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The map label for this gene is tcp [H]

Identifier: 73538961

GI number: 73538961

Start: 1874827

End: 1876626

Strand: Reverse

Name: tcp [H]

Synonym: Reut_B5136

Alternate gene names: 73538961

Gene position: 1876626-1874827 (Counterclockwise)

Preceding gene: 73538962

Following gene: 73538960

Centisome position: 68.84

GC content: 61.39

Gene sequence:

>1800_bases
ATGCTTTCATCGATTCGCACGAAAATTCAGGTCATTTCCACCGGCATTGTCGTGACATCGCTTGCGCTGACCGCTTGTGC
AACCTATGTCATCGTTCGCGACAGCAACCTGGAAACGATCCGGCAAAACCTCGATGCCATCGCTACCGGCCATGCACTCG
CGCTCGATGAATGGGTGACAGGGAAAGCAACCATGGTGGCTGCCGCCGCAGAGCAGATTGCGCCAGGCGACCCACGCGGT
ATTGTTCGTCAGCTGCAGAAGGCCGGCGCATTCCCGATCACCACTGCCGGCTGGCAGGACAAGTCCTTTGTCGCAAGCAA
GGACCAGATGCCGTCAGGCTTCGATCCGACTGCGCGACCCTGGTACAAGGAGACCCTGGCAGCGGCTAAGCCAATCGTGA
CGAAGCCATACGCTGACGCAACGACGGGCAAGCCGTTTGTCTCGTTCGCCGCACCCATCGTGCGAGACGGCGTGACAAGT
GGCGTGGTGTCTGCGGTAGTGTCCCTGGATGGCGTACGCGATGTCGTGACCGCCGTGCGCCCGACGCCCGAGAGTCTTGG
CTTTGTGGTCGACAAGGATGCCAATATCCTGGCGCACCCCGATGCAAAGTACATCCGCAAGCCGGCGTTGGAGTTGTCGC
AAGCGTTGACGCCACAGGCATTGGCATCGCTTGAAAGCGAAGGAAATCCGCTCGAGATCGAGCTCGACGGCAGAATGAAG
CTGCTGCGCGCAAGGCCGATTCACGGCACGAACTGGCAGCTCGTCGTGGCGCTGGATAAGGCAGAGGCCACTGCAGCCCT
GAATCGGGTGATCAAGACCTCGGCGTTAGCCATCGTGCTGCTGGCGGTGGTGGCCGCGGCGCTGAGCGGCTTGTTCACCG
CACGAGCGTTTCGCCGGCTATCCGAAGTGCGAGACGCCATGAATGAAATCGCCACCGGTGACGGCGATCTGACCCGCCGT
CTTCCGGTCGACGGCCGTGACGAGGTCTCGCAGATCGCGACATCCTTCAATACCTTCGTCGAAAAGCTCGGCAGCACACT
GACCAGGATTCGGCGTGGCAGCGAATCGGTGAAGGTCGCGACCAACGAAATCGAGGCTGGAAACCAGGACCTGTCGCGTC
GTACGGAAATGGCGGCGAGCAATCTGGAGGAGACAGCGGCTTCGCTGTCCGAGCTGACCGGATCGGTGAGCCGCTCCGCC
GAAGCAACAGTTCAGGCAACACGTCTTGCATCATCCGCCAGTGACGCGGCGAAGCGTGGCGGCAATGTCGTTTCCGACGT
CGTCGCGACGATGGAGGACATCGCCCGTTCGTCATCGAGGATCGGGGAGATCATCGGCGTCATCGACGGCATTGCCTACC
AGACCAATATCCTTGCACTGAATGCTGCAGTCGAGGCCGCACGCGCTGGCGAACATGGCAAAGGCTTCGCCGTGGTAGCC
GGCGAAGTGCGCAGCCTTGCGCATCGGAGTGCCTCGGCGGCCAAGGAGATCAAGACGCTGATCGAGACCTCCGAAGTCAG
CGTACAGTCCGGGACCCAGCGGGTTCAGGCTGCCGGCGATGCGATGACGGAAATCGTCGACGGCATCCGCCAGGTCTCCT
CGCTCATTTCCGAGATCAGTGCGGCCATGGGCGAACAAAGTACAGGCCTCAGCCAGATCAATCAGGCAGTCGAGGAAATG
GAGCAAGCCACGCAACAGAATGCCGCGCTGGTGGAACAGGCAGCGGCGGCTTCGTCGCTGCTGGATGAGCAGGCCGGCGA
TCTGGCGGAGGCCGTGGCGGGATTCAAGCTGAATAGCTAA

Upstream 100 bases:

>100_bases
GGTTGCAACGCGACAGTCAAACAGCCCGGGGACCTCCCCGGGTTTTTTTACAAGCCTGACGAGACCTGCGCGAAGGCCGC
GCCAATCCTTGCCCTCTCTT

Downstream 100 bases:

>100_bases
GCGGCCCTGCGCCGCTCGCTCAGGGGCGCGAGTGCAGGCGAATGCATCCTTGTGATGCAGGACAAGCCAGGCCTGCAAAA
ATTCACAAGCCACGCGCCCC

Product: histidine kinase

Products: NA

Alternate protein names: Citrate chemoreceptor protein [H]

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MLSSIRTKIQVISTGIVVTSLALTACATYVIVRDSNLETIRQNLDAIATGHALALDEWVTGKATMVAAAAEQIAPGDPRG
IVRQLQKAGAFPITTAGWQDKSFVASKDQMPSGFDPTARPWYKETLAAAKPIVTKPYADATTGKPFVSFAAPIVRDGVTS
GVVSAVVSLDGVRDVVTAVRPTPESLGFVVDKDANILAHPDAKYIRKPALELSQALTPQALASLESEGNPLEIELDGRMK
LLRARPIHGTNWQLVVALDKAEATAALNRVIKTSALAIVLLAVVAAALSGLFTARAFRRLSEVRDAMNEIATGDGDLTRR
LPVDGRDEVSQIATSFNTFVEKLGSTLTRIRRGSESVKVATNEIEAGNQDLSRRTEMAASNLEETAASLSELTGSVSRSA
EATVQATRLASSASDAAKRGGNVVSDVVATMEDIARSSSRIGEIIGVIDGIAYQTNILALNAAVEAARAGEHGKGFAVVA
GEVRSLAHRSASAAKEIKTLIETSEVSVQSGTQRVQAAGDAMTEIVDGIRQVSSLISEISAAMGEQSTGLSQINQAVEEM
EQATQQNAALVEQAAAASSLLDEQAGDLAEAVAGFKLNS

Sequences:

>Translated_599_residues
MLSSIRTKIQVISTGIVVTSLALTACATYVIVRDSNLETIRQNLDAIATGHALALDEWVTGKATMVAAAAEQIAPGDPRG
IVRQLQKAGAFPITTAGWQDKSFVASKDQMPSGFDPTARPWYKETLAAAKPIVTKPYADATTGKPFVSFAAPIVRDGVTS
GVVSAVVSLDGVRDVVTAVRPTPESLGFVVDKDANILAHPDAKYIRKPALELSQALTPQALASLESEGNPLEIELDGRMK
LLRARPIHGTNWQLVVALDKAEATAALNRVIKTSALAIVLLAVVAAALSGLFTARAFRRLSEVRDAMNEIATGDGDLTRR
LPVDGRDEVSQIATSFNTFVEKLGSTLTRIRRGSESVKVATNEIEAGNQDLSRRTEMAASNLEETAASLSELTGSVSRSA
EATVQATRLASSASDAAKRGGNVVSDVVATMEDIARSSSRIGEIIGVIDGIAYQTNILALNAAVEAARAGEHGKGFAVVA
GEVRSLAHRSASAAKEIKTLIETSEVSVQSGTQRVQAAGDAMTEIVDGIRQVSSLISEISAAMGEQSTGLSQINQAVEEM
EQATQQNAALVEQAAAASSLLDEQAGDLAEAVAGFKLNS
>Mature_599_residues
MLSSIRTKIQVISTGIVVTSLALTACATYVIVRDSNLETIRQNLDAIATGHALALDEWVTGKATMVAAAAEQIAPGDPRG
IVRQLQKAGAFPITTAGWQDKSFVASKDQMPSGFDPTARPWYKETLAAAKPIVTKPYADATTGKPFVSFAAPIVRDGVTS
GVVSAVVSLDGVRDVVTAVRPTPESLGFVVDKDANILAHPDAKYIRKPALELSQALTPQALASLESEGNPLEIELDGRMK
LLRARPIHGTNWQLVVALDKAEATAALNRVIKTSALAIVLLAVVAAALSGLFTARAFRRLSEVRDAMNEIATGDGDLTRR
LPVDGRDEVSQIATSFNTFVEKLGSTLTRIRRGSESVKVATNEIEAGNQDLSRRTEMAASNLEETAASLSELTGSVSRSA
EATVQATRLASSASDAAKRGGNVVSDVVATMEDIARSSSRIGEIIGVIDGIAYQTNILALNAAVEAARAGEHGKGFAVVA
GEVRSLAHRSASAAKEIKTLIETSEVSVQSGTQRVQAAGDAMTEIVDGIRQVSSLISEISAAMGEQSTGLSQINQAVEEM
EQATQQNAALVEQAAAASSLLDEQAGDLAEAVAGFKLNS

Specific function: Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=350, Percent_Identity=46.8571428571429, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1788195, Length=283, Percent_Identity=54.416961130742, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI2367378, Length=320, Percent_Identity=51.5625, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI1787690, Length=363, Percent_Identity=44.9035812672176, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789453, Length=335, Percent_Identity=39.4029850746269, Blast_Score=216, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR003122
- InterPro:   IPR004091
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 62780; Mature: 62780

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSIRTKIQVISTGIVVTSLALTACATYVIVRDSNLETIRQNLDAIATGHALALDEWVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHC
GKATMVAAAAEQIAPGDPRGIVRQLQKAGAFPITTAGWQDKSFVASKDQMPSGFDPTARP
CCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCH
WYKETLAAAKPIVTKPYADATTGKPFVSFAAPIVRDGVTSGVVSAVVSLDGVRDVVTAVR
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
PTPESLGFVVDKDANILAHPDAKYIRKPALELSQALTPQALASLESEGNPLEIELDGRMK
CCHHHCCEEEECCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCEE
LLRARPIHGTNWQLVVALDKAEATAALNRVIKTSALAIVLLAVVAAALSGLFTARAFRRL
EHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEVRDAMNEIATGDGDLTRRLPVDGRDEVSQIATSFNTFVEKLGSTLTRIRRGSESVKVA
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TNEIEAGNQDLSRRTEMAASNLEETAASLSELTGSVSRSAEATVQATRLASSASDAAKRG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNVVSDVVATMEDIARSSSRIGEIIGVIDGIAYQTNILALNAAVEAARAGEHGKGFAVVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCCCEEEEH
GEVRSLAHRSASAAKEIKTLIETSEVSVQSGTQRVQAAGDAMTEIVDGIRQVSSLISEIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAMGEQSTGLSQINQAVEEMEQATQQNAALVEQAAAASSLLDEQAGDLAEAVAGFKLNS
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLSSIRTKIQVISTGIVVTSLALTACATYVIVRDSNLETIRQNLDAIATGHALALDEWVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHC
GKATMVAAAAEQIAPGDPRGIVRQLQKAGAFPITTAGWQDKSFVASKDQMPSGFDPTARP
CCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCH
WYKETLAAAKPIVTKPYADATTGKPFVSFAAPIVRDGVTSGVVSAVVSLDGVRDVVTAVR
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
PTPESLGFVVDKDANILAHPDAKYIRKPALELSQALTPQALASLESEGNPLEIELDGRMK
CCHHHCCEEEECCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCEE
LLRARPIHGTNWQLVVALDKAEATAALNRVIKTSALAIVLLAVVAAALSGLFTARAFRRL
EHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEVRDAMNEIATGDGDLTRRLPVDGRDEVSQIATSFNTFVEKLGSTLTRIRRGSESVKVA
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TNEIEAGNQDLSRRTEMAASNLEETAASLSELTGSVSRSAEATVQATRLASSASDAAKRG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNVVSDVVATMEDIARSSSRIGEIIGVIDGIAYQTNILALNAAVEAARAGEHGKGFAVVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCCCEEEEH
GEVRSLAHRSASAAKEIKTLIETSEVSVQSGTQRVQAAGDAMTEIVDGIRQVSSLISEIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAMGEQSTGLSQINQAVEEMEQATQQNAALVEQAAAASSLLDEQAGDLAEAVAGFKLNS
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8419927; 11677609 [H]