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The map label for this gene is mscS [H]

Identifier: 73537870

GI number: 73537870

Start: 679945

End: 680772

Strand: Reverse

Name: mscS [H]

Synonym: Reut_B4037

Alternate gene names: 73537870

Gene position: 680772-679945 (Counterclockwise)

Preceding gene: 73537871

Following gene: 73537868

Centisome position: 24.97

GC content: 62.92

Gene sequence:

>828_bases
ATGGATGCGTCAACGCTGGAGAAGTTGCAGGTTGTGGTGATTGCCTACGCCACGGAGTTCGGAGTCAAGATCCTGGCCGC
CCTGGCCTTCTGGATCATCGGCCGCTGGCTGATCCATGTCGTGGTGCGGATGGTCCAGAATGCGCTGGGCCGGCAGCAGG
TGGATCCGACCCTGCTGCGCTACGTCGGCTCGATCGTGACCGTGGCGCTGAACGTTGTGCTGGTGATTGGCATCCTTGGC
TACTTCGGCATCCAGACCACCACGTTCGCGGCACTGATCGCCGCAGCGGGTGTGGCAATCGGCATGGCCTGGTCAGGGCT
GATGGCCAACTTCGCGGCCGGCGCATTCCTGGTGGTACTGCGGCCGTTCAAGGTCGGGGAATTCGTCACCATCGGCGGTA
TCACCGGCACTGTGCGCGAGATCGGGCTGTTCGCGACAACGCTCGACACCCCGGACAATGTACTGACGGTGATCGGTAAC
AACAAGATTTTCTCGGACACGATCCAGAACTTCAGCGCCAACCCGTTCCGCCGCGTCGACCTGAAGGCCCAGCTCGCCGG
AAGCACCGATGCCTCCGCCGCCGTGACGCTGCTCAAGGAGCGTATCGCGGCGATTCCCAATGTCCTGGCCGATCCGCCGG
TCGACGTCGAGATCCTGGAATTCACGCTGGTCGGGCCCGTGTTGGCCGTCCGCCCGTACTGCCACAACGACCATTACTGG
CAGGTGTATTTCGACACCAACCGCATCATCCGCGAAAGCTTTGGCCAGGCCGGCTATGCCGCGCCCATGCCCGCGCAGAT
GGTGGTGGTAAAGAACGCGGCAGCCTGA

Upstream 100 bases:

>100_bases
AAGTCTTGCGCCACTAACGCGCGCAAGATTTACCAGACAATCTTCGCAGTTCTTCGTTTTCCGGCCGGCATTTGCCGGCC
AACAAACCAGGGGAATGCCG

Downstream 100 bases:

>100_bases
GGGCTCAGGCCGCTGCACGCGCCGACGATCCGGCGCAAGCCCACGCGCGCAACGCCACCGCGCCCATGCCGCACGCGGCC
ATCACGACCGCGAGCGGCAG

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MDASTLEKLQVVVIAYATEFGVKILAALAFWIIGRWLIHVVVRMVQNALGRQQVDPTLLRYVGSIVTVALNVVLVIGILG
YFGIQTTTFAALIAAAGVAIGMAWSGLMANFAAGAFLVVLRPFKVGEFVTIGGITGTVREIGLFATTLDTPDNVLTVIGN
NKIFSDTIQNFSANPFRRVDLKAQLAGSTDASAAVTLLKERIAAIPNVLADPPVDVEILEFTLVGPVLAVRPYCHNDHYW
QVYFDTNRIIRESFGQAGYAAPMPAQMVVVKNAAA

Sequences:

>Translated_275_residues
MDASTLEKLQVVVIAYATEFGVKILAALAFWIIGRWLIHVVVRMVQNALGRQQVDPTLLRYVGSIVTVALNVVLVIGILG
YFGIQTTTFAALIAAAGVAIGMAWSGLMANFAAGAFLVVLRPFKVGEFVTIGGITGTVREIGLFATTLDTPDNVLTVIGN
NKIFSDTIQNFSANPFRRVDLKAQLAGSTDASAAVTLLKERIAAIPNVLADPPVDVEILEFTLVGPVLAVRPYCHNDHYW
QVYFDTNRIIRESFGQAGYAAPMPAQMVVVKNAAA
>Mature_275_residues
MDASTLEKLQVVVIAYATEFGVKILAALAFWIIGRWLIHVVVRMVQNALGRQQVDPTLLRYVGSIVTVALNVVLVIGILG
YFGIQTTTFAALIAAAGVAIGMAWSGLMANFAAGAFLVVLRPFKVGEFVTIGGITGTVREIGLFATTLDTPDNVLTVIGN
NKIFSDTIQNFSANPFRRVDLKAQLAGSTDASAAVTLLKERIAAIPNVLADPPVDVEILEFTLVGPVLAVRPYCHNDHYW
QVYFDTNRIIRESFGQAGYAAPMPAQMVVVKNAAA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=264, Percent_Identity=33.7121212121212, Blast_Score=141, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29551; Mature: 29551

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASTLEKLQVVVIAYATEFGVKILAALAFWIIGRWLIHVVVRMVQNALGRQQVDPTLLR
CCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YVGSIVTVALNVVLVIGILGYFGIQTTTFAALIAAAGVAIGMAWSGLMANFAAGAFLVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
RPFKVGEFVTIGGITGTVREIGLFATTLDTPDNVLTVIGNNKIFSDTIQNFSANPFRRVD
ECCCCCCEEEECCCHHHHHHHHHHEEECCCCCCEEEEEECCCCHHHHHHCCCCCCEEEEC
LKAQLAGSTDASAAVTLLKERIAAIPNVLADPPVDVEILEFTLVGPVLAVRPYCHNDHYW
EEEEECCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHHHCCCCCCCCEE
QVYFDTNRIIRESFGQAGYAAPMPAQMVVVKNAAA
EEEECCHHHHHHHCCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MDASTLEKLQVVVIAYATEFGVKILAALAFWIIGRWLIHVVVRMVQNALGRQQVDPTLLR
CCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YVGSIVTVALNVVLVIGILGYFGIQTTTFAALIAAAGVAIGMAWSGLMANFAAGAFLVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
RPFKVGEFVTIGGITGTVREIGLFATTLDTPDNVLTVIGNNKIFSDTIQNFSANPFRRVD
ECCCCCCEEEECCCHHHHHHHHHHEEECCCCCCEEEEEECCCCHHHHHHCCCCCCEEEEC
LKAQLAGSTDASAAVTLLKERIAAIPNVLADPPVDVEILEFTLVGPVLAVRPYCHNDHYW
EEEEECCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHHHCCCCCCCCEE
QVYFDTNRIIRESFGQAGYAAPMPAQMVVVKNAAA
EEEECCHHHHHHHCCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]