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The map label for this gene is ethA [H]

Identifier: 73538760

GI number: 73538760

Start: 1659658

End: 1661187

Strand: Reverse

Name: ethA [H]

Synonym: Reut_B4935

Alternate gene names: 73538760

Gene position: 1661187-1659658 (Counterclockwise)

Preceding gene: 73538765

Following gene: 73538759

Centisome position: 60.94

GC content: 66.47

Gene sequence:

>1530_bases
ATGACTGCTGCCGCACCTGAAGACACGTTGCTCGATGTGCTGATTGTGGGTGCCGGCCTGTCGGGTATCGGCGCCGCGCG
GCAGTTGCAGCAGCGGTGCCCCGGCAAGCGCTTCGCCATCCTTGAGGCGCGCGACGCCATCGGCGGCACGTGGGACCTGT
TCCGCTATCCGGGCATCCGGTCGGATTCGGATATGTACACGCTTGGCTACCGCTTCAAGCCATGGAAGGGCGCGAAAGCG
ATTGCTGACGGTCCGTCGATCCTGTCCTATATCCGCGAGACCGCCGACGAGGCGGGCATTACGCCGCGCATCCGCTTCGG
ATGCAAGGTGGTGAGCGCGGCGTGGAACAGCCACGATGCCTGCTGGACAGTTACGGCCGAACGCGTTGCCGATGGCAGCC
GGCAGCAGTGGCGCGCACGGTTTCTGTATGTGTGCGCGGGCTACTACAGCTACGCTGCGGGCCACCGGCCGGCTTTCGCG
GGCGAAGAAAGTTTTCGAGGACGCATCGTGCATCCGCAATTTTGGGATGCTTCGCTCGACTACGCCGCCAAGCGCGTGGT
GGTGATCGGCAGTGGCGCCACGGCCGTCACGATGGTGCCTGCCATGGCTGGCACCGCTGCGCACGTGACTATGCTGCAGC
GTTCGCCAAGCTACGTCGTCACGCGGCCCGGTGAGGACGCCATTGCCGCGAAGTTGCGCCGGCTGCTGCCGGAAGGCCTG
GCCTATGCCGCTACGCGCTGGAAGAACGTGCTGCTCGGCATGTTCGTCTTCCAGCTTGCGCGCCGCCGGCCCGAGCGCGT
CAGCGAGCGCATGGTCGGCATGGCCGCCGCGCAGCTCGGTCCTGACATCGATGTCGGCAGGCACTTCACGCCGCGCTACA
AGCCGTGGGACCAGCGTGTATGCCTGGTGCCGGACGGCGACCTGTTCCGCGAGATTCGCGAAGGCCGCGCGTCGGTCGTG
ACCGACGCCATCGAACGCTTTACGGAAGACGGCATCCGGCTGGCGTCGGGCCAGACGCTGCCAGCCGATATCGTCGTGAC
GGCGACCGGGCTCAAGCTCAATATGCTCGGCGATATCGCCATCAGCGTGGATGGCCAGCCGCGCGTGCCGGCCGAGCAGA
TGGCCTACAAGGGCATGATGCTCAGCGACGTGCCGAACCTGGTGCTGGCCTTCGGCTACACCAACGCCTCGTGGACGCTG
AAAGCGGATCTCACGGCCGAGTACGTTTGCCGGCTGCTGAGGTACATGGACCGCCGGGGCTATCGCGCTGCCGTGCCGCG
GCGCGATGCCGCGGTCAAGCCCACGCCGTTCCTCGACTTCACGTCCGGCTATGTGCAGCGCGCCGCTAGCGTGTTGCCCC
GTCAGGGCGACCGCAAGCCATGGCGGCTCTACCAGAACTACCTCATGGACATGCTCACCATCCGCCATGGCCGCATTGCC
GATGGCGTGCTCCAGTTCGATGCCCCACATCCCGCGACGGCGCCGCGCGAAGTGCCGGTCAGCCTGTCAGGCGGCGAGGT
ACAACCATGA

Upstream 100 bases:

>100_bases
GGTAGGCGCGGTCGTCATGGGGCCATTATGACATTCCCTATTGTCAGATTACATCTGACAACCTATGGTGTCAGAAGTGA
CTGCATCCGGGAAATCCGAC

Downstream 100 bases:

>100_bases
CCTTCCTGTTCTATGCGGTGCTGGCCGTTGCGGCGCTCTTCGCCTGCCTGTTCCTTTACACCATGCGCGCGGTGCGGCGC
GTCGAGGCGGCGCTGCCGCC

Product: cyclohexanone monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTAAAPEDTLLDVLIVGAGLSGIGAARQLQQRCPGKRFAILEARDAIGGTWDLFRYPGIRSDSDMYTLGYRFKPWKGAKA
IADGPSILSYIRETADEAGITPRIRFGCKVVSAAWNSHDACWTVTAERVADGSRQQWRARFLYVCAGYYSYAAGHRPAFA
GEESFRGRIVHPQFWDASLDYAAKRVVVIGSGATAVTMVPAMAGTAAHVTMLQRSPSYVVTRPGEDAIAAKLRRLLPEGL
AYAATRWKNVLLGMFVFQLARRRPERVSERMVGMAAAQLGPDIDVGRHFTPRYKPWDQRVCLVPDGDLFREIREGRASVV
TDAIERFTEDGIRLASGQTLPADIVVTATGLKLNMLGDIAISVDGQPRVPAEQMAYKGMMLSDVPNLVLAFGYTNASWTL
KADLTAEYVCRLLRYMDRRGYRAAVPRRDAAVKPTPFLDFTSGYVQRAASVLPRQGDRKPWRLYQNYLMDMLTIRHGRIA
DGVLQFDAPHPATAPREVPVSLSGGEVQP

Sequences:

>Translated_509_residues
MTAAAPEDTLLDVLIVGAGLSGIGAARQLQQRCPGKRFAILEARDAIGGTWDLFRYPGIRSDSDMYTLGYRFKPWKGAKA
IADGPSILSYIRETADEAGITPRIRFGCKVVSAAWNSHDACWTVTAERVADGSRQQWRARFLYVCAGYYSYAAGHRPAFA
GEESFRGRIVHPQFWDASLDYAAKRVVVIGSGATAVTMVPAMAGTAAHVTMLQRSPSYVVTRPGEDAIAAKLRRLLPEGL
AYAATRWKNVLLGMFVFQLARRRPERVSERMVGMAAAQLGPDIDVGRHFTPRYKPWDQRVCLVPDGDLFREIREGRASVV
TDAIERFTEDGIRLASGQTLPADIVVTATGLKLNMLGDIAISVDGQPRVPAEQMAYKGMMLSDVPNLVLAFGYTNASWTL
KADLTAEYVCRLLRYMDRRGYRAAVPRRDAAVKPTPFLDFTSGYVQRAASVLPRQGDRKPWRLYQNYLMDMLTIRHGRIA
DGVLQFDAPHPATAPREVPVSLSGGEVQP
>Mature_508_residues
TAAAPEDTLLDVLIVGAGLSGIGAARQLQQRCPGKRFAILEARDAIGGTWDLFRYPGIRSDSDMYTLGYRFKPWKGAKAI
ADGPSILSYIRETADEAGITPRIRFGCKVVSAAWNSHDACWTVTAERVADGSRQQWRARFLYVCAGYYSYAAGHRPAFAG
EESFRGRIVHPQFWDASLDYAAKRVVVIGSGATAVTMVPAMAGTAAHVTMLQRSPSYVVTRPGEDAIAAKLRRLLPEGLA
YAATRWKNVLLGMFVFQLARRRPERVSERMVGMAAAQLGPDIDVGRHFTPRYKPWDQRVCLVPDGDLFREIREGRASVVT
DAIERFTEDGIRLASGQTLPADIVVTATGLKLNMLGDIAISVDGQPRVPAEQMAYKGMMLSDVPNLVLAFGYTNASWTLK
ADLTAEYVCRLLRYMDRRGYRAAVPRRDAAVKPTPFLDFTSGYVQRAASVLPRQGDRKPWRLYQNYLMDMLTIRHGRIAD
GVLQFDAPHPATAPREVPVSLSGGEVQP

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56149; Mature: 56018

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAAPEDTLLDVLIVGAGLSGIGAARQLQQRCPGKRFAILEARDAIGGTWDLFRYPGIR
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEHHCCCCCCHHHCCCCCC
SDSDMYTLGYRFKPWKGAKAIADGPSILSYIRETADEAGITPRIRFGCKVVSAAWNSHDA
CCCCEEEECEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHCEEEEEHHCCCCCC
CWTVTAERVADGSRQQWRARFLYVCAGYYSYAAGHRPAFAGEESFRGRIVHPQFWDASLD
EEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCHH
YAAKRVVVIGSGATAVTMVPAMAGTAAHVTMLQRSPSYVVTRPGEDAIAAKLRRLLPEGL
HCCEEEEEEECCCCEEEEHHHHCCCHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHHHH
AYAATRWKNVLLGMFVFQLARRRPERVSERMVGMAAAQLGPDIDVGRHFTPRYKPWDQRV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
CLVPDGDLFREIREGRASVVTDAIERFTEDGIRLASGQTLPADIVVTATGLKLNMLGDIA
EECCCHHHHHHHHHCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEEEEEE
ISVDGQPRVPAEQMAYKGMMLSDVPNLVLAFGYTNASWTLKADLTAEYVCRLLRYMDRRG
EEECCCCCCCHHHHHHCCCHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCC
YRAAVPRRDAAVKPTPFLDFTSGYVQRAASVLPRQGDRKPWRLYQNYLMDMLTIRHGRIA
CEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
DGVLQFDAPHPATAPREVPVSLSGGEVQP
CCEEEECCCCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
TAAAPEDTLLDVLIVGAGLSGIGAARQLQQRCPGKRFAILEARDAIGGTWDLFRYPGIR
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEHHCCCCCCHHHCCCCCC
SDSDMYTLGYRFKPWKGAKAIADGPSILSYIRETADEAGITPRIRFGCKVVSAAWNSHDA
CCCCEEEECEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHCEEEEEHHCCCCCC
CWTVTAERVADGSRQQWRARFLYVCAGYYSYAAGHRPAFAGEESFRGRIVHPQFWDASLD
EEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCHH
YAAKRVVVIGSGATAVTMVPAMAGTAAHVTMLQRSPSYVVTRPGEDAIAAKLRRLLPEGL
HCCEEEEEEECCCCEEEEHHHHCCCHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHHHH
AYAATRWKNVLLGMFVFQLARRRPERVSERMVGMAAAQLGPDIDVGRHFTPRYKPWDQRV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
CLVPDGDLFREIREGRASVVTDAIERFTEDGIRLASGQTLPADIVVTATGLKLNMLGDIA
EECCCHHHHHHHHHCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEEEEEE
ISVDGQPRVPAEQMAYKGMMLSDVPNLVLAFGYTNASWTLKADLTAEYVCRLLRYMDRRG
EEECCCCCCCHHHHHHCCCHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCC
YRAAVPRRDAAVKPTPFLDFTSGYVQRAASVLPRQGDRKPWRLYQNYLMDMLTIRHGRIA
CEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
DGVLQFDAPHPATAPREVPVSLSGGEVQP
CCEEEECCCCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]