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The map label for this gene is serA [H]

Identifier: 73538572

GI number: 73538572

Start: 1445734

End: 1447011

Strand: Direct

Name: serA [H]

Synonym: Reut_B4747

Alternate gene names: 73538572

Gene position: 1445734-1447011 (Clockwise)

Preceding gene: 73538571

Following gene: 73538573

Centisome position: 53.03

GC content: 66.74

Gene sequence:

>1278_bases
TTGCCGCGCCGCAGCAGAGGCTGCCGGCGCGCACCTTGTTCTCTCCGAGTCCTATTCTTGCGCGGAAAACTGAACGTGAC
GACTGCGATCCTGCTCGAAAACATCCATGCAAGCGCCACGGCGCGCCTTGGCGAGGCCGGCCTGACGGTCGAGCGCCGCA
CCGGCGCGCTGGCCGGCGACGAACTGCGCCAGGTGCTGGCAAGCCATGACCTCGTCGGCATCCGCTCTGCCACGCACCTG
CGCGGCGACGATATCCGCAGCGCGCCCGCGCTGCTCAGCATCGGCTGCTTCTGCATCGGCACCTCGCAGGTCGATCTGGA
CGCCGCGACCGCGGCTGGCATCCCGGTCTTCAATGCGCCGTTTTCGAACACGCGGTCGGTGGCCGAGCTGGTCGTGTCCG
AGGCCGTGATGCTGCTGCGCAAGATCCCGGAGAAGAATGCGCTAGCTCATGCCGGCAAGTGGGCCAAGGGCGCCAGCGGC
GCGTTCGAGGCGCGCGGCAAGACCATCGCCATCGTCGGCTACGGCAATATCGGCTCTCAGGTCGGCGTATTGGCGGAGTC
GATGGGCATGCGGGTGGTGTACTACGACGTGCTGGCCCGGCTGTCGCTCGGCTCGGCGCGTGCCGCCGGTACGCTCGAAG
AAGCCGTGTCGCAGGCGGACGTGGTCACTCTGCACGTGCCCGCTACGGCCCGCACGCGCAACATGATCGATGCCCACGTG
CTCGCCTGCTTCAAGCCGGGCGCGATCCTGATCAACGCATCGCGCGGCACCGTGGTGGATATCGATGCGCTTGCGGCGGC
ACTGCGCGACAAGCGCCTGGGCGGCGCGGCAATCGACGTGTTCCCGGAAGAGCCGAAGACGAACAACGATCCATTCGTCA
GTCCGCTGCAGCAGCTTCCGAATGTCCTGCTGACGCCCCACATCGGCGGCAGCACTGAAGAGGCGCAGGAGAACATCGGC
ACAGAGGTAGCCGCCAAGCTGCTGAACTACCTGAACACCGGCGGCACCATTGGCGCCGTCAACTTTCCCGAAGTCGATCC
CGGTCCGCTGCACGCGCCGGCACGCCTGCTCAACATCCACAGCAATGCTCCGGGCGCGCTAGCCGCACTGAACACGCTGC
TGGCCCAGGATGGCGTCAACATCAACGGCCAGCACCTGCAGACGCGCGGCCATACCGGCTACGTCGTCACGGATCTCGAC
CGCGTGCCGTCCGACGTGCTGATGGAATCGCTGCGCACGCATGCCGGATTCGTACGTTCGCGGCTGCTGGTGCGCTAA

Upstream 100 bases:

>100_bases
CCGACGCGGACGCTCCCGGTAGGCTGAGCGGCTCCCGATGGTGCCAACGTTGGCGGAAGGGGCACCGGGACCGCGGCAGC
TTTTTCGCGCAGAATAGACA

Downstream 100 bases:

>100_bases
CCCCACCCCTTCGCACCGATTTTTCCTGTCGCACCACATCCGCCGTCTGGCCGCATGCAACGCATGAGGCCAGACGGCGG
ATGACGCCTCTTTTCCGAGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MPRRSRGCRRAPCSLRVLFLRGKLNVTTAILLENIHASATARLGEAGLTVERRTGALAGDELRQVLASHDLVGIRSATHL
RGDDIRSAPALLSIGCFCIGTSQVDLDAATAAGIPVFNAPFSNTRSVAELVVSEAVMLLRKIPEKNALAHAGKWAKGASG
AFEARGKTIAIVGYGNIGSQVGVLAESMGMRVVYYDVLARLSLGSARAAGTLEEAVSQADVVTLHVPATARTRNMIDAHV
LACFKPGAILINASRGTVVDIDALAAALRDKRLGGAAIDVFPEEPKTNNDPFVSPLQQLPNVLLTPHIGGSTEEAQENIG
TEVAAKLLNYLNTGGTIGAVNFPEVDPGPLHAPARLLNIHSNAPGALAALNTLLAQDGVNINGQHLQTRGHTGYVVTDLD
RVPSDVLMESLRTHAGFVRSRLLVR

Sequences:

>Translated_425_residues
MPRRSRGCRRAPCSLRVLFLRGKLNVTTAILLENIHASATARLGEAGLTVERRTGALAGDELRQVLASHDLVGIRSATHL
RGDDIRSAPALLSIGCFCIGTSQVDLDAATAAGIPVFNAPFSNTRSVAELVVSEAVMLLRKIPEKNALAHAGKWAKGASG
AFEARGKTIAIVGYGNIGSQVGVLAESMGMRVVYYDVLARLSLGSARAAGTLEEAVSQADVVTLHVPATARTRNMIDAHV
LACFKPGAILINASRGTVVDIDALAAALRDKRLGGAAIDVFPEEPKTNNDPFVSPLQQLPNVLLTPHIGGSTEEAQENIG
TEVAAKLLNYLNTGGTIGAVNFPEVDPGPLHAPARLLNIHSNAPGALAALNTLLAQDGVNINGQHLQTRGHTGYVVTDLD
RVPSDVLMESLRTHAGFVRSRLLVR
>Mature_424_residues
PRRSRGCRRAPCSLRVLFLRGKLNVTTAILLENIHASATARLGEAGLTVERRTGALAGDELRQVLASHDLVGIRSATHLR
GDDIRSAPALLSIGCFCIGTSQVDLDAATAAGIPVFNAPFSNTRSVAELVVSEAVMLLRKIPEKNALAHAGKWAKGASGA
FEARGKTIAIVGYGNIGSQVGVLAESMGMRVVYYDVLARLSLGSARAAGTLEEAVSQADVVTLHVPATARTRNMIDAHVL
ACFKPGAILINASRGTVVDIDALAAALRDKRLGGAAIDVFPEEPKTNNDPFVSPLQQLPNVLLTPHIGGSTEEAQENIGT
EVAAKLLNYLNTGGTIGAVNFPEVDPGPLHAPARLLNIHSNAPGALAALNTLLAQDGVNINGQHLQTRGHTGYVVTDLDR
VPSDVLMESLRTHAGFVRSRLLVR

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=32.9153605015674, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI61743967, Length=296, Percent_Identity=29.3918918918919, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557497, Length=293, Percent_Identity=29.3515358361775, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI145580578, Length=247, Percent_Identity=31.9838056680162, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4557499, Length=247, Percent_Identity=31.9838056680162, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI145580575, Length=256, Percent_Identity=31.640625, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI6912396, Length=241, Percent_Identity=27.3858921161826, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789279, Length=397, Percent_Identity=54.911838790932, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=29.3233082706767, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=29.0836653386454, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788660, Length=262, Percent_Identity=30.1526717557252, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081824, Length=203, Percent_Identity=29.5566502463054, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=34.6749226006192, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147481, Length=265, Percent_Identity=28.6792452830189, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=420, Percent_Identity=45.2380952380952, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6322116, Length=438, Percent_Identity=44.5205479452055, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6324964, Length=269, Percent_Identity=28.6245353159851, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=256, Percent_Identity=27.734375, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=161, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=30.1775147928994, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=198, Percent_Identity=26.7676767676768, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19921140, Length=310, Percent_Identity=32.258064516129, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=32.046332046332, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=32.046332046332, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=32.046332046332, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=32.046332046332, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=32.046332046332, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28574286, Length=240, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=26.4150943396226, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45551003, Length=256, Percent_Identity=25.390625, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45552429, Length=256, Percent_Identity=25.390625, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28574284, Length=256, Percent_Identity=25.390625, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24585514, Length=256, Percent_Identity=25.390625, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574282, Length=256, Percent_Identity=25.390625, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585516, Length=235, Percent_Identity=22.9787234042553, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44748; Mature: 44617

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRRSRGCRRAPCSLRVLFLRGKLNVTTAILLENIHASATARLGEAGLTVERRTGALAGD
CCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHH
ELRQVLASHDLVGIRSATHLRGDDIRSAPALLSIGCFCIGTSQVDLDAATAAGIPVFNAP
HHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHCCEEEEECCCCCCCHHHHCCCCEECCC
FSNTRSVAELVVSEAVMLLRKIPEKNALAHAGKWAKGASGAFEARGKTIAIVGYGNIGSQ
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEECCCCEEEEEEECCCCHH
VGVLAESMGMRVVYYDVLARLSLGSARAAGTLEEAVSQADVVTLHVPATARTRNMIDAHV
HHHHHHHHCCEEHHHHHHHHHCCCCCHHCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
LACFKPGAILINASRGTVVDIDALAAALRDKRLGGAAIDVFPEEPKTNNDPFVSPLQQLP
HHEECCCEEEEECCCCCEEEHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCC
NVLLTPHIGGSTEEAQENIGTEVAAKLLNYLNTGGTIGAVNFPEVDPGPLHAPARLLNIH
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHEEEEC
SNAPGALAALNTLLAQDGVNINGQHLQTRGHTGYVVTDLDRVPSDVLMESLRTHAGFVRS
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECHHHCCHHHHHHHHHHHHHHHHH
RLLVR
HHHCC
>Mature Secondary Structure 
PRRSRGCRRAPCSLRVLFLRGKLNVTTAILLENIHASATARLGEAGLTVERRTGALAGD
CCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHH
ELRQVLASHDLVGIRSATHLRGDDIRSAPALLSIGCFCIGTSQVDLDAATAAGIPVFNAP
HHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHCCEEEEECCCCCCCHHHHCCCCEECCC
FSNTRSVAELVVSEAVMLLRKIPEKNALAHAGKWAKGASGAFEARGKTIAIVGYGNIGSQ
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEECCCCEEEEEEECCCCHH
VGVLAESMGMRVVYYDVLARLSLGSARAAGTLEEAVSQADVVTLHVPATARTRNMIDAHV
HHHHHHHHCCEEHHHHHHHHHCCCCCHHCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
LACFKPGAILINASRGTVVDIDALAAALRDKRLGGAAIDVFPEEPKTNNDPFVSPLQQLP
HHEECCCEEEEECCCCCEEEHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCC
NVLLTPHIGGSTEEAQENIGTEVAAKLLNYLNTGGTIGAVNFPEVDPGPLHAPARLLNIH
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHEEEEC
SNAPGALAALNTLLAQDGVNINGQHLQTRGHTGYVVTDLDRVPSDVLMESLRTHAGFVRS
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECHHHCCHHHHHHHHHHHHHHHHH
RLLVR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]