Click here to switch to the map view.

The map label for this gene is pdhA [H]

Identifier: 73538509

GI number: 73538509

Start: 1378650

End: 1381325

Strand: Direct

Name: pdhA [H]

Synonym: Reut_B4683

Alternate gene names: 73538509

Gene position: 1378650-1381325 (Clockwise)

Preceding gene: 73538506

Following gene: 73538511

Centisome position: 50.57

GC content: 63.79

Gene sequence:

>2676_bases
ATGGCGTCAGTAATGCCCATCCCCTCCTCCGACAACGACATCGATGCGCAGGAAACCCGTGAATGGCTGGACGCGCTGGA
AGGCGTGATCGCCCACGAGGGTCCGGAGCGCGCGCATTTCCTGATCGAGCAGCTGATCCGGCGCGCGCATGACGCCGGCA
TCTACCTGCCGTTCAGCGCCAACACGGCCTACCTGAACACCATTCCGCTCGAGACCCAGGCCCGCAGCCCCGGCGACCAG
GAACTGGAGCACCGCATCCGCTCCTACATTCGCTGGAATGCCATTGCAGTGGTGCTGCGTGCGGGACGCGATACCAACGT
AGGCGGCCATATCGCCAGCTTCGCATCGGCGGCCACGCTGTACGAAGTTGGCTTCAACCACTTCTGGCACGCGCCGTCCT
CACAGCATGGCGGCGACCTTGTGTTCTTCCAGGGACACTCCGCACCGGGCTTCTATGCGCGCGCGTTCCTCGAAGGCCGG
CTCAGCGAAGCGCAGATGGACAACTTCCGCCAGGAAGTCGGCGGCCAGGGCATCTCGTCCTATCCACACCCGTGGCTCAT
GCCGGACTTCTGGCAGTTCCCGACGGTGTCGATGGGCCTGGGTCCGATCATGGGCATCTACCAGGCTCGCTTCATGAAGT
ATCTGCAGGATCGCGGCTTTGGCGATCACCACGCGCGCAAGGTGTGGGTGTTCTGCGGCGACGGGGAAATGGATGAACCC
GAATCGCGCGGCGCGCTGGGCATGGCCGGGCGCGAGCATCTCGACAACCTGGTCTTCGTGATCAACTGCAATCTGCAACG
GCTGGATGGTCCTGTGCGGGGCAACGGCAAAATCATCCAGGAACTCGAGTCGGAGTTCCGCGGTGCCGGCTGGAACGTGA
TCAAGGTCGTCTGGGGCAGCAAGTGGGATGCGCTGCTCGCGCGCGACAAGAACGGCATCCTTGCGCAGCGGATGATGACG
TGCGTGGATGGCGACTACCAGACCTTCAAGTCGAAAGATGGCGCTTACGTACGGGAGCACTTCTTCAATACGCCGGAGCT
CAAGGCGCTGGTTTCCGACTGGTCCGACGACGATATCTGGCAGCTCAACCGCGGTGGCCACGACCCGCACAAGGTCTTCG
CGGCCTACCAGGCCGCCGCTAACCACACGGGCCAGCCCACTGTGATCCTTGCCAAGACCATCAAGGGCTACGGCATGGGC
GAGGCCGGTGAGGCACAGAACATTACGCACCAGCAAAAGCACATGCGTGTAGAAACACTCGCGCGTTTCCGCGACCGCTT
CCGCCTGCCGCTGAGCGACGAGCAGTTGGCCGATCTCAGCTACCTGAAATTCGAGGAAGGCTCGCCCGAACATGTTTACC
TGCACCAGCGCAGACAAGCACTGGGCGGCTATCTGCCGTCACGCCGGCGCACCGGGCCCGAACTGCCGGTGCCGCCGCTG
TCGGCATTCGACACCCAGCTCAAGGCCAGCGGCGAGGGCCGCGAAGTCTCCACCGCCATGAGCTTTGTGCGCATCCTCAA
CGTGCTGTTGCGTGACAAGGCGCTGGGGCGGCGCATCGTGCCGATCGTCTCGGACGAGTCGCGCACCTTCGGCATGGAAG
GCCTGTTCCGGCAGATCGGCATCTGGTCGCAGCAGGGTCAAACCTACACACCGCAGGACGCGTCGCAACTGAGCTTCTAC
AAGGAGTCGAAGGACGGACAGATCCTGCAGGAAGGCATCAATGAAGCGGGCGCCATGGCCGACTGGATCGCCGCGGCCAC
GTCATACAGCACGCACGGCGAGCCGATGATCCCGTTCTTCATCTTCTACTCGATCTTCGGCTTCCAGCGCTTCGGCGACC
TGGCCTGGGCCGCCGGCGACCAGCGCGCCCGCGGCTTCCTGCTTGGCGGCACAGCTGGCCGCACCACGCTCAACGGCGAA
GGGCTGCAGCATGAAGACGGCCACAGTCTGGTGTGGGGCGGCACCATTCCCAACTGCATCAGCTATGACCCGACCTTCGC
CTACGAACTGGCGGTGATTGTCCAGGACGGCCTGCGCCGCATGCTGCAAGAGCAGGAAGACGTCTATTACTACATCACCG
TGATGAACGAGAACTACGAGCATCCGGCGATGCCCGAAGGCGCGGAGAACGACATCCTGAAAGGCATGTATGCGTTCCGC
CGCGCCGGCGAAGGCACCGGACCACGCGTGCAGTTGCTCGGCGCAGGCACAATCTTCCGTGAAGTCATTGCAGCGGCTGA
CATGCTCGAGCAAGACTGGGGCGTGCAAGCCGACCTGTGGGGTTGTCCAAGCTTCACCGAACTGGCGCGTGAAGGCAACG
CCGCCGCCCGCTGGAATCTGCTGCATCCGGACGAAACGCCGCGACAATCTCACGTGGAGCATTGCCTGGCCGACACGCGC
GGCCCGGTGATCGCCTCGACCGACTACGTGCGCATGCTGGCCGAGCAGATCCGCCCGTTTGTACCGCGCGCGTACACCGT
ACTGGGCACCGACGGCTACGGCCGCTCGGACACCCGCGAGAAGCTGCGGGACTTCTTTGAGGTGGACCGCCGCTGGATCG
TGCTGTCCGCCCTGAAGGCATTGGTCGAAGAAGGCTCGGTGGAGCGCGGCGTGCTGAGGCAGGCCATCTACAAGTACGGG
ATCGACCCGGAGAAGCGCAATCCGCTGCTTGCCTGA

Upstream 100 bases:

>100_bases
TGGCGGCGTCGCGGTGCTAGTCTTTTCCGGCTGTCCTCCCCTTCTTTGCCGCGGCGTTGCCCGCGCTTCTTGCCCCATGC
CGGGCTGACAGGAGACCACC

Downstream 100 bases:

>100_bases
ACCACGCAGCAGCGTCGTGCCGAGCGAATCAGTTGGCTCCGCCCTGCAGCAGGCGGAGCGAACCCGCCGTTTGCGGCTCT
TCCCATGGCGGCCGCGCGAG

Product: 2-oxoacid dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 891; Mature: 890

Protein sequence:

>891_residues
MASVMPIPSSDNDIDAQETREWLDALEGVIAHEGPERAHFLIEQLIRRAHDAGIYLPFSANTAYLNTIPLETQARSPGDQ
ELEHRIRSYIRWNAIAVVLRAGRDTNVGGHIASFASAATLYEVGFNHFWHAPSSQHGGDLVFFQGHSAPGFYARAFLEGR
LSEAQMDNFRQEVGGQGISSYPHPWLMPDFWQFPTVSMGLGPIMGIYQARFMKYLQDRGFGDHHARKVWVFCGDGEMDEP
ESRGALGMAGREHLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVVWGSKWDALLARDKNGILAQRMMT
CVDGDYQTFKSKDGAYVREHFFNTPELKALVSDWSDDDIWQLNRGGHDPHKVFAAYQAAANHTGQPTVILAKTIKGYGMG
EAGEAQNITHQQKHMRVETLARFRDRFRLPLSDEQLADLSYLKFEEGSPEHVYLHQRRQALGGYLPSRRRTGPELPVPPL
SAFDTQLKASGEGREVSTAMSFVRILNVLLRDKALGRRIVPIVSDESRTFGMEGLFRQIGIWSQQGQTYTPQDASQLSFY
KESKDGQILQEGINEAGAMADWIAAATSYSTHGEPMIPFFIFYSIFGFQRFGDLAWAAGDQRARGFLLGGTAGRTTLNGE
GLQHEDGHSLVWGGTIPNCISYDPTFAYELAVIVQDGLRRMLQEQEDVYYYITVMNENYEHPAMPEGAENDILKGMYAFR
RAGEGTGPRVQLLGAGTIFREVIAAADMLEQDWGVQADLWGCPSFTELAREGNAAARWNLLHPDETPRQSHVEHCLADTR
GPVIASTDYVRMLAEQIRPFVPRAYTVLGTDGYGRSDTREKLRDFFEVDRRWIVLSALKALVEEGSVERGVLRQAIYKYG
IDPEKRNPLLA

Sequences:

>Translated_891_residues
MASVMPIPSSDNDIDAQETREWLDALEGVIAHEGPERAHFLIEQLIRRAHDAGIYLPFSANTAYLNTIPLETQARSPGDQ
ELEHRIRSYIRWNAIAVVLRAGRDTNVGGHIASFASAATLYEVGFNHFWHAPSSQHGGDLVFFQGHSAPGFYARAFLEGR
LSEAQMDNFRQEVGGQGISSYPHPWLMPDFWQFPTVSMGLGPIMGIYQARFMKYLQDRGFGDHHARKVWVFCGDGEMDEP
ESRGALGMAGREHLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVVWGSKWDALLARDKNGILAQRMMT
CVDGDYQTFKSKDGAYVREHFFNTPELKALVSDWSDDDIWQLNRGGHDPHKVFAAYQAAANHTGQPTVILAKTIKGYGMG
EAGEAQNITHQQKHMRVETLARFRDRFRLPLSDEQLADLSYLKFEEGSPEHVYLHQRRQALGGYLPSRRRTGPELPVPPL
SAFDTQLKASGEGREVSTAMSFVRILNVLLRDKALGRRIVPIVSDESRTFGMEGLFRQIGIWSQQGQTYTPQDASQLSFY
KESKDGQILQEGINEAGAMADWIAAATSYSTHGEPMIPFFIFYSIFGFQRFGDLAWAAGDQRARGFLLGGTAGRTTLNGE
GLQHEDGHSLVWGGTIPNCISYDPTFAYELAVIVQDGLRRMLQEQEDVYYYITVMNENYEHPAMPEGAENDILKGMYAFR
RAGEGTGPRVQLLGAGTIFREVIAAADMLEQDWGVQADLWGCPSFTELAREGNAAARWNLLHPDETPRQSHVEHCLADTR
GPVIASTDYVRMLAEQIRPFVPRAYTVLGTDGYGRSDTREKLRDFFEVDRRWIVLSALKALVEEGSVERGVLRQAIYKYG
IDPEKRNPLLA
>Mature_890_residues
ASVMPIPSSDNDIDAQETREWLDALEGVIAHEGPERAHFLIEQLIRRAHDAGIYLPFSANTAYLNTIPLETQARSPGDQE
LEHRIRSYIRWNAIAVVLRAGRDTNVGGHIASFASAATLYEVGFNHFWHAPSSQHGGDLVFFQGHSAPGFYARAFLEGRL
SEAQMDNFRQEVGGQGISSYPHPWLMPDFWQFPTVSMGLGPIMGIYQARFMKYLQDRGFGDHHARKVWVFCGDGEMDEPE
SRGALGMAGREHLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVVWGSKWDALLARDKNGILAQRMMTC
VDGDYQTFKSKDGAYVREHFFNTPELKALVSDWSDDDIWQLNRGGHDPHKVFAAYQAAANHTGQPTVILAKTIKGYGMGE
AGEAQNITHQQKHMRVETLARFRDRFRLPLSDEQLADLSYLKFEEGSPEHVYLHQRRQALGGYLPSRRRTGPELPVPPLS
AFDTQLKASGEGREVSTAMSFVRILNVLLRDKALGRRIVPIVSDESRTFGMEGLFRQIGIWSQQGQTYTPQDASQLSFYK
ESKDGQILQEGINEAGAMADWIAAATSYSTHGEPMIPFFIFYSIFGFQRFGDLAWAAGDQRARGFLLGGTAGRTTLNGEG
LQHEDGHSLVWGGTIPNCISYDPTFAYELAVIVQDGLRRMLQEQEDVYYYITVMNENYEHPAMPEGAENDILKGMYAFRR
AGEGTGPRVQLLGAGTIFREVIAAADMLEQDWGVQADLWGCPSFTELAREGNAAARWNLLHPDETPRQSHVEHCLADTRG
PVIASTDYVRMLAEQIRPFVPRAYTVLGTDGYGRSDTREKLRDFFEVDRRWIVLSALKALVEEGSVERGVLRQAIYKYGI
DPEKRNPLLA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=886, Percent_Identity=60.6094808126411, Blast_Score=1106, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99953; Mature: 99822

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVMPIPSSDNDIDAQETREWLDALEGVIAHEGPERAHFLIEQLIRRAHDAGIYLPFSA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECC
NTAYLNTIPLETQARSPGDQELEHRIRSYIRWNAIAVVLRAGRDTNVGGHIASFASAATL
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHH
YEVGFNHFWHAPSSQHGGDLVFFQGHSAPGFYARAFLEGRLSEAQMDNFRQEVGGQGISS
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YPHPWLMPDFWQFPTVSMGLGPIMGIYQARFMKYLQDRGFGDHHARKVWVFCGDGEMDEP
CCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCC
ESRGALGMAGREHLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVVWGS
HHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECC
KWDALLARDKNGILAQRMMTCVDGDYQTFKSKDGAYVREHFFNTPELKALVSDWSDDDIW
CCHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCCCE
QLNRGGHDPHKVFAAYQAAANHTGQPTVILAKTIKGYGMGEAGEAQNITHQQKHMRVETL
ECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
ARFRDRFRLPLSDEQLADLSYLKFEEGSPEHVYLHQRRQALGGYLPSRRRTGPELPVPPL
HHHHHHCCCCCCCHHHHCCHHEEECCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCC
SAFDTQLKASGEGREVSTAMSFVRILNVLLRDKALGRRIVPIVSDESRTFGMEGLFRQIG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECEEECCCCCCCCHHHHHHHHC
IWSQQGQTYTPQDASQLSFYKESKDGQILQEGINEAGAMADWIAAATSYSTHGEPMIPFF
CCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
IFYSIFGFQRFGDLAWAAGDQRARGFLLGGTAGRTTLNGEGLQHEDGHSLVWGGTIPNCI
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCCCCEEEECCCCCCCC
SYDPTFAYELAVIVQDGLRRMLQEQEDVYYYITVMNENYEHPAMPEGAENDILKGMYAFR
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RAGEGTGPRVQLLGAGTIFREVIAAADMLEQDWGVQADLWGCPSFTELAREGNAAARWNL
HCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHCCCCEEEEEC
LHPDETPRQSHVEHCLADTRGPVIASTDYVRMLAEQIRPFVPRAYTVLGTDGYGRSDTRE
CCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
KLRDFFEVDRRWIVLSALKALVEEGSVERGVLRQAIYKYGIDPEKRNPLLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ASVMPIPSSDNDIDAQETREWLDALEGVIAHEGPERAHFLIEQLIRRAHDAGIYLPFSA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECC
NTAYLNTIPLETQARSPGDQELEHRIRSYIRWNAIAVVLRAGRDTNVGGHIASFASAATL
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHH
YEVGFNHFWHAPSSQHGGDLVFFQGHSAPGFYARAFLEGRLSEAQMDNFRQEVGGQGISS
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YPHPWLMPDFWQFPTVSMGLGPIMGIYQARFMKYLQDRGFGDHHARKVWVFCGDGEMDEP
CCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCC
ESRGALGMAGREHLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVVWGS
HHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECC
KWDALLARDKNGILAQRMMTCVDGDYQTFKSKDGAYVREHFFNTPELKALVSDWSDDDIW
CCHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCCCE
QLNRGGHDPHKVFAAYQAAANHTGQPTVILAKTIKGYGMGEAGEAQNITHQQKHMRVETL
ECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
ARFRDRFRLPLSDEQLADLSYLKFEEGSPEHVYLHQRRQALGGYLPSRRRTGPELPVPPL
HHHHHHCCCCCCCHHHHCCHHEEECCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCC
SAFDTQLKASGEGREVSTAMSFVRILNVLLRDKALGRRIVPIVSDESRTFGMEGLFRQIG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECEEECCCCCCCCHHHHHHHHC
IWSQQGQTYTPQDASQLSFYKESKDGQILQEGINEAGAMADWIAAATSYSTHGEPMIPFF
CCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
IFYSIFGFQRFGDLAWAAGDQRARGFLLGGTAGRTTLNGEGLQHEDGHSLVWGGTIPNCI
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCCCCEEEECCCCCCCC
SYDPTFAYELAVIVQDGLRRMLQEQEDVYYYITVMNENYEHPAMPEGAENDILKGMYAFR
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RAGEGTGPRVQLLGAGTIFREVIAAADMLEQDWGVQADLWGCPSFTELAREGNAAARWNL
HCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHCCCCEEEEEC
LHPDETPRQSHVEHCLADTRGPVIASTDYVRMLAEQIRPFVPRAYTVLGTDGYGRSDTRE
CCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
KLRDFFEVDRRWIVLSALKALVEEGSVERGVLRQAIYKYGIDPEKRNPLLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]