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The map label for this gene is serA [H]

Identifier: 73538442

GI number: 73538442

Start: 1303180

End: 1304121

Strand: Reverse

Name: serA [H]

Synonym: Reut_B4615

Alternate gene names: 73538442

Gene position: 1304121-1303180 (Counterclockwise)

Preceding gene: 73538443

Following gene: 73538441

Centisome position: 47.84

GC content: 65.92

Gene sequence:

>942_bases
GTGAGCGAAGCCAGGAAACCCGTTCTGCTCGTCACGGGGAATGACCTGGCGCCGCAGGCGCTGGCGTTGCTCAACGACTT
TGAAGTCTGCTTCGCGGGCAAGCAGTGCAGCGAAGAGACGGTGGTAGCCCTGGCGAAGGAAAAGGATCCCGTTGCCATCA
TCGTGCGGTACGGCAAGATCGGCGCCGCCGTCATGGACGCCGCGCCGTCTCTCAAGGTGATCTCCAAGCACGGCAGCGGC
ATCGACGTGATTGACCAGAATGCCGCGGCGGCTCGCGGCATTGCCGTGAAGGCTGCCGTCGGCGCCAACGCCGCCGCGGT
GGCCGAGCACGCGTGGGCCCTGATTCTCGCGTGCGCAAAGGCAGTGCCCCATCTCAACGAGCGGATGCGCGCAAGTCATT
GGGACAAGGCCGTCCACAAGTCCATCGAGCTGGAGGGGCGTACGCTCGGCATCGTCGGGCTCGGAGAGATCGGCCGTCGC
GCAGCGGCCGTGGGCATCGCGATGCGCATGCGGGTCATCGCATTCGATCCGTTCGCCAAGACCGCGCCGCAAGGCGTCAC
GCTGGCCGAACTGCCGCGGATCTTCTCGGAATCGGACGTCGTATCGCTCCACTGCCCGCTGACCGACGAAAACCGCGGGA
TGCTGAACCGGGAAACGCTGGCCACGTTCAAGGACGGTGCGATCCTTGTCAACACCGCGCGCGGCGGCCTGATCGACGAA
CCCGCGCTGGTCGAAGCCCTGAACAGCGGCAAGCTGTACGCCGCGGGGCTGGACAGCTTCGCCGTGGAACCGATGCCCGT
GCCGCATCCGTTCCAAAGCGTGCCGAACCTGATCCTTTCGCCGCATATCGGCGGGGTGAGCGATGCCGCATACGTGAACA
TGGGCGTGGGCGCGGCGAAAAATGTACTTGCCGTGCTGGAAGCCGGCGTCGTGCCGGCCTGA

Upstream 100 bases:

>100_bases
AAACCCAGCGCATCGCCGCCATCAAGGCCGGCGACCTCCGCCCTGGCTGGCTGGAAGGCGAACTGCGCAAGGCCGGCGTG
CTGGCCGAAGGGGAAGTGCT

Downstream 100 bases:

>100_bases
ATACCCCCGCCCGGTAGCAGGCCACAAACAACGATGCCGCAGGACCCCTCAGGGGCCTCGCGGCAAGGAGACAAAGATGT
TCCACCGCACTTTCGGGTTC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSEARKPVLLVTGNDLAPQALALLNDFEVCFAGKQCSEETVVALAKEKDPVAIIVRYGKIGAAVMDAAPSLKVISKHGSG
IDVIDQNAAAARGIAVKAAVGANAAAVAEHAWALILACAKAVPHLNERMRASHWDKAVHKSIELEGRTLGIVGLGEIGRR
AAAVGIAMRMRVIAFDPFAKTAPQGVTLAELPRIFSESDVVSLHCPLTDENRGMLNRETLATFKDGAILVNTARGGLIDE
PALVEALNSGKLYAAGLDSFAVEPMPVPHPFQSVPNLILSPHIGGVSDAAYVNMGVGAAKNVLAVLEAGVVPA

Sequences:

>Translated_313_residues
MSEARKPVLLVTGNDLAPQALALLNDFEVCFAGKQCSEETVVALAKEKDPVAIIVRYGKIGAAVMDAAPSLKVISKHGSG
IDVIDQNAAAARGIAVKAAVGANAAAVAEHAWALILACAKAVPHLNERMRASHWDKAVHKSIELEGRTLGIVGLGEIGRR
AAAVGIAMRMRVIAFDPFAKTAPQGVTLAELPRIFSESDVVSLHCPLTDENRGMLNRETLATFKDGAILVNTARGGLIDE
PALVEALNSGKLYAAGLDSFAVEPMPVPHPFQSVPNLILSPHIGGVSDAAYVNMGVGAAKNVLAVLEAGVVPA
>Mature_312_residues
SEARKPVLLVTGNDLAPQALALLNDFEVCFAGKQCSEETVVALAKEKDPVAIIVRYGKIGAAVMDAAPSLKVISKHGSGI
DVIDQNAAAARGIAVKAAVGANAAAVAEHAWALILACAKAVPHLNERMRASHWDKAVHKSIELEGRTLGIVGLGEIGRRA
AAVGIAMRMRVIAFDPFAKTAPQGVTLAELPRIFSESDVVSLHCPLTDENRGMLNRETLATFKDGAILVNTARGGLIDEP
ALVEALNSGKLYAAGLDSFAVEPMPVPHPFQSVPNLILSPHIGGVSDAAYVNMGVGAAKNVLAVLEAGVVPA

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=287, Percent_Identity=34.4947735191638, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI4557497, Length=310, Percent_Identity=30, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI61743967, Length=310, Percent_Identity=30, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580578, Length=310, Percent_Identity=30.6451612903226, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4557499, Length=310, Percent_Identity=30.6451612903226, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI6912396, Length=265, Percent_Identity=30.9433962264151, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=33.8775510204082, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1787645, Length=205, Percent_Identity=35.1219512195122, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=32.046332046332, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789279, Length=252, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081824, Length=208, Percent_Identity=29.3269230769231, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788660, Length=228, Percent_Identity=28.0701754385965, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=297, Percent_Identity=34.006734006734, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=319, Percent_Identity=31.0344827586207, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=290, Percent_Identity=32.0689655172414, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=309, Percent_Identity=30.0970873786408, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=346, Percent_Identity=27.7456647398844, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=332, Percent_Identity=30.1204819277108, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=184, Percent_Identity=29.8913043478261, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=27.2189349112426, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921140, Length=260, Percent_Identity=35, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646446, Length=315, Percent_Identity=32.3809523809524, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646448, Length=315, Percent_Identity=32.3809523809524, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646452, Length=315, Percent_Identity=32.3809523809524, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646450, Length=315, Percent_Identity=32.3809523809524, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI62472511, Length=319, Percent_Identity=32.9153605015674, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585516, Length=258, Percent_Identity=30.2325581395349, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574286, Length=322, Percent_Identity=24.8447204968944, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=263, Percent_Identity=31.1787072243346, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45552429, Length=258, Percent_Identity=27.906976744186, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24585514, Length=258, Percent_Identity=27.906976744186, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574282, Length=258, Percent_Identity=27.906976744186, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45551003, Length=258, Percent_Identity=27.906976744186, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28574284, Length=258, Percent_Identity=27.906976744186, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32563; Mature: 32432

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEARKPVLLVTGNDLAPQALALLNDFEVCFAGKQCSEETVVALAKEKDPVAIIVRYGKI
CCCCCCCEEEEECCCCCHHHHHHHHCHHEEECCCCCCCCCEEEEECCCCCEEEEEEECCC
GAAVMDAAPSLKVISKHGSGIDVIDQNAAAARGIAVKAAVGANAAAVAEHAWALILACAK
CHHHHCCCCCEEEEECCCCCCEEEECCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHH
AVPHLNERMRASHWDKAVHKSIELEGRTLGIVGLGEIGRRAAAVGIAMRMRVIAFDPFAK
HHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCHHHHHHHHHHHHHEEEEEEECCHHH
TAPQGVTLAELPRIFSESDVVSLHCPLTDENRGMLNRETLATFKDGAILVNTARGGLIDE
CCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHEECCCEEEEEECCCCCCCC
PALVEALNSGKLYAAGLDSFAVEPMPVPHPFQSVPNLILSPHIGGVSDAAYVNMGVGAAK
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHCCHHEECCCCCCCCCCEEEECCCCHHH
NVLAVLEAGVVPA
HHHHHHHHCCCCC
>Mature Secondary Structure 
SEARKPVLLVTGNDLAPQALALLNDFEVCFAGKQCSEETVVALAKEKDPVAIIVRYGKI
CCCCCCEEEEECCCCCHHHHHHHHCHHEEECCCCCCCCCEEEEECCCCCEEEEEEECCC
GAAVMDAAPSLKVISKHGSGIDVIDQNAAAARGIAVKAAVGANAAAVAEHAWALILACAK
CHHHHCCCCCEEEEECCCCCCEEEECCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHH
AVPHLNERMRASHWDKAVHKSIELEGRTLGIVGLGEIGRRAAAVGIAMRMRVIAFDPFAK
HHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCHHHHHHHHHHHHHEEEEEEECCHHH
TAPQGVTLAELPRIFSESDVVSLHCPLTDENRGMLNRETLATFKDGAILVNTARGGLIDE
CCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHEECCCEEEEEECCCCCCCC
PALVEALNSGKLYAAGLDSFAVEPMPVPHPFQSVPNLILSPHIGGVSDAAYVNMGVGAAK
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHCCHHEECCCCCCCCCCEEEECCCCHHH
NVLAVLEAGVVPA
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]