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The map label for this gene is lon [H]

Identifier: 71893876

GI number: 71893876

Start: 677562

End: 680180

Strand: Reverse

Name: lon [H]

Synonym: MHJ_0525

Alternate gene names: 71893876

Gene position: 680180-677562 (Counterclockwise)

Preceding gene: 71893877

Following gene: 71893875

Centisome position: 75.79

GC content: 33.83

Gene sequence:

>2619_bases
TTAAATATGCCAACTAATTCCTATCGTTTTTTAGTCGCTTCTGAGGACATTTATTTTCAAAATACCCTACAGCAATCTAT
TACTTTCAGCGATCCGGAATCGATTAAAGTTCTCAAAGATTTTTATCATTCAAATTCAAGACCAACACTAACAAATAAGG
ATTTTTTAATTGTTTATCGTAAAGAGAAGGAAAAAGATACTAAAAAAAAGAATTCTAGTGTTATAAAATTTCCAAGAAAT
GATTTTAATAGTTTTGAAGATTCAAAAAATGATATTCAAAATCAGGCAAAAATTCTTAATGGAAAAGTTGGTGATTTTGA
AAATAGCCTTTTACCGCGCATTTATGACCTTGATGAGCTTTCAAAATATGCTTCTTTGGCAAGAATTCAGAGTTATCGGG
CAAAAACAAGTCCAGATAAAAGTGAATGACAAACAGTAATTTTAGATTTTATTGTAACCGAAAAAGTCCAATTAGTCGAG
CTAATCAACGATCCTCAAAATCCAAAAGTTGGCCAAATTATAATAAAACCTGTCCGCGAAACCATAAAAAGTCCCGAAAT
TCATATAAATTTGATCAATGATTTATTAGAGATGGCCCGAAAAGCAAAAAATTTTAGAATTCCAACTGAATTACTTTTAA
TTGTTGATAAATTTGGTGCTAATTCTGAATATAGTACAAACGAATATATAAAAGGTGTAACAAATACCTTATCATGCTCG
CCAAGTCTGACTTATCCCCAGAAATACCAACTTTTTTCTTATAACTCTTATCCAGCAAAAATTAAAAAATTATACGAACA
TATTCATACATTTGCTGAGCAAATTAAACTAGAAGATGAAATTAATGTTATTCTAAAAACAAATTTAGACAAACAACAAA
CTGAATTTATTCTAAAAGAGAAAATTAAAGCAATTAGAAAAAAACTCGGGGAGGATTCCCGTTATGAAGATGAGATCGAA
GAACTTCTTCATTCCGAACTAGGGAAAAAAGTCTTCCCTAAAGAGGTTGCAAAAACAATTATGCGAGAGACAAACAAACT
AAAGTCAATGATAGTAACCTCGCCCGAGTCAAATATCACCAAAAGTTATCTTGATCTTTTAGTCGCTCTCCCTTGAAAAA
AGGTAAAAAAAGATATTCTTGATATTAAAAATGTCAGAGAAAAACTTGAAGAAGCCCATTATGGACTTGATGAAATCAAG
AAGCGGATTATTGAATATCTTGCTGCCTTAATTCATAGGCGCTCGCAATCTGAAGGCAAACCCGAATTGGAAAAAGTTGG
TTCAGATTATATTGATTCAAATTTATTTTTAAGTCATAAAATCCGTAAAGTACGAAGTAATTCAATTCCAATTCTTACTT
TAGTAGGTCCACCAGGAACTGGGAAAACTTCAATTGCAATGGCGGTGGCCGAAGCAATTGGTAAAGAATTTGTCAAAATT
TCCCTTGGCGGAATTCGTGATGAAGCTGAAATCAGAGGACATCGCCGTACTTATGTAGGCGCTCTTCCGGGAAAAATTAT
TCAAGCCCTAAAAAAAGTTGGAGTTTCCAATCCCTTAATTTTACTTGATGAAATTGATAAAATGGGAGCTGATTTTAAAG
GGGATCCATCTGCGGCGATGCTTGAAGTTTTAGATCCTGAACAAAACCGTTTTTTCCAGGATCATTATCTTGAATTAGAA
TATGATCTTTCCCAAGTTTTATTTGTTGCTACTGCCAATGAAATTTATGATATTCCTGAGCCTTTACTTGATCGGGTTGA
GATTATCGAATTATCTTCATATACTTTTATTGAAAAAATCCAGATTGCAAAATCCCACTTAATTCCGGCAGTTTTAAAAG
AAAATGCTCTAGATCCAAAATATTTTCCAATCCAGGATCAAACAATTGACTTTTTGATTCGCCACTATACACGCGAAGCC
GGTGTTAGGGGTCTTAAGCGAGTAATTGATAAAATTGTAAGAAAAATTATTGTAAAATTACTTGAGAAAACATTAGATCA
AAATTTTGTAATTGATATTGAATTTGTTCGTGAACTTTTAGGCATTGAAAAATATGATCCAGATAATGTCGATTCAAGTC
CCCAAATTGGAACGGTAACTGGACTTGGATATTCACCACTTGGCGGATCAACTCTACAGATCGAGGTAAGCACGATTCCC
GGACGAGGCGATATTAAACTAACAGGTTCGCTTAAGGATGTAATGCAAGAATCAGCCCGGATTGCCCTTTCTTATGTTCA
GTCAAAGGCCAAGGATTTTGGGATTAATTTTGATTTTGAAAACACTTTAATTCATATTCATGTACCCGAAGGAGCAATTC
CAAAAGATGGGCCATCAGCAGGGATAACTTTTGCAACAGCAATAATTTCAGCCCTCTCGCAAAAGCCGGTCTCACATAAT
ATTGCAATGACAGGGGAGATAACCTTGCGCGGGAAGGTTTTAGCAATCGGCGGACTAAAAGAAAAGACGATGGGGGCCTA
TAAAAATGGGATTAAAATTATTTTTATTCCAAAGGCGAACGAGAAAAATTTAGTCGATATTCCGCAGGAGGTAAAAGACG
TAATCCAGTTTATTCCCGTTGATACTTATCAACAAATTTATGATTTTATTTTTAAATAG

Upstream 100 bases:

>100_bases
TAGCAATTAAATTTGTTGATTTTTTATGGTATAATTATCGCATTTAAGCAACTTTTGTCATCAAGTATTAAATAAAATAT
AAAACAAAAATGGAGATTTT

Downstream 100 bases:

>100_bases
GAAAACTATTAAAAAATAAAATCAGTTTAAAAACTGCGGTTTTTAAGTAAAATTTCTAAATTATTTTTTTATTAAAAAAA
TTCTTAAAATAATTTTTCAA

Product: heat shock ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 872; Mature: 872

Protein sequence:

>872_residues
MNMPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKEKEKDTKKKNSSVIKFPRN
DFNSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSKYASLARIQSYRAKTSPDKSEWQTVILDFIVTEKVQLVE
LINDPQNPKVGQIIIKPVRETIKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCS
PSLTYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIKAIRKKLGEDSRYEDEIE
ELLHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSYLDLLVALPWKKVKKDILDIKNVREKLEEAHYGLDEIK
KRIIEYLAALIHRRSQSEGKPELEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKI
SLGGIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVLDPEQNRFFQDHYLELE
YDLSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREA
GVRGLKRVIDKIVRKIIVKLLEKTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIP
GRGDIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITFATAIISALSQKPVSHN
IAMTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNLVDIPQEVKDVIQFIPVDTYQQIYDFIFK

Sequences:

>Translated_872_residues
LNMPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKEKEKDTKKKNSSVIKFPRN
DFNSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSKYASLARIQSYRAKTSPDKSE*QTVILDFIVTEKVQLVE
LINDPQNPKVGQIIIKPVRETIKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCS
PSLTYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIKAIRKKLGEDSRYEDEIE
ELLHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSYLDLLVALP*KKVKKDILDIKNVREKLEEAHYGLDEIK
KRIIEYLAALIHRRSQSEGKPELEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKI
SLGGIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVLDPEQNRFFQDHYLELE
YDLSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREA
GVRGLKRVIDKIVRKIIVKLLEKTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIP
GRGDIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITFATAIISALSQKPVSHN
IAMTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNLVDIPQEVKDVIQFIPVDTYQQIYDFIFK
>Mature_872_residues
LNMPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKEKEKDTKKKNSSVIKFPRN
DFNSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSKYASLARIQSYRAKTSPDKSE*QTVILDFIVTEKVQLVE
LINDPQNPKVGQIIIKPVRETIKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCS
PSLTYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIKAIRKKLGEDSRYEDEIE
ELLHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSYLDLLVALP*KKVKKDILDIKNVREKLEEAHYGLDEIK
KRIIEYLAALIHRRSQSEGKPELEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKI
SLGGIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVLDPEQNRFFQDHYLELE
YDLSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREA
GVRGLKRVIDKIVRKIIVKLLEKTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIP
GRGDIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITFATAIISALSQKPVSHN
IAMTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNLVDIPQEVKDVIQFIPVDTYQQIYDFIFK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=597, Percent_Identity=40.7035175879397, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI21396489, Length=623, Percent_Identity=37.8812199036918, Blast_Score=428, Evalue=1e-119,
Organism=Escherichia coli, GI1786643, Length=645, Percent_Identity=43.2558139534884, Blast_Score=522, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17505831, Length=640, Percent_Identity=36.5625, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17556486, Length=561, Percent_Identity=36.0071301247772, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319449, Length=658, Percent_Identity=36.7781155015198, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI221513036, Length=608, Percent_Identity=40.625, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24666867, Length=608, Percent_Identity=40.625, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR001984
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 98548; Mature: 98548

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
LNMPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYR
CCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEE
KEKEKDTKKKNSSVIKFPRNDFNSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDEL
CCCHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHH
SKYASLARIQSYRAKTSPDKSEQTVILDFIVTEKVQLVELINDPQNPKVGQIIIKPVRET
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCSP
HCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHEEHHCCCCCCCCCHHHHHHHHHCCCCCC
SLTYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEK
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
IKAIRKKLGEDSRYEDEIEELLHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITK
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHH
SYLDLLVALPKKVKKDILDIKNVREKLEEAHYGLDEIKKRIIEYLAALIHRRSQSEGKPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCH
LEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKISL
HHHHCCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEC
GGIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLE
CCCCCHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCCHHHHH
VLDPEQNRFFQDHYLELEYDLSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQI
HCCCCHHCCHHHHHEEEEECHHHEEEEEECHHHHCCCHHHHHHHHEEEECCHHHHHHHHH
AKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREAGVRGLKRVIDKIVRKIIVKLLE
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIPGR
HHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCC
GDIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGI
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCCCCCCH
TFATAIISALSQKPVSHNIAMTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEK
HHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCC
NLVDIPQEVKDVIQFIPVDTYQQIYDFIFK
CCCCCCHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA