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The map label for this gene is ethA [H]

Identifier: 73538980

GI number: 73538980

Start: 1895474

End: 1896994

Strand: Direct

Name: ethA [H]

Synonym: Reut_B5155

Alternate gene names: 73538980

Gene position: 1895474-1896994 (Clockwise)

Preceding gene: 73538978

Following gene: 73538981

Centisome position: 69.53

GC content: 61.74

Gene sequence:

>1521_bases
GTGAAGGCCGACTTCGACGTATTGATCATTGGCGCCGGCTTATCCGGCATCGGCATGGCCTGCCACCTGGCCGAGGCTTG
TCCCGACAAGCGCGTCGGCATCCTGGAGCGGCGCAGCGCCATCGGCGGCACATGGGACCTGTTCCGGTACCCCGGCATCC
GGTCGGATTCGGATATGTTCAGCTTCGGCTACAAGTTCCGTCCCTGGCATGAGTTGAAAGTCCTTGCCGACGGGCCCGCG
ATCCGTCGCTACATAGCCGATACCGCGCGCGAGTATGGCGTCGACAAATCCATCCGGTTCGGACTCAAAGTCCTACGTGC
ATCGTGGTCGAGCGAAGATCGGAGTTGGACCGTCACCGTACAGCAGGAAGACAGTCACGAAACCCATTCCCTCACCTGCA
AGTTCCTGATTTCCTGCACGGGCTATTACAACTACGACCACGGGTACCGCCCCGACTTTACGGGTCTCGAGCGGTTCCAG
GGTATCTGCGTCCATCCGCAACACTGGCCTCAAGACCTCGACTACCACGGCAAGCGTGTCATCGTGATCGGAAGTGGTGC
GACGGCGGTCACCCTGGTGCCGTCCATGGCAGGCAAGGCGTCGCACGTCACGATGCTGCAGCGATCGCCGAGTTACGTCT
TCTCAGTGCCGGCCTATGACAAGATATCTGCCGTGCTGCAGAAGATGCTGCCGGCAAGCTGGGTCTTTGGCCTGGCACGC
TGGCGCAATATTCGCCTGCAGCGCTTTATCTACAGGGCGGCAAGACGGTGGCCTCAGCGCGTTCGCGCCTGGCTGCTGTC
GCATGTCGAGCAACAACTCGGCCACGGTGCCGACCTGCGGCACTTTTCGCCGGAATACAACCCGTGGGACCAACGGTTGT
GTGCCGTGCCTGACGGCGATCTCTTCAAGGCCATCCGCGAAGGCAAGGCGTCAGTGGTGACGGACCAGATCGACACCTTT
ACTGAGACCGGCGTTCGCCTGAAGTCGGGCAGGCGCCTCGACGCCGACATCATTGTCACGGCCACTGGCCTTCAGCTTCA
GTCGTTGGGTGGCATGGAAGTACAGGTGGATGGGCAACCGCGCCACGCCAGCAGCCTCATGACCTACAAGAGCGTGCTGA
TGCAGGACGTGCCCAACATGGCCCATCTGTTTGGTTATACCAATGCCCCCTGGACTCTGAAGGTCGACCTTGCTGCCAGC
TACATCTGCCGGCTGCTCGATCATATGGACCGCCACGAGTACGAGGTTGTCACGCCAGGTGCGCCCGCCGGGGAAATGCT
GGATGAAACAGTCATGGATTCCCTGCAGTCCGGCTATGTGCAGCGCGGCCGAAACGTCTTGCCCCGCCAGGGGCGCAAGC
TGCCGTGGCGCGTCGTCCATAACTTCGAGGCCGACCGCGACATGTTGACAAGGCATCCGGTCAGCGATCCCGCGCTGGCG
TTCGTCCGTGCCGCAACCACGGCGCGCACTGGGAAAGCCAGCGAACTTGTGGCAACCAGAATGGACGGAACGGCCGTGTG
A

Upstream 100 bases:

>100_bases
TGGCTCGTAACGTAAATTAAGTGTCTCGTAGTGTCAAGAGTGCTTTCGCGCGGCGCGCTACAGTTTCCGGGCGATCAGGC
AAGACATAAGGAGACGCTGC

Downstream 100 bases:

>100_bases
GTGTCAGCCACATTCCGCCTTGGAGCCTTGCATGGTCAGCATTGAGACTTCCTTCCAAAGTCGCGGTGAGCGTTGTGCAG
CCACGCTGATGCTGCCGAAC

Product: flavin-containing monooxygenase FMO

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MKADFDVLIIGAGLSGIGMACHLAEACPDKRVGILERRSAIGGTWDLFRYPGIRSDSDMFSFGYKFRPWHELKVLADGPA
IRRYIADTAREYGVDKSIRFGLKVLRASWSSEDRSWTVTVQQEDSHETHSLTCKFLISCTGYYNYDHGYRPDFTGLERFQ
GICVHPQHWPQDLDYHGKRVIVIGSGATAVTLVPSMAGKASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPASWVFGLAR
WRNIRLQRFIYRAARRWPQRVRAWLLSHVEQQLGHGADLRHFSPEYNPWDQRLCAVPDGDLFKAIREGKASVVTDQIDTF
TETGVRLKSGRRLDADIIVTATGLQLQSLGGMEVQVDGQPRHASSLMTYKSVLMQDVPNMAHLFGYTNAPWTLKVDLAAS
YICRLLDHMDRHEYEVVTPGAPAGEMLDETVMDSLQSGYVQRGRNVLPRQGRKLPWRVVHNFEADRDMLTRHPVSDPALA
FVRAATTARTGKASELVATRMDGTAV

Sequences:

>Translated_506_residues
MKADFDVLIIGAGLSGIGMACHLAEACPDKRVGILERRSAIGGTWDLFRYPGIRSDSDMFSFGYKFRPWHELKVLADGPA
IRRYIADTAREYGVDKSIRFGLKVLRASWSSEDRSWTVTVQQEDSHETHSLTCKFLISCTGYYNYDHGYRPDFTGLERFQ
GICVHPQHWPQDLDYHGKRVIVIGSGATAVTLVPSMAGKASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPASWVFGLAR
WRNIRLQRFIYRAARRWPQRVRAWLLSHVEQQLGHGADLRHFSPEYNPWDQRLCAVPDGDLFKAIREGKASVVTDQIDTF
TETGVRLKSGRRLDADIIVTATGLQLQSLGGMEVQVDGQPRHASSLMTYKSVLMQDVPNMAHLFGYTNAPWTLKVDLAAS
YICRLLDHMDRHEYEVVTPGAPAGEMLDETVMDSLQSGYVQRGRNVLPRQGRKLPWRVVHNFEADRDMLTRHPVSDPALA
FVRAATTARTGKASELVATRMDGTAV
>Mature_506_residues
MKADFDVLIIGAGLSGIGMACHLAEACPDKRVGILERRSAIGGTWDLFRYPGIRSDSDMFSFGYKFRPWHELKVLADGPA
IRRYIADTAREYGVDKSIRFGLKVLRASWSSEDRSWTVTVQQEDSHETHSLTCKFLISCTGYYNYDHGYRPDFTGLERFQ
GICVHPQHWPQDLDYHGKRVIVIGSGATAVTLVPSMAGKASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPASWVFGLAR
WRNIRLQRFIYRAARRWPQRVRAWLLSHVEQQLGHGADLRHFSPEYNPWDQRLCAVPDGDLFKAIREGKASVVTDQIDTF
TETGVRLKSGRRLDADIIVTATGLQLQSLGGMEVQVDGQPRHASSLMTYKSVLMQDVPNMAHLFGYTNAPWTLKVDLAAS
YICRLLDHMDRHEYEVVTPGAPAGEMLDETVMDSLQSGYVQRGRNVLPRQGRKLPWRVVHNFEADRDMLTRHPVSDPALA
FVRAATTARTGKASELVATRMDGTAV

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=354, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI50541961, Length=354, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25145785, Length=352, Percent_Identity=25, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56944; Mature: 56944

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKADFDVLIIGAGLSGIGMACHLAEACPDKRVGILERRSAIGGTWDLFRYPGIRSDSDMF
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCHH
SFGYKFRPWHELKVLADGPAIRRYIADTAREYGVDKSIRFGLKVLRASWSSEDRSWTVTV
HCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEE
QQEDSHETHSLTCKFLISCTGYYNYDHGYRPDFTGLERFQGICVHPQHWPQDLDYHGKRV
ECCCCCCCHHEEEEEEEEECCEECCCCCCCCCCCHHHHHCCEEECCCCCCCCCCCCCCEE
IVIGSGATAVTLVPSMAGKASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPASWVFGLAR
EEEECCCCEEEEECCCCCCCHHEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHH
WRNIRLQRFIYRAARRWPQRVRAWLLSHVEQQLGHGADLRHFSPEYNPWDQRLCAVPDGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCEEECCCCHH
LFKAIREGKASVVTDQIDTFTETGVRLKSGRRLDADIIVTATGLQLQSLGGMEVQVDGQP
HHHHHHCCCCCEEHHHHHHHHHCCCEECCCCCCCCEEEEEECCCEEECCCCEEEEECCCC
RHASSLMTYKSVLMQDVPNMAHLFGYTNAPWTLKVDLAASYICRLLDHMDRHEYEVVTPG
CHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEECCC
APAGEMLDETVMDSLQSGYVQRGRNVLPRQGRKLPWRVVHNFEADRDMLTRHPVSDPALA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHCCCCCCHHHH
FVRAATTARTGKASELVATRMDGTAV
HHHHHHHHCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MKADFDVLIIGAGLSGIGMACHLAEACPDKRVGILERRSAIGGTWDLFRYPGIRSDSDMF
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCHH
SFGYKFRPWHELKVLADGPAIRRYIADTAREYGVDKSIRFGLKVLRASWSSEDRSWTVTV
HCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEE
QQEDSHETHSLTCKFLISCTGYYNYDHGYRPDFTGLERFQGICVHPQHWPQDLDYHGKRV
ECCCCCCCHHEEEEEEEEECCEECCCCCCCCCCCHHHHHCCEEECCCCCCCCCCCCCCEE
IVIGSGATAVTLVPSMAGKASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPASWVFGLAR
EEEECCCCEEEEECCCCCCCHHEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHH
WRNIRLQRFIYRAARRWPQRVRAWLLSHVEQQLGHGADLRHFSPEYNPWDQRLCAVPDGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCEEECCCCHH
LFKAIREGKASVVTDQIDTFTETGVRLKSGRRLDADIIVTATGLQLQSLGGMEVQVDGQP
HHHHHHCCCCCEEHHHHHHHHHCCCEECCCCCCCCEEEEEECCCEEECCCCEEEEECCCC
RHASSLMTYKSVLMQDVPNMAHLFGYTNAPWTLKVDLAASYICRLLDHMDRHEYEVVTPG
CHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEECCC
APAGEMLDETVMDSLQSGYVQRGRNVLPRQGRKLPWRVVHNFEADRDMLTRHPVSDPALA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHCCCCCCHHHH
FVRAATTARTGKASELVATRMDGTAV
HHHHHHHHCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]