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The map label for this gene is yesM [H]

Identifier: 71911119

GI number: 71911119

Start: 1263245

End: 1264969

Strand: Reverse

Name: yesM [H]

Synonym: M5005_Spy_1306

Alternate gene names: 71911119

Gene position: 1264969-1263245 (Counterclockwise)

Preceding gene: 71911120

Following gene: 71911118

Centisome position: 68.8

GC content: 40.52

Gene sequence:

>1725_bases
ATGAGTGTTAAAACATTGGGAAGGTATGTGACTAACCACTTTAAGCAGGGTTTTTTGATTAATCGACTGATGAAATTATA
TAGCCTGCTAATTGTAAGTTTTTTCACTTTAGCAGCTATTGGCTTGAGCAGTTATTCTATTAGTAGTACTTATAAAAGGG
TGGATGCTGAGGCGCAGATGCGATTGGAGGAGACTCTAGGTAGATTGCAGTCACAAAACGATATTACCCTACGGGTTTTA
GACCAGTTGGTTGGCCGTTCAGAAGATTACCATAATCTCTATCAATACATGACGTTAACCCCAAACCAATATTTTTCAAA
CGTTTTTGAAGACTGGGAAAAAGGAAAAGACACGGTCCTATTTTCTGAAGAGGTGAGGCGTCTTTTTGACTTGTACCCTG
ATGTGACTTCTATGACCCTACTGCTAGAGGACAGTAGTGCTTATCTGTACGCCGATAAGGTCATTAAGACGGGTCGTTTG
CTTTATAGCAAGCCTGAAAAAGTAACCGGAAATGTTTTAGTTCGCTCTATTCGAAATCCAGAATCAGGAGATGTGACAGG
TCGTCTTTACCTGACCTTTGACAAACCACCGACTTTGGTAGAGACACAGCAGGATCACTATTTAGCTACTTTTGCTTTTG
ATTACTATGGCCGCAAACTCTTCCATCAAGGAGGTCGGAGATTTCCTCATTTAGAGGCTGAGGTTAAAAAGGCTATCAAG
GCAGATCGGGCAGCTGATCTTAGTAATCTTAGCAAGGCTTATCGGATGCAGTACAATCGCTCGGGAGACCTCTTGGCTTA
TGTGGCTGTCAGAAAATCCTATTTATTAGCGGAAGCTGTCAGGACAGTTTTTGTGTATGGCCTTGTTTCTCTACTTTTAG
CTTGGCTGTTATTGCAGTTGCTCTTTAGGGTTTTCCGAAATTATATCCAGCAGGTTTCTGAAATTACGGATACTGTTGAA
ATGGTTGCAGCAGGCGATTTGTCTTTAACCATCGACAACAGCCACATGGAATTGGAACTGTATCATATCTCAGAAGCCAT
TAATCAGATGTTGGCCAGCATTAAAGCTTATATTGACGAAGTTTATGTGTTAGAGGTAGAGCAACGAGATGCCCAAATGA
GAGCTCTGCAGTCTCAAATCAACCCTCATTTTTTATACAACACGTTAGAGTATATTCGGATGTACGCCCTTAGTTGTCAA
CAAGAAGAATTAGCAGATGTCATTTATGCCTTTGCGAGTCTGCTTCGCAACAATATTAGCCAAGATAAGATGACCACCTT
AAAAGAAGAACTGGCTTTTTGTGAAAAGTACATTTACCTTTATCAAATGCGGTATCCAGATAGCTTCGCTTATCATGTAA
AAATTGATGAGAGTGTTGCTGACTTAGCCATTCCTAAATTTGTCATTCAACCTCTCGTTGAAAATTATTTTGTGCATGGG
ATTGATTATAGTCGCCATGACAATGCACTAAGCATCAAGGCTTTAGATGAGACGGATTATCTCTTGATTCAGGTGCTTGA
TAATGGACGTGGTATTAGTCAAGAGCGCTTAGCAGATATGGAAAAAAGGCTTCAAGAGCACCAAACAACAGGCAATAGCT
CTATTGGTTTGCAAAATGTTTACCTCCGTCTCTTTCATCATTTTCGAGACAGGGTTTCTTGGTCCATGGCTAAGGAGCCA
AATGGTGGCTTTATCATTCAAATTAGGATTAGAAAGGATGCTTGA

Upstream 100 bases:

>100_bases
CAATACAAAGGTCTTTATCTCTTTTTAACCTTCGGAGCTCTAGTCTTTTGCTTGGACTTTGTCACTAAGGCTAATCGTCG
ACTAGTAGATGGAGTGATTG

Downstream 100 bases:

>100_bases
TGTATAAGGTACTATTAGTTGACGATGAATACATGATTTTACAAGGGCTCACCATGATTATTGATTGGCAGGCACTTGGA
TTTGAAGTGGTTCAAACAGC

Product: two-component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISSTYKRVDAEAQMRLEETLGRLQSQNDITLRVL
DQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTVLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADKVIKTGRL
LYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLLFRVFRNYIQQVSEITDTVE
MVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQ
QEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESVADLAIPKFVIQPLVENYFVHG
IDYSRHDNALSIKALDETDYLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEP
NGGFIIQIRIRKDA

Sequences:

>Translated_574_residues
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISSTYKRVDAEAQMRLEETLGRLQSQNDITLRVL
DQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTVLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADKVIKTGRL
LYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLLFRVFRNYIQQVSEITDTVE
MVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQ
QEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESVADLAIPKFVIQPLVENYFVHG
IDYSRHDNALSIKALDETDYLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEP
NGGFIIQIRIRKDA
>Mature_573_residues
SVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISSTYKRVDAEAQMRLEETLGRLQSQNDITLRVLD
QLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTVLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADKVIKTGRLL
YSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIKA
DRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLLFRVFRNYIQQVSEITDTVEM
VAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQQ
EELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESVADLAIPKFVIQPLVENYFVHGI
DYSRHDNALSIKALDETDYLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEPN
GGFIIQIRIRKDA

Specific function: Member of the two-component regulatory system yesM/yesN. Probably activates yesN by phosphorylation [H]

COG id: COG2972

COG function: function code T; Predicted signal transduction protein with a C-terminal ATPase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=176, Percent_Identity=35.2272727272727, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788446, Length=201, Percent_Identity=24.8756218905473, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR010559
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66561; Mature: 66430

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISSTYKRVDAEAQM
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLEETLGRLQSQNDITLRVLDQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTVL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEE
FSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADKVIKTGRLLYSKPEKVTGNVLVRSIRNP
EHHHHHHHHHHCCCHHHEEEEEECCCCEEEHHHHHHHCHHHCCCCCHHHHHHHHHHCCCC
ESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
CCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQL
HHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHH
VYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQQEELADVIYAFASLLRNNIS
EEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
QDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESVADLAIPKFVIQPLVENYFVHG
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEC
IDYSRHDNALSIKALDETDYLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNV
CCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
YLRLFHHFRDRVSWSMAKEPNGGFIIQIRIRKDA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISSTYKRVDAEAQM
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLEETLGRLQSQNDITLRVLDQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTVL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEE
FSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADKVIKTGRLLYSKPEKVTGNVLVRSIRNP
EHHHHHHHHHHCCCHHHEEEEEECCCCEEEHHHHHHHCHHHCCCCCHHHHHHHHHHCCCC
ESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
CCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQL
HHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHH
VYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQQEELADVIYAFASLLRNNIS
EEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
QDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESVADLAIPKFVIQPLVENYFVHG
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEC
IDYSRHDNALSIKALDETDYLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNV
CCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
YLRLFHHFRDRVSWSMAKEPNGGFIIQIRIRKDA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]