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The map label for this gene is polB [H]

Identifier: 73538411

GI number: 73538411

Start: 1264023

End: 1266389

Strand: Reverse

Name: polB [H]

Synonym: Reut_B4584

Alternate gene names: 73538411

Gene position: 1266389-1264023 (Counterclockwise)

Preceding gene: 73538412

Following gene: 73538408

Centisome position: 46.45

GC content: 64.64

Gene sequence:

>2367_bases
GTGGCACTTCAACAGGGTTTCATCCTGACCCGGCATTGGCGCGATACGCCGGCGGGTACCGAAGTCGAAGTCTGGCTTGC
CACCGACGACGGCCCACGCCTGTTGCGATTGCCGCCGCAACCGTCCGTAGCCTTTGTGCCGGAGGCCCAGCGGCAGCGCG
CCGAGGCCGTGCTGCAGGGTGACGCGACTGTCGATCTGCGTCCGCTCCGACTCCAGGACTTCAACCAGAGGCCCGTGTCT
GGCCTTTACTGTCGTCAGTATCGGCAACTGGGACAGCACAGCCGCGCGCTGCGCGACGCGGGCGTGGACGTCTACGAAGC
CGATATCCGGCCACCGGAGCGCTACCTGATGGAGCGCTTCATCACCGCCCCGGTCTGGTACGACGGCGATGCCGATGGCA
GCGGCGTGGTGCGCAACGCGCAGATGAAACCCGCCACGGACTATCGGCCGACGTTGCGGTTGGTGTCTCTCGATATCGAA
ACCAATGCCTTCGGAGACCTGTACTCGATCGCACTCGAAGGGTGCGGCCAGCGCCAGGTCTACATGCTGTGCCCGGCACC
GTCCGTGCCCGCGGACGTCGAATTCTCGCTCGAATACTGCGAGACGCGGCCGGCATTGCTCGAACGGCTGAACGCGTGGA
TGGGGCGCCATGACCCCGACGCCATCATTGGCTGGAACCTCGTCCAATTCGACCTGCGCGTATTGCATGAGCATGCGCGC
AAATTCCAGGTGCCGTTGCGCCTTGGCCGCGGCGGCGCCGAGATGGAATGGCGCGAGCATGGCAGCCAGCAGCACTATTT
CGCCGGAGCCGCCGGCCGCCTGATCATTGACGGCATCGAAGCGTTGCGCTCCGCCACGTGGACCTTCCCATCGTTCAGCC
TCGAATCGGTAGCCCAGTCACTGCTCGGCGAAGGCAAGGCGATCGACAACCCGTATGACCGCATGGACGCCATCGACCGC
ATGTTCGAGCAGGACAAGCCGGCGCTGGCACGCTACAACTTGCGCGATTGCGAGCTGGTGACACGGATCTTCGACAAGAC
GGAGTTGCTGACCTTCCTGCTGGAACGTGCCACGGTGACGGGCCTTCAGGCGGACCGCAGCGGCGGCTCGGTCGCGGCCT
TCACGCACCTGTACATGCCGCTGATGCACCGCCAGGGCTATGTGGCACCCAACCTCGGCGACAAGGCGCCCGAGGCGAGC
CCCGGCGGCTTTGTCATGGATTCGCGCCCCGGCCTCTACGAATCGGTGCTGGTTCTCGACTACAAGAGCCTCTATCCGTC
GATCATCCGCACGTTCCTGATCGACCCGATCGGCCTGGTGGAAGGGCTTGCTCATCCCGACGATGCCGATTCCGTGGCCG
GCTTTCGTGGCGCGCGGTTCTCCAGGACGAAGCACTGCCTGCCGTCCATCGTGGCCCGCGTCTGGCAGGGCCGCGAAGCT
GCCAAGCGCGACGGCAACAAGCCGCTCTCGCAGGCGCTAAAGATCATCATGAACGCGTTCTACGGTGTGCTCGGATCAAG
CGGCTGCCGCTTCTTCGATCCGCGGCTCGCGTCGTCGATCACGATGCGCGGGCACGAGATCATGCAGCAGACCCGGACCC
TGATCGAGGCGCGCGGCTACGAGGTCATCTACGGCGATACGGATTCCACGTTCGTGTGGTTGCGCCGGGCCCGGACGGAG
GCCGACGCCAGCCAGATCGGCCGCAGCCTGGTGGCCTATGTCAACGACTGGTGGCGTGATCACCTGTGGCAGACCTACGG
GCTCGAAAGCGCGCTGGAACTGCAGTTCGAAACGCACTTCCGGCGCTTCCTGATGCCCACCATCCGCGGCACGGACCTTG
GCAGCAAGAAACGCTATGCCGGCCAGGTGCAGCGGCCCGACGGCCGGGTCGAGATGGTGTTCAAGGGGCTGGAGACCGTG
CGCACGGACTGGTCTCCACTCGCGCAGGAATTCCAGCAGGTACTCTACGAACGGATCTTCAACCGCGAGCCGTACCAGGA
TTACGTGAGGGATATCGTGCGCCGCACGCTGGCTGGCGAACTGGACGAACAGCTGGTGTTCCGCAAGCGGCTGCGCCGCA
AGCTCGACGACTACCAGCGCAACGTGCCGCCGCACGTCCGCGCTGCGCGGATTGCCGATGCCCACAACGAACGCCACGGC
CGCCCGCTGCAATATCAGCATGGCGGCTGGATCAGCTATGTGATGACCGTGGCGGGGCCGGAGCCGCTTGAAGTTCGCTC
GGCGCCCATCGACTATGGGCATTACGTGACAAAGCAACTGCAGCCTATCGCCGATGCCATTCTGCCTTTCCTCGATGAGG
ATTTCGAGACGCTGCTCACGGGGCAGATGGCATTGTTCCCGTCATAG

Upstream 100 bases:

>100_bases
CCACGCTGCTGGCGCTTGTACTGGGCACGGGTAGGCGAGAGAGCGATCCCGCTATCTCCGCTAAACTTGTGCCCGGACAG
CTTCTTCAGGGTTTTGCAGC

Downstream 100 bases:

>100_bases
GGAAAGGGTTGCCTATGCCCGGGCACACTTGATGACCGTATCGAGCGTGCGCGTGGTGATGTCCTTGCCGAACGTGCGTT
CGAGCAGGCTCATGAACACG

Product: DNA polymerase II

Products: NA

Alternate protein names: Pol II [H]

Number of amino acids: Translated: 788; Mature: 787

Protein sequence:

>788_residues
MALQQGFILTRHWRDTPAGTEVEVWLATDDGPRLLRLPPQPSVAFVPEAQRQRAEAVLQGDATVDLRPLRLQDFNQRPVS
GLYCRQYRQLGQHSRALRDAGVDVYEADIRPPERYLMERFITAPVWYDGDADGSGVVRNAQMKPATDYRPTLRLVSLDIE
TNAFGDLYSIALEGCGQRQVYMLCPAPSVPADVEFSLEYCETRPALLERLNAWMGRHDPDAIIGWNLVQFDLRVLHEHAR
KFQVPLRLGRGGAEMEWREHGSQQHYFAGAAGRLIIDGIEALRSATWTFPSFSLESVAQSLLGEGKAIDNPYDRMDAIDR
MFEQDKPALARYNLRDCELVTRIFDKTELLTFLLERATVTGLQADRSGGSVAAFTHLYMPLMHRQGYVAPNLGDKAPEAS
PGGFVMDSRPGLYESVLVLDYKSLYPSIIRTFLIDPIGLVEGLAHPDDADSVAGFRGARFSRTKHCLPSIVARVWQGREA
AKRDGNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMQQTRTLIEARGYEVIYGDTDSTFVWLRRARTE
ADASQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHFRRFLMPTIRGTDLGSKKRYAGQVQRPDGRVEMVFKGLETV
RTDWSPLAQEFQQVLYERIFNREPYQDYVRDIVRRTLAGELDEQLVFRKRLRRKLDDYQRNVPPHVRAARIADAHNERHG
RPLQYQHGGWISYVMTVAGPEPLEVRSAPIDYGHYVTKQLQPIADAILPFLDEDFETLLTGQMALFPS

Sequences:

>Translated_788_residues
MALQQGFILTRHWRDTPAGTEVEVWLATDDGPRLLRLPPQPSVAFVPEAQRQRAEAVLQGDATVDLRPLRLQDFNQRPVS
GLYCRQYRQLGQHSRALRDAGVDVYEADIRPPERYLMERFITAPVWYDGDADGSGVVRNAQMKPATDYRPTLRLVSLDIE
TNAFGDLYSIALEGCGQRQVYMLCPAPSVPADVEFSLEYCETRPALLERLNAWMGRHDPDAIIGWNLVQFDLRVLHEHAR
KFQVPLRLGRGGAEMEWREHGSQQHYFAGAAGRLIIDGIEALRSATWTFPSFSLESVAQSLLGEGKAIDNPYDRMDAIDR
MFEQDKPALARYNLRDCELVTRIFDKTELLTFLLERATVTGLQADRSGGSVAAFTHLYMPLMHRQGYVAPNLGDKAPEAS
PGGFVMDSRPGLYESVLVLDYKSLYPSIIRTFLIDPIGLVEGLAHPDDADSVAGFRGARFSRTKHCLPSIVARVWQGREA
AKRDGNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMQQTRTLIEARGYEVIYGDTDSTFVWLRRARTE
ADASQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHFRRFLMPTIRGTDLGSKKRYAGQVQRPDGRVEMVFKGLETV
RTDWSPLAQEFQQVLYERIFNREPYQDYVRDIVRRTLAGELDEQLVFRKRLRRKLDDYQRNVPPHVRAARIADAHNERHG
RPLQYQHGGWISYVMTVAGPEPLEVRSAPIDYGHYVTKQLQPIADAILPFLDEDFETLLTGQMALFPS
>Mature_787_residues
ALQQGFILTRHWRDTPAGTEVEVWLATDDGPRLLRLPPQPSVAFVPEAQRQRAEAVLQGDATVDLRPLRLQDFNQRPVSG
LYCRQYRQLGQHSRALRDAGVDVYEADIRPPERYLMERFITAPVWYDGDADGSGVVRNAQMKPATDYRPTLRLVSLDIET
NAFGDLYSIALEGCGQRQVYMLCPAPSVPADVEFSLEYCETRPALLERLNAWMGRHDPDAIIGWNLVQFDLRVLHEHARK
FQVPLRLGRGGAEMEWREHGSQQHYFAGAAGRLIIDGIEALRSATWTFPSFSLESVAQSLLGEGKAIDNPYDRMDAIDRM
FEQDKPALARYNLRDCELVTRIFDKTELLTFLLERATVTGLQADRSGGSVAAFTHLYMPLMHRQGYVAPNLGDKAPEASP
GGFVMDSRPGLYESVLVLDYKSLYPSIIRTFLIDPIGLVEGLAHPDDADSVAGFRGARFSRTKHCLPSIVARVWQGREAA
KRDGNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMQQTRTLIEARGYEVIYGDTDSTFVWLRRARTEA
DASQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHFRRFLMPTIRGTDLGSKKRYAGQVQRPDGRVEMVFKGLETVR
TDWSPLAQEFQQVLYERIFNREPYQDYVRDIVRRTLAGELDEQLVFRKRLRRKLDDYQRNVPPHVRAARIADAHNERHGR
PLQYQHGGWISYVMTVAGPEPLEVRSAPIDYGHYVTKQLQPIADAILPFLDEDFETLLTGQMALFPS

Specific function: Thought to be involved in DNA repair and/or mutagenesis [H]

COG id: COG0417

COG function: function code L; DNA polymerase elongation subunit (family B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase type-B family [H]

Homologues:

Organism=Homo sapiens, GI156616275, Length=635, Percent_Identity=27.5590551181102, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI106507301, Length=668, Percent_Identity=24.7005988023952, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1786246, Length=784, Percent_Identity=67.0918367346939, Blast_Score=1093, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559488, Length=646, Percent_Identity=26.625386996904, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565317, Length=781, Percent_Identity=24.3277848911652, Blast_Score=144, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI86563326, Length=548, Percent_Identity=25, Blast_Score=86, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320101, Length=656, Percent_Identity=26.0670731707317, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324227, Length=664, Percent_Identity=25.1506024096386, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24664937, Length=637, Percent_Identity=25.5886970172684, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24648780, Length=646, Percent_Identity=23.6842105263158, Blast_Score=118, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006172
- InterPro:   IPR017964
- InterPro:   IPR006133
- InterPro:   IPR006134
- InterPro:   IPR023211
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00136 DNA_pol_B; PF03104 DNA_pol_B_exo [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 89670; Mature: 89539

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00116 DNA_POLYMERASE_B

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQQGFILTRHWRDTPAGTEVEVWLATDDGPRLLRLPPQPSVAFVPEAQRQRAEAVLQG
CCCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEEECCCCCCEEECCCHHHHHHHHHHCC
DATVDLRPLRLQDFNQRPVSGLYCRQYRQLGQHSRALRDAGVDVYEADIRPPERYLMERF
CCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
ITAPVWYDGDADGSGVVRNAQMKPATDYRPTLRLVSLDIETNAFGDLYSIALEGCGQRQV
HHCCEEECCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCEE
YMLCPAPSVPADVEFSLEYCETRPALLERLNAWMGRHDPDAIIGWNLVQFDLRVLHEHAR
EEEECCCCCCCCCEEHHHHHCCCHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHH
KFQVPLRLGRGGAEMEWREHGSQQHYFAGAAGRLIIDGIEALRSATWTFPSFSLESVAQS
HEECCCEECCCCCCCHHHHCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LLGEGKAIDNPYDRMDAIDRMFEQDKPALARYNLRDCELVTRIFDKTELLTFLLERATVT
HHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLQADRSGGSVAAFTHLYMPLMHRQGYVAPNLGDKAPEASPGGFVMDSRPGLYESVLVLD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHH
YKSLYPSIIRTFLIDPIGLVEGLAHPDDADSVAGFRGARFSRTKHCLPSIVARVWQGREA
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHH
AKRDGNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMQQTRTLIEARGY
HHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
EVIYGDTDSTFVWLRRARTEADASQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHF
EEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RRFLMPTIRGTDLGSKKRYAGQVQRPDGRVEMVFKGLETVRTDWSPLAQEFQQVLYERIF
HHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
NREPYQDYVRDIVRRTLAGELDEQLVFRKRLRRKLDDYQRNVPPHVRAARIADAHNERHG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
RPLQYQHGGWISYVMTVAGPEPLEVRSAPIDYGHYVTKQLQPIADAILPFLDEDFETLLT
CCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQMALFPS
CCHHCCCC
>Mature Secondary Structure 
ALQQGFILTRHWRDTPAGTEVEVWLATDDGPRLLRLPPQPSVAFVPEAQRQRAEAVLQG
CCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEEECCCCCCEEECCCHHHHHHHHHHCC
DATVDLRPLRLQDFNQRPVSGLYCRQYRQLGQHSRALRDAGVDVYEADIRPPERYLMERF
CCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
ITAPVWYDGDADGSGVVRNAQMKPATDYRPTLRLVSLDIETNAFGDLYSIALEGCGQRQV
HHCCEEECCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCEE
YMLCPAPSVPADVEFSLEYCETRPALLERLNAWMGRHDPDAIIGWNLVQFDLRVLHEHAR
EEEECCCCCCCCCEEHHHHHCCCHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHH
KFQVPLRLGRGGAEMEWREHGSQQHYFAGAAGRLIIDGIEALRSATWTFPSFSLESVAQS
HEECCCEECCCCCCCHHHHCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LLGEGKAIDNPYDRMDAIDRMFEQDKPALARYNLRDCELVTRIFDKTELLTFLLERATVT
HHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLQADRSGGSVAAFTHLYMPLMHRQGYVAPNLGDKAPEASPGGFVMDSRPGLYESVLVLD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHH
YKSLYPSIIRTFLIDPIGLVEGLAHPDDADSVAGFRGARFSRTKHCLPSIVARVWQGREA
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHH
AKRDGNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMQQTRTLIEARGY
HHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
EVIYGDTDSTFVWLRRARTEADASQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHF
EEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RRFLMPTIRGTDLGSKKRYAGQVQRPDGRVEMVFKGLETVRTDWSPLAQEFQQVLYERIF
HHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
NREPYQDYVRDIVRRTLAGELDEQLVFRKRLRRKLDDYQRNVPPHVRAARIADAHNERHG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
RPLQYQHGGWISYVMTVAGPEPLEVRSAPIDYGHYVTKQLQPIADAILPFLDEDFETLLT
CCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQMALFPS
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034216; 2261080; 1630901; 9278503; 2217198; 9079692 [H]