Click here to switch to the map view.

The map label for this gene is gnd [H]

Identifier: 71892243

GI number: 71892243

Start: 577078

End: 578487

Strand: Reverse

Name: gnd [H]

Synonym: BPEN_485

Alternate gene names: 71892243

Gene position: 578487-577078 (Counterclockwise)

Preceding gene: 71892245

Following gene: 71892234

Centisome position: 73.07

GC content: 32.27

Gene sequence:

>1410_bases
ATGTTCAAACAAAAAAAGATTGGTATTATCGGTATGGGTGTTATGGGTCGAAATTTAGCATTAAACATTGAAAGTAAAGG
TTATTGTGTTACGATTTATAATCGTTCTAAGGATAAAACCGATGCAGTTGTTACTAATAATCCAAAAAAAAATATCATCC
CATGTTATTCAATAGAGGAGTTCGCGCTATCTTTAAATAAACCTCGTTTTATATTTTTAATGATTACATCAGGAACGCAT
ATCGATAATGTTATAAAAATATTGTCCCCTTATATGAATCCGGGAGATATTTTAATTGACGGAGGTAATTCATTTTATAA
AGATACTATGCGTCGTAATCTTGAGTTATCAAAAAAAGGGATAAATTTTATTGGAACTGGTATTTCTGGGGGAGAAGAAG
GGGCTTTAAAAGGGCCATCGATTATGCCTGGAGGGAACATAGATGCATATAAAATGGTTGAGTCGGTTTTTAAGAAAATT
GCTGCTCGTGTTAATGATGAAACTTGTGTTGCATATATAGGACCAAATGGATCTGGTCATTATGTGAAGATGATACATAA
CGGCATAGAGTACGGAGATATGCAAATAATTGCTGAAATATATTTTTTTATAAAAAATATATTTCATTTAACTCATGAAG
CATTAGGAGAAATTTTTGATAAATGGAATCAAGGCGAATTAAATAGTTATCTTATCGAAATAACAAGTCGCATCTTCGTT
AGAAAAGATGCCAAGCATGGTTACATTCTTGATTCTATATTAGATGTGGCTAGAAATAAGGGTACTGGGGCATGGGCTAG
TCAAGATGCAATTGATTTAGGCATACCATTAAGTATGATTACTGAATCAGTGTTTGCTCGTTATATGTCTGTACTTAAAC
AACAACGTCTTAAAGCATCAAAAATATTGTTAGGACCTAATAGAGAAAATTGTTTTGAAAGCAAATGTTTATACGTAGAA
AAGGCGCGAAAAGCGTTATATCTCAGCAAGATTATTTTATATGCACAAGGTTTTTATCAATTGAAAATTGCGTCCGATAA
GTATCATTGGGATTTGAATTACAAACAAATTGCTCAGATTTTTCGTGCGGGATGTATAATTAGATCAAAATTTTTACAAA
AAATTATTGATATTTATTCTCAAACTCCAGATATTACTAATTTGTTATTGTCTCCGTATTGTGTCAATATCGCGAATGAT
TACCAACAAATGTTGAGAGAGGTGGTAGTGTGCGGCATTAAATACGGTATTCCCATGCCTACATTATCTGCTGCTATATC
TTACTATGATAGTTATCGCAGTAATGTGTTACCTGCAAATCTTATTCAAGCTCAAAGAGATTGTTTCGGAGCACATACTT
ATACGTGTTTTGATAAAAAAGGTACGTTTCACACTGATTGGTTAAAATAA

Upstream 100 bases:

>100_bases
ATTTATGTATAATATGTTCATATTATGAACTAGATACAAATTAGTCATTATTTAACTATTATTAAAATATATAACATACT
TATACCCCAGAGGAGCAGAT

Downstream 100 bases:

>100_bases
ATATAAGGTGGTGAATATTATTTCAATAATAATTGAATAATTTAAGTAATAACCAATATCCCATGATATGTGGGATATTG
GAGATATCGCAATTTATTAG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MFKQKKIGIIGMGVMGRNLALNIESKGYCVTIYNRSKDKTDAVVTNNPKKNIIPCYSIEEFALSLNKPRFIFLMITSGTH
IDNVIKILSPYMNPGDILIDGGNSFYKDTMRRNLELSKKGINFIGTGISGGEEGALKGPSIMPGGNIDAYKMVESVFKKI
AARVNDETCVAYIGPNGSGHYVKMIHNGIEYGDMQIIAEIYFFIKNIFHLTHEALGEIFDKWNQGELNSYLIEITSRIFV
RKDAKHGYILDSILDVARNKGTGAWASQDAIDLGIPLSMITESVFARYMSVLKQQRLKASKILLGPNRENCFESKCLYVE
KARKALYLSKIILYAQGFYQLKIASDKYHWDLNYKQIAQIFRAGCIIRSKFLQKIIDIYSQTPDITNLLLSPYCVNIAND
YQQMLREVVVCGIKYGIPMPTLSAAISYYDSYRSNVLPANLIQAQRDCFGAHTYTCFDKKGTFHTDWLK

Sequences:

>Translated_469_residues
MFKQKKIGIIGMGVMGRNLALNIESKGYCVTIYNRSKDKTDAVVTNNPKKNIIPCYSIEEFALSLNKPRFIFLMITSGTH
IDNVIKILSPYMNPGDILIDGGNSFYKDTMRRNLELSKKGINFIGTGISGGEEGALKGPSIMPGGNIDAYKMVESVFKKI
AARVNDETCVAYIGPNGSGHYVKMIHNGIEYGDMQIIAEIYFFIKNIFHLTHEALGEIFDKWNQGELNSYLIEITSRIFV
RKDAKHGYILDSILDVARNKGTGAWASQDAIDLGIPLSMITESVFARYMSVLKQQRLKASKILLGPNRENCFESKCLYVE
KARKALYLSKIILYAQGFYQLKIASDKYHWDLNYKQIAQIFRAGCIIRSKFLQKIIDIYSQTPDITNLLLSPYCVNIAND
YQQMLREVVVCGIKYGIPMPTLSAAISYYDSYRSNVLPANLIQAQRDCFGAHTYTCFDKKGTFHTDWLK
>Mature_469_residues
MFKQKKIGIIGMGVMGRNLALNIESKGYCVTIYNRSKDKTDAVVTNNPKKNIIPCYSIEEFALSLNKPRFIFLMITSGTH
IDNVIKILSPYMNPGDILIDGGNSFYKDTMRRNLELSKKGINFIGTGISGGEEGALKGPSIMPGGNIDAYKMVESVFKKI
AARVNDETCVAYIGPNGSGHYVKMIHNGIEYGDMQIIAEIYFFIKNIFHLTHEALGEIFDKWNQGELNSYLIEITSRIFV
RKDAKHGYILDSILDVARNKGTGAWASQDAIDLGIPLSMITESVFARYMSVLKQQRLKASKILLGPNRENCFESKCLYVE
KARKALYLSKIILYAQGFYQLKIASDKYHWDLNYKQIAQIFRAGCIIRSKFLQKIIDIYSQTPDITNLLLSPYCVNIAND
YQQMLREVVVCGIKYGIPMPTLSAAISYYDSYRSNVLPANLIQAQRDCFGAHTYTCFDKKGTFHTDWLK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=467, Percent_Identity=46.2526766595289, Blast_Score=422, Evalue=1e-118,
Organism=Escherichia coli, GI1788341, Length=466, Percent_Identity=61.1587982832618, Blast_Score=618, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17542558, Length=468, Percent_Identity=45.5128205128205, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321695, Length=460, Percent_Identity=46.7391304347826, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321977, Length=449, Percent_Identity=46.1024498886414, Blast_Score=408, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24639279, Length=469, Percent_Identity=44.7761194029851, Blast_Score=411, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52984; Mature: 52984

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKQKKIGIIGMGVMGRNLALNIESKGYCVTIYNRSKDKTDAVVTNNPKKNIIPCYSIEE
CCCCCCCCEEEECCCCCCEEEEECCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCHHH
FALSLNKPRFIFLMITSGTHIDNVIKILSPYMNPGDILIDGGNSFYKDTMRRNLELSKKG
HHHHCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCHHHCCC
INFIGTGISGGEEGALKGPSIMPGGNIDAYKMVESVFKKIAARVNDETCVAYIGPNGSGH
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
YVKMIHNGIEYGDMQIIAEIYFFIKNIFHLTHEALGEIFDKWNQGELNSYLIEITSRIFV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHE
RKDAKHGYILDSILDVARNKGTGAWASQDAIDLGIPLSMITESVFARYMSVLKQQRLKAS
EECCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
KILLGPNRENCFESKCLYVEKARKALYLSKIILYAQGFYQLKIASDKYHWDLNYKQIAQI
HEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEECCCHHHHHHH
FRAGCIIRSKFLQKIIDIYSQTPDITNLLLSPYCVNIANDYQQMLREVVVCGIKYGIPMP
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
TLSAAISYYDSYRSNVLPANLIQAQRDCFGAHTYTCFDKKGTFHTDWLK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MFKQKKIGIIGMGVMGRNLALNIESKGYCVTIYNRSKDKTDAVVTNNPKKNIIPCYSIEE
CCCCCCCCEEEECCCCCCEEEEECCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCHHH
FALSLNKPRFIFLMITSGTHIDNVIKILSPYMNPGDILIDGGNSFYKDTMRRNLELSKKG
HHHHCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCHHHCCC
INFIGTGISGGEEGALKGPSIMPGGNIDAYKMVESVFKKIAARVNDETCVAYIGPNGSGH
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
YVKMIHNGIEYGDMQIIAEIYFFIKNIFHLTHEALGEIFDKWNQGELNSYLIEITSRIFV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHE
RKDAKHGYILDSILDVARNKGTGAWASQDAIDLGIPLSMITESVFARYMSVLKQQRLKAS
EECCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
KILLGPNRENCFESKCLYVEKARKALYLSKIILYAQGFYQLKIASDKYHWDLNYKQIAQI
HEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEECCCHHHHHHH
FRAGCIIRSKFLQKIIDIYSQTPDITNLLLSPYCVNIANDYQQMLREVVVCGIKYGIPMP
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
TLSAAISYYDSYRSNVLPANLIQAQRDCFGAHTYTCFDKKGTFHTDWLK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]