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The map label for this gene is tkt [H]

Identifier: 68536069

GI number: 68536069

Start: 1172229

End: 1174319

Strand: Direct

Name: tkt [H]

Synonym: jk0992

Alternate gene names: 68536069

Gene position: 1172229-1174319 (Clockwise)

Preceding gene: 68536067

Following gene: 68536070

Centisome position: 47.6

GC content: 65.61

Gene sequence:

>2091_bases
GTGACTCTCTCCCCAGAACAGCAGGCACTCACCGTGCGCAACTACCCAGCGGACTGGACGGAGACCGACACGCGCGCGGT
CGACCTTGCCCGTGTGCTGGCCGCAGACGCAGTGGAAAACTGCGGCTCGGGCCACCCCGGCACGGCGATGAGCCTGGCGC
CGCTGGCCTACACGCTGTACCAGCGCGTACTTCGCCACGATCCGCAGGACGTGCACTGGGTCGGTAGGGATCGCTTCGTA
TTGTCTGCGGGCCACTCGTCTCTGACCCAGTACATCCAGCTGTACCTGGGTGGCTTCGGCTTGGAGCTGGAGGATCTTCA
GGCCCTGCGCACCTGGGGGTCCAAGACCCCGGGCCACCCCGAGGTGCACCACACCGATGGCGTGGAGATCACCACCGGCC
CGCTGGGCCAGGGACTGGCATCCGCGGTGGGTATGGCGATGGCCTCCCGCCGCGAGCGCGCATTGTTCGACCCTGAGGCT
CCGGCCGGAGAGTCCCCATTCGACCACTTCATCTACGTCATCGCTTCCGACGGCGACGTCCAGGAGGGCGTGACTTCCGA
GGCTTCCTCCCTGGCGGGTACCCAACAGCTGGGTAACCTCATTGTCTTCTGGGACGATAACGGCATCTCCATCGAGGACC
AGACCGAGATTGCCTTTAACGAGGACGTCTCTGCTCGCTACGCCGCCTACGGCTGGCAGACCCTGGAGGTCACCGGTGAG
GATGTCGAGGGAATCCTGGACGCGGTCGAGCGCGCCAAGGCAGAGACCTCCCGCCCAACCTTCATTCGCCTCCGTAGCGT
CATTGCCTACCCAGCCCCGACGAAGATGGATACCGGTGCCTCCCACGGTGCGGCCCTCGGCGCGGAAGAGATCAAGGGCA
TTAAGCAGGCCCTGGACTTCCCCGATGAGCCGTTCCCGGTGGAGGACAACGTAATCACCCACACCCGCGGTCTGATCGAT
CGTGCCGCGGAGGCGCACAAGCAGTGGCAGGTTCTTTTTGACGCTTGGGCGGAGAACAACCCGGAGAACAAGGCTCTGTT
CGACCGTCTGTACTCCCGCGAACTTCCGGAGGGCTTCGACGCCGAGGTTCCCAGCTGGGAGGCCGGGGAGTCCCTGGCCA
CCCGCAAGGCTTCGGAGGCTACCCTGCAGGCTCTGGGGAAGACTTTGCCGGAGCTGTGGGGTGGTTCCGCTGACTTGGCT
GGCTCCACCAACACCATCATTAAGGGCTCCCCGAGTTTCGGCCCGGAGGCCATCAGCACTCGCAATTTCACTGCGGAGCC
GGGTGGCCGCAACCTGCACTTCGGTATCCGCGAGCACGGCATGGTCGCCATCCTGAACGGCATCGCCCTGCACGGCCCGA
CTCGCCCTTACGGTGCGACGTTCCTGCAGTTCTCCGACTACGCACGCGGCGCGGTGCGCCTGGGCGCCCTGATGAAGTCG
GATGTTTACCACGTGTGGACGCACGACTCCATTGGCCTGGGCGAGGACGGCCCCACCCACCAGCCAGTCGAGCACCTGGC
ATCCCTGCGTGCAATCCCCCACCTGGCGGTTATCCGCCCGGCGGACGCTAACGAGACCGCTGCGGGCTGGGTGGCTGCCC
TGCAGGCTGAGGAGTCCCCGAAGGCTCTGATCTTGACCCGCCAGAACGTCCCCGTGCTGGAGGGAACTCAACAGAAGGCT
GCAGAGGGCGTGGCCCGCGGCGCGTACGTGTTGGTCGAGGAGTCGACGGACACTCCGGAGGTCATCCTGCTGGCCACCGG
CTCCGAGGTGCAGCTGGCCGTGGAGGCCGCCAAGGAACTGGAGAGCCAGGGCGTGGGCACCCGCGTGGTCTCCATGCCGG
TCATGGAGTGGTTCCTTGAGCAGGATGCCGAGTACCAAGAGCAGGTTCTGCCGAGCAACGTGACGGCTCGCGTGTCCGTG
GAGGCCGGAATCGCCATGCCGTGGCACCGCTTTGTTGGCCTGAACGGCCGGACTATCTCTCTGGAGCACTACGGCGCTTC
GGCCGACTACCAGACGCTCTACCGCGAGTTCGGCATCACTTCCGAGGCAGTCGTCGCTGCCGCGCACGACTCCATCGCGG
CGAACAAGTAA

Upstream 100 bases:

>100_bases
CCAAAAATCCGGGCGGCAATGGCGCCCACTAGCCACAGCAACGGGATACGCCCATTAGTATGTATTGGGTACTCAGCTTG
ACGAAGAAAGGCAACTGACA

Downstream 100 bases:

>100_bases
ACCCCACAACCCCACCCCAAGGACTGATTCCTTCTATGAGCACTCCCGCGAACATTAACGCACTCGCCAATGCCGGCACT
TCCGTATGGCTGGACGACCT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MTLSPEQQALTVRNYPADWTETDTRAVDLARVLAADAVENCGSGHPGTAMSLAPLAYTLYQRVLRHDPQDVHWVGRDRFV
LSAGHSSLTQYIQLYLGGFGLELEDLQALRTWGSKTPGHPEVHHTDGVEITTGPLGQGLASAVGMAMASRRERALFDPEA
PAGESPFDHFIYVIASDGDVQEGVTSEASSLAGTQQLGNLIVFWDDNGISIEDQTEIAFNEDVSARYAAYGWQTLEVTGE
DVEGILDAVERAKAETSRPTFIRLRSVIAYPAPTKMDTGASHGAALGAEEIKGIKQALDFPDEPFPVEDNVITHTRGLID
RAAEAHKQWQVLFDAWAENNPENKALFDRLYSRELPEGFDAEVPSWEAGESLATRKASEATLQALGKTLPELWGGSADLA
GSTNTIIKGSPSFGPEAISTRNFTAEPGGRNLHFGIREHGMVAILNGIALHGPTRPYGATFLQFSDYARGAVRLGALMKS
DVYHVWTHDSIGLGEDGPTHQPVEHLASLRAIPHLAVIRPADANETAAGWVAALQAEESPKALILTRQNVPVLEGTQQKA
AEGVARGAYVLVEESTDTPEVILLATGSEVQLAVEAAKELESQGVGTRVVSMPVMEWFLEQDAEYQEQVLPSNVTARVSV
EAGIAMPWHRFVGLNGRTISLEHYGASADYQTLYREFGITSEAVVAAAHDSIAANK

Sequences:

>Translated_696_residues
MTLSPEQQALTVRNYPADWTETDTRAVDLARVLAADAVENCGSGHPGTAMSLAPLAYTLYQRVLRHDPQDVHWVGRDRFV
LSAGHSSLTQYIQLYLGGFGLELEDLQALRTWGSKTPGHPEVHHTDGVEITTGPLGQGLASAVGMAMASRRERALFDPEA
PAGESPFDHFIYVIASDGDVQEGVTSEASSLAGTQQLGNLIVFWDDNGISIEDQTEIAFNEDVSARYAAYGWQTLEVTGE
DVEGILDAVERAKAETSRPTFIRLRSVIAYPAPTKMDTGASHGAALGAEEIKGIKQALDFPDEPFPVEDNVITHTRGLID
RAAEAHKQWQVLFDAWAENNPENKALFDRLYSRELPEGFDAEVPSWEAGESLATRKASEATLQALGKTLPELWGGSADLA
GSTNTIIKGSPSFGPEAISTRNFTAEPGGRNLHFGIREHGMVAILNGIALHGPTRPYGATFLQFSDYARGAVRLGALMKS
DVYHVWTHDSIGLGEDGPTHQPVEHLASLRAIPHLAVIRPADANETAAGWVAALQAEESPKALILTRQNVPVLEGTQQKA
AEGVARGAYVLVEESTDTPEVILLATGSEVQLAVEAAKELESQGVGTRVVSMPVMEWFLEQDAEYQEQVLPSNVTARVSV
EAGIAMPWHRFVGLNGRTISLEHYGASADYQTLYREFGITSEAVVAAAHDSIAANK
>Mature_695_residues
TLSPEQQALTVRNYPADWTETDTRAVDLARVLAADAVENCGSGHPGTAMSLAPLAYTLYQRVLRHDPQDVHWVGRDRFVL
SAGHSSLTQYIQLYLGGFGLELEDLQALRTWGSKTPGHPEVHHTDGVEITTGPLGQGLASAVGMAMASRRERALFDPEAP
AGESPFDHFIYVIASDGDVQEGVTSEASSLAGTQQLGNLIVFWDDNGISIEDQTEIAFNEDVSARYAAYGWQTLEVTGED
VEGILDAVERAKAETSRPTFIRLRSVIAYPAPTKMDTGASHGAALGAEEIKGIKQALDFPDEPFPVEDNVITHTRGLIDR
AAEAHKQWQVLFDAWAENNPENKALFDRLYSRELPEGFDAEVPSWEAGESLATRKASEATLQALGKTLPELWGGSADLAG
STNTIIKGSPSFGPEAISTRNFTAEPGGRNLHFGIREHGMVAILNGIALHGPTRPYGATFLQFSDYARGAVRLGALMKSD
VYHVWTHDSIGLGEDGPTHQPVEHLASLRAIPHLAVIRPADANETAAGWVAALQAEESPKALILTRQNVPVLEGTQQKAA
EGVARGAYVLVEESTDTPEVILLATGSEVQLAVEAAKELESQGVGTRVVSMPVMEWFLEQDAEYQEQVLPSNVTARVSVE
AGIAMPWHRFVGLNGRTISLEHYGASADYQTLYREFGITSEAVVAAAHDSIAANK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=586, Percent_Identity=25.938566552901, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4507521, Length=586, Percent_Identity=25.938566552901, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI133778974, Length=585, Percent_Identity=24.7863247863248, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI225637459, Length=587, Percent_Identity=24.190800681431, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI225637463, Length=490, Percent_Identity=25.7142857142857, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI225637461, Length=490, Percent_Identity=25.7142857142857, Blast_Score=115, Evalue=2e-25,
Organism=Escherichia coli, GI48994911, Length=667, Percent_Identity=45.2773613193403, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1788808, Length=674, Percent_Identity=45.6973293768546, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17539652, Length=589, Percent_Identity=25.4668930390492, Blast_Score=152, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=684, Percent_Identity=42.6900584795322, Blast_Score=513, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6319593, Length=687, Percent_Identity=41.0480349344978, Blast_Score=499, Evalue=1e-142,
Organism=Drosophila melanogaster, GI45551847, Length=599, Percent_Identity=27.3789649415693, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI45550715, Length=599, Percent_Identity=27.3789649415693, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24645119, Length=547, Percent_Identity=27.4223034734918, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24666278, Length=586, Percent_Identity=24.7440273037543, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 75155; Mature: 75024

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSPEQQALTVRNYPADWTETDTRAVDLARVLAADAVENCGSGHPGTAMSLAPLAYTLY
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QRVLRHDPQDVHWVGRDRFVLSAGHSSLTQYIQLYLGGFGLELEDLQALRTWGSKTPGHP
HHHHHCCCCCEEEECCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
EVHHTDGVEITTGPLGQGLASAVGMAMASRRERALFDPEAPAGESPFDHFIYVIASDGDV
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCC
QEGVTSEASSLAGTQQLGNLIVFWDDNGISIEDQTEIAFNEDVSARYAAYGWQTLEVTGE
HHCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCCCCHHHHHCCCEEEEECCC
DVEGILDAVERAKAETSRPTFIRLRSVIAYPAPTKMDTGASHGAALGAEEIKGIKQALDF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
PDEPFPVEDNVITHTRGLIDRAAEAHKQWQVLFDAWAENNPENKALFDRLYSRELPEGFD
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
AEVPSWEAGESLATRKASEATLQALGKTLPELWGGSADLAGSTNTIIKGSPSFGPEAIST
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCC
RNFTAEPGGRNLHFGIREHGMVAILNGIALHGPTRPYGATFLQFSDYARGAVRLGALMKS
CCCCCCCCCCEEEECCCCCCEEEEECCEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHC
DVYHVWTHDSIGLGEDGPTHQPVEHLASLRAIPHLAVIRPADANETAAGWVAALQAEESP
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHEEECCCCC
KALILTRQNVPVLEGTQQKAAEGVARGAYVLVEESTDTPEVILLATGSEVQLAVEAAKEL
CEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHH
ESQGVGTRVVSMPVMEWFLEQDAEYQEQVLPSNVTARVSVEAGIAMPWHRFVGLNGRTIS
HHCCCCEEHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCCCEEE
LEHYGASADYQTLYREFGITSEAVVAAAHDSIAANK
EECCCCCCHHHHHHHHHCCCHHHHEEECCCHHCCCC
>Mature Secondary Structure 
TLSPEQQALTVRNYPADWTETDTRAVDLARVLAADAVENCGSGHPGTAMSLAPLAYTLY
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QRVLRHDPQDVHWVGRDRFVLSAGHSSLTQYIQLYLGGFGLELEDLQALRTWGSKTPGHP
HHHHHCCCCCEEEECCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
EVHHTDGVEITTGPLGQGLASAVGMAMASRRERALFDPEAPAGESPFDHFIYVIASDGDV
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCC
QEGVTSEASSLAGTQQLGNLIVFWDDNGISIEDQTEIAFNEDVSARYAAYGWQTLEVTGE
HHCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCCCCHHHHHCCCEEEEECCC
DVEGILDAVERAKAETSRPTFIRLRSVIAYPAPTKMDTGASHGAALGAEEIKGIKQALDF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
PDEPFPVEDNVITHTRGLIDRAAEAHKQWQVLFDAWAENNPENKALFDRLYSRELPEGFD
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
AEVPSWEAGESLATRKASEATLQALGKTLPELWGGSADLAGSTNTIIKGSPSFGPEAIST
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCC
RNFTAEPGGRNLHFGIREHGMVAILNGIALHGPTRPYGATFLQFSDYARGAVRLGALMKS
CCCCCCCCCCEEEECCCCCCEEEEECCEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHC
DVYHVWTHDSIGLGEDGPTHQPVEHLASLRAIPHLAVIRPADANETAAGWVAALQAEESP
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHEEECCCCC
KALILTRQNVPVLEGTQQKAAEGVARGAYVLVEESTDTPEVILLATGSEVQLAVEAAKEL
CEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHH
ESQGVGTRVVSMPVMEWFLEQDAEYQEQVLPSNVTARVSVEAGIAMPWHRFVGLNGRTIS
HHCCCCEEHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCCCEEE
LEHYGASADYQTLYREFGITSEAVVAAAHDSIAANK
EECCCCCCHHHHHHHHHCCCHHHHEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]