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The map label for this gene is msrA1 [H]

Identifier: 73537987

GI number: 73537987

Start: 796679

End: 797185

Strand: Direct

Name: msrA1 [H]

Synonym: Reut_B4156

Alternate gene names: 73537987

Gene position: 796679-797185 (Clockwise)

Preceding gene: 73537986

Following gene: 73537989

Centisome position: 29.22

GC content: 62.13

Gene sequence:

>507_bases
ATGACGACACAAAGCGAAACGGCCATCCTGGCAGGCGGCTGCTTCTGGGGTATGCAGGACCTGCTGCGGCGGTATCCGGG
CGTATTGGCCACGCGCGTAGGCTACAGCGGCGGCGACGTGCCGAATGCCACCTACCGCAACCATGGCACCCACGCAGAAG
CGATCGAGATCGTGTTCGACCCGCAGCAGATCAGCTACCGACAGATCCTGGAGTTCTTCTTCCAGATCCACGATCCGACC
ACAAGGAACCGCCAGGGCAACGATATCGGCACAAGCTACCGCTCGGCCATCTTTTATCGCGACGATGCGCAGAAGCAAGT
GGCCGAAGACACGATCGCCGACGTCAACGCGTCCGGTCTGTGGCCCGGCAAAGTCGTGACGAAGCTTGCGCCCGCAGGCC
CGTTCTGGGAGGCCGAGCCGGAGCACCAGGACTATCTGGAACGCTATCCGAACGGCTACACATGCCACTTCATCCGGCCA
GGCTGGAAACTGCCTCAGCGCGGATGA

Upstream 100 bases:

>100_bases
TAGCCGCACGCCGCGGCGGACAATCGTGCACAATGCGCGAATGTGCCGGCGCAGCGTGTCATGCGCGTTGCGGCAGCGAT
CGAACGGAGAGGACAGAACC

Downstream 100 bases:

>100_bases
TGCGCGGATGATGCGCAAAGGGCGGTGTCGCTAGCGCGTCAGCGTCCACTTGTAGCTGAAGCGGTCACCCCGAAAATAGA
GCTCGGCGCACAACAAGGGG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1 [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MTTQSETAILAGGCFWGMQDLLRRYPGVLATRVGYSGGDVPNATYRNHGTHAEAIEIVFDPQQISYRQILEFFFQIHDPT
TRNRQGNDIGTSYRSAIFYRDDAQKQVAEDTIADVNASGLWPGKVVTKLAPAGPFWEAEPEHQDYLERYPNGYTCHFIRP
GWKLPQRG

Sequences:

>Translated_168_residues
MTTQSETAILAGGCFWGMQDLLRRYPGVLATRVGYSGGDVPNATYRNHGTHAEAIEIVFDPQQISYRQILEFFFQIHDPT
TRNRQGNDIGTSYRSAIFYRDDAQKQVAEDTIADVNASGLWPGKVVTKLAPAGPFWEAEPEHQDYLERYPNGYTCHFIRP
GWKLPQRG
>Mature_167_residues
TTQSETAILAGGCFWGMQDLLRRYPGVLATRVGYSGGDVPNATYRNHGTHAEAIEIVFDPQQISYRQILEFFFQIHDPTT
RNRQGNDIGTSYRSAIFYRDDAQKQVAEDTIADVNASGLWPGKVVTKLAPAGPFWEAEPEHQDYLERYPNGYTCHFIRPG
WKLPQRG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=36.3057324840764, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=36.3057324840764, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=38.3177570093458, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=44.7368421052632, Blast_Score=124, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=140, Percent_Identity=39.2857142857143, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=36.5853658536585, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=38.0281690140845, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.2352941176471, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=36.8055555555556, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19012; Mature: 18881

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQSETAILAGGCFWGMQDLLRRYPGVLATRVGYSGGDVPNATYRNHGTHAEAIEIVFD
CCCCCCCEEEECHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
PQQISYRQILEFFFQIHDPTTRNRQGNDIGTSYRSAIFYRDDAQKQVAEDTIADVNASGL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEECCCHHHHHHHHHHHCCCCCCC
WPGKVVTKLAPAGPFWEAEPEHQDYLERYPNGYTCHFIRPGWKLPQRG
CCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TTQSETAILAGGCFWGMQDLLRRYPGVLATRVGYSGGDVPNATYRNHGTHAEAIEIVFD
CCCCCCEEEECHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
PQQISYRQILEFFFQIHDPTTRNRQGNDIGTSYRSAIFYRDDAQKQVAEDTIADVNASGL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEECCCHHHHHHHHHHHCCCCCCC
WPGKVVTKLAPAGPFWEAEPEHQDYLERYPNGYTCHFIRPGWKLPQRG
CCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]