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The map label for this gene is rnc [H]

Identifier: 71893762

GI number: 71893762

Start: 499414

End: 500097

Strand: Reverse

Name: rnc [H]

Synonym: MHJ_0411

Alternate gene names: 71893762

Gene position: 500097-499414 (Counterclockwise)

Preceding gene: 71893763

Following gene: 71893761

Centisome position: 55.73

GC content: 30.7

Gene sequence:

>684_bases
ATGGAAATTGAAGATAAAATTCTTGAACTTTTAAAAAAATTAAAAATAATCCCAAATTCAAAACAGATTTACATTCAAGC
GCTAACTCATAAAAGTTATAATTTTATTAATCCTGATAAACCACATTATGAAATGCTTGAGTTTCTTGGTGATTCGGTAA
TTAATTATGCGGTTTCAAAGGTGATTTATGATAATTTTTATAAAAATGAGGGAAATTCAACCCAAATTCGATCCTTACTT
ACATCAACTTCGAGTTTAGCAAATGCAACAAAAAAAGTTGGGCTAATGAATTATGTCTTGCTTGGTAGAGGTGCTAGTGA
AATTCGTGAAAACAACAAGTTAAAAGCCGATATTTTTGAATCTTTTTGTGCGGCGATTTTATTAGATCAAGGTTTTGAGA
AATTAAACGAATTCTTGTCTGAGTATTTATATAAAGATGTAAATTTTGATACTGAAAAACAGTATAAAGACCCAAAGTCA
ATTTTTCAGGAAAAAATTCAAACTTTTTCAACCTCAAACAAGATCCACTACCTACACACAAAATTAGTTGATGGAACTTT
CCGCGTTGATCTTATTTGGGAGAAAAAAAAGTACGGAATTGGATATGGCAGATCGATAAAGGAAGCAGAATTTGCCGCTG
CTACTAACGCCTTAAATATTTTTGCAGAGACTGAGGAAAAGTAA

Upstream 100 bases:

>100_bases
CAACAAAGTTTTAAAATAAATTTTCTTGCCGATTAATTTAATTTTAAAATATTATTTAGACAAAAATTTTTAAAATTTTC
TATAAAAAATAAGGAGATAA

Downstream 100 bases:

>100_bases
AATTAGTTTTTAAAAATAAATTTTAAAAATAAATTCATTAATTTTTTAGTTTTTGATTGATATTAGTAACAATAAAAATT
AAAATATTGCCTAATTTAGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MEIEDKILELLKKLKIIPNSKQIYIQALTHKSYNFINPDKPHYEMLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLL
TSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFESFCAAILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKS
IFQEKIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGRSIKEAEFAAATNALNIFAETEEK

Sequences:

>Translated_227_residues
MEIEDKILELLKKLKIIPNSKQIYIQALTHKSYNFINPDKPHYEMLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLL
TSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFESFCAAILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKS
IFQEKIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGRSIKEAEFAAATNALNIFAETEEK
>Mature_227_residues
MEIEDKILELLKKLKIIPNSKQIYIQALTHKSYNFINPDKPHYEMLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLL
TSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFESFCAAILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKS
IFQEKIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGRSIKEAEFAAATNALNIFAETEEK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=224, Percent_Identity=26.3392857142857, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI155030236, Length=224, Percent_Identity=26.3392857142857, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788920, Length=165, Percent_Identity=31.5151515151515, Blast_Score=69, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137682, Length=208, Percent_Identity=25.9615384615385, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26188; Mature: 26188

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEDKILELLKKLKIIPNSKQIYIQALTHKSYNFINPDKPHYEMLEFLGDSVINYAVSK
CCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VIYDNFYKNEGNSTQIRSLLTSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHH
SFCAAILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKSIFQEKIQTFSTSNKIHYLHT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEEEEEH
KLVDGTFRVDLIWEKKKYGIGYGRSIKEAEFAAATNALNIFAETEEK
HHCCCEEEEEEEEECHHCCCCCCCCCHHHHHHHHHHHHHEEECCCCC
>Mature Secondary Structure
MEIEDKILELLKKLKIIPNSKQIYIQALTHKSYNFINPDKPHYEMLEFLGDSVINYAVSK
CCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VIYDNFYKNEGNSTQIRSLLTSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHH
SFCAAILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKSIFQEKIQTFSTSNKIHYLHT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEEEEEH
KLVDGTFRVDLIWEKKKYGIGYGRSIKEAEFAAATNALNIFAETEEK
HHCCCEEEEEEEEECHHCCCCCCCCCHHHHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA