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The map label for this gene is dmlR [H]

Identifier: 73537947

GI number: 73537947

Start: 756400

End: 756582

Strand: Direct

Name: dmlR [H]

Synonym: Reut_B4116

Alternate gene names: 73537947

Gene position: 756400-756582 (Clockwise)

Preceding gene: 73537944

Following gene: 73537948

Centisome position: 27.75

GC content: 66.12

Gene sequence:

>183_bases
GTGAATAATCTGCCCCCACTGGAAGACCTGCGGGTGTTCTGCCTGGTCGCGCAGCGCGCCAGCTTCGTGGCTGCTGCGGA
AGAGCTGGGCAATTCGCCGGCCTATGTCAGCAAGCGCGTCAAGGCGCTGGAGCAGGCGAAGGCCCGCAACTGCTGCACCG
GAGCACGCGCCAGGTGTCGCTGA

Upstream 100 bases:

>100_bases
CGCTCGGGTCTGGTGTGTCTGGTGGTCTGGACGCGATCGAGGATGCCGGTAAACCGCGCGCGGATCATCCGCGCAAGCGT
GGATACAGGAAACACGAATC

Downstream 100 bases:

>100_bases
CCGAAAGCGGCGACCGCGTGTGCCGCTAGGCGCACGAGTTCGATTTCCGCCTGTATCAGCCCGACGGCAGCATCCGCTGG
ATCTCATCGCGCGCCACGCC

Product: hypothetical protein

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 60; Mature: 60

Protein sequence:

>60_residues
MNNLPPLEDLRVFCLVAQRASFVAAAEELGNSPAYVSKRVKALEQAKARNCCTGARARCR

Sequences:

>Translated_60_residues
MNNLPPLEDLRVFCLVAQRASFVAAAEELGNSPAYVSKRVKALEQAKARNCCTGARARCR
>Mature_60_residues
MNNLPPLEDLRVFCLVAQRASFVAAAEELGNSPAYVSKRVKALEQAKARNCCTGARARCR

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=45, Percent_Identity=73.3333333333333, Blast_Score=69, Evalue=6e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 6566; Mature: 6566

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
6.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLPPLEDLRVFCLVAQRASFVAAAEELGNSPAYVSKRVKALEQAKARNCCTGARARCR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNNLPPLEDLRVFCLVAQRASFVAAAEELGNSPAYVSKRVKALEQAKARNCCTGARARCR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]