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The map label for this gene is pgl [H]

Identifier: 68536073

GI number: 68536073

Start: 1178227

End: 1179060

Strand: Direct

Name: pgl [H]

Synonym: jk0996

Alternate gene names: 68536073

Gene position: 1178227-1179060 (Clockwise)

Preceding gene: 68536072

Following gene: 68536119

Centisome position: 47.85

GC content: 66.79

Gene sequence:

>834_bases
ATGAAGCCCACGCAGAATAACCGCCGCACCGCTGTTGTCAGCGACAAGACAGGGGTGGAGCTGCGTCCCCGCGACAACAA
GCAGGACCTGGCAACCGCCGCAGCCCGCGAGTTCATCAACACCGTGGCGGAACTGCAGCGCACCGGGGACACCGTGACGG
GCGACGGCATCGTCCGCGTGGTGCTAACCGGCGGCGGGGCGGGCATCGCCACCCTGGCGGAGATCGCCGCCCTGGATCAC
GCGGCGCAGCAGACGGCGGAGGACTTCCCCGTCACCGCGATCGACTGGTCCCAGGTATATGTTTTCTTCGGTGACGAGCG
CTTCCTGGCTGCGGGCGACGCGGAGCGTAACGACAAGCAGGCCTTCGATGCCCTGCTGCGCCACGTGAACATCCCCTCAC
TGAACGTGTTCCGTGTTCCGGCCCTGGCCGCCGGTGAAGAGGCCGACGGCCCGGCGCTGGATGCCGCCGCCGAGTTCTAC
GGCAAGACGGTGGATCAGGTGGCTCCCGAGGGCTTCGACATCCACCTGCTGGGAATGGGGCCGGAGGGGCACATCAACTC
GCTGTTCCCGCATACGGACGCGCTACTGCACGCCGAGGGTTCGGTGGTTGCGGTGCGCGAGTGCCCGAAGCCCCCGGCAG
AGCGCATCAGCCTGACCATGCAGGCGGTCAACCGCTCCCGGCAGGTGTGGCTGCTAGTCAGCGGTGAGGAAAAGAAAGAA
GCTGCGGGCCAGGTGTTTAACGGCGGCAATGGCGCCGAATGGCCCGCAGCTTTGGCCTCCGGTACGAAGGCGACGCTGCT
GTGGGTTGACGAGGCCGCCAACCCACTGCTTTAA

Upstream 100 bases:

>100_bases
GTGTGCAAACCCCCGAGCCGCGAGAGGACAAGCTGGACCGCTGGACCTCCCGCGATGCCCGCGAAACCTATAACGCCTTC
GATGGTCAGGAGTCTCTACG

Downstream 100 bases:

>100_bases
GTTGTTTAAACGGTCGTCTGGCCTTCTAGGCCAGGCCGTAGTGCAGAACCAGGTTCAGGCCGACTAGGGCCAGCAGCCAG
ATCACTGCGGTGCCCACGGT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKPTQNNRRTAVVSDKTGVELRPRDNKQDLATAAAREFINTVAELQRTGDTVTGDGIVRVVLTGGGAGIATLAEIAALDH
AAQQTAEDFPVTAIDWSQVYVFFGDERFLAAGDAERNDKQAFDALLRHVNIPSLNVFRVPALAAGEEADGPALDAAAEFY
GKTVDQVAPEGFDIHLLGMGPEGHINSLFPHTDALLHAEGSVVAVRECPKPPAERISLTMQAVNRSRQVWLLVSGEEKKE
AAGQVFNGGNGAEWPAALASGTKATLLWVDEAANPLL

Sequences:

>Translated_277_residues
MKPTQNNRRTAVVSDKTGVELRPRDNKQDLATAAAREFINTVAELQRTGDTVTGDGIVRVVLTGGGAGIATLAEIAALDH
AAQQTAEDFPVTAIDWSQVYVFFGDERFLAAGDAERNDKQAFDALLRHVNIPSLNVFRVPALAAGEEADGPALDAAAEFY
GKTVDQVAPEGFDIHLLGMGPEGHINSLFPHTDALLHAEGSVVAVRECPKPPAERISLTMQAVNRSRQVWLLVSGEEKKE
AAGQVFNGGNGAEWPAALASGTKATLLWVDEAANPLL
>Mature_277_residues
MKPTQNNRRTAVVSDKTGVELRPRDNKQDLATAAAREFINTVAELQRTGDTVTGDGIVRVVLTGGGAGIATLAEIAALDH
AAQQTAEDFPVTAIDWSQVYVFFGDERFLAAGDAERNDKQAFDALLRHVNIPSLNVFRVPALAAGEEADGPALDAAAEFY
GKTVDQVAPEGFDIHLLGMGPEGHINSLFPHTDALLHAEGSVVAVRECPKPPAERISLTMQAVNRSRQVWLLVSGEEKKE
AAGQVFNGGNGAEWPAALASGTKATLLWVDEAANPLL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=257, Percent_Identity=29.1828793774319, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI6912586, Length=177, Percent_Identity=32.7683615819209, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115533060, Length=191, Percent_Identity=28.2722513089005, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115533058, Length=191, Percent_Identity=28.2722513089005, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321687, Length=251, Percent_Identity=29.4820717131474, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321957, Length=208, Percent_Identity=27.8846153846154, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641119, Length=172, Percent_Identity=31.9767441860465, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 29471; Mature: 29471

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTQNNRRTAVVSDKTGVELRPRDNKQDLATAAAREFINTVAELQRTGDTVTGDGIVRV
CCCCCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEE
VLTGGGAGIATLAEIAALDHAAQQTAEDFPVTAIDWSQVYVFFGDERFLAAGDAERNDKQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEECCCEEEECCCCCCCHHH
AFDALLRHVNIPSLNVFRVPALAAGEEADGPALDAAAEFYGKTVDQVAPEGFDIHLLGMG
HHHHHHHHCCCCCCEEEECCCEECCCCCCCCHHHHHHHHHCCCHHHHCCCCCEEEEEEEC
PEGHINSLFPHTDALLHAEGSVVAVRECPKPPAERISLTMQAVNRSRQVWLLVSGEEKKE
CCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHH
AAGQVFNGGNGAEWPAALASGTKATLLWVDEAANPLL
HHCCEECCCCCCCCCHHHHCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MKPTQNNRRTAVVSDKTGVELRPRDNKQDLATAAAREFINTVAELQRTGDTVTGDGIVRV
CCCCCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEE
VLTGGGAGIATLAEIAALDHAAQQTAEDFPVTAIDWSQVYVFFGDERFLAAGDAERNDKQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEECCCEEEECCCCCCCHHH
AFDALLRHVNIPSLNVFRVPALAAGEEADGPALDAAAEFYGKTVDQVAPEGFDIHLLGMG
HHHHHHHHCCCCCCEEEECCCEECCCCCCCCHHHHHHHHHCCCHHHHCCCCCEEEEEEEC
PEGHINSLFPHTDALLHAEGSVVAVRECPKPPAERISLTMQAVNRSRQVWLLVSGEEKKE
CCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHH
AAGQVFNGGNGAEWPAALASGTKATLLWVDEAANPLL
HHCCEECCCCCCCCCHHHHCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]