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The map label for this gene is yngI [H]

Identifier: 73538138

GI number: 73538138

Start: 966034

End: 967668

Strand: Reverse

Name: yngI [H]

Synonym: Reut_B4308

Alternate gene names: 73538138

Gene position: 967668-966034 (Counterclockwise)

Preceding gene: 73538141

Following gene: 73538134

Centisome position: 35.5

GC content: 65.57

Gene sequence:

>1635_bases
ATGCCCACCGATTTCGACAGCGGCCTCGGCCGCAACGCGGCCAATTTCGTGCCGATCACCCCGATTGATTTCCTGGTCCG
CGCCGCCGAGGTATACGGCGACCGGCCAGCTATCGTGCACGGCCCGGTGCGCCAGAACTGGCGCGACACCTATGTGCGGG
CGCGCCGCCTGGCCAGTGCGCTCGCGCGAGCGGGCGTGGGCAAGGGCGATACCGTCGCAGCGCTGCTGCCCAATACGCCA
GCCATGGTGGAGGCGCACTTCGGTGTGCCGATGGCCGGCGCGGTGCTCAATGCGCTCAATATTCGACTGGACGCTGCGAA
CCTGGTGTTCATGCTGCGCCATGGCGAGGCGCGCGTGCTGCTGGCCGATACCGAGTTCGCCGACCTCGCACGCCAGATGG
CGCTGGAAATCCCGGGCCTGAAGGTCATCGCCGTGGAAGATGCGCTGGGCCCGCAGGCGGAGCGTTTCGGCGATACCGAC
TACGAGTCGTTCCTCGCTTCGGGCGATCCTGAGTACGCGTGGAAGATGCCTGACGACGAATGGGATGCGATTGCGCTGAA
CTACACATCGGGCACGACGGGTGACCCGAAGGGCGTGGTGTACCATCACCGCGGCGCGGCCATGAATGCGATCTCGAACA
TCCTCGAGTGGGACCTGCCCAAGCATCCGGTCTACCTGTGGACGCTGCCGTTATTCCACTGCAATGGCTGGTGCTTTCCG
TGGACCATTGCGGCACGTGCGGGCGTCAACGTGTGCCTGCGCAAGTTCGAGCCGCGGCTCGTGTTCGATCTTATGCGCGA
CGAAGGCGTGACCCACTACTGCGCGGCGCCGATCGTGCATACCGCGCTCGTCAATGCACCACCGTCGTGGCGCGAAGGCC
TGCGCGGCCCCGTGCGCGGCATGGTGGCCGGCGCGCCGCCGCCCGCCGCGGTGCTCGCTCAGATGGAGGCGATGGGGTTC
GAGCTGACGCACGTGTACGGCCTCACGGAGGTGTACGGGCCGGCTGCCGTATGCGCCGAGCAGGACGGCTGGGACAGTCT
GTCGCAGGAAGAGCGTGCGGTGAAGAAGGCACGGCAGGGCGTGCGCTATCACCTGCAGTCGGGCGTGGCCGTGCTCGATC
CCGATTCGATGCAGCCGGTGCCGGCCGATGGCGAGACCATCGGCGAAATCATGTTCCGCGGCAACATCTGCATGAAGGGT
TACCTCAAGAATGAGAAGGCGACGCGCGAGGCCTTTGCGGGCGGCTGGTTCCACACCGGCGATCTCGGCGTATGCATGGC
GGACGGCTACATCAAGATCAAGGACCGCAGCAAGGACATCATCATTTCGGGCGGCGAGAACATTTCGAGCGTCGAGGTGG
AGGATGCGCTCTACCGCCATCCGGCCGTGCTTGCGGCAGCAGTCGTGGCGCAGCCGGATGCCAAATGGGGCGAAACGCCG
TGCGCGTTCGTCGAGCTGAAAGATGGGGCGAGTGCGACGGCAGAGGAACTGATGGCCCATTGCCGCACGCTGCTGGCGGG
CTTCAAGGTGCCGAAGGCTGTGTATTTCGGACCGCTGCCGAAGACCTCGACCGGCAAGATCCAGAAGTTCGAGCTGCGCC
GCAAGGTCAAGTCGGATTCGGCGATCGACGTCTGA

Upstream 100 bases:

>100_bases
TGTCGTCCGGATGACAGTGCGCAAGCGTGTGCGATGATAGCCTTGTGGAAGAAAAAGTTACAGCGCCCCCGTGCCAGACA
GCTAAGCGGAGACACCAATC

Downstream 100 bases:

>100_bases
GGCGACGATCAGGAGAACGAAGCCTCTTCCTCGGCTTGCCGGTTCGCGATCAGGCGGTCGATGGTTTCGCGACCCCACGC
CAGCCCTGCACGGCTGGCGT

Product: acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MPTDFDSGLGRNAANFVPITPIDFLVRAAEVYGDRPAIVHGPVRQNWRDTYVRARRLASALARAGVGKGDTVAALLPNTP
AMVEAHFGVPMAGAVLNALNIRLDAANLVFMLRHGEARVLLADTEFADLARQMALEIPGLKVIAVEDALGPQAERFGDTD
YESFLASGDPEYAWKMPDDEWDAIALNYTSGTTGDPKGVVYHHRGAAMNAISNILEWDLPKHPVYLWTLPLFHCNGWCFP
WTIAARAGVNVCLRKFEPRLVFDLMRDEGVTHYCAAPIVHTALVNAPPSWREGLRGPVRGMVAGAPPPAAVLAQMEAMGF
ELTHVYGLTEVYGPAAVCAEQDGWDSLSQEERAVKKARQGVRYHLQSGVAVLDPDSMQPVPADGETIGEIMFRGNICMKG
YLKNEKATREAFAGGWFHTGDLGVCMADGYIKIKDRSKDIIISGGENISSVEVEDALYRHPAVLAAAVVAQPDAKWGETP
CAFVELKDGASATAEELMAHCRTLLAGFKVPKAVYFGPLPKTSTGKIQKFELRRKVKSDSAIDV

Sequences:

>Translated_544_residues
MPTDFDSGLGRNAANFVPITPIDFLVRAAEVYGDRPAIVHGPVRQNWRDTYVRARRLASALARAGVGKGDTVAALLPNTP
AMVEAHFGVPMAGAVLNALNIRLDAANLVFMLRHGEARVLLADTEFADLARQMALEIPGLKVIAVEDALGPQAERFGDTD
YESFLASGDPEYAWKMPDDEWDAIALNYTSGTTGDPKGVVYHHRGAAMNAISNILEWDLPKHPVYLWTLPLFHCNGWCFP
WTIAARAGVNVCLRKFEPRLVFDLMRDEGVTHYCAAPIVHTALVNAPPSWREGLRGPVRGMVAGAPPPAAVLAQMEAMGF
ELTHVYGLTEVYGPAAVCAEQDGWDSLSQEERAVKKARQGVRYHLQSGVAVLDPDSMQPVPADGETIGEIMFRGNICMKG
YLKNEKATREAFAGGWFHTGDLGVCMADGYIKIKDRSKDIIISGGENISSVEVEDALYRHPAVLAAAVVAQPDAKWGETP
CAFVELKDGASATAEELMAHCRTLLAGFKVPKAVYFGPLPKTSTGKIQKFELRRKVKSDSAIDV
>Mature_543_residues
PTDFDSGLGRNAANFVPITPIDFLVRAAEVYGDRPAIVHGPVRQNWRDTYVRARRLASALARAGVGKGDTVAALLPNTPA
MVEAHFGVPMAGAVLNALNIRLDAANLVFMLRHGEARVLLADTEFADLARQMALEIPGLKVIAVEDALGPQAERFGDTDY
ESFLASGDPEYAWKMPDDEWDAIALNYTSGTTGDPKGVVYHHRGAAMNAISNILEWDLPKHPVYLWTLPLFHCNGWCFPW
TIAARAGVNVCLRKFEPRLVFDLMRDEGVTHYCAAPIVHTALVNAPPSWREGLRGPVRGMVAGAPPPAAVLAQMEAMGFE
LTHVYGLTEVYGPAAVCAEQDGWDSLSQEERAVKKARQGVRYHLQSGVAVLDPDSMQPVPADGETIGEIMFRGNICMKGY
LKNEKATREAFAGGWFHTGDLGVCMADGYIKIKDRSKDIIISGGENISSVEVEDALYRHPAVLAAAVVAQPDAKWGETPC
AFVELKDGASATAEELMAHCRTLLAGFKVPKAVYFGPLPKTSTGKIQKFELRRKVKSDSAIDV

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=544, Percent_Identity=28.6764705882353, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI187761345, Length=543, Percent_Identity=29.097605893186, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI187761343, Length=543, Percent_Identity=29.097605893186, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI122937307, Length=530, Percent_Identity=27.5471698113208, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI157311624, Length=509, Percent_Identity=25.3438113948919, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI157311622, Length=509, Percent_Identity=25.3438113948919, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI58082049, Length=506, Percent_Identity=25.296442687747, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI42544132, Length=504, Percent_Identity=27.1825396825397, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI38505220, Length=499, Percent_Identity=25.8517034068136, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI115511026, Length=512, Percent_Identity=25.390625, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI42794760, Length=485, Percent_Identity=24.5360824742268, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI42794758, Length=485, Percent_Identity=24.5360824742268, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI42794756, Length=485, Percent_Identity=24.5360824742268, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI40807491, Length=462, Percent_Identity=25.974025974026, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI28416953, Length=130, Percent_Identity=33.8461538461538, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI8923896, Length=129, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI253970489, Length=129, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI27477105, Length=109, Percent_Identity=37.6146788990826, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI221142682, Length=517, Percent_Identity=28.0464216634429, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI145693145, Length=544, Percent_Identity=31.4338235294118, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788107, Length=548, Percent_Identity=28.1021897810219, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI1786810, Length=558, Percent_Identity=26.3440860215054, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1786801, Length=488, Percent_Identity=23.155737704918, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994703, Length=532, Percent_Identity=27.8195488721804, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71994694, Length=532, Percent_Identity=27.8195488721804, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71994690, Length=532, Percent_Identity=27.8195488721804, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17560308, Length=531, Percent_Identity=27.8719397363465, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17558820, Length=498, Percent_Identity=27.3092369477912, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=503, Percent_Identity=25.844930417495, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=522, Percent_Identity=24.1379310344828, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=527, Percent_Identity=25.2371916508539, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17557194, Length=511, Percent_Identity=23.679060665362, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=514, Percent_Identity=24.3190661478599, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17560140, Length=547, Percent_Identity=25.2285191956124, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=528, Percent_Identity=22.5378787878788, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983001, Length=557, Percent_Identity=24.9551166965889, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71982997, Length=557, Percent_Identity=24.9551166965889, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17510401, Length=182, Percent_Identity=33.5164835164835, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=353, Percent_Identity=28.8951841359773, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323182, Length=143, Percent_Identity=34.965034965035, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24581924, Length=550, Percent_Identity=28.3636363636364, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355181, Length=532, Percent_Identity=25, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859661, Length=519, Percent_Identity=27.5529865125241, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19922652, Length=511, Percent_Identity=27.0058708414873, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24583465, Length=467, Percent_Identity=23.5546038543897, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583463, Length=467, Percent_Identity=23.5546038543897, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281364798, Length=460, Percent_Identity=23.695652173913, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281365686, Length=474, Percent_Identity=22.3628691983122, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356947, Length=496, Percent_Identity=21.7741935483871, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356441, Length=464, Percent_Identity=21.551724137931, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20130357, Length=361, Percent_Identity=24.6537396121884, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648257, Length=469, Percent_Identity=23.454157782516, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 59123; Mature: 58992

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDFDSGLGRNAANFVPITPIDFLVRAAEVYGDRPAIVHGPVRQNWRDTYVRARRLASA
CCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCEEECCHHCCHHHHHHHHHHHHHH
LARAGVGKGDTVAALLPNTPAMVEAHFGVPMAGAVLNALNIRLDAANLVFMLRHGEARVL
HHHCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHEEEECCEEEEEEECCCEEEE
LADTEFADLARQMALEIPGLKVIAVEDALGPQAERFGDTDYESFLASGDPEYAWKMPDDE
EECCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHCCCCCHHHHHHCCCCCEEEECCCCC
WDAIALNYTSGTTGDPKGVVYHHRGAAMNAISNILEWDLPKHPVYLWTLPLFHCNGWCFP
CCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEEHHCCCCCCH
WTIAARAGVNVCLRKFEPRLVFDLMRDEGVTHYCAAPIVHTALVNAPPSWREGLRGPVRG
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHH
MVAGAPPPAAVLAQMEAMGFELTHVYGLTEVYGPAAVCAEQDGWDSLSQEERAVKKARQG
EECCCCCHHHHHHHHHHCCEEEEHHHHHHHHCCCHHEECCCCCCCHHHHHHHHHHHHHHH
VRYHLQSGVAVLDPDSMQPVPADGETIGEIMFRGNICMKGYLKNEKATREAFAGGWFHTG
HHHHHHCCEEEECCCCCCCCCCCCHHHHHHHEECCEEEEEEECCCHHHHHHHCCCCEEEC
DLGVCMADGYIKIKDRSKDIIISGGENISSVEVEDALYRHPAVLAAAVVAQPDAKWGETP
CCEEEEECCEEEEECCCCEEEEECCCCCCEEEHHHHHHHCHHHHHHHHHCCCCCCCCCCC
CAFVELKDGASATAEELMAHCRTLLAGFKVPKAVYFGPLPKTSTGKIQKFELRRKVKSDS
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCC
AIDV
CCCC
>Mature Secondary Structure 
PTDFDSGLGRNAANFVPITPIDFLVRAAEVYGDRPAIVHGPVRQNWRDTYVRARRLASA
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCEEECCHHCCHHHHHHHHHHHHHH
LARAGVGKGDTVAALLPNTPAMVEAHFGVPMAGAVLNALNIRLDAANLVFMLRHGEARVL
HHHCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHEEEECCEEEEEEECCCEEEE
LADTEFADLARQMALEIPGLKVIAVEDALGPQAERFGDTDYESFLASGDPEYAWKMPDDE
EECCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHCCCCCHHHHHHCCCCCEEEECCCCC
WDAIALNYTSGTTGDPKGVVYHHRGAAMNAISNILEWDLPKHPVYLWTLPLFHCNGWCFP
CCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEEHHCCCCCCH
WTIAARAGVNVCLRKFEPRLVFDLMRDEGVTHYCAAPIVHTALVNAPPSWREGLRGPVRG
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHH
MVAGAPPPAAVLAQMEAMGFELTHVYGLTEVYGPAAVCAEQDGWDSLSQEERAVKKARQG
EECCCCCHHHHHHHHHHCCEEEEHHHHHHHHCCCHHEECCCCCCCHHHHHHHHHHHHHHH
VRYHLQSGVAVLDPDSMQPVPADGETIGEIMFRGNICMKGYLKNEKATREAFAGGWFHTG
HHHHHHCCEEEECCCCCCCCCCCCHHHHHHHEECCEEEEEEECCCHHHHHHHCCCCEEEC
DLGVCMADGYIKIKDRSKDIIISGGENISSVEVEDALYRHPAVLAAAVVAQPDAKWGETP
CCEEEEECCEEEEECCCCEEEEECCCCCCEEEHHHHHHHCHHHHHHHHHCCCCCCCCCCC
CAFVELKDGASATAEELMAHCRTLLAGFKVPKAVYFGPLPKTSTGKIQKFELRRKVKSDS
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCC
AIDV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]