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The map label for this gene is Hgd [H]

Identifier: 73537961

GI number: 73537961

Start: 768624

End: 769508

Strand: Direct

Name: Hgd [H]

Synonym: Reut_B4130

Alternate gene names: 73537961

Gene position: 768624-769508 (Clockwise)

Preceding gene: 73537960

Following gene: 73537963

Centisome position: 28.19

GC content: 66.33

Gene sequence:

>885_bases
ATGAGGATCGGATTCATTGGCACCGGCAAGATGGGCCTGCCGATGGCGCGCCACATCGCCGCTGCGGGCCATGACGTCGT
CGCCTATGACATCGCGCCGGAACAGGCATCGGCGGCGCGACACGCCGGCCTGGCGGTGGCCCCGTCCCTTGCGGACGCTG
TCAGCGCAGCCGAGGTCATTTTCAGTTCGATGCCGAATGACGGCGCGTTCAGTGCGGTGGCGGGCCAGATTGCCAAAGCG
GCCCGGCCCGGCGCGCTCTATATCGACACCAGCACGGTCTCTCCCGCGGCGTCGGCGGCAGTAGCGCCGTTGCTCGCGGC
GCGTGATATCGCCTATCTGCGCGTCACGGTGTCCGGCAACAACCACATGGCCGAGGCCGCGAAGCTCACTGCATTGGTAT
CCGGACCCGCAGACGCGTACGAGCGCATCAAGCCGCTGCTGGCCGCATTGGGTCCGGCCCAGTTCTATCTGGGCGATGCC
GAACAGGCCCGGCTGATGAAGCTCGTCGTCAACCTGCTGATCGCGCTGACTGGTGGCATGCTGGCTGAGGCCCTAACGCT
GGGCAGCAAGGGCGGACTAGAGTGGCAGGCGATGTGGGATGTGATCACGGCCAGTGCGGTCGCCTCACCGATCGTCAAGG
CCAAGGCCGCACAGCTTGCCGTGCATGACTACACGCCGACCTTCACGGTCGAGCAGATGCTCAAGGACGTTGGGCTGATC
CTGGATGCCGGCGCACAGCTGCACGTGCCGATGGGGCTCACCGCCCTGCTCGGCCAGATGCTGCATGGCGCCGCTGCGCA
AGGCATGGCCGGCGATGACTACGCCGCCATCATCAAATCCGCTGAGCTGGCGGCGGGCATGCAGCCGGGTCAACGTCAAC
CATAG

Upstream 100 bases:

>100_bases
TCGAGCGCGAGCCGATCCGTGCCCTGCTCCAGGCTGCCTACGAAGGCGTGCGGCCGGACTGACGCTGCGTGGCACGCAGA
ATTTCCAGACAGGAGAAGAT

Downstream 100 bases:

>100_bases
CCTCCGGCCCGCTCGCCACGCATTTGCAGAGCGGGCGCGTCACGACGTCCACTTGCGTTCGTAGTCCATACGCTCGAAGT
GCGACACCAGTAGCTCGATA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRIGFIGTGKMGLPMARHIAAAGHDVVAYDIAPEQASAARHAGLAVAPSLADAVSAAEVIFSSMPNDGAFSAVAGQIAKA
ARPGALYIDTSTVSPAASAAVAPLLAARDIAYLRVTVSGNNHMAEAAKLTALVSGPADAYERIKPLLAALGPAQFYLGDA
EQARLMKLVVNLLIALTGGMLAEALTLGSKGGLEWQAMWDVITASAVASPIVKAKAAQLAVHDYTPTFTVEQMLKDVGLI
LDAGAQLHVPMGLTALLGQMLHGAAAQGMAGDDYAAIIKSAELAAGMQPGQRQP

Sequences:

>Translated_294_residues
MRIGFIGTGKMGLPMARHIAAAGHDVVAYDIAPEQASAARHAGLAVAPSLADAVSAAEVIFSSMPNDGAFSAVAGQIAKA
ARPGALYIDTSTVSPAASAAVAPLLAARDIAYLRVTVSGNNHMAEAAKLTALVSGPADAYERIKPLLAALGPAQFYLGDA
EQARLMKLVVNLLIALTGGMLAEALTLGSKGGLEWQAMWDVITASAVASPIVKAKAAQLAVHDYTPTFTVEQMLKDVGLI
LDAGAQLHVPMGLTALLGQMLHGAAAQGMAGDDYAAIIKSAELAAGMQPGQRQP
>Mature_294_residues
MRIGFIGTGKMGLPMARHIAAAGHDVVAYDIAPEQASAARHAGLAVAPSLADAVSAAEVIFSSMPNDGAFSAVAGQIAKA
ARPGALYIDTSTVSPAASAAVAPLLAARDIAYLRVTVSGNNHMAEAAKLTALVSGPADAYERIKPLLAALGPAQFYLGDA
EQARLMKLVVNLLIALTGGMLAEALTLGSKGGLEWQAMWDVITASAVASPIVKAKAAQLAVHDYTPTFTVEQMLKDVGLI
LDAGAQLHVPMGLTALLGQMLHGAAAQGMAGDDYAAIIKSAELAAGMQPGQRQP

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=287, Percent_Identity=27.8745644599303, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=25.6227758007117, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=28.2142857142857, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790315, Length=292, Percent_Identity=29.1095890410959, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=26.7361111111111, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=26.7605633802817, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17557316, Length=269, Percent_Identity=27.5092936802974, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=24.1992882562278, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24655230, Length=284, Percent_Identity=23.943661971831, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19922568, Length=284, Percent_Identity=23.943661971831, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 29955; Mature: 29955

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGFIGTGKMGLPMARHIAAAGHDVVAYDIAPEQASAARHAGLAVAPSLADAVSAAEVI
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCEECHHHHHHHHHHHHH
FSSMPNDGAFSAVAGQIAKAARPGALYIDTSTVSPAASAAVAPLLAARDIAYLRVTVSGN
HHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCC
NHMAEAAKLTALVSGPADAYERIKPLLAALGPAQFYLGDAEQARLMKLVVNLLIALTGGM
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHH
LAEALTLGSKGGLEWQAMWDVITASAVASPIVKAKAAQLAVHDYTPTFTVEQMLKDVGLI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHE
LDAGAQLHVPMGLTALLGQMLHGAAAQGMAGDDYAAIIKSAELAAGMQPGQRQP
EECCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRIGFIGTGKMGLPMARHIAAAGHDVVAYDIAPEQASAARHAGLAVAPSLADAVSAAEVI
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCEECHHHHHHHHHHHHH
FSSMPNDGAFSAVAGQIAKAARPGALYIDTSTVSPAASAAVAPLLAARDIAYLRVTVSGN
HHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCC
NHMAEAAKLTALVSGPADAYERIKPLLAALGPAQFYLGDAEQARLMKLVVNLLIALTGGM
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHH
LAEALTLGSKGGLEWQAMWDVITASAVASPIVKAKAAQLAVHDYTPTFTVEQMLKDVGLI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHE
LDAGAQLHVPMGLTALLGQMLHGAAAQGMAGDDYAAIIKSAELAAGMQPGQRQP
EECCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA