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The map label for this gene is hsrA [H]

Identifier: 68536002

GI number: 68536002

Start: 1102213

End: 1103544

Strand: Direct

Name: hsrA [H]

Synonym: jk0925

Alternate gene names: 68536002

Gene position: 1102213-1103544 (Clockwise)

Preceding gene: 68536001

Following gene: 68536003

Centisome position: 44.76

GC content: 49.32

Gene sequence:

>1332_bases
ATGAATTACTTAAACGGCCGCATAACTGTCGCACTCTTATTGGCCACCATACTGCCGCTGCTTGATTCGAGTTTAGTCAA
TGTTCTTTTGCCATCAATTAGCGCCGATTTCGGCGTTAGTGAAGCTTCGGCCCAACTAGGAATCTCTACCTATATGCTCG
CCGCCACGGCGGGGATAGTTTTATCAACAACGTTGTTACGTCGCTTTGGGAGTAGGCGTATTTGGATAGCTTCTGTCGTG
GTCTTCGTGGTCGCCTCTACGGCTGTCGGTTGTAGTACTAGCGTGGCTATTTTCGTCATTGCCCGGATAGTCCAAGGCGC
AGCCTGCGGATTCATTATGCCTGCTGTACAGAAGATAGCGGTGGAGTTAGTTGGTAAAGATGGAATGCGCGCGGTTCTAG
CGACGATCGGGCTGCCTGCTGTAATTGCACCAGCCTTTGGCCCGCTTTTTGGTGGAGTTTTGGTTGAAACAATCGGGTGG
AGACCAATGTTTATAGTGAACATTCCACTAGTTTTGACAGCTTTGTTGCTCGCCAATAATGAATTACCGAAGTCCTACGG
CAGCCGTGTGCCAATAGGTATAAAACAAGCGTCTGCTGCGCTTGCTGGCATGGTCGGGCTTCTTTGGTGCATTTCCAGTA
TTAGCTCCATGACAGTCGGCTGGCTCTCGATGGTTTTTGTTTTATCGGTATGGTTTTTATCTCTATTTTGCTACATGGAT
TTAAAAGCGTCTACGCCTTTACTTGATGTCGCGATTTTTAAAAATATCCGCTTCGCGATAGCGATGATGCTTTGTTTTTT
AGTCGGCTTAGTCTTTTATGGAACTCTTTTATCGACCTCGCTTCACATTCAAACAGATCTTGGTAAGCCTGCATGGTGTG
CCGGATGTGTGCTTGCTGTTCAAGGTATAGGTGCATGGGCTGTTCGTTCACTGATCAAAGGCCCGTGGAAAGCTGTTAAT
CCTTTCCAGGTGATTGCCGCCGGTCTTATTCTCAGCGCCATTGGAACTGTTGGGATACAGCTGGTGACACAGTGGTCTGC
TGTGCAATTGGTGGTCTTGTTCTTAAGCGCTCTAATTAGAGGACTTGGCATTGGCGGATGCACCCTAATGGCGCTCTCAG
CGGCATATGAAGTCGTGACTGCTGATGACGCGGGAGTCGTGGGAGCTCATACGAGATTGATGCTGCAATTGGGTGGCGCC
CTGGGAGCTGCTGCGGTGGGAGTCTGGAGTGGATCGGCTATTGGTTTGGGTGTATTGACCGCAGTTATGGCATTCGCCGG
TGCCCTCGCATCACTTGTCTTGGTGATCAATCAACGACAGCCGAAAGTTTGA

Upstream 100 bases:

>100_bases
GTCAGTGGCAGCTTGTTCCACACTCGCTTGTTGAAGCTGGGCTCTATACACGTGGACCTATCCGGCTTTGCTTAGAAAAG
GTTGGGGGGTGATTGGTGGG

Downstream 100 bases:

>100_bases
AGCGTATGTCCTAGAATGGCTCCATGGAAGATCACAGTTCTACCGGTGCCGAATTCGGGCGCCGGTTGAGGCATGCCCGG
TTGGATAGGGGGCTTTCCCA

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNYLNGRITVALLLATILPLLDSSLVNVLLPSISADFGVSEASAQLGISTYMLAATAGIVLSTTLLRRFGSRRIWIASVV
VFVVASTAVGCSTSVAIFVIARIVQGAACGFIMPAVQKIAVELVGKDGMRAVLATIGLPAVIAPAFGPLFGGVLVETIGW
RPMFIVNIPLVLTALLLANNELPKSYGSRVPIGIKQASAALAGMVGLLWCISSISSMTVGWLSMVFVLSVWFLSLFCYMD
LKASTPLLDVAIFKNIRFAIAMMLCFLVGLVFYGTLLSTSLHIQTDLGKPAWCAGCVLAVQGIGAWAVRSLIKGPWKAVN
PFQVIAAGLILSAIGTVGIQLVTQWSAVQLVVLFLSALIRGLGIGGCTLMALSAAYEVVTADDAGVVGAHTRLMLQLGGA
LGAAAVGVWSGSAIGLGVLTAVMAFAGALASLVLVINQRQPKV

Sequences:

>Translated_443_residues
MNYLNGRITVALLLATILPLLDSSLVNVLLPSISADFGVSEASAQLGISTYMLAATAGIVLSTTLLRRFGSRRIWIASVV
VFVVASTAVGCSTSVAIFVIARIVQGAACGFIMPAVQKIAVELVGKDGMRAVLATIGLPAVIAPAFGPLFGGVLVETIGW
RPMFIVNIPLVLTALLLANNELPKSYGSRVPIGIKQASAALAGMVGLLWCISSISSMTVGWLSMVFVLSVWFLSLFCYMD
LKASTPLLDVAIFKNIRFAIAMMLCFLVGLVFYGTLLSTSLHIQTDLGKPAWCAGCVLAVQGIGAWAVRSLIKGPWKAVN
PFQVIAAGLILSAIGTVGIQLVTQWSAVQLVVLFLSALIRGLGIGGCTLMALSAAYEVVTADDAGVVGAHTRLMLQLGGA
LGAAAVGVWSGSAIGLGVLTAVMAFAGALASLVLVINQRQPKV
>Mature_443_residues
MNYLNGRITVALLLATILPLLDSSLVNVLLPSISADFGVSEASAQLGISTYMLAATAGIVLSTTLLRRFGSRRIWIASVV
VFVVASTAVGCSTSVAIFVIARIVQGAACGFIMPAVQKIAVELVGKDGMRAVLATIGLPAVIAPAFGPLFGGVLVETIGW
RPMFIVNIPLVLTALLLANNELPKSYGSRVPIGIKQASAALAGMVGLLWCISSISSMTVGWLSMVFVLSVWFLSLFCYMD
LKASTPLLDVAIFKNIRFAIAMMLCFLVGLVFYGTLLSTSLHIQTDLGKPAWCAGCVLAVQGIGAWAVRSLIKGPWKAVN
PFQVIAAGLILSAIGTVGIQLVTQWSAVQLVVLFLSALIRGLGIGGCTLMALSAAYEVVTADDAGVVGAHTRLMLQLGGA
LGAAAVGVWSGSAIGLGVLTAVMAFAGALASLVLVINQRQPKV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=414, Percent_Identity=26.3285024154589, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789042, Length=306, Percent_Identity=25.8169934640523, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788710, Length=313, Percent_Identity=26.8370607028754, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081983, Length=172, Percent_Identity=30.2325581395349, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45975; Mature: 45975

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLNGRITVALLLATILPLLDSSLVNVLLPSISADFGVSEASAQLGISTYMLAATAGIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LSTTLLRRFGSRRIWIASVVVFVVASTAVGCSTSVAIFVIARIVQGAACGFIMPAVQKIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VELVGKDGMRAVLATIGLPAVIAPAFGPLFGGVLVETIGWRPMFIVNIPLVLTALLLANN
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCC
ELPKSYGSRVPIGIKQASAALAGMVGLLWCISSISSMTVGWLSMVFVLSVWFLSLFCYMD
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LKASTPLLDVAIFKNIRFAIAMMLCFLVGLVFYGTLLSTSLHIQTDLGKPAWCAGCVLAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHH
QGIGAWAVRSLIKGPWKAVNPFQVIAAGLILSAIGTVGIQLVTQWSAVQLVVLFLSALIR
HCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIGGCTLMALSAAYEVVTADDAGVVGAHTRLMLQLGGALGAAAVGVWSGSAIGLGVLT
HCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHH
AVMAFAGALASLVLVINQRQPKV
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNYLNGRITVALLLATILPLLDSSLVNVLLPSISADFGVSEASAQLGISTYMLAATAGIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LSTTLLRRFGSRRIWIASVVVFVVASTAVGCSTSVAIFVIARIVQGAACGFIMPAVQKIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VELVGKDGMRAVLATIGLPAVIAPAFGPLFGGVLVETIGWRPMFIVNIPLVLTALLLANN
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCC
ELPKSYGSRVPIGIKQASAALAGMVGLLWCISSISSMTVGWLSMVFVLSVWFLSLFCYMD
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LKASTPLLDVAIFKNIRFAIAMMLCFLVGLVFYGTLLSTSLHIQTDLGKPAWCAGCVLAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHH
QGIGAWAVRSLIKGPWKAVNPFQVIAAGLILSAIGTVGIQLVTQWSAVQLVVLFLSALIR
HCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIGGCTLMALSAAYEVVTADDAGVVGAHTRLMLQLGGALGAAAVGVWSGSAIGLGVLT
HCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHH
AVMAFAGALASLVLVINQRQPKV
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]