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The map label for this gene is hmp [H]

Identifier: 73538639

GI number: 73538639

Start: 1514443

End: 1515603

Strand: Reverse

Name: hmp [H]

Synonym: Reut_B4814

Alternate gene names: 73538639

Gene position: 1515603-1514443 (Counterclockwise)

Preceding gene: 73538640

Following gene: 73538638

Centisome position: 55.59

GC content: 64.51

Gene sequence:

>1161_bases
ATGGAGATGATGCGCGATGCAGTCCAATTCGAGCCAGCCGACAGCCGGGTGACGCGCCCGTCGTTCTGGAGTTCGCTCCC
GGAGCGCTGGACGAGCGACGTCGAGGAGACGCTTGTGTGCTGCCACGTGCGGCAGGAAACGCACGACGTGAAGAGCTTCT
TCTTCCATTCGCCGGACGGTCGCGCGTTCGTGTTCGAGCCGGGGCAGTTCATCACGCTGGAGCTCGAGATCGAGGGCGAG
ACCATCAACCGGTGCTACACGATTTCGTCGTCGCCCGCGCGACCACACACGCTCTCCATCACGGTCAAGCGTGTGCCGGG
CGGCAAGGTGTCGAACTGGCTGCACGATAACGTGCGGCCAGGAACGCCGATCCGGGTGCTCGGTCCTGCCGGCGAGTTCA
CCTGCGCGCGGCATCCGGCGCGCAAGTACCTGTTCCTGTCCGCAGGCTCCGGCATCACGCCCCTGATGTCGATGAGCCGT
GCACACCATGATCTTGGCGAGGATCGCGACATCGTGTTCGTGCACAGCGCGCGTACGCCGGACGACATCATCTTCTCGCG
CGAGCTTGACCTGATCGCGTCGAACCACGCGAACTTCCGCACCTCCTTTGTCTGCGAAAGCGTTGGCGCGCGTACCAGCT
GGCCAGGCGTGACGGGGTTCCTGTCGCTCCCGCTCCTGAAGCTGATCGCGCCGGACTTCATGGAGCGCGAGATCTTTACG
TGTGGGCCGGCGCCGTACATGAAGGCGGTGCGCGACCTGCTCGACGAAGGCGGCTTTGATCGCAGGCGCTACCACGAGGA
AAGTTTCTCGTTCGAGACGCTGACGGCCGATGGACCGGCCGATGCGCCTGCCCCGGACACGGGCGTCGCATCGGCACCAC
ATGGCATTGCGGACATGGCGGCGTTCAGCGTCAGCTTCGCGAAGAGCCGACGCGAGATCGTCTGCAGTTCGGGCCAGCAT
GTACTTGAAGCGGCGCGGCAGTCGGGCGTGCGGTTGCCAGCGTCATGCACGCAGGGCATGTGCGGGACCTGCAAGGTCAA
GCTCGTATCCGGCCAGGTCGAGATGAAACACAACGGCGGCATCCGCCAGCGCGAGATCGACCAGGGGATGGTGCTGTTGT
GCTGCAGCAAGCCGCTGTCGGATCTCGTCATCGACAAGTAG

Upstream 100 bases:

>100_bases
CTCGCCGTTCACCGAAGGCCTCGTCGAAAAGTTCTCGGCCTGGTATATCCGCCGGCTCGCAGAGCACGTCGGCGCATAGG
CGCAAGCAAAGGAAGCGGAG

Downstream 100 bases:

>100_bases
GCGCTGCAGCGCCTGCTCCGCGGCTGATGGCCGCACGCTCGACGGTTCTAACTACACGGAGCGGTTCCGCTCCGGCCAAT
GGAGGTATGCCATGAAGCTT

Product: ferredoxin:oxidoreductase FAD/NAD(P)-binding:oxidoreductase FAD-binding region

Products: NA

Alternate protein names: Rieske-type oxygenase; RO [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MEMMRDAVQFEPADSRVTRPSFWSSLPERWTSDVEETLVCCHVRQETHDVKSFFFHSPDGRAFVFEPGQFITLELEIEGE
TINRCYTISSSPARPHTLSITVKRVPGGKVSNWLHDNVRPGTPIRVLGPAGEFTCARHPARKYLFLSAGSGITPLMSMSR
AHHDLGEDRDIVFVHSARTPDDIIFSRELDLIASNHANFRTSFVCESVGARTSWPGVTGFLSLPLLKLIAPDFMEREIFT
CGPAPYMKAVRDLLDEGGFDRRRYHEESFSFETLTADGPADAPAPDTGVASAPHGIADMAAFSVSFAKSRREIVCSSGQH
VLEAARQSGVRLPASCTQGMCGTCKVKLVSGQVEMKHNGGIRQREIDQGMVLLCCSKPLSDLVIDK

Sequences:

>Translated_386_residues
MEMMRDAVQFEPADSRVTRPSFWSSLPERWTSDVEETLVCCHVRQETHDVKSFFFHSPDGRAFVFEPGQFITLELEIEGE
TINRCYTISSSPARPHTLSITVKRVPGGKVSNWLHDNVRPGTPIRVLGPAGEFTCARHPARKYLFLSAGSGITPLMSMSR
AHHDLGEDRDIVFVHSARTPDDIIFSRELDLIASNHANFRTSFVCESVGARTSWPGVTGFLSLPLLKLIAPDFMEREIFT
CGPAPYMKAVRDLLDEGGFDRRRYHEESFSFETLTADGPADAPAPDTGVASAPHGIADMAAFSVSFAKSRREIVCSSGQH
VLEAARQSGVRLPASCTQGMCGTCKVKLVSGQVEMKHNGGIRQREIDQGMVLLCCSKPLSDLVIDK
>Mature_386_residues
MEMMRDAVQFEPADSRVTRPSFWSSLPERWTSDVEETLVCCHVRQETHDVKSFFFHSPDGRAFVFEPGQFITLELEIEGE
TINRCYTISSSPARPHTLSITVKRVPGGKVSNWLHDNVRPGTPIRVLGPAGEFTCARHPARKYLFLSAGSGITPLMSMSR
AHHDLGEDRDIVFVHSARTPDDIIFSRELDLIASNHANFRTSFVCESVGARTSWPGVTGFLSLPLLKLIAPDFMEREIFT
CGPAPYMKAVRDLLDEGGFDRRRYHEESFSFETLTADGPADAPAPDTGVASAPHGIADMAAFSVSFAKSRREIVCSSGQH
VLEAARQSGVRLPASCTQGMCGTCKVKLVSGQVEMKHNGGIRQREIDQGMVLLCCSKPLSDLVIDK

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI84875541, Length=238, Percent_Identity=27.3109243697479, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787098, Length=345, Percent_Identity=31.0144927536232, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787658, Length=359, Percent_Identity=28.133704735376, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788903, Length=230, Percent_Identity=27.3913043478261, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790359, Length=179, Percent_Identity=29.608938547486, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322146, Length=236, Percent_Identity=25.8474576271186, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323552, Length=194, Percent_Identity=26.2886597938144, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322699, Length=219, Percent_Identity=24.2009132420091, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323510, Length=224, Percent_Identity=23.6607142857143, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 42618; Mature: 42618

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMMRDAVQFEPADSRVTRPSFWSSLPERWTSDVEETLVCCHVRQETHDVKSFFFHSPDG
CCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
RAFVFEPGQFITLELEIEGETINRCYTISSSPARPHTLSITVKRVPGGKVSNWLHDNVRP
CEEEECCCCEEEEEEEECCCEEEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHCCCCC
GTPIRVLGPAGEFTCARHPARKYLFLSAGSGITPLMSMSRAHHDLGEDRDIVFVHSARTP
CCCEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCC
DDIIFSRELDLIASNHANFRTSFVCESVGARTSWPGVTGFLSLPLLKLIAPDFMEREIFT
CCEEEECCHHEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCEE
CGPAPYMKAVRDLLDEGGFDRRRYHEESFSFETLTADGPADAPAPDTGVASAPHGIADMA
CCCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
AFSVSFAKSRREIVCSSGQHVLEAARQSGVRLPASCTQGMCGTCKVKLVSGQVEMKHNGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEEECEEEEECCCC
IRQREIDQGMVLLCCSKPLSDLVIDK
CCHHECCCCEEEEEECCCHHHHHCCC
>Mature Secondary Structure
MEMMRDAVQFEPADSRVTRPSFWSSLPERWTSDVEETLVCCHVRQETHDVKSFFFHSPDG
CCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
RAFVFEPGQFITLELEIEGETINRCYTISSSPARPHTLSITVKRVPGGKVSNWLHDNVRP
CEEEECCCCEEEEEEEECCCEEEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHCCCCC
GTPIRVLGPAGEFTCARHPARKYLFLSAGSGITPLMSMSRAHHDLGEDRDIVFVHSARTP
CCCEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCC
DDIIFSRELDLIASNHANFRTSFVCESVGARTSWPGVTGFLSLPLLKLIAPDFMEREIFT
CCEEEECCHHEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCEE
CGPAPYMKAVRDLLDEGGFDRRRYHEESFSFETLTADGPADAPAPDTGVASAPHGIADMA
CCCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
AFSVSFAKSRREIVCSSGQHVLEAARQSGVRLPASCTQGMCGTCKVKLVSGQVEMKHNGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEEECEEEEECCCC
IRQREIDQGMVLLCCSKPLSDLVIDK
CCHHECCCCEEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]