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The map label for this gene is pbuX [H]

Identifier: 73538358

GI number: 73538358

Start: 1203763

End: 1205094

Strand: Reverse

Name: pbuX [H]

Synonym: Reut_B4531

Alternate gene names: 73538358

Gene position: 1205094-1203763 (Counterclockwise)

Preceding gene: 73538368

Following gene: 73538357

Centisome position: 44.2

GC content: 66.44

Gene sequence:

>1332_bases
ATGTCCCAACCCGCCCCCGCCCCGGTGGATGAACGCCTGCCATGGCGGCAGCTGTTCGTCTTCGGCCTCCAGCACGTGCT
GGTCATGGCGGCATCGCCCATTGCGGCGGTGTTCCTGATGAGCAAGGCCCTGAATCTTCCGTCCGCGCTGTCGGTGCAGT
TGTTGAGCGCGACTTTCGTGGTCTGCGGGCTTGGCACGTTGCTGCAGTCGCTTGGCCGTCGCGGCATTGGTGCGCGGCTG
CCGTTCGTGATGCTTCCTGGCGGCGCACCCATCGTGCTGTTCATCCTGATCGCCCAGCAGACCAGCGTGCAGACCGCGGC
CGGGGCGGTAATCATCACTGGCCTGTTCTACTTCTGTGCGCTGCCGGTGTTCCGGCGCTGCCTGCGCTATTTCCCGCCGG
TGGTGGTCGGAACCATGCTGCTGCTGGTGGCGATCAACCTTGCGCAGGTTTCGGGGCGGCTGATTGCCGGACATCCTGCG
GCAGGGGCATCGGTCGATCCGATGAACCTGTTGCTGGCCTTCGTGACCATCGCCTGCACCGTGGCGGCGTCTCGGTGGTT
CGGCGGCACGCTGGCACGGCTGGCGATCCTGATCGGACTCGTTGGCGGTGCGTTGTCGGCCATGGCGCTCGGCGTATTTC
ATGCCGGGCAGGTGTCGGCATCGCCGTTGCTGGCCTTGCCAACGCCTTTCCCATTTGGCTGGCCGCAGTTCGATGTCGTG
GCCGCCATTCCGCTGGTGGTGTTTGCCGTGATCTCGATGGTCGAGGCCACCGGCCAGACCCTCGCCATCAGCGATGCCGT
GGGACGGCCGGTCGACGGCGAGCGCGATGTGCCGCGCACCATCCGCGCCGATGCGCTGGCGTCGCTGCTTGGCGGCGTGT
TCGGGACATCGCTGATTATCACCAGCGGGGAGAACATCGGCATCGTGCGCGCCACCGGCGTGCGTTCCCGCTATGTCACC
GCGGTATCGGGTCTCATCCTTGTGGCGTTCGGCCTGCTGGTACCGGTGTCGTCACTAATCAGCGCGATCCCGGAAGCGGT
GGTCGGCGGCACGGGTCTCGTGGTGTTCTGCATCGTGGGCACCATGGGCATTGACGTGCTGCGCCGTGTCGACCTGCGCG
ACCACGCCAATATGTATGTGGTGGCCGTGGCGCTCGCGGCCGGACTGCTGCCGATCCTCGTTCCCGGCATCTACGGCGCA
CTGCCGCCCAACCTGCGCATCCTGCTGGGCAATGGCGTGGCGATGGGCGCCTTCACTGCCGCCTTGCTCAACTTCCTGTT
CTTCCACACGGGCGCCAGGCGCGTCGCCGACGTGGCGCCTGTTACGCACTGA

Upstream 100 bases:

>100_bases
AATAAAAAACGTGCGGATTGACGCCAACAGCGCACAGACGCAGGGCCCCTCCGCGAGGTCACCGGTGCAACGACTGACCC
ACCAATCGAGGAGCAACGAC

Downstream 100 bases:

>100_bases
AACCGTATCCGGAAATCCGAATGACACATCGATCCGCATTCCAGCCAGCGTGGCCTGGCGATCTGGCGCCGCCCCTGGAC
CCGGCACGCCTTGCCGAACC

Product: xanthine/uracil/vitamin C permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSQPAPAPVDERLPWRQLFVFGLQHVLVMAASPIAAVFLMSKALNLPSALSVQLLSATFVVCGLGTLLQSLGRRGIGARL
PFVMLPGGAPIVLFILIAQQTSVQTAAGAVIITGLFYFCALPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGRLIAGHPA
AGASVDPMNLLLAFVTIACTVAASRWFGGTLARLAILIGLVGGALSAMALGVFHAGQVSASPLLALPTPFPFGWPQFDVV
AAIPLVVFAVISMVEATGQTLAISDAVGRPVDGERDVPRTIRADALASLLGGVFGTSLIITSGENIGIVRATGVRSRYVT
AVSGLILVAFGLLVPVSSLISAIPEAVVGGTGLVVFCIVGTMGIDVLRRVDLRDHANMYVVAVALAAGLLPILVPGIYGA
LPPNLRILLGNGVAMGAFTAALLNFLFFHTGARRVADVAPVTH

Sequences:

>Translated_443_residues
MSQPAPAPVDERLPWRQLFVFGLQHVLVMAASPIAAVFLMSKALNLPSALSVQLLSATFVVCGLGTLLQSLGRRGIGARL
PFVMLPGGAPIVLFILIAQQTSVQTAAGAVIITGLFYFCALPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGRLIAGHPA
AGASVDPMNLLLAFVTIACTVAASRWFGGTLARLAILIGLVGGALSAMALGVFHAGQVSASPLLALPTPFPFGWPQFDVV
AAIPLVVFAVISMVEATGQTLAISDAVGRPVDGERDVPRTIRADALASLLGGVFGTSLIITSGENIGIVRATGVRSRYVT
AVSGLILVAFGLLVPVSSLISAIPEAVVGGTGLVVFCIVGTMGIDVLRRVDLRDHANMYVVAVALAAGLLPILVPGIYGA
LPPNLRILLGNGVAMGAFTAALLNFLFFHTGARRVADVAPVTH
>Mature_442_residues
SQPAPAPVDERLPWRQLFVFGLQHVLVMAASPIAAVFLMSKALNLPSALSVQLLSATFVVCGLGTLLQSLGRRGIGARLP
FVMLPGGAPIVLFILIAQQTSVQTAAGAVIITGLFYFCALPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGRLIAGHPAA
GASVDPMNLLLAFVTIACTVAASRWFGGTLARLAILIGLVGGALSAMALGVFHAGQVSASPLLALPTPFPFGWPQFDVVA
AIPLVVFAVISMVEATGQTLAISDAVGRPVDGERDVPRTIRADALASLLGGVFGTSLIITSGENIGIVRATGVRSRYVTA
VSGLILVAFGLLVPVSSLISAIPEAVVGGTGLVVFCIVGTMGIDVLRRVDLRDHANMYVVAVALAAGLLPILVPGIYGAL
PPNLRILLGNGVAMGAFTAALLNFLFFHTGARRVADVAPVTH

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=212, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40316845, Length=212, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082181, Length=441, Percent_Identity=30.8390022675737, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1790087, Length=442, Percent_Identity=28.9592760180996, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87082178, Length=466, Percent_Identity=26.8240343347639, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI87081818, Length=453, Percent_Identity=29.1390728476821, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1788843, Length=394, Percent_Identity=27.4111675126904, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17558856, Length=465, Percent_Identity=24.5161290322581, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541904, Length=420, Percent_Identity=22.3809523809524, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=172, Percent_Identity=22.6744186046512, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356175, Length=444, Percent_Identity=21.3963963963964, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45828; Mature: 45697

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPAPAPVDERLPWRQLFVFGLQHVLVMAASPIAAVFLMSKALNLPSALSVQLLSATFV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VCGLGTLLQSLGRRGIGARLPFVMLPGGAPIVLFILIAQQTSVQTAAGAVIITGLFYFCA
HHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGRLIAGHPAAGASVDPMNLLLAFVTIACT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
VAASRWFGGTLARLAILIGLVGGALSAMALGVFHAGQVSASPLLALPTPFPFGWPQFDVV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHH
AAIPLVVFAVISMVEATGQTLAISDAVGRPVDGERDVPRTIRADALASLLGGVFGTSLII
HHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEE
TSGENIGIVRATGVRSRYVTAVSGLILVAFGLLVPVSSLISAIPEAVVGGTGLVVFCIVG
ECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TMGIDVLRRVDLRDHANMYVVAVALAAGLLPILVPGIYGALPPNLRILLGNGVAMGAFTA
HHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
ALLNFLFFHTGARRVADVAPVTH
HHHHHHHHHCCHHHHHHHCCCCC
>Mature Secondary Structure 
SQPAPAPVDERLPWRQLFVFGLQHVLVMAASPIAAVFLMSKALNLPSALSVQLLSATFV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VCGLGTLLQSLGRRGIGARLPFVMLPGGAPIVLFILIAQQTSVQTAAGAVIITGLFYFCA
HHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGRLIAGHPAAGASVDPMNLLLAFVTIACT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
VAASRWFGGTLARLAILIGLVGGALSAMALGVFHAGQVSASPLLALPTPFPFGWPQFDVV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHH
AAIPLVVFAVISMVEATGQTLAISDAVGRPVDGERDVPRTIRADALASLLGGVFGTSLII
HHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEE
TSGENIGIVRATGVRSRYVTAVSGLILVAFGLLVPVSSLISAIPEAVVGGTGLVVFCIVG
ECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TMGIDVLRRVDLRDHANMYVVAVALAAGLLPILVPGIYGALPPNLRILLGNGVAMGAFTA
HHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
ALLNFLFFHTGARRVADVAPVTH
HHHHHHHHHCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]