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The map label for this gene is fadA2 [H]

Identifier: 68535898

GI number: 68535898

Start: 978416

End: 979732

Strand: Direct

Name: fadA2 [H]

Synonym: jk0823

Alternate gene names: 68535898

Gene position: 978416-979732 (Clockwise)

Preceding gene: 161986623

Following gene: 68535900

Centisome position: 39.73

GC content: 66.36

Gene sequence:

>1317_bases
ATGACTAACGGAGCACCCCGCAAGGTCGCCATCCTGGGCGGCAACCGCATCCCGTTCGCCCGTTCCAACAAGGAGTACGC
GAACGCGTCTAACCAAGACATGCTGACCGCCGCCATCGATGGCCTGGTCGCACGCTACGGCCTGCAGGGCGAGGAGCTGG
GCCAGGTCGTCGCCGGCGCCGTGCTGAAGCACTCCCGCGACTTCAACCTGACCCGCGAGACCGTCCTCGGCTCCGCACTG
TCCTCCACCACCCCGGCCTTCGACCTGCAGATGGCCTGCGGCACCGGCCTAGCTGCCCTGGTGCAGGTTGCAGACGCAAT
CGCCCTGGGCCGCGTCGAGTCCGGCATCGGCGGCGGCGTGGACACCACCTCCGACGCACCGCTGGCCGTTAACGATCAGC
TGCGCAAGACCCTGATCAAGCTGAACAACGCAAAGACCACCACCGACCGCCTGAAGCTGGTCGGCCAGATCCGCCCCTCC
CAGCTGGCCCCGGAGCAGCCGAACAACGGTGAGCCCCGCACCGGGCTTTCCATGGGTGACCACGCGGCCATCACCGCCCG
CGAGTTCGGCCTGACCCGCGAGGAGCAGGACCAGCTGGCAGCTGAGTCCCACCAGAAGCTGGCCAAGGCATACGACGAGG
GCTTCTTCGAGGACCTCATCACCCCGTACCTGGGCGTGCAGCGCGACACCAACCTGCGCCCGGACTCCAACGTAGAGAAG
TTGGCCAAGCTGAAGCCGGTCTTCGGCAAGAAGGACGCCGAGCAGCACGGCACCAAGGCCACCATGACCGCCGGTAACTC
CACCCCGCTGACCGACGGTGCTTCCGCAGTCCTGATCTCCTCCGAGGAGTGGGCGGCAGAGCACAACATCCCGGTTAAGG
CATACCTGGTGGACTCCGAGGTTGCTTCCGTGGACTTCATCAACGGCCGCGACGGCATGACCCCGGACGGTCTGCTGATG
TCCCCGACCTACGCGGTTGCGCGCCTGCTGAAGCGCAACAACCTTTCCCTGCAGGACTTCGACTTCTACGAGATCCACGA
GGCTTTCGCCTCCCAGACCTGCGCCACCCTGAAGGCTTGGGAGTCCGACGAGTACTGCCGCGAGCGCCTGGGCCTGGATG
GCGCCCTGGGTGCCATCGACCGCGCAAAGCTGAACGTTAAGGGCTCCTCCCTGGCAGCCGGCCACCCGTTCGCCGCTACC
GGCGGCCGCATCATCGCCACCGCTGCGAAGGTGCTGGAGGAAAACGGCGGCGGCCGCACCCTGGTTTCCATCTGTGCAGC
AGGTGGTCAGGGTATCGTCGCCATCATCGAGCGCTAA

Upstream 100 bases:

>100_bases
ACAATGTATGTTCTCATGTATAACCATACGGTGTGATCGAGCACACCGTGTAGGAATACGTTCTTTCAATTCACATTCTT
CGATGGAGTGACACAAAAAT

Downstream 100 bases:

>100_bases
AGCGCCGCTAGCCGCTAGCTGCTAGTTAGCCGCTAGCTTCTAGCGGCCAGCGGCTGCGAGCCGCCGGTTGCTAGAACACC
TTCGCCAGATCGGTCTTGTA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTNGAPRKVAILGGNRIPFARSNKEYANASNQDMLTAAIDGLVARYGLQGEELGQVVAGAVLKHSRDFNLTRETVLGSAL
SSTTPAFDLQMACGTGLAALVQVADAIALGRVESGIGGGVDTTSDAPLAVNDQLRKTLIKLNNAKTTTDRLKLVGQIRPS
QLAPEQPNNGEPRTGLSMGDHAAITAREFGLTREEQDQLAAESHQKLAKAYDEGFFEDLITPYLGVQRDTNLRPDSNVEK
LAKLKPVFGKKDAEQHGTKATMTAGNSTPLTDGASAVLISSEEWAAEHNIPVKAYLVDSEVASVDFINGRDGMTPDGLLM
SPTYAVARLLKRNNLSLQDFDFYEIHEAFASQTCATLKAWESDEYCRERLGLDGALGAIDRAKLNVKGSSLAAGHPFAAT
GGRIIATAAKVLEENGGGRTLVSICAAGGQGIVAIIER

Sequences:

>Translated_438_residues
MTNGAPRKVAILGGNRIPFARSNKEYANASNQDMLTAAIDGLVARYGLQGEELGQVVAGAVLKHSRDFNLTRETVLGSAL
SSTTPAFDLQMACGTGLAALVQVADAIALGRVESGIGGGVDTTSDAPLAVNDQLRKTLIKLNNAKTTTDRLKLVGQIRPS
QLAPEQPNNGEPRTGLSMGDHAAITAREFGLTREEQDQLAAESHQKLAKAYDEGFFEDLITPYLGVQRDTNLRPDSNVEK
LAKLKPVFGKKDAEQHGTKATMTAGNSTPLTDGASAVLISSEEWAAEHNIPVKAYLVDSEVASVDFINGRDGMTPDGLLM
SPTYAVARLLKRNNLSLQDFDFYEIHEAFASQTCATLKAWESDEYCRERLGLDGALGAIDRAKLNVKGSSLAAGHPFAAT
GGRIIATAAKVLEENGGGRTLVSICAAGGQGIVAIIER
>Mature_437_residues
TNGAPRKVAILGGNRIPFARSNKEYANASNQDMLTAAIDGLVARYGLQGEELGQVVAGAVLKHSRDFNLTRETVLGSALS
STTPAFDLQMACGTGLAALVQVADAIALGRVESGIGGGVDTTSDAPLAVNDQLRKTLIKLNNAKTTTDRLKLVGQIRPSQ
LAPEQPNNGEPRTGLSMGDHAAITAREFGLTREEQDQLAAESHQKLAKAYDEGFFEDLITPYLGVQRDTNLRPDSNVEKL
AKLKPVFGKKDAEQHGTKATMTAGNSTPLTDGASAVLISSEEWAAEHNIPVKAYLVDSEVASVDFINGRDGMTPDGLLMS
PTYAVARLLKRNNLSLQDFDFYEIHEAFASQTCATLKAWESDEYCRERLGLDGALGAIDRAKLNVKGSSLAAGHPFAATG
GRIIATAAKVLEENGGGRTLVSICAAGGQGIVAIIER

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=436, Percent_Identity=37.8440366972477, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI167614485, Length=440, Percent_Identity=29.5454545454545, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI4501853, Length=454, Percent_Identity=28.8546255506608, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI148539872, Length=445, Percent_Identity=27.6404494382022, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4557237, Length=443, Percent_Identity=25.2821670428894, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=36.7298578199052, Blast_Score=267, Evalue=8e-73,
Organism=Escherichia coli, GI87082165, Length=442, Percent_Identity=29.6380090497738, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1787663, Length=443, Percent_Identity=28.2167042889391, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788554, Length=444, Percent_Identity=28.3783783783784, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI48994986, Length=443, Percent_Identity=27.765237020316, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17551802, Length=434, Percent_Identity=35.7142857142857, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI133906874, Length=444, Percent_Identity=27.4774774774775, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17535921, Length=440, Percent_Identity=27.5, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25147385, Length=437, Percent_Identity=23.5697940503432, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322031, Length=441, Percent_Identity=28.7981859410431, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6325229, Length=445, Percent_Identity=25.1685393258427, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI17137578, Length=437, Percent_Identity=37.2997711670481, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24655093, Length=440, Percent_Identity=26.1363636363636, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17648125, Length=450, Percent_Identity=28.2222222222222, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24640423, Length=445, Percent_Identity=24.4943820224719, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46419; Mature: 46288

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNGAPRKVAILGGNRIPFARSNKEYANASNQDMLTAAIDGLVARYGLQGEELGQVVAGA
CCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLKHSRDFNLTRETVLGSALSSTTPAFDLQMACGTGLAALVQVADAIALGRVESGIGGGV
HHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
DTTSDAPLAVNDQLRKTLIKLNNAKTTTDRLKLVGQIRPSQLAPEQPNNGEPRTGLSMGD
CCCCCCCEEECHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
HAAITAREFGLTREEQDQLAAESHQKLAKAYDEGFFEDLITPYLGVQRDTNLRPDSNVEK
CCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LAKLKPVFGKKDAEQHGTKATMTAGNSTPLTDGASAVLISSEEWAAEHNIPVKAYLVDSE
HHHHCCCCCCCCHHHCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHCCCCEEEEEECCC
VASVDFINGRDGMTPDGLLMSPTYAVARLLKRNNLSLQDFDFYEIHEAFASQTCATLKAW
CCEEEEECCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
ESDEYCRERLGLDGALGAIDRAKLNVKGSSLAAGHPFAATGGRIIATAAKVLEENGGGRT
CCHHHHHHHCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCE
LVSICAAGGQGIVAIIER
EHHHHHCCCCEEEEEEEC
>Mature Secondary Structure 
TNGAPRKVAILGGNRIPFARSNKEYANASNQDMLTAAIDGLVARYGLQGEELGQVVAGA
CCCCCCEEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLKHSRDFNLTRETVLGSALSSTTPAFDLQMACGTGLAALVQVADAIALGRVESGIGGGV
HHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
DTTSDAPLAVNDQLRKTLIKLNNAKTTTDRLKLVGQIRPSQLAPEQPNNGEPRTGLSMGD
CCCCCCCEEECHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
HAAITAREFGLTREEQDQLAAESHQKLAKAYDEGFFEDLITPYLGVQRDTNLRPDSNVEK
CCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LAKLKPVFGKKDAEQHGTKATMTAGNSTPLTDGASAVLISSEEWAAEHNIPVKAYLVDSE
HHHHCCCCCCCCHHHCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHCCCCEEEEEECCC
VASVDFINGRDGMTPDGLLMSPTYAVARLLKRNNLSLQDFDFYEIHEAFASQTCATLKAW
CCEEEEECCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
ESDEYCRERLGLDGALGAIDRAKLNVKGSSLAAGHPFAATGGRIIATAAKVLEENGGGRT
CCHHHHHHHCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCE
LVSICAAGGQGIVAIIER
EHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA