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The map label for this gene is accC [H]

Identifier: 71892073

GI number: 71892073

Start: 349344

End: 350699

Strand: Reverse

Name: accC [H]

Synonym: BPEN_299

Alternate gene names: 71892073

Gene position: 350699-349344 (Counterclockwise)

Preceding gene: 71892074

Following gene: 71892071

Centisome position: 44.3

GC content: 33.85

Gene sequence:

>1356_bases
ATGTTAGAAAAAATTGTCATTGCAAATAGAGGAGAGATAGCTTTGCGCATTTTGCGCGCATGTAAAGAATTAGGGATACA
AACAGTGGCTGTGCATTCAACCATAGATCGTGATCTGAAACACGTGTTGTTGGCCGATGAAACTGTTTGTATAGGACCTC
CCCCTGCAATACATAGTTATTTAAATATTCCAGCTATTATTTCAGCTGCAGAAATTACTGGATCATCAGGAATTCATCCT
GGTTATGGATTTTTATCAGAAAACGCTGACTTTGCAGAACAAGTTGAACGTTCCGGTTTTGTTTTTATTGGACCGCGGTC
AGAAACTATTCGTTTAATGGGAAATAAAATATCTGCTATAGCTATTATGAAAGAATCAGGAATAATGACTGTTCCTGGTT
GGGATTATAAACTGAATAAAAACATAAATAATAAAATTTATAATTTTTCATGTCAAAATTTACACATTAATTATCCAATT
ATCATAAAATCTGCTCATGGAGGAGGAGGGCGTGGCATGTGTGTAGTTAAAAAAGAATCAGATTTACAAGATGCTATACG
CATGATACGAGCAGAAGCAAAAAACACGTTTAATGATGATACTATTTATGCAGAACAATACTTGGCACATCCTAGGCATA
TAGAAATACAAGTGTTATCTGATGGAAAAGGCAATATAATTTATTTGACAGAACGTGATTGTTCTGTACAAAGAAAACAT
CAAAAGATAGTAGAGGAGAGTCCTGCGTTAGGTATTAGCTCTGCAATGTGGAAACATATAGGAGAAAGTTGTGTAAAAAT
TTGTTATAAAATTGGATATCGTGGGGTCGGTACATTTGAATTTTTATATGAGAATAATGAATTCTTTTTCATTGAAATGA
ATACTCGTATTCAAGTGGAACATCCTATTACAGAAATGATTACCGGAATAGATCTCATTAGAGAGCAGCTAAAAATTGCT
TCTGGATATACGTTAAACATTACACAAGATTCAATTAAATCTGAAGGACACGCTATAGAATGCCGCATTAATGCTGAAGA
TCCTCATAACTTTATACCTAGTTCAGGATGTATTACTAGGTTCCACGCTCCCGGAGGATTAGGTGTGCGTTGGGAATCTC
ATATTTATTCTGGCTACTCGGTGCCTCCTTATTATGATGCAATGATAGGAAAATTAATTTGTTTTGGGGAAACACGTGAT
ATAGCTATTGCTCGTATGAAAAACGCGTTATCAGAGTTAATTATTGATGGAATAAATACCAATATCGAATTACAATTAAA
AATTGTAACCGATGAGACCTTTCAAAAAGGTAATGGAATTAATATTCATTATTTAGAAAACAAACTTAATATCTAA

Upstream 100 bases:

>100_bases
CAATCAGATAAATCAGGTGTAATCAAAGCAATTTTGATTGATAACGGTCAACCGGTCGAATTTAATGAGCCATTACTTAT
CATCGAATAACGAGAACAGA

Downstream 100 bases:

>100_bases
ATAATTAGAAAATAAAACATATATATATTTTCACATAAAAGTGATTGTTGATCTTTAATTAAGGGAATAATATAGCTTCT
TAAGTATTAAAATTATAACA

Product: acetyl CoA carboxylase, biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLEKIVIANRGEIALRILRACKELGIQTVAVHSTIDRDLKHVLLADETVCIGPPPAIHSYLNIPAIISAAEITGSSGIHP
GYGFLSENADFAEQVERSGFVFIGPRSETIRLMGNKISAIAIMKESGIMTVPGWDYKLNKNINNKIYNFSCQNLHINYPI
IIKSAHGGGGRGMCVVKKESDLQDAIRMIRAEAKNTFNDDTIYAEQYLAHPRHIEIQVLSDGKGNIIYLTERDCSVQRKH
QKIVEESPALGISSAMWKHIGESCVKICYKIGYRGVGTFEFLYENNEFFFIEMNTRIQVEHPITEMITGIDLIREQLKIA
SGYTLNITQDSIKSEGHAIECRINAEDPHNFIPSSGCITRFHAPGGLGVRWESHIYSGYSVPPYYDAMIGKLICFGETRD
IAIARMKNALSELIIDGINTNIELQLKIVTDETFQKGNGINIHYLENKLNI

Sequences:

>Translated_451_residues
MLEKIVIANRGEIALRILRACKELGIQTVAVHSTIDRDLKHVLLADETVCIGPPPAIHSYLNIPAIISAAEITGSSGIHP
GYGFLSENADFAEQVERSGFVFIGPRSETIRLMGNKISAIAIMKESGIMTVPGWDYKLNKNINNKIYNFSCQNLHINYPI
IIKSAHGGGGRGMCVVKKESDLQDAIRMIRAEAKNTFNDDTIYAEQYLAHPRHIEIQVLSDGKGNIIYLTERDCSVQRKH
QKIVEESPALGISSAMWKHIGESCVKICYKIGYRGVGTFEFLYENNEFFFIEMNTRIQVEHPITEMITGIDLIREQLKIA
SGYTLNITQDSIKSEGHAIECRINAEDPHNFIPSSGCITRFHAPGGLGVRWESHIYSGYSVPPYYDAMIGKLICFGETRD
IAIARMKNALSELIIDGINTNIELQLKIVTDETFQKGNGINIHYLENKLNI
>Mature_451_residues
MLEKIVIANRGEIALRILRACKELGIQTVAVHSTIDRDLKHVLLADETVCIGPPPAIHSYLNIPAIISAAEITGSSGIHP
GYGFLSENADFAEQVERSGFVFIGPRSETIRLMGNKISAIAIMKESGIMTVPGWDYKLNKNINNKIYNFSCQNLHINYPI
IIKSAHGGGGRGMCVVKKESDLQDAIRMIRAEAKNTFNDDTIYAEQYLAHPRHIEIQVLSDGKGNIIYLTERDCSVQRKH
QKIVEESPALGISSAMWKHIGESCVKICYKIGYRGVGTFEFLYENNEFFFIEMNTRIQVEHPITEMITGIDLIREQLKIA
SGYTLNITQDSIKSEGHAIECRINAEDPHNFIPSSGCITRFHAPGGLGVRWESHIYSGYSVPPYYDAMIGKLICFGETRD
IAIARMKNALSELIIDGINTNIELQLKIVTDETFQKGNGINIHYLENKLNI

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=43.7923250564334, Blast_Score=387, Evalue=1e-108,
Organism=Homo sapiens, GI189095269, Length=450, Percent_Identity=42.4444444444444, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=42.4444444444444, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=450, Percent_Identity=42.4444444444444, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=39.8648648648649, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=39.8648648648649, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=39.8648648648649, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI38679974, Length=512, Percent_Identity=30.859375, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679977, Length=512, Percent_Identity=30.859375, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679967, Length=512, Percent_Identity=30.859375, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=512, Percent_Identity=30.859375, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679960, Length=512, Percent_Identity=30.859375, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=29.2156862745098, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1789654, Length=451, Percent_Identity=69.4013303769401, Blast_Score=649, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17567343, Length=449, Percent_Identity=42.0935412026726, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=41.3636363636364, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17562816, Length=438, Percent_Identity=39.4977168949772, Blast_Score=318, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=27.9022403258656, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71997168, Length=522, Percent_Identity=26.8199233716475, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71997163, Length=522, Percent_Identity=26.8199233716475, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319695, Length=444, Percent_Identity=42.5675675675676, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6321376, Length=444, Percent_Identity=43.4684684684685, Blast_Score=312, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6319685, Length=440, Percent_Identity=36.5909090909091, Blast_Score=305, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6324343, Length=519, Percent_Identity=28.9017341040462, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323863, Length=461, Percent_Identity=29.9349240780911, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=41.5349887133183, Blast_Score=358, Evalue=5e-99,
Organism=Drosophila melanogaster, GI24652212, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24652210, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24652214, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI19921944, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24652216, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI281363050, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24652224, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24652222, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24652220, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24652218, Length=443, Percent_Identity=41.0835214446953, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24651759, Length=404, Percent_Identity=40.8415841584158, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=28.1746031746032, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=28.1746031746032, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=28.1746031746032, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=28.1746031746032, Blast_Score=201, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50401; Mature: 50401

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKIVIANRGEIALRILRACKELGIQTVAVHSTIDRDLKHVLLADETVCIGPPPAIHSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHEEECCEEEECCCHHHHHH
LNIPAIISAAEITGSSGIHPGYGFLSENADFAEQVERSGFVFIGPRSETIRLMGNKISAI
CCCCHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCEEEE
AIMKESGIMTVPGWDYKLNKNINNKIYNFSCQNLHINYPIIIKSAHGGGGRGMCVVKKES
EEEECCCEEECCCCCEEECCCCCCCEEEEEECEEEECCEEEEEECCCCCCCCEEEEECCC
DLQDAIRMIRAEAKNTFNDDTIYAEQYLAHPRHIEIQVLSDGKGNIIYLTERDCSVQRKH
CHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCHHHHH
QKIVEESPALGISSAMWKHIGESCVKICYKIGYRGVGTFEFLYENNEFFFIEMNTRIQVE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCEEEEC
HPITEMITGIDLIREQLKIASGYTLNITQDSIKSEGHAIECRINAEDPHNFIPSSGCITR
CCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEE
FHAPGGLGVRWESHIYSGYSVPPYYDAMIGKLICFGETRDIAIARMKNALSELIIDGINT
EECCCCCCEEEHHHEECCCCCCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
NIELQLKIVTDETFQKGNGINIHYLENKLNI
CEEEEEEEEECCHHCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MLEKIVIANRGEIALRILRACKELGIQTVAVHSTIDRDLKHVLLADETVCIGPPPAIHSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHEEECCEEEECCCHHHHHH
LNIPAIISAAEITGSSGIHPGYGFLSENADFAEQVERSGFVFIGPRSETIRLMGNKISAI
CCCCHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCEEEE
AIMKESGIMTVPGWDYKLNKNINNKIYNFSCQNLHINYPIIIKSAHGGGGRGMCVVKKES
EEEECCCEEECCCCCEEECCCCCCCEEEEEECEEEECCEEEEEECCCCCCCCEEEEECCC
DLQDAIRMIRAEAKNTFNDDTIYAEQYLAHPRHIEIQVLSDGKGNIIYLTERDCSVQRKH
CHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCHHHHH
QKIVEESPALGISSAMWKHIGESCVKICYKIGYRGVGTFEFLYENNEFFFIEMNTRIQVE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCEEEEC
HPITEMITGIDLIREQLKIASGYTLNITQDSIKSEGHAIECRINAEDPHNFIPSSGCITR
CCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEE
FHAPGGLGVRWESHIYSGYSVPPYYDAMIGKLICFGETRDIAIARMKNALSELIIDGINT
EECCCCCCEEEHHHEECCCCCCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
NIELQLKIVTDETFQKGNGINIHYLENKLNI
CEEEEEEEEECCHHCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]