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The map label for this gene is lagD [H]

Identifier: 71893512

GI number: 71893512

Start: 189921

End: 191960

Strand: Reverse

Name: lagD [H]

Synonym: MHJ_0156

Alternate gene names: 71893512

Gene position: 191960-189921 (Counterclockwise)

Preceding gene: 71893519

Following gene: 71893511

Centisome position: 21.39

GC content: 24.61

Gene sequence:

>2040_bases
ATGAAATTATTTTTGCAAAAAGACTTAAGGGATTGCGGACTTGCGGTTCTCCAATCAATTTATTATCATTTTTATGATAA
AAAAATCTCAATAAATGACCTAAAAACAAAGGCATTTTATTCACATGATGGCATAAATATTGCAAATCTTGAACGTGTTG
CCAAGGATTTTGGCATTATTCTTGAATCATATGGCGGATCATTTGAAAATCTACAAGAACTAGAACTCGGAAAACCAACA
ATTATTTTAATTAAAACAGGCGATCTAAATCATTATGTTTTACTAACAAAAATTACAAAAAGGAAATTTGAAATTATCGA
CCCTTTAAAAGGAAAAATGAAAATTACTAAAACTGAAATGCAGAAAATTTTCCAAAACGTCGTGATTTTTGCCCAAAAAG
ATTTTGATTATAAAAAATCAAAAAAAAAAGATAAAAGCTGAAATAATTGGTGGTTTTTCCTTGAGGCAAAAAGTAATTGG
TATTTACTTTTTTTATTTTTTATTACTGCGGTTAGTAATTTTGTCTCCTCATTATTTATGAAAACTGTTATTGATAAAGT
TTTCCCGCAGACTGAATTTTCGCTTTTGGTCAAAGTTTGTATTTTTTTTATCTGGATTGCTTTTTGGCGGATTTTACAAG
ATATTTTTAAAAAAACTTATATTCATAAAATTGAACTTAAAATTGAAAAGGAAATTTTTGATCGATTTTTTAGCGCCTTA
AAAACAGGGGAAAATTTTCAACTTTTAAAATTAGATAATCATGATTATATTCGACGAATAAATTTAATTCCTAGTTTTGC
TAGTTTTTCTGCTAGCTTTTATTACCATATTTTTAATGAATTAATCACTTTTTTAATTTCATTTTTTATTCTTATTTGAA
TTGATGTAAAAATTTTTGGGCTAATTATTGCTATCAGTATAGTTTATCTTTTAGTTAGTATATTTGTTAGAAAAAATATC
ACAAAAAACCATCGATTTTTAATGGAAGATCAATTAAATAGTCTTACAAGCACTAATGATTTAATTTTTTCAATTGAAAA
TTTAAAGCGGGATGATGTTTATAAAAATTTAAAGCGTCAATTTGATGAAAAATACTACCGTTATAAAAATACTGAATTTA
ACATTTGAAAAAAAGAAAATTATTTGTCAAGTTTTAATAATTTTATTTTTTCAATTTCGCCAATCCTAATTGTTTTAGTG
TCTTCATTTTGAATTTTTGATAAAAAATTATCGATTGGAGAACTTTTGCTTTTTTTAAGTTTTTTTAGTTTTTTTATCAA
TCCACTCTCATCTTTTGTCGATATAGTTACAAATTTACCGATATTTTTAAGAGAATTAGAACTATTAAATTTTGTTTTAA
ATATTGACAAGGAAGCAAAAGGTAAATACCACCAAAAAATTTCTGATATTAAATTAAAAGATTTAAGCGTTAGTTACTAT
AAAAACAAGACACTTTTTTATATTGATAAAATGCGGATTAACGGGAATTTACGAATAATTGGGAAAAATGGAAGTGGGAA
ATCCACTTTTTTAAGACTTTTAAATCAAGATATTGTCTATAATGGCGAGTTTTTAATTAATAATCTTGATCTAAAGTATT
ATGACCAAAACGAACTTCGCAAAAGAATTTGTTATATAAAATCCCATAATTACTTTCCAAGTATTTCGGTTCTTTCTTTT
ATTACAAACGAAAATCCTGAAAAAATTCAGAATTTAATAAATAATTTTCAGCGTTTTGATATTCAGGAAATGCTTTATGA
ATGACAAATTTCACTTGATGCAAAATTTGTTAATAATGGCTCAAATTTTTCAAGTGGGCAAAAGCAAATAATCGCACTTT
TGCAATTATTAACACAAGATTTTGACTTAATTTTACTTGATGAGGCTTTTGAAAATATTGATGAAAAAAATTTTGAATTT
TTAAAAAAAGTTATTACAAATTATCAAAAAAATGCTTTTTTTATCGAAATTTCCCACTCAAAAAGATTTATAAACGAGGA
AGGAGAAATACTTGATATCAAAAATATATCAAAACAGTAA

Upstream 100 bases:

>100_bases
CTTTTAAATTTATAGTTTTTCATAATTTTACTTTTGTTTTTCCTATTTTTTTCACTTTTTTTTATAATTTTACTATTTTT
ATCATAATTTCCAACAGAGA

Downstream 100 bases:

>100_bases
AATTTCATTATTAATTAGTATAATTTTATTAATTTTAATGTCGATTAGTCTTTATTATTTTTTCCAAATAAAAACATATA
AAACAATTAATTTTATACTT

Product: putative ABC transporter ATP-binding and permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGIILESYGGSFENLQELELGKPT
IILIKTGDLNHYVLLTKITKRKFEIIDPLKGKMKITKTEMQKIFQNVVIFAQKDFDYKKSKKKDKSWNNWWFFLEAKSNW
YLLFLFFITAVSNFVSSLFMKTVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSAL
KTGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILIWIDVKIFGLIIAISIVYLLVSIFVRKNI
TKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFDEKYYRYKNTEFNIWKKENYLSSFNNFIFSISPILIVLV
SSFWIFDKKLSIGELLLFLSFFSFFINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYY
KNKTLFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRICYIKSHNYFPSISVLSF
ITNENPEKIQNLINNFQRFDIQEMLYEWQISLDAKFVNNGSNFSSGQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEF
LKKVITNYQKNAFFIEISHSKRFINEEGEILDIKNISKQ

Sequences:

>Translated_679_residues
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGIILESYGGSFENLQELELGKPT
IILIKTGDLNHYVLLTKITKRKFEIIDPLKGKMKITKTEMQKIFQNVVIFAQKDFDYKKSKKKDKS*NNWWFFLEAKSNW
YLLFLFFITAVSNFVSSLFMKTVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSAL
KTGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILI*IDVKIFGLIIAISIVYLLVSIFVRKNI
TKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFDEKYYRYKNTEFNI*KKENYLSSFNNFIFSISPILIVLV
SSF*IFDKKLSIGELLLFLSFFSFFINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYY
KNKTLFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRICYIKSHNYFPSISVLSF
ITNENPEKIQNLINNFQRFDIQEMLYE*QISLDAKFVNNGSNFSSGQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEF
LKKVITNYQKNAFFIEISHSKRFINEEGEILDIKNISKQ
>Mature_679_residues
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGIILESYGGSFENLQELELGKPT
IILIKTGDLNHYVLLTKITKRKFEIIDPLKGKMKITKTEMQKIFQNVVIFAQKDFDYKKSKKKDKS*NNWWFFLEAKSNW
YLLFLFFITAVSNFVSSLFMKTVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSAL
KTGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILI*IDVKIFGLIIAISIVYLLVSIFVRKNI
TKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFDEKYYRYKNTEFNI*KKENYLSSFNNFIFSISPILIVLV
SSF*IFDKKLSIGELLLFLSFFSFFINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYY
KNKTLFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRICYIKSHNYFPSISVLSF
ITNENPEKIQNLINNFQRFDIQEMLYE*QISLDAKFVNNGSNFSSGQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEF
LKKVITNYQKNAFFIEISHSKRFINEEGEILDIKNISKQ

Specific function: LagD (TC 3.A.1) is involved in processing the signal peptide and probably also in export of the bacteriocin lactococcin G [H]

COG id: COG2274

COG function: function code V; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 peptidase C39 domain [H]

Homologues:

Organism=Homo sapiens, GI157502201, Length=275, Percent_Identity=21.4545454545455, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1787143, Length=560, Percent_Identity=21.4285714285714, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR005897
- InterPro:   IPR005074 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran; PF03412 Peptidase_C39 [H]

EC number: NA

Molecular weight: Translated: 79735; Mature: 79735

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50990 PEPTIDASE_C39 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGII
CCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHEECCCCCCHHHHHHHHHHHHHH
LESYGGSFENLQELELGKPTIILIKTGDLNHYVLLTKITKRKFEIIDPLKGKMKITKTEM
HHHCCCCHHCHHHHCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCEEEEHHHH
QKIFQNVVIFAQKDFDYKKSKKKDKSNNWWFFLEAKSNWYLLFLFFITAVSNFVSSLFMK
HHHHHHHEEEEECCCCHHHHCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHH
TVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSALK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHH
TGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILIIDVKIFGLI
CCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAISIVYLLVSIFVRKNITKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHH
EKYYRYKNTEFNIKKENYLSSFNNFIFSISPILIVLVSSFIFDKKLSIGELLLFLSFFSF
HHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYYKNKT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHCCEEEECEEEEECCCE
LFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRIC
EEEEEEEEECCEEEEEECCCCCHHHHHHHHHHCCEECCEEEEEECCEEEECHHHHHHHHH
YIKSHNYFPSISVLSFITNENPEKIQNLINNFQRFDIQEMLYEQISLDAKFVNNGSNFSS
HHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEECCCCCCCC
GQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEFLKKVITNYQKNAFFIEISHSKRFIN
HHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHCC
EEGEILDIKNISKQ
CCCCEEECCCCCCC
>Mature Secondary Structure
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGII
CCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHEECCCCCCHHHHHHHHHHHHHH
LESYGGSFENLQELELGKPTIILIKTGDLNHYVLLTKITKRKFEIIDPLKGKMKITKTEM
HHHCCCCHHCHHHHCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCEEEEHHHH
QKIFQNVVIFAQKDFDYKKSKKKDKSNNWWFFLEAKSNWYLLFLFFITAVSNFVSSLFMK
HHHHHHHEEEEECCCCHHHHCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHH
TVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSALK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHH
TGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILIIDVKIFGLI
CCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAISIVYLLVSIFVRKNITKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHH
EKYYRYKNTEFNIKKENYLSSFNNFIFSISPILIVLVSSFIFDKKLSIGELLLFLSFFSF
HHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYYKNKT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHCCEEEECEEEEECCCE
LFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRIC
EEEEEEEEECCEEEEEECCCCCHHHHHHHHHHCCEECCEEEEEECCEEEECHHHHHHHHH
YIKSHNYFPSISVLSFITNENPEKIQNLINNFQRFDIQEMLYEQISLDAKFVNNGSNFSS
HHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEECCCCCCCC
GQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEFLKKVITNYQKNAFFIEISHSKRFIN
HHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHCC
EEGEILDIKNISKQ
CCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7565085 [H]