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The map label for this gene is ctpA1 [H]

Identifier: 68535710

GI number: 68535710

Start: 767315

End: 769435

Strand: Direct

Name: ctpA1 [H]

Synonym: jk0638

Alternate gene names: 68535710

Gene position: 767315-769435 (Clockwise)

Preceding gene: 68535709

Following gene: 68535711

Centisome position: 31.16

GC content: 66.38

Gene sequence:

>2121_bases
ATGACTGTAATAGATCTCGACATCACAGGCATGACCTGCGCCTCCTGCGCGAACCGCATCGAAAAGAAACTGAACAAGCA
GGAGGGCGTGACCGCCACCGTTAACTACGCCACCGAGAAGGCGCACATCGAAACGGGGGAGGGCGCGGCCGCCGACGCGG
ATTCCTACATCGCCATCGTGGAGAAGCTCGGCTACGGCGGTAGCGTGCCTAAGCCGGAGAAGCCCGCCGGCGACGACCCC
GCTGCCAAGGAGCTGCGCGGTCTGAAGCGCCGCCTGGTGGTCGCCATCGCGTTGGCCACCCCGGTGATCCTGCTGGCGAT
GATCCCGCCGCTGCAGTTCGACTACTGGCAATGGGTCAGCTTCGCCCTGGCCACCCCGGTGATCCTGTGGGCGGGTTGGC
CTTTTCACAAGGCCACGTGGGTGAACCTGAAGCATGGTGCGGCGACGATGGATACCCTCATCACCGTCGGCACCTCGGCG
GCCTTCCTGTGGTCGCTGTATGCCCTGTTCTTCGGCCATGCGGGCGATCCCGGCATGCGCCACGGCTGGTCCATCCTGAA
CCATGCGGGCGACCCGATGGGGGACATCTATTTTGAGGTCGCCGCGGGCGTAGTGACGTTCGTGCTGGCGGGACGGTACT
TCGAGAAGCGCTCCAAGCAGCGCGCCGGGGATGCCATCCGCGCGCTGACGGACATGGGTGCCAAGCAGGTCACCGTGCTG
CGGGATGGCGGGGAAACGTTGCTCCCTATCGAGCAGCTGCAGATCGGCGACCACTTCCTGGCTCGCCCGGGCGAGAAGAT
CGCCACGGACGGGCGCATCGTGGATGGCCTGTCCGCGATTGACCAGTCGATGCTCACCGGTGAGTCCGTGCCCGTCGACG
TCGGCCCTGGCGATGAGGTCACGGGTGCCACCATCAACACCTCCGGCCGCCTGGTCGTGGAGGCCACTCGCGTGGGTGAG
CAGACGAAGCTCGCGCAGATGGCGAAGCTGATCGACGAGGCTCAGTCCGGAAAGGCCGACGTGCAGCGCCTGGCCGACAA
GGTCTCCGGCATTTTCGTTCCTGTCGTCATCGCGATCGCGCTGGTCACGCTGCTGTTCGCGGGCTTTAGCAATGCGGTCG
CGGTGCTGATCATCGCGTGCCCCTGCGCTCTTGGTCTAGCGACGCCCACAGCCCTGCTTGTCGGCACGGGTCGCGGGGCC
GAGCAGGGCATTCTGATCCGCGGCCCCGAGGTTTTGGAGGGCGCGCACGCCATCACCACCGTTGTGATGGATAAGACCGG
CACGGTGACCACGGGCACCATGCGGGTGGTCGACGTGGCCCCGACAGGCGCCGCCCGCGAGGAGGTCCTGCGCGCCGCTG
CGGCAGTGGAGGCGTACTCCGAGCACCCCATCGGCCGGGCCATTGCCGAGGCCGGCCGGGAGGAGTTCGGCAGCCTGCCG
GAGGTCTCCGGCTTTAGGAACCTGCCTGGACACGGCGTGGAGGGAACCGTCGACGGCCAGGTGATACGGGTTGGTCGAGG
GGACGAGGGGGCGTCCACAAATAAGGCAACCACAGTCAGCGTGAGCGCGGATGGGCGGGCGATCGGCACCATCAGCGTGG
CCGATACGGTGCGGTCCACCAGTGCCGAAGCGGTGCGGAAGATGCACGAGATGGGGCTGAAGACCGTGCTGCTGACCGGT
GATAATCAGCAGGTGGCGGACGCCGTGGCGCGCGAGGTTGGCATCGATGAGGTGATCGCCGGGGTGATGCCGGAGGACAA
GGTGGCGCACATCCGCTCGCTGGAGAACGTGGCGATGGTCGGCGACGGCGTGAATGATGCAGCGGCGCTGGCGAGCGCGG
ACCTGGGCATCGCGATGGGGTCGGGCACGGACGCGGCGATTGAGGCGGCGGACATTACCGTGATGCGCGATGACCTGCTG
GCGGTGGCGGATGCGCTGCGGCTGGCGCGCAAGACGCTACGGACGATCAAGATGAACCTGTTCTGGGCGTTTGCCTACAA
CGTGGCGGCGATCCCGCTGGCCGCATTCGGGCTGCTGAACCCGATGTTGGCCGGGGCGGCGATGGCGCTATCCAGCGTGT
TTGTGGTGAGCAACAGCCTGCGGTTGAAAGGATTCAAATAA

Upstream 100 bases:

>100_bases
CCCGGCCACGGTGACACCACCACGGTGGGCGCTGAGGCTGCGCGCATCGAGGAGTACATCGAACGTGGATACTGATACCC
CCTAGGGGTATACTGGGGGC

Downstream 100 bases:

>100_bases
TGCACGGTTACTTGAGCGACAAGGAGCGCTACCTGGCGCGGCTGAAGCGGATCGAAGGTCAGGTGCGCGGGCTGCAGCGG
ATGGTGGATGAGGAGCAGTA

Product: putative cation-transporting P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MTVIDLDITGMTCASCANRIEKKLNKQEGVTATVNYATEKAHIETGEGAAADADSYIAIVEKLGYGGSVPKPEKPAGDDP
AAKELRGLKRRLVVAIALATPVILLAMIPPLQFDYWQWVSFALATPVILWAGWPFHKATWVNLKHGAATMDTLITVGTSA
AFLWSLYALFFGHAGDPGMRHGWSILNHAGDPMGDIYFEVAAGVVTFVLAGRYFEKRSKQRAGDAIRALTDMGAKQVTVL
RDGGETLLPIEQLQIGDHFLARPGEKIATDGRIVDGLSAIDQSMLTGESVPVDVGPGDEVTGATINTSGRLVVEATRVGE
QTKLAQMAKLIDEAQSGKADVQRLADKVSGIFVPVVIAIALVTLLFAGFSNAVAVLIIACPCALGLATPTALLVGTGRGA
EQGILIRGPEVLEGAHAITTVVMDKTGTVTTGTMRVVDVAPTGAAREEVLRAAAAVEAYSEHPIGRAIAEAGREEFGSLP
EVSGFRNLPGHGVEGTVDGQVIRVGRGDEGASTNKATTVSVSADGRAIGTISVADTVRSTSAEAVRKMHEMGLKTVLLTG
DNQQVADAVAREVGIDEVIAGVMPEDKVAHIRSLENVAMVGDGVNDAAALASADLGIAMGSGTDAAIEAADITVMRDDLL
AVADALRLARKTLRTIKMNLFWAFAYNVAAIPLAAFGLLNPMLAGAAMALSSVFVVSNSLRLKGFK

Sequences:

>Translated_706_residues
MTVIDLDITGMTCASCANRIEKKLNKQEGVTATVNYATEKAHIETGEGAAADADSYIAIVEKLGYGGSVPKPEKPAGDDP
AAKELRGLKRRLVVAIALATPVILLAMIPPLQFDYWQWVSFALATPVILWAGWPFHKATWVNLKHGAATMDTLITVGTSA
AFLWSLYALFFGHAGDPGMRHGWSILNHAGDPMGDIYFEVAAGVVTFVLAGRYFEKRSKQRAGDAIRALTDMGAKQVTVL
RDGGETLLPIEQLQIGDHFLARPGEKIATDGRIVDGLSAIDQSMLTGESVPVDVGPGDEVTGATINTSGRLVVEATRVGE
QTKLAQMAKLIDEAQSGKADVQRLADKVSGIFVPVVIAIALVTLLFAGFSNAVAVLIIACPCALGLATPTALLVGTGRGA
EQGILIRGPEVLEGAHAITTVVMDKTGTVTTGTMRVVDVAPTGAAREEVLRAAAAVEAYSEHPIGRAIAEAGREEFGSLP
EVSGFRNLPGHGVEGTVDGQVIRVGRGDEGASTNKATTVSVSADGRAIGTISVADTVRSTSAEAVRKMHEMGLKTVLLTG
DNQQVADAVAREVGIDEVIAGVMPEDKVAHIRSLENVAMVGDGVNDAAALASADLGIAMGSGTDAAIEAADITVMRDDLL
AVADALRLARKTLRTIKMNLFWAFAYNVAAIPLAAFGLLNPMLAGAAMALSSVFVVSNSLRLKGFK
>Mature_705_residues
TVIDLDITGMTCASCANRIEKKLNKQEGVTATVNYATEKAHIETGEGAAADADSYIAIVEKLGYGGSVPKPEKPAGDDPA
AKELRGLKRRLVVAIALATPVILLAMIPPLQFDYWQWVSFALATPVILWAGWPFHKATWVNLKHGAATMDTLITVGTSAA
FLWSLYALFFGHAGDPGMRHGWSILNHAGDPMGDIYFEVAAGVVTFVLAGRYFEKRSKQRAGDAIRALTDMGAKQVTVLR
DGGETLLPIEQLQIGDHFLARPGEKIATDGRIVDGLSAIDQSMLTGESVPVDVGPGDEVTGATINTSGRLVVEATRVGEQ
TKLAQMAKLIDEAQSGKADVQRLADKVSGIFVPVVIAIALVTLLFAGFSNAVAVLIIACPCALGLATPTALLVGTGRGAE
QGILIRGPEVLEGAHAITTVVMDKTGTVTTGTMRVVDVAPTGAAREEVLRAAAAVEAYSEHPIGRAIAEAGREEFGSLPE
VSGFRNLPGHGVEGTVDGQVIRVGRGDEGASTNKATTVSVSADGRAIGTISVADTVRSTSAEAVRKMHEMGLKTVLLTGD
NQQVADAVAREVGIDEVIAGVMPEDKVAHIRSLENVAMVGDGVNDAAALASADLGIAMGSGTDAAIEAADITVMRDDLLA
VADALRLARKTLRTIKMNLFWAFAYNVAAIPLAAFGLLNPMLAGAAMALSSVFVVSNSLRLKGFK

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=798, Percent_Identity=34.3358395989975, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI115529486, Length=834, Percent_Identity=30.2158273381295, Blast_Score=337, Evalue=3e-92,
Organism=Homo sapiens, GI55743073, Length=544, Percent_Identity=36.2132352941176, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI118498343, Length=191, Percent_Identity=30.8900523560209, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI48762685, Length=193, Percent_Identity=30.0518134715026, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI48762689, Length=193, Percent_Identity=30.0518134715026, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI48762691, Length=193, Percent_Identity=30.0518134715026, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI48762687, Length=193, Percent_Identity=30.0518134715026, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786691, Length=750, Percent_Identity=38.2666666666667, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1789879, Length=725, Percent_Identity=30.6206896551724, Blast_Score=265, Evalue=1e-71,
Organism=Escherichia coli, GI1786914, Length=454, Percent_Identity=29.9559471365639, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI2367363, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=807, Percent_Identity=33.3333333333333, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71997275, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997262, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566766, Length=302, Percent_Identity=24.5033112582781, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557770, Length=302, Percent_Identity=24.5033112582781, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17541776, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17557486, Length=256, Percent_Identity=25.78125, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997269, Length=256, Percent_Identity=27.734375, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=705, Percent_Identity=34.7517730496454, Blast_Score=353, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6319772, Length=662, Percent_Identity=26.8882175226586, Blast_Score=246, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6321430, Length=543, Percent_Identity=25.414364640884, Blast_Score=120, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6325221, Length=544, Percent_Identity=24.2647058823529, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320244, Length=213, Percent_Identity=30.9859154929577, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320243, Length=213, Percent_Identity=30.9859154929577, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321271, Length=194, Percent_Identity=30.4123711340206, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320245, Length=213, Percent_Identity=30.5164319248826, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321432, Length=182, Percent_Identity=31.3186813186813, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221329854, Length=580, Percent_Identity=31.551724137931, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24668708, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161085803, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668704, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366617, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668696, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 73831; Mature: 73700

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIDLDITGMTCASCANRIEKKLNKQEGVTATVNYATEKAHIETGEGAAADADSYIAIV
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCCCCHHHHHHH
EKLGYGGSVPKPEKPAGDDPAAKELRGLKRRLVVAIALATPVILLAMIPPLQFDYWQWVS
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FALATPVILWAGWPFHKATWVNLKHGAATMDTLITVGTSAAFLWSLYALFFGHAGDPGMR
HHHHHHHHEECCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHH
HGWSILNHAGDPMGDIYFEVAAGVVTFVLAGRYFEKRSKQRAGDAIRALTDMGAKQVTVL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RDGGETLLPIEQLQIGDHFLARPGEKIATDGRIVDGLSAIDQSMLTGESVPVDVGPGDEV
ECCCCCCCCHHHHHCCCHHHHCCCCHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCC
TGATINTSGRLVVEATRVGEQTKLAQMAKLIDEAQSGKADVQRLADKVSGIFVPVVIAIA
CCCEECCCCEEEEEEHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
LVTLLFAGFSNAVAVLIIACPCALGLATPTALLVGTGRGAEQGILIRGPEVLEGAHAITT
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECHHHHCCHHHHEE
VVMDKTGTVTTGTMRVVDVAPTGAAREEVLRAAAAVEAYSEHPIGRAIAEAGREEFGSLP
EEECCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHCCCC
EVSGFRNLPGHGVEGTVDGQVIRVGRGDEGASTNKATTVSVSADGRAIGTISVADTVRST
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEEHHHHHHHH
SAEAVRKMHEMGLKTVLLTGDNQQVADAVAREVGIDEVIAGVMPEDKVAHIRSLENVAMV
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHEE
GDGVNDAAALASADLGIAMGSGTDAAIEAADITVMRDDLLAVADALRLARKTLRTIKMNL
CCCCCHHHHHHHCCCCEEECCCCCCEEEHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
FWAFAYNVAAIPLAAFGLLNPMLAGAAMALSSVFVVSNSLRLKGFK
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure 
TVIDLDITGMTCASCANRIEKKLNKQEGVTATVNYATEKAHIETGEGAAADADSYIAIV
EEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCCCCHHHHHHH
EKLGYGGSVPKPEKPAGDDPAAKELRGLKRRLVVAIALATPVILLAMIPPLQFDYWQWVS
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FALATPVILWAGWPFHKATWVNLKHGAATMDTLITVGTSAAFLWSLYALFFGHAGDPGMR
HHHHHHHHEECCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHH
HGWSILNHAGDPMGDIYFEVAAGVVTFVLAGRYFEKRSKQRAGDAIRALTDMGAKQVTVL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RDGGETLLPIEQLQIGDHFLARPGEKIATDGRIVDGLSAIDQSMLTGESVPVDVGPGDEV
ECCCCCCCCHHHHHCCCHHHHCCCCHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCC
TGATINTSGRLVVEATRVGEQTKLAQMAKLIDEAQSGKADVQRLADKVSGIFVPVVIAIA
CCCEECCCCEEEEEEHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
LVTLLFAGFSNAVAVLIIACPCALGLATPTALLVGTGRGAEQGILIRGPEVLEGAHAITT
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECHHHHCCHHHHEE
VVMDKTGTVTTGTMRVVDVAPTGAAREEVLRAAAAVEAYSEHPIGRAIAEAGREEFGSLP
EEECCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHCCCC
EVSGFRNLPGHGVEGTVDGQVIRVGRGDEGASTNKATTVSVSADGRAIGTISVADTVRST
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEEHHHHHHHH
SAEAVRKMHEMGLKTVLLTGDNQQVADAVAREVGIDEVIAGVMPEDKVAHIRSLENVAMV
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHEE
GDGVNDAAALASADLGIAMGSGTDAAIEAADITVMRDDLLAVADALRLARKTLRTIKMNL
CCCCCHHHHHHHCCCCEEECCCCCCEEEHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
FWAFAYNVAAIPLAAFGLLNPMLAGAAMALSSVFVVSNSLRLKGFK
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA