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The map label for this gene is qor [C]

Identifier: 73538557

GI number: 73538557

Start: 1431589

End: 1432575

Strand: Direct

Name: qor [C]

Synonym: Reut_B4732

Alternate gene names: 73538557

Gene position: 1431589-1432575 (Clockwise)

Preceding gene: 73538555

Following gene: 73538558

Centisome position: 52.51

GC content: 66.67

Gene sequence:

>987_bases
ATGTCCATGCAAGCACTGGTGCTGACCCGGCACAACGGCCCCCTCGAACTCACCACCGTGCCGCGCCCTGACGCCGCTCC
GGGCCAGGTACTTGTACGTATCGCGGCGAGTGGCCTCAATCCTCTCGATACCAAGATCCGCGCCGGTGCCGCAGCGCATG
CGCGGCACCCGCTGCCACTGGTCCTCGGCATCGACATGGCTGGCACGGTCGAGGCCGTCGGCGCTGGCGTCAGCGCGTTC
AAACCCGGCGACGAGGTCTACGGCATGACCGGTGGCGTCGGCGGCATCCAGGGTTCGCTCGCGCAATACGCCGCTGTCGA
TGCGGCGCTGCTCGCACATAAACCGGCGAACCTGTCGATGCGCGAGGCGGCCGCGTTGCCGCTTGCCTTCATCACCGCCT
ACGCCGGCATCGTCGACCGCGCACATCTGCAGGCTGGTCAGACCGTCCTTGTCCAGGGCGGCGCTGGTGGCGTGGGCCAT
ATTGCGGTGCAACTGGCACGCGCGCTTGGTGCCGAAGTGTTCGCCACCGCCAGCGAAGCGAACCTCGATCTCGTCCGGCA
ACTCGGCGCCACGCCGATCGACTACCGTGCGCAGCCGGTTGAAGCCTATGTCGAGGCCCACACCGGGGGCGAAGGGTTCG
ATCTGGTTGTCGATACGGTGGGCGGTGCGACGCTTGATACCTCGTTTGCCGCGGTGAAGCACTTCGGCCACGTTGTCAGC
GCACTCGGCTGGGGCACGCATGCGCTGGCTCCGCTGTCGTTTCGCGAGGCAAGCTATTCCGGGGTGTTTACGCTTTATCC
CTTGCTGACCGGCAAACACCGCGCGCATCACGGTGAAATGCTGCGTGAAGCCACGCGTCTGGCCGAAGCCGGTGCGCTGA
AACCCGTGGTCGATCCGCGCCATTTCGGCCTCGGCACGGCGGAAGCCGGCTATGAAGTTGTTGCGGCAGGCACCGGGCGG
GTCAAGGTGGTGGTGGACGTCCGGTAG

Upstream 100 bases:

>100_bases
CATTCATATTTGACTGACGGTTATTCAATTCTGTCAATTTACATGCAAATTCGCATGAACCATGATGACTCCACTGTTCA
CTGTTTCCAAGGAGATCACG

Downstream 100 bases:

>100_bases
GGGTGGTGCGACGGGGGACTGGAGACCCAAATCTCCTCGCCACGGGCCTCCCCCGCAACATATACTCCGTCAGTATCGAC
GTAGTGATCGCGGCGCCGCT

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSMQALVLTRHNGPLELTTVPRPDAAPGQVLVRIAASGLNPLDTKIRAGAAAHARHPLPLVLGIDMAGTVEAVGAGVSAF
KPGDEVYGMTGGVGGIQGSLAQYAAVDAALLAHKPANLSMREAAALPLAFITAYAGIVDRAHLQAGQTVLVQGGAGGVGH
IAVQLARALGAEVFATASEANLDLVRQLGATPIDYRAQPVEAYVEAHTGGEGFDLVVDTVGGATLDTSFAAVKHFGHVVS
ALGWGTHALAPLSFREASYSGVFTLYPLLTGKHRAHHGEMLREATRLAEAGALKPVVDPRHFGLGTAEAGYEVVAAGTGR
VKVVVDVR

Sequences:

>Translated_328_residues
MSMQALVLTRHNGPLELTTVPRPDAAPGQVLVRIAASGLNPLDTKIRAGAAAHARHPLPLVLGIDMAGTVEAVGAGVSAF
KPGDEVYGMTGGVGGIQGSLAQYAAVDAALLAHKPANLSMREAAALPLAFITAYAGIVDRAHLQAGQTVLVQGGAGGVGH
IAVQLARALGAEVFATASEANLDLVRQLGATPIDYRAQPVEAYVEAHTGGEGFDLVVDTVGGATLDTSFAAVKHFGHVVS
ALGWGTHALAPLSFREASYSGVFTLYPLLTGKHRAHHGEMLREATRLAEAGALKPVVDPRHFGLGTAEAGYEVVAAGTGR
VKVVVDVR
>Mature_327_residues
SMQALVLTRHNGPLELTTVPRPDAAPGQVLVRIAASGLNPLDTKIRAGAAAHARHPLPLVLGIDMAGTVEAVGAGVSAFK
PGDEVYGMTGGVGGIQGSLAQYAAVDAALLAHKPANLSMREAAALPLAFITAYAGIVDRAHLQAGQTVLVQGGAGGVGHI
AVQLARALGAEVFATASEANLDLVRQLGATPIDYRAQPVEAYVEAHTGGEGFDLVVDTVGGATLDTSFAAVKHFGHVVSA
LGWGTHALAPLSFREASYSGVFTLYPLLTGKHRAHHGEMLREATRLAEAGALKPVVDPRHFGLGTAEAGYEVVAAGTGRV
KVVVDVR

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=325, Percent_Identity=32, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI13236495, Length=325, Percent_Identity=32, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI47519420, Length=216, Percent_Identity=36.5740740740741, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI194239676, Length=193, Percent_Identity=37.8238341968912, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI18379349, Length=216, Percent_Identity=37.037037037037, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI24308257, Length=324, Percent_Identity=28.0864197530864, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI22538446, Length=245, Percent_Identity=31.8367346938775, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI22538444, Length=245, Percent_Identity=31.8367346938775, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI41872631, Length=254, Percent_Identity=28.740157480315, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI90669511, Length=360, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI28557745, Length=246, Percent_Identity=30.8943089430894, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790485, Length=315, Percent_Identity=29.2063492063492, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789651, Length=253, Percent_Identity=30.4347826086957, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987554, Length=381, Percent_Identity=30.7086614173228, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17507255, Length=243, Percent_Identity=34.156378600823, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=197, Percent_Identity=28.9340101522843, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=308, Percent_Identity=28.2467532467532, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=257, Percent_Identity=29.1828793774319, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=240, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=240, Percent_Identity=28.75, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319401, Length=182, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=268, Percent_Identity=26.4925373134328, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581339, Length=352, Percent_Identity=27.5568181818182, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581341, Length=352, Percent_Identity=27.5568181818182, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581345, Length=243, Percent_Identity=26.3374485596708, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550423, Length=310, Percent_Identity=26.7741935483871, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 33624; Mature: 33493

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMQALVLTRHNGPLELTTVPRPDAAPGQVLVRIAASGLNPLDTKIRAGAAAHARHPLPL
CCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCEE
VLGIDMAGTVEAVGAGVSAFKPGDEVYGMTGGVGGIQGSLAQYAAVDAALLAHKPANLSM
EEECCCCCCHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
REAAALPLAFITAYAGIVDRAHLQAGQTVLVQGGAGGVGHIAVQLARALGAEVFATASEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCHHHEEECCCC
NLDLVRQLGATPIDYRAQPVEAYVEAHTGGEGFDLVVDTVGGATLDTSFAAVKHFGHVVS
CHHHHHHHCCCCCCCCCCCHHHHEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ALGWGTHALAPLSFREASYSGVFTLYPLLTGKHRAHHGEMLREATRLAEAGALKPVVDPR
HHCCCCHHCCCCEECCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HFGLGTAEAGYEVVAAGTGRVKVVVDVR
HCCCCCCCCCCEEEEECCCEEEEEEEEC
>Mature Secondary Structure 
SMQALVLTRHNGPLELTTVPRPDAAPGQVLVRIAASGLNPLDTKIRAGAAAHARHPLPL
CCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCEE
VLGIDMAGTVEAVGAGVSAFKPGDEVYGMTGGVGGIQGSLAQYAAVDAALLAHKPANLSM
EEECCCCCCHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
REAAALPLAFITAYAGIVDRAHLQAGQTVLVQGGAGGVGHIAVQLARALGAEVFATASEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCHHHEEECCCC
NLDLVRQLGATPIDYRAQPVEAYVEAHTGGEGFDLVVDTVGGATLDTSFAAVKHFGHVVS
CHHHHHHHCCCCCCCCCCCHHHHEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ALGWGTHALAPLSFREASYSGVFTLYPLLTGKHRAHHGEMLREATRLAEAGALKPVVDPR
HHCCCCHHCCCCEECCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HFGLGTAEAGYEVVAAGTGRVKVVVDVR
HCCCCCCCCCCEEEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]