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The map label for this gene is fabZ

Identifier: 71911300

GI number: 71911300

Start: 1443869

End: 1444291

Strand: Reverse

Name: fabZ

Synonym: M5005_Spy_1487

Alternate gene names: 71911300

Gene position: 1444291-1443869 (Counterclockwise)

Preceding gene: 71911301

Following gene: 71911299

Centisome position: 78.56

GC content: 42.79

Gene sequence:

>423_bases
ATGATGGATATTAGAGAAATTCAAGCGGCTTTGCCTCATCGCTACCCAATGTTATTGGTTGATCGTGTGTTAGAAGTGTC
AGACGACCATATCGTTGCCATTAAAAATGTGACTATTAATGAGCCTTTCTTTAACGGGCATTTTCCTCACTATCCTGTGA
TGCCAGGTGTTCTGATTATGGAAGCTTTGGCTCAAACAGCTGGTGTCTTAGAATTGTCAAAAGAAGAAAATAAAGGCAAG
TTGGTCTTTTACGCTGGAATGGATAAAGTGAAGTTCAAAAAACAAGTCGTCCCTGGTGATCAACTTGTGATGACAGCAAC
CTTTATCAAGCGTCGCGGTACCATTGCTGTCGTTGAAGCCAGGGCAGAAGTTGATGGCAAGCTAGCAGCAAGTGGAACAT
TAACCTTTGCCTGTGGGCAATGA

Upstream 100 bases:

>100_bases
TGATGAACGAAGTGCCAGCGCCATGTGATGGTGTGATTACAGAAATTTTGGTATCAAATGAAGATGTCATTGAATTTGGA
CAAGGATTGGTGCGGATCAA

Downstream 100 bases:

>100_bases
GAATGATTGTTCTGCGGAGGAAGAAACCCTTATGTTTAAAAAAATCTTAATTGCTAATCGTGGTGAAATTGCAGTGCGTA
TCATTCGTGCTGCACGAGAA

Product: (3R)-hydroxymyristoyl-ACP dehydratase

Products: 2-decenoyl-[acyl-carrier protein]; 3-decenoyl-[acyl-carrier protein]; H2O

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MMDIREIQAALPHRYPMLLVDRVLEVSDDHIVAIKNVTINEPFFNGHFPHYPVMPGVLIMEALAQTAGVLELSKEENKGK
LVFYAGMDKVKFKKQVVPGDQLVMTATFIKRRGTIAVVEARAEVDGKLAASGTLTFACGQ

Sequences:

>Translated_140_residues
MMDIREIQAALPHRYPMLLVDRVLEVSDDHIVAIKNVTINEPFFNGHFPHYPVMPGVLIMEALAQTAGVLELSKEENKGK
LVFYAGMDKVKFKKQVVPGDQLVMTATFIKRRGTIAVVEARAEVDGKLAASGTLTFACGQ
>Mature_140_residues
MMDIREIQAALPHRYPMLLVDRVLEVSDDHIVAIKNVTINEPFFNGHFPHYPVMPGVLIMEALAQTAGVLELSKEENKGK
LVFYAGMDKVKFKKQVVPGDQLVMTATFIKRRGTIAVVEARAEVDGKLAASGTLTFACGQ

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=139, Percent_Identity=46.7625899280576, Blast_Score=133, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_STRPZ (B5XHX8)

Other databases:

- EMBL:   CP000829
- RefSeq:   YP_002286335.1
- ProteinModelPortal:   B5XHX8
- SMR:   B5XHX8
- EnsemblBacteria:   EBSTRT00000050348
- GeneID:   6984745
- GenomeReviews:   CP000829_GR
- KEGG:   soz:Spy49_1362c
- GeneTree:   EBGT00050000027699
- HOGENOM:   HBG433282
- OMA:   KERRGVA
- ProtClustDB:   PRK00006
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.60

Molecular weight: Translated: 15455; Mature: 15455

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: ACT_SITE 47-47

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDIREIQAALPHRYPMLLVDRVLEVSDDHIVAIKNVTINEPFFNGHFPHYPVMPGVLIM
CCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHH
EALAQTAGVLELSKEENKGKLVFYAGMDKVKFKKQVVPGDQLVMTATFIKRRGTIAVVEA
HHHHHHCCEEEECCCCCCCCEEEEECCCCHHHHHHCCCCCCEEEEEEHHHCCCCEEEEEE
RAEVDGKLAASGTLTFACGQ
CCCCCCEEECCCEEEEEECC
>Mature Secondary Structure
MMDIREIQAALPHRYPMLLVDRVLEVSDDHIVAIKNVTINEPFFNGHFPHYPVMPGVLIM
CCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHH
EALAQTAGVLELSKEENKGKLVFYAGMDKVKFKKQVVPGDQLVMTATFIKRRGTIAVVEA
HHHHHHCCEEEECCCCCCCCEEEEECCCCHHHHHHCCCCCCEEEEEEHHHCCCCEEEEEE
RAEVDGKLAASGTLTFACGQ
CCCCCCEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxydecanoyl-[acyl-carrier protein]

Specific reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2-decenoyl-[acyl- $carrier protein] (or 3-decenoyl-[acyl-carrier protein]) + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA