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The map label for this gene is adhC [C]

Identifier: 68535708

GI number: 68535708

Start: 765505

End: 766605

Strand: Direct

Name: adhC [C]

Synonym: jk0636

Alternate gene names: 68535708

Gene position: 765505-766605 (Clockwise)

Preceding gene: 68535706

Following gene: 68535709

Centisome position: 31.09

GC content: 63.03

Gene sequence:

>1101_bases
ATGACTACCACTGTGAAGGCTGTAATTTCCCGAGCGAAGAACGAACCCGTCGAGCTGACCGACATCGTGATCCCCGAACC
GGGCGAAAACGACGTGATCGTCCGCATCCAGGCCTGCGGCGTATGCCACACCGACCTTGCCTACCGCGATGGCGGCATTG
CGGACAACTACCCGTTCCTGCTGGGCCACGAGGCCGCGGGTGTGGTCGAGCAGGTGGGCGACCGCGTGACCCACGTGGAG
GTCGGCGACTATGTGGTGCTGAACTGGCGTGCCGTGTGTGGCCAGTGCCGCGCCTGCAAGAAGGGCGAGCCGAAATACTG
CTTCGATACCCACAATGCCTCGAAGAAGATGACCCTCACCGACGGCACGGAGCTGGAAGCCGCCCTGGGCATTGGCGCTT
TCGCTGAAAAGACGCTGGTCCACGAAGGACAGTGCACCAAGGTGGACTCCGAGGCCGACCCTGCGGTCGCGGGTCTGCTG
GGATGTGGCGTCATGGCCGGTCTCGGCGCCGCAGTGAACACCGGTGAGGTCAAGCGCGGCGAGTCCATCGCCGTCATCGG
AGTAGGTGGCGTGGGCATGGCCGCGATTGCCGGTGCGGCCGTTGCGGGTGCGACGAAGATCATTGCTATCGATATTTCTG
ACGCCAAGCTTGCCCGCGCAAAGGAAGAATTCGGTGCTACCCACACGATCAATAGCTCGGGGCTTTCGGACGACGAGCTG
GTGGAGAAGGTCCAGGAGATCAACGGTGGATTCGGCGTGGACGTGGCTGTGGACGCCGTGGGGGTACCGCAGACGTACAA
GCAGGCCTTCTATGTGCGCGACCTGGCGGGCCGCGTGGTGCTGGTGGGCGTGCCGACCCCGGATATGACCCTGGAGCTGC
CATTCCTGGACGTGTTCAGCCACGGTGGTGCGCTGAAGTCCTCTTGGTACGGCGACTGCCTGCCGGAGCGCGACTTCCCG
ATGTACGTGGACCTGTACCAGGAGGGCCGCTTCCCGCTGGATCGCTTCGTGGACGATCGCATCAGTATCGATGGCGTGGA
AGATGCCTTCGAGAAGATGAAGCAGGGCAAGGTTCTGCGCTCCGTGGTGGAGTTCAAGTAA

Upstream 100 bases:

>100_bases
CTACGCGAAGCCTCCGACTGCGCAGAACAGGGTGCTGTGCCCGGCACCAACTGGTGCAGGCTGGTTGCCGCCTTTCCGAA
CCGCCCGTACAGTGGGTGAC

Downstream 100 bases:

>100_bases
GCAAGCGCGAGAGATAGAAGTCCGAGAGATACAAGAGGAAGCATGAGCAAGCAGAGGTTGGAAAACCCGCAGATCGAGCA
GTTCGAGACCTCCGGCAAAT

Product: putative Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTTTVKAVISRAKNEPVELTDIVIPEPGENDVIVRIQACGVCHTDLAYRDGGIADNYPFLLGHEAAGVVEQVGDRVTHVE
VGDYVVLNWRAVCGQCRACKKGEPKYCFDTHNASKKMTLTDGTELEAALGIGAFAEKTLVHEGQCTKVDSEADPAVAGLL
GCGVMAGLGAAVNTGEVKRGESIAVIGVGGVGMAAIAGAAVAGATKIIAIDISDAKLARAKEEFGATHTINSSGLSDDEL
VEKVQEINGGFGVDVAVDAVGVPQTYKQAFYVRDLAGRVVLVGVPTPDMTLELPFLDVFSHGGALKSSWYGDCLPERDFP
MYVDLYQEGRFPLDRFVDDRISIDGVEDAFEKMKQGKVLRSVVEFK

Sequences:

>Translated_366_residues
MTTTVKAVISRAKNEPVELTDIVIPEPGENDVIVRIQACGVCHTDLAYRDGGIADNYPFLLGHEAAGVVEQVGDRVTHVE
VGDYVVLNWRAVCGQCRACKKGEPKYCFDTHNASKKMTLTDGTELEAALGIGAFAEKTLVHEGQCTKVDSEADPAVAGLL
GCGVMAGLGAAVNTGEVKRGESIAVIGVGGVGMAAIAGAAVAGATKIIAIDISDAKLARAKEEFGATHTINSSGLSDDEL
VEKVQEINGGFGVDVAVDAVGVPQTYKQAFYVRDLAGRVVLVGVPTPDMTLELPFLDVFSHGGALKSSWYGDCLPERDFP
MYVDLYQEGRFPLDRFVDDRISIDGVEDAFEKMKQGKVLRSVVEFK
>Mature_365_residues
TTTVKAVISRAKNEPVELTDIVIPEPGENDVIVRIQACGVCHTDLAYRDGGIADNYPFLLGHEAAGVVEQVGDRVTHVEV
GDYVVLNWRAVCGQCRACKKGEPKYCFDTHNASKKMTLTDGTELEAALGIGAFAEKTLVHEGQCTKVDSEADPAVAGLLG
CGVMAGLGAAVNTGEVKRGESIAVIGVGGVGMAAIAGAAVAGATKIIAIDISDAKLARAKEEFGATHTINSSGLSDDELV
EKVQEINGGFGVDVAVDAVGVPQTYKQAFYVRDLAGRVVLVGVPTPDMTLELPFLDVFSHGGALKSSWYGDCLPERDFPM
YVDLYQEGRFPLDRFVDDRISIDGVEDAFEKMKQGKVLRSVVEFK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=32.7913279132791, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=30.8943089430894, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=32.2493224932249, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=33.4231805929919, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI71565152, Length=376, Percent_Identity=31.6489361702128, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=30.3523035230352, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=30.3523035230352, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI156523966, Length=381, Percent_Identity=29.9212598425197, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4501939, Length=375, Percent_Identity=30.1333333333333, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI156627571, Length=369, Percent_Identity=26.5582655826558, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=33.1536388140162, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1790045, Length=371, Percent_Identity=25.3369272237197, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788073, Length=354, Percent_Identity=25.7062146892655, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87081918, Length=361, Percent_Identity=28.808864265928, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788407, Length=355, Percent_Identity=28.169014084507, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082125, Length=377, Percent_Identity=26.790450928382, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787863, Length=357, Percent_Identity=24.3697478991597, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=23.5127478753541, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786518, Length=359, Percent_Identity=29.2479108635098, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786825, Length=256, Percent_Identity=28.90625, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=348, Percent_Identity=23.8505747126437, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790718, Length=327, Percent_Identity=25.6880733944954, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=377, Percent_Identity=32.6259946949602, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71997431, Length=379, Percent_Identity=32.4538258575198, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=33.5276967930029, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17562876, Length=357, Percent_Identity=24.9299719887955, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=366, Percent_Identity=24.0437158469945, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=370, Percent_Identity=27.2972972972973, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=373, Percent_Identity=24.9329758713137, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=31.7204301075269, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6322619, Length=260, Percent_Identity=34.2307692307692, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=260, Percent_Identity=34.2307692307692, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=376, Percent_Identity=27.6595744680851, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=360, Percent_Identity=26.1111111111111, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=372, Percent_Identity=27.9569892473118, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=309, Percent_Identity=26.537216828479, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=371, Percent_Identity=26.9541778975741, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=31.4666666666667, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17137530, Length=368, Percent_Identity=25.2717391304348, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737897, Length=364, Percent_Identity=25.5494505494505, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221457811, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45550770, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45551930, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 38885; Mature: 38753

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTVKAVISRAKNEPVELTDIVIPEPGENDVIVRIQACGVCHTDLAYRDGGIADNYPFL
CCCHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCEE
LGHEAAGVVEQVGDRVTHVEVGDYVVLNWRAVCGQCRACKKGEPKYCFDTHNASKKMTLT
ECCHHHHHHHHHCCCEEEEEECCEEEEEHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEC
DGTELEAALGIGAFAEKTLVHEGQCTKVDSEADPAVAGLLGCGVMAGLGAAVNTGEVKRG
CCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
ESIAVIGVGGVGMAAIAGAAVAGATKIIAIDISDAKLARAKEEFGATHTINSSGLSDDEL
CEEEEEEECCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCEEEECCCCCCHHHH
VEKVQEINGGFGVDVAVDAVGVPQTYKQAFYVRDLAGRVVLVGVPTPDMTLELPFLDVFS
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHEECCCCEEEEEECCCCCEEECCHHHHHC
HGGALKSSWYGDCLPERDFPMYVDLYQEGRFPLDRFVDDRISIDGVEDAFEKMKQGKVLR
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SVVEFK
HHHHCC
>Mature Secondary Structure 
TTTVKAVISRAKNEPVELTDIVIPEPGENDVIVRIQACGVCHTDLAYRDGGIADNYPFL
CCHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCEE
LGHEAAGVVEQVGDRVTHVEVGDYVVLNWRAVCGQCRACKKGEPKYCFDTHNASKKMTLT
ECCHHHHHHHHHCCCEEEEEECCEEEEEHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEC
DGTELEAALGIGAFAEKTLVHEGQCTKVDSEADPAVAGLLGCGVMAGLGAAVNTGEVKRG
CCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
ESIAVIGVGGVGMAAIAGAAVAGATKIIAIDISDAKLARAKEEFGATHTINSSGLSDDEL
CEEEEEEECCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCEEEECCCCCCHHHH
VEKVQEINGGFGVDVAVDAVGVPQTYKQAFYVRDLAGRVVLVGVPTPDMTLELPFLDVFS
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHEECCCCEEEEEECCCCCEEECCHHHHHC
HGGALKSSWYGDCLPERDFPMYVDLYQEGRFPLDRFVDDRISIDGVEDAFEKMKQGKVLR
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SVVEFK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]