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The map label for this gene is envZ [H]

Identifier: 66767105

GI number: 66767105

Start: 925326

End: 926822

Strand: Reverse

Name: envZ [H]

Synonym: XC_0769

Alternate gene names: 66767105

Gene position: 926822-925326 (Counterclockwise)

Preceding gene: 66767106

Following gene: 66767102

Centisome position: 18.0

GC content: 71.21

Gene sequence:

>1497_bases
GTGAGTGAACCGGCACGCCGCGGGCTGTCGATCTTTGCCCGCACCTTCGTCCTGCTGGCGGTGGCCCTGGTCACCGCACA
GGCGGTCGGCATCGCCCTGCTGGTGATGCGCACCCCCGTCTATGAGCCGCCGGTGCATCCGCCGGAGGTCGTGGCCCTGC
TGTCCACCCGCATGCCGGCCGGCACCCAGACGCTCAAGGTGCACGAGGCCCGCCAGGCGCCCACGCCACCGCCTGGCCAG
GTCCGCGACGGCTTCGCCGAAATGCTTCTGGCGCATTGGCTGGATGTGGACAGCGCGCGCGTGCGCTTCTATCGCAGTGC
CGATGACGGCGAGGCGCCACGGCTCCTGCCGAGCGAGGGCACATCGAACCGGACATCGGCCCAGACCAGCGCGGCTAGCG
CGGGCAGCGAGCAACTCCCAGCCGGGGCACCGCCATTCGGCAAGGACTGGCCACGCCCCAGCCCCGAGGGCGCGCCCTTC
GGCAACGGGCTGCGACCTGACGACCCGCGCGGTGATTGGGAAAGCGAACGCCTGACCCCGGGCGTGCCGCTGCTGGACGG
CTTCACCGCCGCGCTGCAACAGCCCGACGGCCGCTGGCGCACCGTGGAATCGCCGCGGCGTCGCCTCTCGGCCGAGTTCA
AGACCCACGTGGTGCTGCTGTTCCTGGCCGGCCTGCTGGCCAACGTGCCGCTGGCGTGGTGGTTCTCGCGTGCGCTGTCG
GCGCCGATCAAGCGCTTTGCCGAAGCCGCCGACCGCCTGGGCCGCAATCCCGACGCGGCGGCCCTGCAACGTAGCGGCCC
GCCGGAGATCGTGCGCGCGGCCGATTCGTTCAACGCCATGCAGGCACGCCTGAACCGGCTGATCAACGAGCGCACCCACA
TGGTGGCGGCGATCGCGCACGACCTGCGCACCCCGCTGGCGCGGCTGTCGTTCCGCCTGGACGACCTGCAAGCGCCGCTG
CGCGACAAGGCGCTGGCTGACATCGACGAGATGAAGGCGATGATTTCTGCGGCGCTGGATTTCATCCAGAACGACCGCCA
TCGCGGCGAGCGCGCCCCGCTGGACCTGCGCCTGCTGGTGGAGAGCGTGGTCGACAATACGGTGGACACCGGCGCCGATG
CCGAACTGCTGCCAGGCCCGGCGATCACCCTGGACGGCGACCCGCTGGCGTTGCGGCGCGCGGTGATGAATCTGCTGGAA
AACGCGCTGAAATACGGCCGGCGCGCGCGCCTGCGGCTGCATCGCGAAGGCGAGGACGGCGTGCTGTGGATCGACGACGA
CGGCCCGGGCATCGACCCCAGCCAGCGTGAACAACTGCTGCTGCCGTTCGTGCGCGGCGAATCCTCGCGCAACCGCGACA
CCGGCGGAATCGGGCTGGGGCTGTCGGTGGCGCACAGCATCGTGCTGGCGCATGGCGGCGCACTGCGGCTGGACAATCGC
GACGGTGGCGGGCTGCGGGTGACCGTGCGCCTGCCGTGCATGCCGGAACGGCGCTGA

Upstream 100 bases:

>100_bases
TCAGCCGGCTGCGCCGCAAGATCAACGAACGCGTGCACACCGAGCTGATTCGCACCGTGCGCAACGAGGGCTACATGCTG
CTGCCGAGCGTCGCGCGTCT

Downstream 100 bases:

>100_bases
CGGTGACGCAGGCAGGCCTGCGCCGCACGGCTCACTGACTCAGTACGCGAACTCGCGGAACACCGGGTCGATATCACCCT
TCCAGGCACCGTGATACAGC

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSEPARRGLSIFARTFVLLAVALVTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHEARQAPTPPPGQ
VRDGFAEMLLAHWLDVDSARVRFYRSADDGEAPRLLPSEGTSNRTSAQTSAASAGSEQLPAGAPPFGKDWPRPSPEGAPF
GNGLRPDDPRGDWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSAEFKTHVVLLFLAGLLANVPLAWWFSRALS
APIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLDDLQAPL
RDKALADIDEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNTVDTGADAELLPGPAITLDGDPLALRRAVMNLLE
NALKYGRRARLRLHREGEDGVLWIDDDGPGIDPSQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGALRLDNR
DGGGLRVTVRLPCMPERR

Sequences:

>Translated_498_residues
MSEPARRGLSIFARTFVLLAVALVTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHEARQAPTPPPGQ
VRDGFAEMLLAHWLDVDSARVRFYRSADDGEAPRLLPSEGTSNRTSAQTSAASAGSEQLPAGAPPFGKDWPRPSPEGAPF
GNGLRPDDPRGDWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSAEFKTHVVLLFLAGLLANVPLAWWFSRALS
APIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLDDLQAPL
RDKALADIDEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNTVDTGADAELLPGPAITLDGDPLALRRAVMNLLE
NALKYGRRARLRLHREGEDGVLWIDDDGPGIDPSQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGALRLDNR
DGGGLRVTVRLPCMPERR
>Mature_497_residues
SEPARRGLSIFARTFVLLAVALVTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHEARQAPTPPPGQV
RDGFAEMLLAHWLDVDSARVRFYRSADDGEAPRLLPSEGTSNRTSAQTSAASAGSEQLPAGAPPFGKDWPRPSPEGAPFG
NGLRPDDPRGDWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSAEFKTHVVLLFLAGLLANVPLAWWFSRALSA
PIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLDDLQAPLR
DKALADIDEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNTVDTGADAELLPGPAITLDGDPLALRRAVMNLLEN
ALKYGRRARLRLHREGEDGVLWIDDDGPGIDPSQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGALRLDNRD
GGGLRVTVRLPCMPERR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=284, Percent_Identity=33.4507042253521, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787894, Length=259, Percent_Identity=34.7490347490347, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790346, Length=293, Percent_Identity=29.6928327645051, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=28.9377289377289, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790551, Length=247, Percent_Identity=31.9838056680162, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=311, Percent_Identity=27.6527331189711, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=31.5068493150685, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=25.390625, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=26.7241379310345, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=310, Percent_Identity=25.1612903225806, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=111, Percent_Identity=35.1351351351351, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=26.0089686098655, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54269; Mature: 54137

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPARRGLSIFARTFVLLAVALVTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
GTQTLKVHEARQAPTPPPGQVRDGFAEMLLAHWLDVDSARVRFYRSADDGEAPRLLPSEG
CCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCC
TSNRTSAQTSAASAGSEQLPAGAPPFGKDWPRPSPEGAPFGNGLRPDDPRGDWESERLTP
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GVPLLDGFTAALQQPDGRWRTVESPRRRLSAEFKTHVVLLFLAGLLANVPLAWWFSRALS
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
APIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAH
HHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRTPLARLSFRLDDLQAPLRDKALADIDEMKAMISAALDFIQNDRHRGERAPLDLRLLV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
ESVVDNTVDTGADAELLPGPAITLDGDPLALRRAVMNLLENALKYGRRARLRLHREGEDG
HHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
VLWIDDDGPGIDPSQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGALRLDNR
EEEECCCCCCCCHHCHHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCC
DGGGLRVTVRLPCMPERR
CCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
SEPARRGLSIFARTFVLLAVALVTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
GTQTLKVHEARQAPTPPPGQVRDGFAEMLLAHWLDVDSARVRFYRSADDGEAPRLLPSEG
CCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCC
TSNRTSAQTSAASAGSEQLPAGAPPFGKDWPRPSPEGAPFGNGLRPDDPRGDWESERLTP
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GVPLLDGFTAALQQPDGRWRTVESPRRRLSAEFKTHVVLLFLAGLLANVPLAWWFSRALS
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
APIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAH
HHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRTPLARLSFRLDDLQAPLRDKALADIDEMKAMISAALDFIQNDRHRGERAPLDLRLLV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
ESVVDNTVDTGADAELLPGPAITLDGDPLALRRAVMNLLENALKYGRRARLRLHREGEDG
HHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
VLWIDDDGPGIDPSQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGALRLDNR
EEEECCCCCCCCHHCHHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCC
DGGGLRVTVRLPCMPERR
CCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]