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The map label for this gene is pepC [H]

Identifier: 71911169

GI number: 71911169

Start: 1324784

End: 1326121

Strand: Reverse

Name: pepC [H]

Synonym: M5005_Spy_1356

Alternate gene names: 71911169

Gene position: 1326121-1324784 (Counterclockwise)

Preceding gene: 71911170

Following gene: 71911166

Centisome position: 72.13

GC content: 39.16

Gene sequence:

>1338_bases
ATGTCAGCATTAACAGAGACATTTACAGAACAATTATTTGCTCATTACGAAGCCAATGCAAAATTTTCAGCTATTGAGAA
TGCCGTTACGCATAATGGTTTGCTAAAATCATTAGAAACCCGTCAAAGTGAAGTGGACAATGATTTTGTGTTTTCTATTG
ATTTAACTAAAGATAAGGTATCTAACCAAAAGGCTTCTGGTCGTTGCTGGATGTTTGCTGCCTTGAACACTTTCCGACAC
AAATTAATCACAGAATTTAAGTTAGAAAATTTTGAACTGTCACAAGCTCATACTTTCTTTTGGGATAAGTATGAAAAAGC
TAACTGGTTTATGGAGCAGGTCATTGCTACAGCTGACCAAGAATTAACCAGTCGTAAAGTTAAGTTTCTCTTGGATGTTC
CACAACAAGATGGTGGTCAGTGGGACATGGTGGTTTCCTTGTTTGAGAAGTATGGAGTGGTGCCAAAATCTGTTTACCCA
GAATCAATCTCATCAAGTAACAGTCGTGAATTAAACCAGTATTTGAATAAATTATTGCGCCAAGATGCTCAAATTCTTCG
TGACCTGATTGCGTCAGGTGCTAAGGCAGACCAAGTTGAGGATCGAAAAGCAGAGCTTCTTCAGGAAATTTTTAACTTCT
TGGCCATGACCCTTGGTTTACCACCTCGTCATTTTGATTTTGCCTACCGTGATAAAGATGACCACTATCATGTTGAGAAA
GGTTTGACACCGCAAGCGTTTTACGACAAATTTGTTGGCTTAAAGCTTTCTGATTATGTGTCTGTTATTAATGCGCCAAC
TGCTGATAAGCCTTATGGCAAATCATACACTGTTGAGATGCTAGGAAATGTGGTCGGTAGTCGTGAGGTTCGCTACCTCA
ACCTTGATATGAAACGTTTCAAAGAACTAGCTATCAAGCAGATGCAGGCTGGTGAGTCCGTTTGGTTTGGCTCTGATGTG
GGTCAAGTTTCAGATCGTCAAAAAGGCATTTTAGCAACTAATACTTACGATTTTGAAGCTAGTATGGATATCAATCTTAG
TCAAGATAAGGCTGGACGTTTGGATTATAGTGAAAGTTTGATGACACATGCTATGGTTTTAACAGGTGTTGACTTAGATG
AAACAGGAAAACCGTTAAAATGGAAGGTTGAAAATTCATGGGGTGAGAAGGTTGGTGACAAAGGTTACTTTGTTGCTTCA
GATGCTTGGATGGATGAATATACCTATCAAATTGTTGTCCGTAAAGAATTCTTAACAGCTGACGAGTTAGCGGCTTATGA
AAAAGAGCCACAAGTACTAGCTCCTTGGGATCCAATGGGTGCTTTAGCACAATACTAA

Upstream 100 bases:

>100_bases
TATAATAGAAGTAATCCTTTAGAATAGAATGGCTGGATAATAACCATCTTGCCAATATTATTTCAGGTGAAGCTTATCTT
AATATTTTAGGAGGACAATA

Downstream 100 bases:

>100_bases
TTCCTTTCTTTGCGACTGTATGAAATCTAAAAGCTGGACAAAACGAACAGCAAACGGATTGGACTCCGCATAAGAAAGTG
AACATGAAAAAAATTATTAT

Product: aminopeptidase C

Products: NA

Alternate protein names: Bleomycin hydrolase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSALTETFTEQLFAHYEANAKFSAIENAVTHNGLLKSLETRQSEVDNDFVFSIDLTKDKVSNQKASGRCWMFAALNTFRH
KLITEFKLENFELSQAHTFFWDKYEKANWFMEQVIATADQELTSRKVKFLLDVPQQDGGQWDMVVSLFEKYGVVPKSVYP
ESISSSNSRELNQYLNKLLRQDAQILRDLIASGAKADQVEDRKAELLQEIFNFLAMTLGLPPRHFDFAYRDKDDHYHVEK
GLTPQAFYDKFVGLKLSDYVSVINAPTADKPYGKSYTVEMLGNVVGSREVRYLNLDMKRFKELAIKQMQAGESVWFGSDV
GQVSDRQKGILATNTYDFEASMDINLSQDKAGRLDYSESLMTHAMVLTGVDLDETGKPLKWKVENSWGEKVGDKGYFVAS
DAWMDEYTYQIVVRKEFLTADELAAYEKEPQVLAPWDPMGALAQY

Sequences:

>Translated_445_residues
MSALTETFTEQLFAHYEANAKFSAIENAVTHNGLLKSLETRQSEVDNDFVFSIDLTKDKVSNQKASGRCWMFAALNTFRH
KLITEFKLENFELSQAHTFFWDKYEKANWFMEQVIATADQELTSRKVKFLLDVPQQDGGQWDMVVSLFEKYGVVPKSVYP
ESISSSNSRELNQYLNKLLRQDAQILRDLIASGAKADQVEDRKAELLQEIFNFLAMTLGLPPRHFDFAYRDKDDHYHVEK
GLTPQAFYDKFVGLKLSDYVSVINAPTADKPYGKSYTVEMLGNVVGSREVRYLNLDMKRFKELAIKQMQAGESVWFGSDV
GQVSDRQKGILATNTYDFEASMDINLSQDKAGRLDYSESLMTHAMVLTGVDLDETGKPLKWKVENSWGEKVGDKGYFVAS
DAWMDEYTYQIVVRKEFLTADELAAYEKEPQVLAPWDPMGALAQY
>Mature_444_residues
SALTETFTEQLFAHYEANAKFSAIENAVTHNGLLKSLETRQSEVDNDFVFSIDLTKDKVSNQKASGRCWMFAALNTFRHK
LITEFKLENFELSQAHTFFWDKYEKANWFMEQVIATADQELTSRKVKFLLDVPQQDGGQWDMVVSLFEKYGVVPKSVYPE
SISSSNSRELNQYLNKLLRQDAQILRDLIASGAKADQVEDRKAELLQEIFNFLAMTLGLPPRHFDFAYRDKDDHYHVEKG
LTPQAFYDKFVGLKLSDYVSVINAPTADKPYGKSYTVEMLGNVVGSREVRYLNLDMKRFKELAIKQMQAGESVWFGSDVG
QVSDRQKGILATNTYDFEASMDINLSQDKAGRLDYSESLMTHAMVLTGVDLDETGKPLKWKVENSWGEKVGDKGYFVASD
AWMDEYTYQIVVRKEFLTADELAAYEKEPQVLAPWDPMGALAQY

Specific function: Unknown

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family [H]

Homologues:

Organism=Homo sapiens, GI4557367, Length=452, Percent_Identity=38.2743362831858, Blast_Score=332, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6324090, Length=418, Percent_Identity=41.1483253588517, Blast_Score=313, Evalue=4e-86,
Organism=Drosophila melanogaster, GI161077632, Length=455, Percent_Identity=37.1428571428571, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24640588, Length=455, Percent_Identity=37.1428571428571, Blast_Score=317, Evalue=7e-87,
Organism=Drosophila melanogaster, GI161077630, Length=365, Percent_Identity=38.9041095890411, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI20130175, Length=422, Percent_Identity=27.7251184834123, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000169
- InterPro:   IPR004134 [H]

Pfam domain/function: PF03051 Peptidase_C1_2 [H]

EC number: =3.4.22.40 [H]

Molecular weight: Translated: 50865; Mature: 50734

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00139 THIOL_PROTEASE_CYS ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALTETFTEQLFAHYEANAKFSAIENAVTHNGLLKSLETRQSEVDNDFVFSIDLTKDKV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHH
SNQKASGRCWMFAALNTFRHKLITEFKLENFELSQAHTFFWDKYEKANWFMEQVIATADQ
CCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTSRKVKFLLDVPQQDGGQWDMVVSLFEKYGVVPKSVYPESISSSNSRELNQYLNKLLR
HHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHH
QDAQILRDLIASGAKADQVEDRKAELLQEIFNFLAMTLGLPPRHFDFAYRDKDDHYHVEK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCEECCC
GLTPQAFYDKFVGLKLSDYVSVINAPTADKPYGKSYTVEMLGNVVGSREVRYLNLDMKRF
CCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHH
KELAIKQMQAGESVWFGSDVGQVSDRQKGILATNTYDFEASMDINLSQDKAGRLDYSESL
HHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEECEECEEEEEECCCCCCCCCCCCHHHHH
MTHAMVLTGVDLDETGKPLKWKVENSWGEKVGDKGYFVASDAWMDEYTYQIVVRKEFLTA
HHHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCCCEEEECCCHHCCEEEEEEEEHHHCCH
DELAAYEKEPQVLAPWDPMGALAQY
HHHHHHCCCCCEECCCCCHHHHHCC
>Mature Secondary Structure 
SALTETFTEQLFAHYEANAKFSAIENAVTHNGLLKSLETRQSEVDNDFVFSIDLTKDKV
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHH
SNQKASGRCWMFAALNTFRHKLITEFKLENFELSQAHTFFWDKYEKANWFMEQVIATADQ
CCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTSRKVKFLLDVPQQDGGQWDMVVSLFEKYGVVPKSVYPESISSSNSRELNQYLNKLLR
HHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHH
QDAQILRDLIASGAKADQVEDRKAELLQEIFNFLAMTLGLPPRHFDFAYRDKDDHYHVEK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCEECCC
GLTPQAFYDKFVGLKLSDYVSVINAPTADKPYGKSYTVEMLGNVVGSREVRYLNLDMKRF
CCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHH
KELAIKQMQAGESVWFGSDVGQVSDRQKGILATNTYDFEASMDINLSQDKAGRLDYSESL
HHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEECEECEEEEEECCCCCCCCCCCCHHHHH
MTHAMVLTGVDLDETGKPLKWKVENSWGEKVGDKGYFVASDAWMDEYTYQIVVRKEFLTA
HHHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCCCEEEECCCHHCCEEEEEEEEHHHCCH
DELAAYEKEPQVLAPWDPMGALAQY
HHHHHHCCCCCEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7925365 [H]