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The map label for this gene is fadA [H]

Identifier: 73537446

GI number: 73537446

Start: 173280

End: 174458

Strand: Direct

Name: fadA [H]

Synonym: Reut_B3611

Alternate gene names: 73537446

Gene position: 173280-174458 (Clockwise)

Preceding gene: 73537445

Following gene: 73537449

Centisome position: 6.36

GC content: 66.41

Gene sequence:

>1179_bases
ATGGCAGAGGCATACATCGTTGGCGCGGTACGTACCGCAGGCGGACGCAAGGGCGGCAAGCTGGCCGGCTGGCATCCGGC
TGATCTGGCGGCGGAGGTGCTGAACGCGCTGCTCGACCGCACCGGTGCCGATCCCGCGCTCATCGAAGACGTAATCATGG
GTTGCGTGAGCCAGGTTGGCGAGCAGGCCGGCAACGTGGCCCGCAACGCCATTCTGGCGTCGCGGCTGCCCGAAAGCGTG
CCGGGCACCTCGGTCGACCGCCAGTGCGGGTCGTCGCAGCAGGCGTTGCACTTTGCCGCGCAGGCCGTGATGTCGGGCGC
GATGGACATCGTCATCGCGGCGGGCGTGGAAAGCATGACGCGCGTGCCGATGGGACTGTCGTCGCAACTGCCGGCCAAGA
ACGGCTTTGGCGTGCCGAAGAGCCCGAATGTCGAACAGCGCTACCCGGGCGTGCAGTTCAGCCAGTTCACGGGCGCCGAG
ATGATCGCGCGCAACTATGGCTTTTCGCGCGAGGATCTCGACCGCTATGCGCTGCAGAGCCACCAGCGCGCCGCCGCTGC
GACGCGTGCGGGCCGGTTCAATGCCGAGATCGTGCCGGTGGAAGTTCGTCTGGCCGACGGCACTCGCAATGGCGAGATGC
ACACGGCGGATGAAGGTATTCGTGCGGACGCCACGCTGGAATCGATCGGCAGCGTCAAGCTGATCGCAGAGGGCGGCCGT
GTGACCGCCGCTACGGCCAGCCAGATTTGCGATGGCGCGGCGGGCCTGATGGTCGTCAACGAAGCCGGCCTGAAGAAGCT
GGGCGTCAAGCCGCTGGCGCGCGTGCACCACATGACCGTGATCGGCCACGATCCGGTGATCATGCTCGAAGCGCCACTGC
CGGCCACGCAGCACGCGCTGAAGAAGGCAGGCATGAACATCAACGACATCGACCTGTTCGAAGTGAACGAGGCCTTCGCG
CCGGTGCCGCTCGCCTGGCTGAAGGCCACCGGTGCCGATCCGGAACGCCTGAACATCCACGGCGGCGCGATCGCACTGGG
CCACCCGCTGGGCGGCTCGGGCGCAAAGCTGATGACCACGCTGATCCACAGCCTGCATACGCACGGCAAGCGTTATGGCT
TGCAGACCATGTGTGAAGGCGGTGGGCTGGCCAACGTCACCATTATCGAGCGCCTGTAA

Upstream 100 bases:

>100_bases
CGTCGCTTTCGACGACGCGCGCGCCGTTCCGCCTCAGCAGAATACGTGCATCCACGCTTTATGGCTGGCCCCTTTCGCCG
GCACCGTTCAAGGAGATCAC

Downstream 100 bases:

>100_bases
GCGCTGCGCCGGGCAACCGGCATCCGCCTCAATGGTGGAGAAAAAGGGGTAAAGGGAGCAGGACCGGCGGCGCAGGCATG
TCAAAGTGCCTGCGCCAGTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAEAYIVGAVRTAGGRKGGKLAGWHPADLAAEVLNALLDRTGADPALIEDVIMGCVSQVGEQAGNVARNAILASRLPESV
PGTSVDRQCGSSQQALHFAAQAVMSGAMDIVIAAGVESMTRVPMGLSSQLPAKNGFGVPKSPNVEQRYPGVQFSQFTGAE
MIARNYGFSREDLDRYALQSHQRAAAATRAGRFNAEIVPVEVRLADGTRNGEMHTADEGIRADATLESIGSVKLIAEGGR
VTAATASQICDGAAGLMVVNEAGLKKLGVKPLARVHHMTVIGHDPVIMLEAPLPATQHALKKAGMNINDIDLFEVNEAFA
PVPLAWLKATGADPERLNIHGGAIALGHPLGGSGAKLMTTLIHSLHTHGKRYGLQTMCEGGGLANVTIIERL

Sequences:

>Translated_392_residues
MAEAYIVGAVRTAGGRKGGKLAGWHPADLAAEVLNALLDRTGADPALIEDVIMGCVSQVGEQAGNVARNAILASRLPESV
PGTSVDRQCGSSQQALHFAAQAVMSGAMDIVIAAGVESMTRVPMGLSSQLPAKNGFGVPKSPNVEQRYPGVQFSQFTGAE
MIARNYGFSREDLDRYALQSHQRAAAATRAGRFNAEIVPVEVRLADGTRNGEMHTADEGIRADATLESIGSVKLIAEGGR
VTAATASQICDGAAGLMVVNEAGLKKLGVKPLARVHHMTVIGHDPVIMLEAPLPATQHALKKAGMNINDIDLFEVNEAFA
PVPLAWLKATGADPERLNIHGGAIALGHPLGGSGAKLMTTLIHSLHTHGKRYGLQTMCEGGGLANVTIIERL
>Mature_391_residues
AEAYIVGAVRTAGGRKGGKLAGWHPADLAAEVLNALLDRTGADPALIEDVIMGCVSQVGEQAGNVARNAILASRLPESVP
GTSVDRQCGSSQQALHFAAQAVMSGAMDIVIAAGVESMTRVPMGLSSQLPAKNGFGVPKSPNVEQRYPGVQFSQFTGAEM
IARNYGFSREDLDRYALQSHQRAAAATRAGRFNAEIVPVEVRLADGTRNGEMHTADEGIRADATLESIGSVKLIAEGGRV
TAATASQICDGAAGLMVVNEAGLKKLGVKPLARVHHMTVIGHDPVIMLEAPLPATQHALKKAGMNINDIDLFEVNEAFAP
VPLAWLKATGADPERLNIHGGAIALGHPLGGSGAKLMTTLIHSLHTHGKRYGLQTMCEGGGLANVTIIERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=37.1794871794872, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI148539872, Length=396, Percent_Identity=36.3636363636364, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=36.1809045226131, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=33.6683417085427, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=30.8235294117647, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=30.7888040712468, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=41.8546365914787, Blast_Score=270, Evalue=8e-74,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=40.9429280397022, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=40.4522613065327, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=39.4014962593516, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=30.1435406698565, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=37.7215189873418, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI25147385, Length=395, Percent_Identity=33.6708860759494, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=32.1078431372549, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=30.0236406619385, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=30.2267002518892, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=34.2431761786601, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=34.0909090909091, Blast_Score=182, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24655093, Length=395, Percent_Identity=35.6962025316456, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17648125, Length=397, Percent_Identity=35.7682619647355, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=33.3333333333333, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=29.03981264637, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40973; Mature: 40842

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIVGAVRTAGGRKGGKLAGWHPADLAAEVLNALLDRTGADPALIEDVIMGCVSQVG
CCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EQAGNVARNAILASRLPESVPGTSVDRQCGSSQQALHFAAQAVMSGAMDIVIAAGVESMT
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCHHEEEECCHHHHH
RVPMGLSSQLPAKNGFGVPKSPNVEQRYPGVQFSQFTGAEMIARNYGFSREDLDRYALQS
HCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHCCCHHHHHHHCCCCHHHHHHHHHHH
HQRAAAATRAGRFNAEIVPVEVRLADGTRNGEMHTADEGIRADATLESIGSVKLIAEGGR
HHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCE
VTAATASQICDGAAGLMVVNEAGLKKLGVKPLARVHHMTVIGHDPVIMLEAPLPATQHAL
EEEHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHEEEEECCCCEEEEECCCCHHHHHH
KKAGMNINDIDLFEVNEAFAPVPLAWLKATGADPERLNIHGGAIALGHPLGGSGAKLMTT
HHCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
LIHSLHTHGKRYGLQTMCEGGGLANVTIIERL
HHHHHHHHHHHHCHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
AEAYIVGAVRTAGGRKGGKLAGWHPADLAAEVLNALLDRTGADPALIEDVIMGCVSQVG
CCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EQAGNVARNAILASRLPESVPGTSVDRQCGSSQQALHFAAQAVMSGAMDIVIAAGVESMT
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCHHEEEECCHHHHH
RVPMGLSSQLPAKNGFGVPKSPNVEQRYPGVQFSQFTGAEMIARNYGFSREDLDRYALQS
HCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHCCCHHHHHHHCCCCHHHHHHHHHHH
HQRAAAATRAGRFNAEIVPVEVRLADGTRNGEMHTADEGIRADATLESIGSVKLIAEGGR
HHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCE
VTAATASQICDGAAGLMVVNEAGLKKLGVKPLARVHHMTVIGHDPVIMLEAPLPATQHAL
EEEHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHEEEEECCCCEEEEECCCCHHHHHH
KKAGMNINDIDLFEVNEAFAPVPLAWLKATGADPERLNIHGGAIALGHPLGGSGAKLMTT
HHCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
LIHSLHTHGKRYGLQTMCEGGGLANVTIIERL
HHHHHHHHHHHHCHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA