKNRFQDALHATRAAVDEGIVAGGGVALLR
HHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ARTVLQDWQAPNAEQAAGARIVHAALAAPMRQIVANAGADADAVVHRVCEASGTIGYDAG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
GERFGDMLELGVIDPVKVVRTALQNAVSIASLLLTTDCMIAIERIPHGSAENAAAGARMF
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
GEEF
CCCC
>Mature Secondary Structure 
PEKTLIFHQSARREMLHGVELLARAVKVTLGPGGRNVIVERRDMVPLVANSGVVVAKSV
CCCEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCEEEECCCEEEEECC
SLPDPFADMGARLLCEAAVRTSEIAGDGTTTATTLAHAIVAEGVKYVEAGHDPMQLKRGI
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHH
EAAGKLVSEHLLASAKPCGGTDEMRQIATISASGDHTVGTLVAQAVEHVGKDGAISVEDG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEECCC
SKLDDELDIAEGALIDRGYLSPLFATTESRAVVLESPLVLLCDASISSIAQLLPILEAVT
CCCCCHHHHHCCCEECCCCCCHHHHCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHH
RAGRSLLVIANDVEGEALATLVVNNLRGALKSCAVKSPGFGDSRTEQLGDLAALTGATVV
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEE
SPQTGTSLEHVGLEQLGEARRVEINKDATTLVGSGADASRVAARIAVLRSRVPDARSDYD
CCCCCCCHHHCCHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
REGLQRRIARLTGGVAVIKVGAATESALHERKNRFQDALHATRAAVDEGIVAGGGVALLR
HHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ARTVLQDWQAPNAEQAAGARIVHAALAAPMRQIVANAGADADAVVHRVCEASGTIGYDAG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
GERFGDMLELGVIDPVKVVRTALQNAVSIASLLLTTDCMIAIERIPHGSAENAAAGARMF
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
GEEF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA