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The map label for this gene is ilvG [H]

Identifier: 71892358

GI number: 71892358

Start: 735323

End: 736963

Strand: Reverse

Name: ilvG [H]

Synonym: BPEN_614

Alternate gene names: 71892358

Gene position: 736963-735323 (Counterclockwise)

Preceding gene: 71892359

Following gene: 71892357

Centisome position: 93.09

GC content: 36.38

Gene sequence:

>1641_bases
ATGAACGGAGCTCAGTGGACCATAAAAGCGCTGAGAAAAAAAGGTGTGGAAATTATTTTTGGTTATCCGGGTGGAGCAAT
TATGCCGATATATGATGCATTGTTTGACTCTGAAGTAGAGCATTTATTATGTAGGCATGAGCAAGGTGCAATTATGTCTG
CTATAGGATACGCTCGAGCTACTGGAAAAATTGGTGTATGTTTTGCGACTTCTGGTCCGGGAGCTACTAACCTCATCACT
GGATTAGCTGATGCATTATTAGATTCCATCCCTATAGTAGCTATTACTGGACAAGTGGGATTAGAATTTATTGGTACTGA
TGCATTTCAAGAAATAGATGTATTAGGTTTATCTTTAGCTTGCACTAAACATAGCTTTTTAGTACATTCATTAAATATGC
TACCTGATATTATTGATGAAGCGTTTTTTATTGCTTCTGAAGGCAGACCAGGTCCAGTGTTAATAGATATACCAAAAGAT
ATTCAATTGTCTACTGGAAAATTAATCTCAAACTACTGTATTAATAAAAAAGATATTTGTAGTATTGAAAGTGATATAGA
ACAAGCTCGAGTGCTCATGCTGCAAGCATGTCAACCGATACTTTACGTAGGCGGAGGTGTGGGTATGGCTGGAGCAGTAA
CTTCATTACGTACATTTATTTCTAAAACCAAAATACCTACTGTAGTTACGTTAAAAGGACTAGGTGCGCCAGATTATACA
GAAGATTGTTATCTAGGAATGTTAGGCATGCATGGAAATCAAGCAGCTAATTTAGCAGTACAAAAATCTGATTTATTAAT
TGCGATAGGAGCTCGATTTGATGATAGAGTAACTGGACGATTACATACTTTTGCTCCACACGCAAAAGTAATTCATGTGG
ATATTGATCCTTCAGAATTTAGTAAATTGCGCTTAGCGAATGTTTCTTTATCTGGCAATTTAAACGATTTGTTATCTGCT
CTAACACAATCCTTATCTATTGATCCATGGAGAAAAAAAGTAAAATCTTTAAAGTTGAAGTACCGTTGGTCTTATCAATC
ATCTGATGATAAGATTTATGCTCCAACTTTATTACGAACAATCAGTGAAAATGCTCCTTACGATACTGTGGTTACTACAG
ATGTTGGGCAACATCAAATGTGGGCTGCTCAACACATGCAATTCAGTCGTCCAGAGAATTTTATTACTTCTGGAGGGCTG
GGAACCATGGGGTTTGGCACGCCCGCAGCTATTGGGGCTCAAATTGGTCGACCCAATCATATGGTGATATGTATTTCTGG
TGATGGTTCATTTATGATGAACATACAAGAACTCGCTACTATTAAACGTAAAAATTTGCCTATTAAAATTGTTTTGTTAG
ATAACCAGCGTTTAGGAATGGTGCGTCAATGGCAACAATTATTTTTCAATAAACGTTACAGTGAAACTACATTAACAGAT
AATCCCAACTTTCTTGTTTTGGCTAAAGCGTTTGATATTCATGGAATATGTATTACTTATACATCTCAAATTTTAGACGC
AATTAATATGTTATTTACGCACACAGGACCTTTTTTATTACATGCGCTGATTAATGAACATGAAAACGTTTGGCCATTAG
TTCCACCTGGTTCTTCAAATGATGCTATGTTGGAGCAGTAA

Upstream 100 bases:

>100_bases
AATGTCCATACACTTTGCAATTGATTCAAAATCGGTTGATTTACATTAGTAGCCTGATTAGATTATTATTTCATTTATAA
AATCATACGAGGAAAAAAAC

Downstream 100 bases:

>100_bases
TATGACATATTATTCGCTGTTTATAAAAGCCAGGTTTTGCCCAGAGGTGCTTGAACGTATTCTCCGGGTTATTCGTCATC
GTGGATTTGAGTTACATACA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MNGAQWTIKALRKKGVEIIFGYPGGAIMPIYDALFDSEVEHLLCRHEQGAIMSAIGYARATGKIGVCFATSGPGATNLIT
GLADALLDSIPIVAITGQVGLEFIGTDAFQEIDVLGLSLACTKHSFLVHSLNMLPDIIDEAFFIASEGRPGPVLIDIPKD
IQLSTGKLISNYCINKKDICSIESDIEQARVLMLQACQPILYVGGGVGMAGAVTSLRTFISKTKIPTVVTLKGLGAPDYT
EDCYLGMLGMHGNQAANLAVQKSDLLIAIGARFDDRVTGRLHTFAPHAKVIHVDIDPSEFSKLRLANVSLSGNLNDLLSA
LTQSLSIDPWRKKVKSLKLKYRWSYQSSDDKIYAPTLLRTISENAPYDTVVTTDVGQHQMWAAQHMQFSRPENFITSGGL
GTMGFGTPAAIGAQIGRPNHMVICISGDGSFMMNIQELATIKRKNLPIKIVLLDNQRLGMVRQWQQLFFNKRYSETTLTD
NPNFLVLAKAFDIHGICITYTSQILDAINMLFTHTGPFLLHALINEHENVWPLVPPGSSNDAMLEQ

Sequences:

>Translated_546_residues
MNGAQWTIKALRKKGVEIIFGYPGGAIMPIYDALFDSEVEHLLCRHEQGAIMSAIGYARATGKIGVCFATSGPGATNLIT
GLADALLDSIPIVAITGQVGLEFIGTDAFQEIDVLGLSLACTKHSFLVHSLNMLPDIIDEAFFIASEGRPGPVLIDIPKD
IQLSTGKLISNYCINKKDICSIESDIEQARVLMLQACQPILYVGGGVGMAGAVTSLRTFISKTKIPTVVTLKGLGAPDYT
EDCYLGMLGMHGNQAANLAVQKSDLLIAIGARFDDRVTGRLHTFAPHAKVIHVDIDPSEFSKLRLANVSLSGNLNDLLSA
LTQSLSIDPWRKKVKSLKLKYRWSYQSSDDKIYAPTLLRTISENAPYDTVVTTDVGQHQMWAAQHMQFSRPENFITSGGL
GTMGFGTPAAIGAQIGRPNHMVICISGDGSFMMNIQELATIKRKNLPIKIVLLDNQRLGMVRQWQQLFFNKRYSETTLTD
NPNFLVLAKAFDIHGICITYTSQILDAINMLFTHTGPFLLHALINEHENVWPLVPPGSSNDAMLEQ
>Mature_546_residues
MNGAQWTIKALRKKGVEIIFGYPGGAIMPIYDALFDSEVEHLLCRHEQGAIMSAIGYARATGKIGVCFATSGPGATNLIT
GLADALLDSIPIVAITGQVGLEFIGTDAFQEIDVLGLSLACTKHSFLVHSLNMLPDIIDEAFFIASEGRPGPVLIDIPKD
IQLSTGKLISNYCINKKDICSIESDIEQARVLMLQACQPILYVGGGVGMAGAVTSLRTFISKTKIPTVVTLKGLGAPDYT
EDCYLGMLGMHGNQAANLAVQKSDLLIAIGARFDDRVTGRLHTFAPHAKVIHVDIDPSEFSKLRLANVSLSGNLNDLLSA
LTQSLSIDPWRKKVKSLKLKYRWSYQSSDDKIYAPTLLRTISENAPYDTVVTTDVGQHQMWAAQHMQFSRPENFITSGGL
GTMGFGTPAAIGAQIGRPNHMVICISGDGSFMMNIQELATIKRKNLPIKIVLLDNQRLGMVRQWQQLFFNKRYSETTLTD
NPNFLVLAKAFDIHGICITYTSQILDAINMLFTHTGPFLLHALINEHENVWPLVPPGSSNDAMLEQ

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=477, Percent_Identity=27.6729559748428, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI21361361, Length=496, Percent_Identity=26.008064516129, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1790104, Length=549, Percent_Identity=42.4408014571949, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI87081685, Length=565, Percent_Identity=39.646017699115, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1786717, Length=491, Percent_Identity=32.3828920570265, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1787096, Length=541, Percent_Identity=27.5415896487985, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1788716, Length=556, Percent_Identity=24.6402877697842, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17531301, Length=552, Percent_Identity=28.0797101449275, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17531299, Length=552, Percent_Identity=28.0797101449275, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17542570, Length=507, Percent_Identity=24.8520710059172, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=579, Percent_Identity=41.4507772020725, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320816, Length=474, Percent_Identity=22.7848101265823, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922626, Length=541, Percent_Identity=25.6931608133087, Blast_Score=165, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59606; Mature: 59606

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAQWTIKALRKKGVEIIFGYPGGAIMPIYDALFDSEVEHLLCRHEQGAIMSAIGYARA
CCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TGKIGVCFATSGPGATNLITGLADALLDSIPIVAITGQVGLEFIGTDAFQEIDVLGLSLA
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHEEEEE
CTKHSFLVHSLNMLPDIIDEAFFIASEGRPGPVLIDIPKDIQLSTGKLISNYCINKKDIC
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCEECCCHHHHHHCCCCCHHH
SIESDIEQARVLMLQACQPILYVGGGVGMAGAVTSLRTFISKTKIPTVVTLKGLGAPDYT
CHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
EDCYLGMLGMHGNQAANLAVQKSDLLIAIGARFDDRVTGRLHTFAPHAKVIHVDIDPSEF
CCHHEEEEECCCCCCCEEEEEECCEEEEECCCCCCCCCCEEEEECCCCEEEEEECCHHHH
SKLRLANVSLSGNLNDLLSALTQSLSIDPWRKKVKSLKLKYRWSYQSSDDKIYAPTLLRT
CEEEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHEEEEEEECCCCCCCCEEHHHHHHH
ISENAPYDTVVTTDVGQHQMWAAQHMQFSRPENFITSGGLGTMGFGTPAAIGAQIGRPNH
HHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHCCCCCE
MVICISGDGSFMMNIQELATIKRKNLPIKIVLLDNQRLGMVRQWQQLFFNKRYSETTLTD
EEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEECC
NPNFLVLAKAFDIHGICITYTSQILDAINMLFTHTGPFLLHALINEHENVWPLVPPGSSN
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCCCC
DAMLEQ
CCCCCC
>Mature Secondary Structure
MNGAQWTIKALRKKGVEIIFGYPGGAIMPIYDALFDSEVEHLLCRHEQGAIMSAIGYARA
CCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TGKIGVCFATSGPGATNLITGLADALLDSIPIVAITGQVGLEFIGTDAFQEIDVLGLSLA
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHEEEEE
CTKHSFLVHSLNMLPDIIDEAFFIASEGRPGPVLIDIPKDIQLSTGKLISNYCINKKDIC
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCEECCCHHHHHHCCCCCHHH
SIESDIEQARVLMLQACQPILYVGGGVGMAGAVTSLRTFISKTKIPTVVTLKGLGAPDYT
CHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
EDCYLGMLGMHGNQAANLAVQKSDLLIAIGARFDDRVTGRLHTFAPHAKVIHVDIDPSEF
CCHHEEEEECCCCCCCEEEEEECCEEEEECCCCCCCCCCEEEEECCCCEEEEEECCHHHH
SKLRLANVSLSGNLNDLLSALTQSLSIDPWRKKVKSLKLKYRWSYQSSDDKIYAPTLLRT
CEEEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHEEEEEEECCCCCCCCEEHHHHHHH
ISENAPYDTVVTTDVGQHQMWAAQHMQFSRPENFITSGGLGTMGFGTPAAIGAQIGRPNH
HHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHCCCCCE
MVICISGDGSFMMNIQELATIKRKNLPIKIVLLDNQRLGMVRQWQQLFFNKRYSETTLTD
EEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEECC
NPNFLVLAKAFDIHGICITYTSQILDAINMLFTHTGPFLLHALINEHENVWPLVPPGSSN
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCCCC
DAMLEQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]