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The map label for this gene is mdtD [H]

Identifier: 73538132

GI number: 73538132

Start: 961287

End: 962687

Strand: Reverse

Name: mdtD [H]

Synonym: Reut_B4302

Alternate gene names: 73538132

Gene position: 962687-961287 (Counterclockwise)

Preceding gene: 73538134

Following gene: 73538129

Centisome position: 35.31

GC content: 64.81

Gene sequence:

>1401_bases
ATGAGCCAAGCTTTCGCCCCCTCTCTCAAGGCCATGTTGTGGATCGTCGCTGCGGGTTTCTTCATGCAGACGCTCGATAC
CACCATCGTCAACACCGCACTGCCTTCGATGGCACACAGCCTCGGGCGCAAGCCACTGGAGTTGCAACCCGTGGTTGTCG
CGTACACGCTGACCATGGCGATGCTGACCCCTGCGTCGGGCTGGCTCGCCGACCGCTTCGGCACGCGGCGGGTTTACTTC
TGCGCCATCCTCATCTTCGTGTTGGGATCCCTGTTCTGCGCGGGCGCGCAAACATTGCCGGAACTGGTAGTGGCGCGAGT
GCTGCAAGGCGTCGGCGGCTCCATGCTGCTGCCGATCGGCCGGCTCGCCGTGCTGCGCAATGTATCGGGCGAGCAGTACA
TTGCCGCGCTCGCCTTTGTCTCCGTGGCGGGGCAGGTAGGTCCGATCTTCGGGCCGGTGCTCGGCGGCTGGCTGGTGCAG
CACGTTTCATGGCACTGGATTTTCCTGATCAACGTGCCTGTCGGCGTTGTCGGTTTGCTCGCCGTGCGGCGCTATCTGCC
TGCCGGCGACACAGCGGGCGCGCCGGCGTTCGACTGGGTCGGTTGCGGCTTGCTGTCGCTGTGCATGGTGGCGTTTTCGC
TGGCACTCGATGCGCCGCTGCAGGAAAACCATGCAAGCTGGAGCGCCGGCCTCGCCGCGATCAGCGTGGTTGCCGCTATG
TTGTATATCCCGCATGCGCGCCGCAGCCGCGTGCCGCTGTTCCGGCTGGCACTGTTTCGCGAGCCGAATTTCAGCGTGGG
GCTGGTCGGGAATCTAGTCTGCCGCATCGGCTCCGGCGCGGTGCCGTTCCTGCTGCCGCTGCTGATGCAACTGCAGCTCG
GCTACTCGCCGTTCCACGCGGGGCTGATGCTGCTGCCGGCCGCACTGGCGGGGGCGGTGTCCAAACGCTGGATCGTGCCG
CTGGTGAAACGCTTCGGCTATGACAACTTCCTGCTCGTCAACACCGCACTGGTCGGCGCATCGATCGCGTCGTTCGGGGC
GATGTCGCCGGGCTGGCCACTGGCGCTCTCCATTGCGCAACTGGCGTTGTTCGGCGCGACCAATTCGATGCAATTCGCTG
CCATGAACAGCGTGACGCTCAAGGACCTCAGCGTCGAGGATGCGGGTAGCGGCAACAGCCTGTTCTCGATGGTGCAGATG
TTGGCCATCGGACTAGGCGTGACCGTGGGCGGCGGGCTCGTGACCTTGTTTTCCGATCGGATCGGGGATGCGGGTCCCGC
TTATCGGCTGGCCTTTGTGGTTGTCGGGACGATCACGCTTCTGTCGGCGCTGGTGTTTCGTCGGCTGGATATTGGGGAGC
TTGGAAAAGGGCGGCGCGCAGCTGCGGCGCGCACGCCTTGA

Upstream 100 bases:

>100_bases
GGTGGGTGGTGACTATGATCGGTTCCATGGCCTGGCTGCCAGGGCTTTGCCGACATCGTCCGCCTTGGTTGCATGCTGTG
CCACGCACAATCCCACACCC

Downstream 100 bases:

>100_bases
GTTGCAAACACGGGCTCAGGCCGCGTGAGTCTTTCGTCCCACGCTGCGGATCAGTTCCGTGACGCGAGCCTGGTACTGGT
CGAAGTACTTGTTCGCCTGC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSQAFAPSLKAMLWIVAAGFFMQTLDTTIVNTALPSMAHSLGRKPLELQPVVVAYTLTMAMLTPASGWLADRFGTRRVYF
CAILIFVLGSLFCAGAQTLPELVVARVLQGVGGSMLLPIGRLAVLRNVSGEQYIAALAFVSVAGQVGPIFGPVLGGWLVQ
HVSWHWIFLINVPVGVVGLLAVRRYLPAGDTAGAPAFDWVGCGLLSLCMVAFSLALDAPLQENHASWSAGLAAISVVAAM
LYIPHARRSRVPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLMQLQLGYSPFHAGLMLLPAALAGAVSKRWIVP
LVKRFGYDNFLLVNTALVGASIASFGAMSPGWPLALSIAQLALFGATNSMQFAAMNSVTLKDLSVEDAGSGNSLFSMVQM
LAIGLGVTVGGGLVTLFSDRIGDAGPAYRLAFVVVGTITLLSALVFRRLDIGELGKGRRAAAARTP

Sequences:

>Translated_466_residues
MSQAFAPSLKAMLWIVAAGFFMQTLDTTIVNTALPSMAHSLGRKPLELQPVVVAYTLTMAMLTPASGWLADRFGTRRVYF
CAILIFVLGSLFCAGAQTLPELVVARVLQGVGGSMLLPIGRLAVLRNVSGEQYIAALAFVSVAGQVGPIFGPVLGGWLVQ
HVSWHWIFLINVPVGVVGLLAVRRYLPAGDTAGAPAFDWVGCGLLSLCMVAFSLALDAPLQENHASWSAGLAAISVVAAM
LYIPHARRSRVPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLMQLQLGYSPFHAGLMLLPAALAGAVSKRWIVP
LVKRFGYDNFLLVNTALVGASIASFGAMSPGWPLALSIAQLALFGATNSMQFAAMNSVTLKDLSVEDAGSGNSLFSMVQM
LAIGLGVTVGGGLVTLFSDRIGDAGPAYRLAFVVVGTITLLSALVFRRLDIGELGKGRRAAAARTP
>Mature_465_residues
SQAFAPSLKAMLWIVAAGFFMQTLDTTIVNTALPSMAHSLGRKPLELQPVVVAYTLTMAMLTPASGWLADRFGTRRVYFC
AILIFVLGSLFCAGAQTLPELVVARVLQGVGGSMLLPIGRLAVLRNVSGEQYIAALAFVSVAGQVGPIFGPVLGGWLVQH
VSWHWIFLINVPVGVVGLLAVRRYLPAGDTAGAPAFDWVGCGLLSLCMVAFSLALDAPLQENHASWSAGLAAISVVAAML
YIPHARRSRVPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLMQLQLGYSPFHAGLMLLPAALAGAVSKRWIVPL
VKRFGYDNFLLVNTALVGASIASFGAMSPGWPLALSIAQLALFGATNSMQFAAMNSVTLKDLSVEDAGSGNSLFSMVQML
AIGLGVTVGGGLVTLFSDRIGDAGPAYRLAFVVVGTITLLSALVFRRLDIGELGKGRRAAAARTP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=472, Percent_Identity=43.4322033898305, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1788392, Length=458, Percent_Identity=46.7248908296943, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1788710, Length=330, Percent_Identity=33.030303030303, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI87081983, Length=434, Percent_Identity=29.4930875576037, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1789042, Length=412, Percent_Identity=28.1553398058252, Blast_Score=138, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6322958, Length=343, Percent_Identity=26.2390670553936, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=154, Percent_Identity=31.8181818181818, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=150, Percent_Identity=30.6666666666667, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49123; Mature: 48992

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAFAPSLKAMLWIVAAGFFMQTLDTTIVNTALPSMAHSLGRKPLELQPVVVAYTLTMA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
MLTPASGWLADRFGTRRVYFCAILIFVLGSLFCAGAQTLPELVVARVLQGVGGSMLLPIG
HHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
RLAVLRNVSGEQYIAALAFVSVAGQVGPIFGPVLGGWLVQHVSWHWIFLINVPVGVVGLL
HHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHH
AVRRYLPAGDTAGAPAFDWVGCGLLSLCMVAFSLALDAPLQENHASWSAGLAAISVVAAM
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHH
LYIPHARRSRVPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLMQLQLGYSPFHA
HHCCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHH
GLMLLPAALAGAVSKRWIVPLVKRFGYDNFLLVNTALVGASIASFGAMSPGWPLALSIAQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LALFGATNSMQFAAMNSVTLKDLSVEDAGSGNSLFSMVQMLAIGLGVTVGGGLVTLFSDR
HHHHCCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IGDAGPAYRLAFVVVGTITLLSALVFRRLDIGELGKGRRAAAARTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQAFAPSLKAMLWIVAAGFFMQTLDTTIVNTALPSMAHSLGRKPLELQPVVVAYTLTMA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
MLTPASGWLADRFGTRRVYFCAILIFVLGSLFCAGAQTLPELVVARVLQGVGGSMLLPIG
HHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
RLAVLRNVSGEQYIAALAFVSVAGQVGPIFGPVLGGWLVQHVSWHWIFLINVPVGVVGLL
HHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHH
AVRRYLPAGDTAGAPAFDWVGCGLLSLCMVAFSLALDAPLQENHASWSAGLAAISVVAAM
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHH
LYIPHARRSRVPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLMQLQLGYSPFHA
HHCCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHH
GLMLLPAALAGAVSKRWIVPLVKRFGYDNFLLVNTALVGASIASFGAMSPGWPLALSIAQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LALFGATNSMQFAAMNSVTLKDLSVEDAGSGNSLFSMVQMLAIGLGVTVGGGLVTLFSDR
HHHHCCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IGDAGPAYRLAFVVVGTITLLSALVFRRLDIGELGKGRRAAAARTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA