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The map label for this gene is yngJ [H]

Identifier: 73537705

GI number: 73537705

Start: 488542

End: 489705

Strand: Reverse

Name: yngJ [H]

Synonym: Reut_B3870

Alternate gene names: 73537705

Gene position: 489705-488542 (Counterclockwise)

Preceding gene: 73537706

Following gene: 73537704

Centisome position: 17.96

GC content: 63.57

Gene sequence:

>1164_bases
ATGGTTGATTCCAGCATTGACGTCGACGGCCTCGATGCCGACCAGCGGCTGCTGCGCGACAACATCCGCCGCTACCTGAA
GGAAACCTTCACCCCGCACATCCGCCAGGCCGAGCGCGACAAGCGCTTTCCGCACGAACTGATGACGGGCCTGATCGACT
TCGGCTACTTCGGCGGCGTCCTGCCAGAGGCCGATGGCGGCCTGGGCCTGGACTACCTGACGTGGGCCGTGATGATGGAA
GAAGCCGGTTACTGCTGGCTGTCGCTGCGCATCCTGATCAACGGCCTGAACATCGTCTCCGGCATCATCAACGCCTACGG
CACCGAAGTGCAAAAGGAACGCTTCGTACGCCCGCTGCTGCGCAACGAGCGCAAGCCATTCGTGTCGATCTCGGAACCGG
ACGTCGGCTCCAACGTGGCCGAGGTGAAGACCCGTGCCGACAAGAAGGGCGACCGCTACGTGCTCAACGGCAGCAAGCTG
TGGGTCACCAACGGCATGTTCGCCGACTTCGGCATCGTGGTCGCGCGCACCTACAGCGAGACCTGCAACGGCGAGCTGTC
GCTGTTCCTGGTCGAGCGCGATGTGACCAAATACACGGCCGAACCGGTGGACGTCATGTTCACGCGCAGCACTGGCACAG
CGGCCTTTACGTTCGAGAACGCCGAGATTCCCGCCGCCAACCTGATCGGCGTGGAAGGCCAGGGCCTGCGCCAGATCCTG
ATCGGCCTGAACTTCGGCCGCCTGAACGTGGCCATGGGTGCGGTCGGCGCGGCCCAGTGCGCGCTCGACCTGTCGGTCGA
CTACGTGCTGCAACGCAAGCAGTTTGGCCGCCAGATCGGTTCATTCCAGCTGATCCAGAAACACATTGTCGACATGACGA
TGCGCGTGCAAGCCTCGCGCTCGCTCGGCTACCGCGCCGCCCGCTCGATGCAGAACGGCACCTCGCGCACGGAATGCTCG
ATCGCCAAGCTATACGCGACGGAAGCCGCGTTCGAAGTATCGAACCTCGCGCTGCAGGTGCATGGCGGCATCGGTTATGC
CACTGAGTACCCGATCGAACGCATCTTCCGCGACACGCGCGGCGGGATGATCCCCGAGGGCACCACGGAGATCCAGACGC
TGATTATCGCGCGCGAGATTCTGGGGATCAGTGCGCTGACCTGA

Upstream 100 bases:

>100_bases
CCGGGCCAGACCAGCGATATCGCCGGCGCCGTGGCCTTCATGGCATCGGAGCATGCCCGCTATATCACCGGCACCACCCT
GTTCGTGACCGGAGGCCGCT

Downstream 100 bases:

>100_bases
GCGTCGCCAACGTCGACACCACTTGAAGAAGGCTCCTCTCTCCTGCTTGCGGGAGAGGGGAGAAACCCTGAAAAGCCACA
GAAGCACCGAACACCGAGAC

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MVDSSIDVDGLDADQRLLRDNIRRYLKETFTPHIRQAERDKRFPHELMTGLIDFGYFGGVLPEADGGLGLDYLTWAVMME
EAGYCWLSLRILINGLNIVSGIINAYGTEVQKERFVRPLLRNERKPFVSISEPDVGSNVAEVKTRADKKGDRYVLNGSKL
WVTNGMFADFGIVVARTYSETCNGELSLFLVERDVTKYTAEPVDVMFTRSTGTAAFTFENAEIPAANLIGVEGQGLRQIL
IGLNFGRLNVAMGAVGAAQCALDLSVDYVLQRKQFGRQIGSFQLIQKHIVDMTMRVQASRSLGYRAARSMQNGTSRTECS
IAKLYATEAAFEVSNLALQVHGGIGYATEYPIERIFRDTRGGMIPEGTTEIQTLIIAREILGISALT

Sequences:

>Translated_387_residues
MVDSSIDVDGLDADQRLLRDNIRRYLKETFTPHIRQAERDKRFPHELMTGLIDFGYFGGVLPEADGGLGLDYLTWAVMME
EAGYCWLSLRILINGLNIVSGIINAYGTEVQKERFVRPLLRNERKPFVSISEPDVGSNVAEVKTRADKKGDRYVLNGSKL
WVTNGMFADFGIVVARTYSETCNGELSLFLVERDVTKYTAEPVDVMFTRSTGTAAFTFENAEIPAANLIGVEGQGLRQIL
IGLNFGRLNVAMGAVGAAQCALDLSVDYVLQRKQFGRQIGSFQLIQKHIVDMTMRVQASRSLGYRAARSMQNGTSRTECS
IAKLYATEAAFEVSNLALQVHGGIGYATEYPIERIFRDTRGGMIPEGTTEIQTLIIAREILGISALT
>Mature_387_residues
MVDSSIDVDGLDADQRLLRDNIRRYLKETFTPHIRQAERDKRFPHELMTGLIDFGYFGGVLPEADGGLGLDYLTWAVMME
EAGYCWLSLRILINGLNIVSGIINAYGTEVQKERFVRPLLRNERKPFVSISEPDVGSNVAEVKTRADKKGDRYVLNGSKL
WVTNGMFADFGIVVARTYSETCNGELSLFLVERDVTKYTAEPVDVMFTRSTGTAAFTFENAEIPAANLIGVEGQGLRQIL
IGLNFGRLNVAMGAVGAAQCALDLSVDYVLQRKQFGRQIGSFQLIQKHIVDMTMRVQASRSLGYRAARSMQNGTSRTECS
IAKLYATEAAFEVSNLALQVHGGIGYATEYPIERIFRDTRGGMIPEGTTEIQTLIIAREILGISALT

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=387, Percent_Identity=34.8837209302326, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=34.4919786096257, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4501859, Length=370, Percent_Identity=31.3513513513514, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=33.420365535248, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=35.3801169590643, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI187960098, Length=370, Percent_Identity=32.1621621621622, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4557231, Length=370, Percent_Identity=32.1621621621622, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI21361497, Length=366, Percent_Identity=33.0601092896175, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=30.2872062663185, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=32.3529411764706, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI76496475, Length=398, Percent_Identity=30.6532663316583, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI4503943, Length=395, Percent_Identity=28.6075949367089, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=27.9005524861878, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI38505218, Length=324, Percent_Identity=26.8518518518519, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI48976061, Length=400, Percent_Identity=23, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI211971008, Length=400, Percent_Identity=23, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=27.6595744680851, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081958, Length=375, Percent_Identity=27.2, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87082384, Length=301, Percent_Identity=26.2458471760797, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=34.5646437994723, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=34.6456692913386, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=32.9787234042553, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17569725, Length=377, Percent_Identity=31.5649867374005, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=30.4582210242588, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=30.5039787798408, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=29.973474801061, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71985184, Length=345, Percent_Identity=31.8840579710145, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=31.2997347480106, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=27.7333333333333, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=28.4595300261097, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=30.0341296928328, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=292, Percent_Identity=29.7945205479452, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=26.2773722627737, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=30.2631578947368, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=338, Percent_Identity=24.8520710059172, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=27.8008298755187, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=310, Percent_Identity=26.7741935483871, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=306, Percent_Identity=26.797385620915, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=34.3163538873995, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=32.8042328042328, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=35.6020942408377, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=32.8, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=29.7587131367292, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI281363737, Length=384, Percent_Identity=30.7291666666667, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI19920834, Length=387, Percent_Identity=26.3565891472868, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42878; Mature: 42878

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSSIDVDGLDADQRLLRDNIRRYLKETFTPHIRQAERDKRFPHELMTGLIDFGYFGGV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
LPEADGGLGLDYLTWAVMMEEAGYCWLSLRILINGLNIVSGIINAYGTEVQKERFVRPLL
CCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RNERKPFVSISEPDVGSNVAEVKTRADKKGDRYVLNGSKLWVTNGMFADFGIVVARTYSE
HCCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCEEEEECCCHHHHHEEEEEEHHH
TCNGELSLFLVERDVTKYTAEPVDVMFTRSTGTAAFTFENAEIPAANLIGVEGQGLRQIL
CCCCCEEEEEEECCHHHHCCCCEEEEEECCCCCEEEEECCCCCCHHHEECCCCCCHHHHH
IGLNFGRLNVAMGAVGAAQCALDLSVDYVLQRKQFGRQIGSFQLIQKHIVDMTMRVQASR
HHCCCCHHHHHHHCCHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGYRAARSMQNGTSRTECSIAKLYATEAAFEVSNLALQVHGGIGYATEYPIERIFRDTR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHCHHHHHHHHHC
GGMIPEGTTEIQTLIIAREILGISALT
CCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVDSSIDVDGLDADQRLLRDNIRRYLKETFTPHIRQAERDKRFPHELMTGLIDFGYFGGV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
LPEADGGLGLDYLTWAVMMEEAGYCWLSLRILINGLNIVSGIINAYGTEVQKERFVRPLL
CCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RNERKPFVSISEPDVGSNVAEVKTRADKKGDRYVLNGSKLWVTNGMFADFGIVVARTYSE
HCCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCEEEEECCCHHHHHEEEEEEHHH
TCNGELSLFLVERDVTKYTAEPVDVMFTRSTGTAAFTFENAEIPAANLIGVEGQGLRQIL
CCCCCEEEEEEECCHHHHCCCCEEEEEECCCCCEEEEECCCCCCHHHEECCCCCCHHHHH
IGLNFGRLNVAMGAVGAAQCALDLSVDYVLQRKQFGRQIGSFQLIQKHIVDMTMRVQASR
HHCCCCHHHHHHHCCHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGYRAARSMQNGTSRTECSIAKLYATEAAFEVSNLALQVHGGIGYATEYPIERIFRDTR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHCHHHHHHHHHC
GGMIPEGTTEIQTLIIAREILGISALT
CCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]