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The map label for this gene is pcaR [H]

Identifier: 73538422

GI number: 73538422

Start: 1279812

End: 1280618

Strand: Reverse

Name: pcaR [H]

Synonym: Reut_B4595

Alternate gene names: 73538422

Gene position: 1280618-1279812 (Counterclockwise)

Preceding gene: 73538423

Following gene: 73538421

Centisome position: 46.98

GC content: 66.29

Gene sequence:

>807_bases
GTGGATCCGCAAGATGCAAGTCGCCGGGCACGTGGCCGTCCGGCCAACCTGCAGGCCAATCGCTCGCTTGAGCGCGGCCT
CGAGATCCTGCGGGCGTTCCGGCCGGGTTCCGAAATCCTGGGAAACAGCGAACTCGCCGAACGGACCGGCCTGCCGCGCT
CGACGGTAAGCCGACTCACGCAGAGCCTGGTGGAGACCGGCTTCCTCCAGTACGACGCGGGACTGCGTGCCTACCGTCTC
GGCGTCCCCGTGCTTAGTCTCGCGCATGCGATGCGCGGGGGCTCCGCTGTACTGCAGGTCGCGGCCCCGTTCATGCGTAA
GCTTGCGGAAAGCGAACACCTGAACGTTGGCCTGGCGATGGCCGACCGCGACGAGATGGTCTACCTTGAATCGATCCGCT
ACAGCCGCAAGGCGTCCCTGCGCAGCGTCGTGGCGGGTCAGCGTGTGCCGATAGCCCTCACTTCCCTTGGACGCGCCTGG
CTGGCCGTAGCAACCGAAGCTGAACGCGCTGGCCTGATGGCGGCCTTCTCGACACGCTTCGCCCACTGGCGAACGGTTGA
AGCGGAAATCCGGCATGCCATTGCACATGTCCAGCGGCACGGATGGTGTGCCGCCAGTTGGCAACCTGAGGTCGTGGCGG
TCTCCACCCCGCTACAGCCTGGATCGCATCCGGTTCACGCCCTCAACGTCAGCCTGTCGACCAAGTTGCCGGCCGCGGAA
GCCGCCGCCCGACTGGCGCCGTTGCTGATGCGCCTGTCCTGCGATATCGGTTCAGCATTTCTTGCGGCGCAGCCGCCGTC
TGTCTGA

Upstream 100 bases:

>100_bases
AACCCCATCTTCGTGCTGCCCGCGGGCCAGGGCGTGCGCGCGGCGGACGGCGTGGCGGTGATCGGCAGCCAATGACAACA
AGCCCGCGGGAGACGGCACG

Downstream 100 bases:

>100_bases
AGCTGTCCGACGTCACAACCGAACGGGCGAGACGCAGGCTTTTGTGTCCTGATGCGCCACCGTTCAGTTTGCAACCACCG
GAGCATTACCATCGCTAACG

Product: regulatory protein IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MDPQDASRRARGRPANLQANRSLERGLEILRAFRPGSEILGNSELAERTGLPRSTVSRLTQSLVETGFLQYDAGLRAYRL
GVPVLSLAHAMRGGSAVLQVAAPFMRKLAESEHLNVGLAMADRDEMVYLESIRYSRKASLRSVVAGQRVPIALTSLGRAW
LAVATEAERAGLMAAFSTRFAHWRTVEAEIRHAIAHVQRHGWCAASWQPEVVAVSTPLQPGSHPVHALNVSLSTKLPAAE
AAARLAPLLMRLSCDIGSAFLAAQPPSV

Sequences:

>Translated_268_residues
MDPQDASRRARGRPANLQANRSLERGLEILRAFRPGSEILGNSELAERTGLPRSTVSRLTQSLVETGFLQYDAGLRAYRL
GVPVLSLAHAMRGGSAVLQVAAPFMRKLAESEHLNVGLAMADRDEMVYLESIRYSRKASLRSVVAGQRVPIALTSLGRAW
LAVATEAERAGLMAAFSTRFAHWRTVEAEIRHAIAHVQRHGWCAASWQPEVVAVSTPLQPGSHPVHALNVSLSTKLPAAE
AAARLAPLLMRLSCDIGSAFLAAQPPSV
>Mature_268_residues
MDPQDASRRARGRPANLQANRSLERGLEILRAFRPGSEILGNSELAERTGLPRSTVSRLTQSLVETGFLQYDAGLRAYRL
GVPVLSLAHAMRGGSAVLQVAAPFMRKLAESEHLNVGLAMADRDEMVYLESIRYSRKASLRSVVAGQRVPIALTSLGRAW
LAVATEAERAGLMAAFSTRFAHWRTVEAEIRHAIAHVQRHGWCAASWQPEVVAVSTPLQPGSHPVHALNVSLSTKLPAAE
AAARLAPLLMRLSCDIGSAFLAAQPPSV

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=221, Percent_Identity=27.1493212669683, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786468, Length=228, Percent_Identity=26.7543859649123, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28980; Mature: 28980

Theoretical pI: Translated: 10.95; Mature: 10.95

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPQDASRRARGRPANLQANRSLERGLEILRAFRPGSEILGNSELAERTGLPRSTVSRLT
CCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHH
QSLVETGFLQYDAGLRAYRLGVPVLSLAHAMRGGSAVLQVAAPFMRKLAESEHLNVGLAM
HHHHHHCCHHCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEE
ADRDEMVYLESIRYSRKASLRSVVAGQRVPIALTSLGRAWLAVATEAERAGLMAAFSTRF
ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
AHWRTVEAEIRHAIAHVQRHGWCAASWQPEVVAVSTPLQPGSHPVHALNVSLSTKLPAAE
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCHHH
AAARLAPLLMRLSCDIGSAFLAAQPPSV
HHHHHHHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure
MDPQDASRRARGRPANLQANRSLERGLEILRAFRPGSEILGNSELAERTGLPRSTVSRLT
CCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHH
QSLVETGFLQYDAGLRAYRLGVPVLSLAHAMRGGSAVLQVAAPFMRKLAESEHLNVGLAM
HHHHHHCCHHCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEE
ADRDEMVYLESIRYSRKASLRSVVAGQRVPIALTSLGRAWLAVATEAERAGLMAAFSTRF
ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
AHWRTVEAEIRHAIAHVQRHGWCAASWQPEVVAVSTPLQPGSHPVHALNVSLSTKLPAAE
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCHHH
AAARLAPLLMRLSCDIGSAFLAAQPPSV
HHHHHHHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]