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The map label for this gene is sppA [H]

Identifier: 71892212

GI number: 71892212

Start: 534585

End: 536462

Strand: Direct

Name: sppA [H]

Synonym: BPEN_450

Alternate gene names: 71892212

Gene position: 534585-536462 (Clockwise)

Preceding gene: 71892211

Following gene: 71892213

Centisome position: 67.53

GC content: 29.82

Gene sequence:

>1878_bases
ATGTTTTTAATGATAAAGTCGTTCATCCAGAATATATGGAAGATCATTTATAAAATACTTAGATATAGCATACGTACACT
GCATCTTATACGAACAGTAATAATAAATATATTTTTCATCATTTTCATTGTAATTAGTGTGGGAGTATATTTAAATTTAC
GTGATTCTTCTGCCTCGTTATCAAAGTGCTCTGCATTAATTCTAGATCTTTCTGGCATTATTGTAGATAAACCAGTGACA
TACAGTAAATTTCAAAAATTCAGTCAACATTTATTAAATACAAATAAACCAAATGCTAAAGAAAACTCACTATTTGATAT
TATTAATATATTACGTCAAGCCAAAAATGATCCACATATAACTGGATTGATATTATCATTAAAAAACTTTTGTGGAAGCA
ATCAAACATCATTAGAATATATTGGTAAAGCATTACGTGAATTCAAAGAATCTGGTAAACCAATTTATGCTATTTCTGAT
TATTACAATCAATCACAGTATTTGCTCGCTAGTTATGCCAATAAAATCTATCTCACACCACATGGATTTGTAGATTTACG
AGGAATTTCTACCAGCAAATTATATTATAAATCTCTATTAAATAATTTAAAAATTAATACTCATATTTTTAGAGTAGGTA
GATATAAATCTGCTGTTGAACCATTTATTCAAGATCAAATGTCTGATCATGTGCGACATGAAGAAACAAAATTGGTAAAT
CGTTTATGGGATCAATATTTACAAATAATATCTATTAATCGTAACACAACAACACGATCAATTTTTCCGGGAATCAACAA
TATATTAAATGAATTGCATCGAATGCAAGGCGATACTGCAGCTTATGCGCTGAAAAATAAATGGATCGATGAAATCGCAT
CCCATTTTGTTATAGAAAATACGATGAAAGAAATATTTGGATCTAATAAACAAGGCACTTCGTTTAATGCAATTAGCATG
TATGATTATAATCTTATAGCTCCTGCAAAAAAAGATAACCAAATAGCAATAATATGTATTAATGGCCCTATCGTGGATGG
ACCTGATATACCAGGTTCAATTGGTGGTGATACTATAGCGCATAAAATCCGCAGCGCTCGATTTGATCCTAAAATAAAAG
CAATAGTACTTCGTGTCAATAGTCCCGGTGGAAGCGTAAATGCTTCTGAATTAATTAGATTAGAATTAATAGCTGTCAGA
GATTCTGGTAAACCAGTAGTGGTTTCTATGGGTGGCATAGCAGCATCTGGCGGATATTGGATATCAACGCCAGCCAATGT
TATTATTGCAAGTAACAGTACTATTACGGGTTCTATCGGTATATTTGGTATTATTAATACATTTGAAAAATCTCTTGACA
CCATCGGTATTCATAGTGACGGAGTAAATACATCCCCTATATCAAATATTTCAATAACTACCCCGTTACCTACTGAATAT
ATAAATATGATGCAACTTTATGTAAATACCAGCTATCATTATTTTATTAACACTGTGGCTGAATCTCGCTGTAAAACTAC
AGAAGATATCCATAAAATTGCTCAAGGCCATGTATGGCTTGGCTATGATGCAATAAAAAATGGATTAATTGACAATATAG
GAGATTTAGATGACGCAATAAATAAAGCTATTGAACTAGCTCACTTAAAAGAATATCAACTGAATTGGTACGAAAATAAA
ATAAATTGGATAGATGTTTTAATACAACAAGCTAATAAAGTTATTCATACTATAATTATAAATTTATTAAATCATTACGT
TTCATTAATTAATTTTGATAACAATATAAAAATAAATAACTCTAATATCCTCCAATTTTCGTGGAATGATCCAAAAAATT
GCTATGCTCTTGATTTAAATTATTCAGAACAATTATAA

Upstream 100 bases:

>100_bases
AATCATAAAAATTTCATAATTTTCATTTAATTTATACGTATTTTGTGATACCTAATTTGATTTAAATGTGAAAATATAAA
GTTAATGTGGATATTGTATA

Downstream 100 bases:

>100_bases
GATATAATAAAAATTTTATTTACATACTTATAGCATTGAAAAATGATGATTTAATCACAAAACATCACATTAATAAATTC
ATTTAATTTAAGTACCTATA

Product: protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MFLMIKSFIQNIWKIIYKILRYSIRTLHLIRTVIINIFFIIFIVISVGVYLNLRDSSASLSKCSALILDLSGIIVDKPVT
YSKFQKFSQHLLNTNKPNAKENSLFDIINILRQAKNDPHITGLILSLKNFCGSNQTSLEYIGKALREFKESGKPIYAISD
YYNQSQYLLASYANKIYLTPHGFVDLRGISTSKLYYKSLLNNLKINTHIFRVGRYKSAVEPFIQDQMSDHVRHEETKLVN
RLWDQYLQIISINRNTTTRSIFPGINNILNELHRMQGDTAAYALKNKWIDEIASHFVIENTMKEIFGSNKQGTSFNAISM
YDYNLIAPAKKDNQIAIICINGPIVDGPDIPGSIGGDTIAHKIRSARFDPKIKAIVLRVNSPGGSVNASELIRLELIAVR
DSGKPVVVSMGGIAASGGYWISTPANVIIASNSTITGSIGIFGIINTFEKSLDTIGIHSDGVNTSPISNISITTPLPTEY
INMMQLYVNTSYHYFINTVAESRCKTTEDIHKIAQGHVWLGYDAIKNGLIDNIGDLDDAINKAIELAHLKEYQLNWYENK
INWIDVLIQQANKVIHTIIINLLNHYVSLINFDNNIKINNSNILQFSWNDPKNCYALDLNYSEQL

Sequences:

>Translated_625_residues
MFLMIKSFIQNIWKIIYKILRYSIRTLHLIRTVIINIFFIIFIVISVGVYLNLRDSSASLSKCSALILDLSGIIVDKPVT
YSKFQKFSQHLLNTNKPNAKENSLFDIINILRQAKNDPHITGLILSLKNFCGSNQTSLEYIGKALREFKESGKPIYAISD
YYNQSQYLLASYANKIYLTPHGFVDLRGISTSKLYYKSLLNNLKINTHIFRVGRYKSAVEPFIQDQMSDHVRHEETKLVN
RLWDQYLQIISINRNTTTRSIFPGINNILNELHRMQGDTAAYALKNKWIDEIASHFVIENTMKEIFGSNKQGTSFNAISM
YDYNLIAPAKKDNQIAIICINGPIVDGPDIPGSIGGDTIAHKIRSARFDPKIKAIVLRVNSPGGSVNASELIRLELIAVR
DSGKPVVVSMGGIAASGGYWISTPANVIIASNSTITGSIGIFGIINTFEKSLDTIGIHSDGVNTSPISNISITTPLPTEY
INMMQLYVNTSYHYFINTVAESRCKTTEDIHKIAQGHVWLGYDAIKNGLIDNIGDLDDAINKAIELAHLKEYQLNWYENK
INWIDVLIQQANKVIHTIIINLLNHYVSLINFDNNIKINNSNILQFSWNDPKNCYALDLNYSEQL
>Mature_625_residues
MFLMIKSFIQNIWKIIYKILRYSIRTLHLIRTVIINIFFIIFIVISVGVYLNLRDSSASLSKCSALILDLSGIIVDKPVT
YSKFQKFSQHLLNTNKPNAKENSLFDIINILRQAKNDPHITGLILSLKNFCGSNQTSLEYIGKALREFKESGKPIYAISD
YYNQSQYLLASYANKIYLTPHGFVDLRGISTSKLYYKSLLNNLKINTHIFRVGRYKSAVEPFIQDQMSDHVRHEETKLVN
RLWDQYLQIISINRNTTTRSIFPGINNILNELHRMQGDTAAYALKNKWIDEIASHFVIENTMKEIFGSNKQGTSFNAISM
YDYNLIAPAKKDNQIAIICINGPIVDGPDIPGSIGGDTIAHKIRSARFDPKIKAIVLRVNSPGGSVNASELIRLELIAVR
DSGKPVVVSMGGIAASGGYWISTPANVIIASNSTITGSIGIFGIINTFEKSLDTIGIHSDGVNTSPISNISITTPLPTEY
INMMQLYVNTSYHYFINTVAESRCKTTEDIHKIAQGHVWLGYDAIKNGLIDNIGDLDDAINKAIELAHLKEYQLNWYENK
INWIDVLIQQANKVIHTIIINLLNHYVSLINFDNNIKINNSNILQFSWNDPKNCYALDLNYSEQL

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=615, Percent_Identity=48.9430894308943, Blast_Score=626, Evalue=1e-180,
Organism=Escherichia coli, GI1787527, Length=203, Percent_Identity=30.5418719211823, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 70513; Mature: 70513

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLMIKSFIQNIWKIIYKILRYSIRTLHLIRTVIINIFFIIFIVISVGVYLNLRDSSASL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHH
SKCSALILDLSGIIVDKPVTYSKFQKFSQHLLNTNKPNAKENSLFDIINILRQAKNDPHI
HHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCH
TGLILSLKNFCGSNQTSLEYIGKALREFKESGKPIYAISDYYNQSQYLLASYANKIYLTP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHCCCEEEECC
HGFVDLRGISTSKLYYKSLLNNLKINTHIFRVGRYKSAVEPFIQDQMSDHVRHEETKLVN
CCCEEECCCCHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
RLWDQYLQIISINRNTTTRSIFPGINNILNELHRMQGDTAAYALKNKWIDEIASHFVIEN
HHHHHHHHHEECCCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
TMKEIFGSNKQGTSFNAISMYDYNLIAPAKKDNQIAIICINGPIVDGPDIPGSIGGDTIA
HHHHHHCCCCCCCCCCEEEEECCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHH
HKIRSARFDPKIKAIVLRVNSPGGSVNASELIRLELIAVRDSGKPVVVSMGGIAASGGYW
HHHHHCCCCCCEEEEEEEEECCCCCCCHHHEEEEEEEEEECCCCEEEEEECCEEECCCEE
ISTPANVIIASNSTITGSIGIFGIINTFEKSLDTIGIHSDGVNTSPISNISITTPLPTEY
EECCCEEEEECCCEEEECCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEEECCCCHHH
INMMQLYVNTSYHYFINTVAESRCKTTEDIHKIAQGHVWLGYDAIKNGLIDNIGDLDDAI
HHHHHHHHCCCHHEEHHHHHHHHCCCHHHHHHHHCCCEEEEHHHHHCCCCCCCCHHHHHH
NKAIELAHLKEYQLNWYENKINWIDVLIQQANKVIHTIIINLLNHYVSLINFDNNIKINN
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECC
SNILQFSWNDPKNCYALDLNYSEQL
CEEEEEECCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MFLMIKSFIQNIWKIIYKILRYSIRTLHLIRTVIINIFFIIFIVISVGVYLNLRDSSASL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHH
SKCSALILDLSGIIVDKPVTYSKFQKFSQHLLNTNKPNAKENSLFDIINILRQAKNDPHI
HHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCH
TGLILSLKNFCGSNQTSLEYIGKALREFKESGKPIYAISDYYNQSQYLLASYANKIYLTP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHCCCEEEECC
HGFVDLRGISTSKLYYKSLLNNLKINTHIFRVGRYKSAVEPFIQDQMSDHVRHEETKLVN
CCCEEECCCCHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
RLWDQYLQIISINRNTTTRSIFPGINNILNELHRMQGDTAAYALKNKWIDEIASHFVIEN
HHHHHHHHHEECCCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
TMKEIFGSNKQGTSFNAISMYDYNLIAPAKKDNQIAIICINGPIVDGPDIPGSIGGDTIA
HHHHHHCCCCCCCCCCEEEEECCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHH
HKIRSARFDPKIKAIVLRVNSPGGSVNASELIRLELIAVRDSGKPVVVSMGGIAASGGYW
HHHHHCCCCCCEEEEEEEEECCCCCCCHHHEEEEEEEEEECCCCEEEEEECCEEECCCEE
ISTPANVIIASNSTITGSIGIFGIINTFEKSLDTIGIHSDGVNTSPISNISITTPLPTEY
EECCCEEEEECCCEEEECCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEEECCCCHHH
INMMQLYVNTSYHYFINTVAESRCKTTEDIHKIAQGHVWLGYDAIKNGLIDNIGDLDDAI
HHHHHHHHCCCHHEEHHHHHHHHCCCHHHHHHHHCCCEEEEHHHHHCCCCCCCCHHHHHH
NKAIELAHLKEYQLNWYENKINWIDVLIQQANKVIHTIIINLLNHYVSLINFDNNIKINN
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECC
SNILQFSWNDPKNCYALDLNYSEQL
CEEEEEECCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]